Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

J. Tatlock · SciRah

Researcher profile · Semantic Scholar

J. Tatlock

Share profile

J. Tatlock — researcher profile on SciRah

h-index: 18
Works: 45
Citations: 1,553

Most-cited papers

Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.
S. Kaldor, V. Kalish, J. Davies, Bhasker V. Shetty +16 more
1997Journal of Medicinal Chemistry538 citations Open access
Semantic Scholar
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
D. Barsyte-Lovejoy, Feng-Ling Li, M. Oudhoff, J. Tatlock +29 more
2014Proceedings of the National Academy of Sciences of the United States of America171 citations Open access
Semantic Scholar
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.
M. Oudhoff, Mitchell Braam, S. Freeman, Denise Wong +15 more
2016Developmental Cell112 citations Open access
Semantic Scholar
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
Hui Li, J. Tatlock, A. Linton, Javier Gonzalez +15 more
2009Journal of Medicinal Chemistry110 citations Open access
Semantic Scholar
Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase
Stephanie T. Shi, K. J. Herlihy, J. Graham, J. Nonomiya +10 more
2009Antimicrobial Agents and Chemotherapy74 citations Open access
Semantic Scholar
SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance
K. Jensen-Pergakes, J. Tatlock, K. Maegley, Indrawan J. McAlpine +30 more
2021Molecular Cancer Therapeutics57 citations
Semantic Scholar
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
Pei-Pei Kung, E. Rui, S. Bergqvist, Patrick Bingham +34 more
2016Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.
Hui Li, J. Tatlock, A. Linton, Javier Gonzalez +14 more
2006Bioorganic & Medicinal Chemistry Letters51 citations Open access
Semantic Scholar
Structure-based design of novel, urea-containing FKBP12 inhibitors.
P. Dragovich, John E. Barker, J. French, Michael Imbacuan +12 more
1996Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyri
L. Zehnder, M. Bennett, J. Meng, Buwen Huang +22 more
2011Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling.
Patrick J. Metz, Keith A. Ching, Tao Xie, Paulina Delgado Cuenca +4 more
2020Cell Reports38 citations Open access
Semantic Scholar
Structure-based design of novel calcineurin (PP2B) inhibitors
J. Tatlock, M. A. Linton, Xinjun Hou, C. Kissinger +4 more
199737 citations
Semantic Scholar
Allosteric inhibitors of hepatitis C polymerase: discovery of potent and orally bioavailable carbon-linked dihydropyrones.
Hui Li, A. Linton, J. Tatlock, Javier Gonzalez +14 more
2007Journal of Medicinal Chemistry29 citations
Semantic Scholar
Crystal-structure-based design and synthesis of novel C-terminal inhibitors of HIV protease.
M. Varney, K. Appelt, V. Kalish, M. R. Reddy +5 more
1994Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers
Luping Qiu, Kymberly K. Levine, K. Gajiwala, C. N. Cronin +7 more
2018PLoS ONE23 citations Open access
Semantic Scholar
SAH derived potent and selective EZH2 inhibitors.
Pei-Pei Kung, Buwen Huang, L. Zehnder, J. Tatlock +6 more
2015Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Oxidation of Alkynyl Ethers with Potassium Permanganate. A New Acyl Anion Equivalent for the Preparation of .alpha.-Keto Esters
J. Tatlock
199521 citations
Semantic Scholar
Structure-based drug design of nonpeptidic P2 substituents for HIV-1 protease inhibitors
V. Kalish, J. Tatlock, J. Davies, S. Kaldor +7 more
199520 citations
Semantic Scholar
Selective, small molecule co-factor binding site inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax (SET) domain containing lysine methyltransferase.
Alexandria P. Taylor, M. Szewczyk, Steven M. Kennedy, V. Trush +17 more
2019Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Design and Synthesis of Pyridone-Containing 3 , 4-Dihydroisoquinoline-1 ( 2 H ) ‐ ones as a Novel Class of Enhancer of Zeste Homolog 2 ( EZH 2 ) Inhibitors
Pei-Pei Kung, E. Rui, S. Bergqvist, Patrick Bingham +34 more
201612 citations
Semantic Scholar
DESIGN, SYNTHESIS AND X-RAY CRYSTALLOGRAPHIC STUDIES OF 7.3.1 AND 8.3.1 MACROCYCLIC FKBP-12 LIGANDS
R. Babine, T. Bleckman, E. S. Littlefield, H. Parge +8 more
19969 citations
Semantic Scholar
Review article: HCV ? STAT-C era of therapy
C. Lange, Chris Sarrazin, S. Zeuzem, M. Fried +496 more
20108 citations
Semantic Scholar
High-affinity FKBP-12 ligands derived from (R)-(−)-carvone. Synthesis and evaluation of FK506 pyranose ring replacements
J. Tatlock, V. Kalish, H. Parge, D. Knighton +4 more
19958 citations
Semantic Scholar
All PARP inhibitors are not equal: An in vitro mechanistic comparison of PF-01367338 to iniparib.
K. Maegley, Patrick Bingham, J. Tatlock, Huw D. Thomas
2011Journal of Clinical Oncology7 citations
