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G. Rena · SciRah

Researcher profile · Semantic Scholar

G. Rena

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G. Rena — researcher profile on SciRah

h-index: 23
Works: 57
Citations: 6,977

Most-cited papers

The mechanisms of action of metformin
G. Rena, D. G. Hardie, E. Pearson
2017Diabetologia2,107 citations Open access
Semantic Scholar
Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B*
G. Rena, Shao-Dong Guo, Stephen C. Cichy, T. Unterman +1 more
1999Journal of Biological Chemistry785 citations Open access
Semantic Scholar
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
Amy R. Cameron, V. Morrison, Daniel Levin, M. Mohan +12 more
2016Circulation Research617 citations Open access
Semantic Scholar
Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence*
Shao-Dong Guo, G. Rena, S. Cichy, Xiao-Wei He +2 more
1999Journal of Biological Chemistry571 citations Open access
Semantic Scholar
Molecular mechanism of action of metformin: old or new insights?
G. Rena, E. Pearson, K. Sakamoto
2013Diabetologia470 citations Open access
Semantic Scholar
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
Yvonne L. Woods, G. Rena, N. Morrice, A. Barthel +4 more
2001Biochemical Journal270 citations Open access
Semantic Scholar
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.
G. Rena, Alan R. Prescott, Shaodong Guo, Philip Cohen +1 more
2001Biochemical Journal265 citations Open access
Semantic Scholar
D4476, a cell‐permeant inhibitor of CK1, suppresses the site‐specific phosphorylation and nuclear exclusion of FOXO1a
G. Rena, Jenny Bain, M. Elliott, P. Cohen
2004EMBO Reports263 citations Open access
Semantic Scholar
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion
G. Rena, Yvonne L. Woods, Alan R. Prescott, M. Peggie +3 more
2002EMBO Journal252 citations Open access
Semantic Scholar
Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association–European Society of Cardiology
C. Maack, M. Lehrke, J. Backs, F. Heinzel +31 more
2018European Heart Journal215 citations Open access
Semantic Scholar
Metformin selectively targets redox control of complex I energy transduction
Amy R. Cameron, L. Logie, Kashyap A. Patel, S. Erhardt +14 more
2017Redox Biology137 citations Open access
Semantic Scholar
Repurposing Metformin for Cardiovascular Disease.
G. Rena, C. Lang
2018Circulation119 citations Open access
Semantic Scholar
Cellular Responses to the Metal-Binding Properties of Metformin
L. Logie, J. Harthill, Kashyap A. Patel, S. Bacon +9 more
2012Diabetes118 citations Open access
Semantic Scholar
Membrane Localization of Cyclic Nucleotide Phosphodiesterase 3 (PDE3)
Y. Shakur, Kazuyo Takeda, Yael Kenan, Zu-Xi Yu +6 more
2000Journal of Biological Chemistry115 citations Open access
Semantic Scholar
Epigallocatechin gallate (EGCG) mimics insulin action on the transcription factor FOXO1a and elicits cellular responses in the presence and absence of insulin.
Siobhan Anton, Laura Melville, G. Rena
2007Cellular Signalling69 citations
Semantic Scholar
Black tea polyphenols mimic insulin/insulin‐like growth factor‐1 signalling to the longevity factor FOXO1a
Amy R. Cameron, Siobhan Anton, Laura Melville, N. Houston +4 more
2008Aging Cell66 citations
Semantic Scholar
Left Ventricular Hypertrophy in Diabetic Cardiomyopathy: A Target for Intervention
M. Mohan, A. Dihoum, I. Mordi, A. Choy +2 more
2021Frontiers in Cardiovascular Medicine63 citations Open access
Semantic Scholar
Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRL1 and AFX.
Yvonne L. Woods, G. Rena
2001Biochemical Society Transactions56 citations
Semantic Scholar
Biomolecular mode of action of metformin in relation to its copper binding properties.
Peter Repiscak, S. Erhardt, G. Rena, M. Paterson
2014Biochemistry55 citations
Semantic Scholar
Insulin Regulation of Insulin-like Growth Factor-binding Protein-1 Gene Expression Is Dependent on the Mammalian Target of Rapamycin, but Independent of Ribosomal S6 Kinase Activity*
Satish Patel, P. Lochhead, G. Rena, S. Fumagalli +4 more
2002Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Inflammation as a therapeutic target in heart failure with preserved ejection fraction
Zhen Hui Peh, A. Dihoum, Dana Hutton, J. S. Arthur +4 more
2023Frontiers in Cardiovascular Medicine36 citations Open access
Semantic Scholar
AMPK integrates metabolite and kinase-based immunometabolic control in macrophages
Iain R. Phair, Raid B. Nisr, Andrew J. M. Howden, Magdalena Sovakova +5 more
2022Molecular Metabolism29 citations Open access
Semantic Scholar
Metformin: evidence from preclinical and clinical studies for potential novel applications in cardiovascular disease
A. Dihoum, G. Rena, E. Pearson, C. Lang +1 more
2023Expert Opinion on Investigational Drugs24 citations Open access
Semantic Scholar
The copper binding properties of metformin--QCM-D, XPS and nanobead agglomeration.
Xueling Quan, Rokon Uddin, Arto Heiskanen, Mattias Parmvi +5 more
2015Chemical Communications23 citations Open access
Semantic Scholar
Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes.
Amy R. Cameron, Siji Anil, E. Sutherland, J. Harthill +1 more
2010Metallomics22 citations
Semantic Scholar
Salicylic acid: old and new implications for the treatment of type 2 diabetes?
G. Rena, K. Sakamoto
2014Diabetology International21 citations Open access
Semantic Scholar
D 4476 , a cell-permeant inhibitor of CK 1 , suppresses the site-specific phosphorylationandnuclear exclusion of FOXO 1 a
G. Rena, Jenny Bain, M. Elliott, P. Cohen
201321 citations
Semantic Scholar
Molecular action and pharmacogenetics of metformin: current understanding of an old drug
G. Rena, E. Pearson, K. Sakamoto
201221 citations
Semantic Scholar
Metformin: still the sweet spot for CV protection in diabetes?
G. Rena, I. Mordi, C. Lang
2020Current opinion in pharmacology (Print)16 citations Open access
Semantic Scholar
Editorial: Metformin: Beyond Diabetes
F. Bost, G. Rena, B. Viollet
2019Frontiers in Endocrinology16 citations Open access
Semantic Scholar
Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression.
Satish Patel, P. Lochhead, G. Rena, C. Sutherland
2001Biochemical Journal16 citations Open access
Semantic Scholar
Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1)
L. Logie, Z. Lees, J. Allwood, G. McDougall +2 more
2018Diabetes, obesity and metabolism15 citations Open access
Semantic Scholar
New Evidence for the Mechanism of Action of a Type-2 Diabetes Drug Using a Magnetic Bead-Based Automated Biosensing Platform
Rokon Uddin, Nur-E.-Habiba, G. Rena, E. Hwu +1 more
2017ACS Sensors11 citations Open access
Semantic Scholar
Amino acid homeostasis is a target of metformin therapy
C. Forteath, I. Mordi, Raid B. Nisr, Erika J. Gutiérrez-Lara +16 more
2023Molecular Metabolism10 citations Open access
Semantic Scholar
Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug
Amy R. Cameron, L. Logie, Kashyap A. Patel, S. Bacon +10 more
2016Biochimica et Biophysica Acta10 citations Open access
Semantic Scholar
The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a.
Amy R. Cameron, K. Wallace, L. Logie, A. Prescott +3 more
2012Biochemical Journal9 citations
Semantic Scholar
Factors affecting resting heart rate in free-living healthy humans
Jason Alexander, Magdalena Sovakova, G. Rena
2022Digital Health8 citations Open access
Semantic Scholar
Upregulation of cAMP-specific PDE-4 activity following ligation of the TCR complex on thymocytes is blocked by selective inhibitors of protein kinase C and tyrosyl kinases
A. Michie, G. Rena, M. Harnett, M. Houslay
1998Cell Biochemistry and Biophysics5 citations
Semantic Scholar
Anti-inflammatory effects of metformin and their relationship to the therapeutic action of the drug
Amy R. Cameron, C. Forteath, C. Beall, G. Rena
20154 citations
Semantic Scholar
Comparison of effects of biguanide and diguanidine antihyperglycaemic drugs on cell signalling responses
S. Bacon, J. Harthill, J. Coates, D. Stewart +2 more
20124 citations
Semantic Scholar
Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland.
T. Cacciottolo, A. Perikari, A. V. D. Van Der. Klaauw, E. Henning +107 more
2019QJM : monthly journal of the Association of Physicians2 citations Open access
Semantic Scholar
In a cohort of individuals with type 2 diabetes using the drug sulfasalazine, HbA1c lowering is associated with haematological changes
Samira M S N'Dow, L. Donnelly, E. Pearson, G. Rena
2020Diabetic Medicine1 citations Open access
Semantic Scholar
P13 Anti-inflammatory effects of metformin – useful in cardiovascular disease?
AR Cameron, M. Mohan, C. Forteath, A. McNeilly +5 more
2016Poster Presentation Abstracts1 citations Open access
Semantic Scholar
キナーゼDYRK1Aは転写因子FKHRをin vivoの新しいりん酸化部位であるSer 329 をin vitroりん酸化する | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
L. WoodsY, G. Rena, Nick Morrice, A. Barthel +4 more
20011 citations
Semantic Scholar
Corrigendum to "Metformin: Still the sweet spot for CV protection in diabetes?" [Curr Opin Pharmacol 54 (2020) 202-208].
G. Rena, I. Mordi, C. Lang
2021Current opinion in pharmacology (Print)0 citations Open access
Semantic Scholar
University of Dundee Metformin and its Potential for Heart Failure with Preserved Ejection Fraction
M. Mohan, Zaid Iskandar, I. Mordi, Casserene Yeow +5 more
20190 citations
Semantic Scholar
metformin and its potential for heart failure with preserved ejection fraction
M. Mohan, Zaid Iskandar, I. Mordi, Casserene Yeow +4 more
20190 citations
Semantic Scholar
University of Dundee The mechanisms of action of metformin
G. Rena, D. Hardie, E. Pearson
20170 citations
Semantic Scholar
Investigation of metal-binding properties of clinically significant compounds using magnetic bead-based agglutination assay
Rokon Uddin, E. Hwu, G. Rena, A. Boisen
20160 citations
Semantic Scholar
Randomized Placebo-Controlled Study : Metformin Exposure and Cytokine Levels in Nondiabetic Heart Failure Patients
Amy R. Cameron, V. Morrison, Daniel Levin, M. Mohan +12 more
20160 citations
Semantic Scholar

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