Semantic Scholar
ITERATIVE PROTEIN STRUCTURE-BASED DRUG DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS
V. Kalish, S. Kaldor, B. Shetty, J. Tatlock +9 more
1995European Journal of Medicinal Chemistry6 citations
Semantic Scholar
Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
Pei-Pei Kung, E. Rui, S. Bergqvist, Patrick Bingham +34 more
2016Journal of Medicinal Chemistry5 citations Open access
Semantic Scholar
High‐Affinity FKBP‐12 Ligands Derived from (R)‐(‐)‐Carvone. Synthesis and Evaluation of FK506 Pyranose Ring Replacements.
J. Tatlock, V. Kalish, H. Parge, D. Knighton +4 more
19965 citations
Semantic Scholar
Abstract 4857: Discovery of PF-06855800, a SAM competitive PRMT5 inhibitor with potent antitumor activity
Indrawan J. McAlpine, J. Tatlock, J. Billitti, J. Braganza +18 more
2018Experimental and Molecular Therapeutics3 citations
Semantic Scholar
Reductive Condensation between β-KetoEsters and Aldehydes: Preparation of Novel Carbon-Linked DihydropyroneInhibitors of Hepatitis C Virus Polymerase
M. A. Linton, Javier Gonzalez, Hui Li, J. Tatlock +6 more
20102 citations
Semantic Scholar
SETD 7 controls intestinal regeneration and tumorigenesis by 1 regulating Wnt / β-Catenin and Hippo / YAP signaling 2 3
M. Oudhoff, Mitchell Braam, S. Freeman, Denise Wong +15 more
20161 citations
Semantic Scholar
Design, Synthesis and X‐Ray Crystallographic Studies of (7.3.1) and (8. 3.1) Macrocyclic FKBP‐12 Ligands.
R. Babine, T. Bleckman, E. S. Littlefield, H. Parge +8 more
19961 citations
Semantic Scholar
Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497
Hong Zeng, A. Dong, Ashley Hutchinson, A. Seitova +10 more
20180 citations
Semantic Scholar
X-ray diffraction data for the crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497 (6CBX)
Hong Zeng, A. Dong, Ashley Hutchinson, A. Seitova +10 more
20180 citations
Semantic Scholar
SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine
A. Dong, Hong Wu, H. Zeng, Hee-won Park +10 more
20130 citations
Semantic Scholar
SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine
J. Walker, H. Ouyang, A. Dong, P. Fish +11 more
20120 citations
Semantic Scholar
Inhibitors of RNA-dependent RNA polymerase of hepatitis C virus and compositions and treatments involving the use of these
Javier Gonzalez, T. Jewell, Hui Li, A. Linton +1 more
20050 citations
Semantic Scholar
Inhibitors of RNA-dependent RNA polymerase of hepatitis C virus, and compositions and treatments in which they are used.
Hui Li, J. Tatlock, Javier Gonzalez, M. Goble
20040 citations
Semantic Scholar
Compounds, compositions and methods for stimulation of neuronal growth and extension
S. Katoh, H. Kawakami, H. Tada, M. A. Linton +3 more
19990 citations
Semantic Scholar
Design, synthesis and evaluation of novel 6-arylsulfonylamino-3-chlorobenzo thiophene-2-carboxyamides Potent, lipophilic inhibitors of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase
J. Tatlock, M. A. Linton, B. Condon, J. F. Ii. Davies +9 more
19990 citations
Semantic Scholar
Structure‐Based Design of Novel Calcineurin (PP2B) Inhibitors.
J. Tatlock, M. A. Linton, Xinjun Hou, C. Kissinger +4 more
19970 citations
Semantic Scholar
Oxidation of Alkynyl Ethers with Potassium Permanganate. A New Acyl Anion Equivalent for the Preparation of α‐Keto Esters.
J. Tatlock
19960 citations
Semantic Scholar
Structure-based design of calcineurin inhibitors
C. Kissinger, H. Parge, D. Knighton, L. Pelletier +3 more
19960 citations Open access
Semantic Scholar
Structure-Based Drug Design of Nonpeptidic P2 Substituents for HIV-1 Protease Inhibitors.
V. Kalish, J. Tatlock, J. Davies, S. Kaldor +7 more
19950 citations
Semantic Scholar
Crystal Structure Based Design and Synthesis of Novel C-Terminal Inhibitors of HIV Protease.
M. Varney, K. Appelt, V. Kalish, M. R. Reddy +5 more
19940 citations
Semantic Scholar
Synthesis of α-Substituted 1,2-Benzenedimethanamines.
Robert E. Johnson, J. T. Hane, D. Schlegel, R. Perni +7 more
19920 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

V. Kalish×10
Invite
V. Kalish — researcher profile on SciRah
C. Lewis×9
Invite
C. Lewis — researcher profile on SciRah
P. Brown×8
Invite
P. Brown — researcher profile on SciRah
H. Parge×8
Invite
H. Parge — researcher profile on SciRah

×8

Invite

K. Maegley — researcher profile on SciRah

J. Villafranca×8

Invite

J. Villafranca — researcher profile on SciRah

Invite

Hui Li — researcher profile on SciRah

Javier Gonzalez×7

Invite

Javier Gonzalez — researcher profile on SciRah

Invite

R. Kumpf — researcher profile on SciRah

Invite

M. Wythes — researcher profile on SciRah

R. Showalter×7

Invite

R. Showalter — researcher profile on SciRah

Invite

K. Appelt — researcher profile on SciRah