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G. Coombs · SciRah

Researcher profile · Semantic Scholar

G. Coombs

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G. Coombs — researcher profile on SciRah

h-index: 78
Works: 398
Citations: 26K

Most-cited papers

Guidelines for the use and interpretation of assays for monitoring autophagy
D. Klionsky, F. C. Abdalla, H. Abeliovich, Robert T. Abraham +496 more
20124,979 citations Open access
Semantic Scholar
Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652
D. Klionsky, K. Abdelmohsen, A. Abe, M. Abedin +496 more
20161,544 citations Open access
Semantic Scholar
Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis
J. Carlton, R. Hirt, Joana C. Silva, A. Delcher +61 more
2007Science814 citations Open access
Semantic Scholar
Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.
Tim Downing, H. Imamura, Saskia Decuypere, T. Clark +16 more
2011Genome Research433 citations Open access
Semantic Scholar
from in the Gut
K. McLuskey, J. Grewal, D. Das, A. Godzik +6 more
2016327 citations
Semantic Scholar
Endosome Sorting and Autophagy Are Essential for Differentiation and Virulence of Leishmania major*
Sébastien Besteiro, R. Williams, L. Morrison, G. Coombs +1 more
2006Journal of Biological Chemistry228 citations Open access
Semantic Scholar
Metabolism of Leishmania: proven and predicted.
F. Opperdoes, G. Coombs
2007Trends in Parasitology199 citations
Semantic Scholar
Autophagy in protists
M. Duszenko, M. Ginger, Ana E. Brennand, Melisa Gualdrón-López +14 more
2011Autophagy171 citations Open access
Semantic Scholar
Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana
Roderick A. M. Williams, L. Tetley, J. Mottram, G. Coombs
2006Molecular Microbiology164 citations Open access
Semantic Scholar
Cell death in parasitic protozoa: regulated or incidental?
William R. Proto, G. Coombs, J. Mottram
2012Nature Reviews Microbiology163 citations
Semantic Scholar
Protein turnover and differentiation in Leishmania
Sébastien Besteiro, Roderick A. M. Williams, G. Coombs, J. Mottram
2007International Journal of Parasitology149 citations Open access
Semantic Scholar
An essential role for the Leishmania major metacaspase in cell cycle progression
A. Ambit, Nicolas J. Fasel, G. Coombs, J. Mottram
2008Cell Death and Differentiation120 citations
Semantic Scholar
Metabolomics to Unveil and Understand Phenotypic Diversity between Pathogen Populations
R. T'kindt, Richard A. Scheltema, A. Jankevics, K. Brunker +6 more
2010PLoS Neglected Tropical Diseases106 citations Open access
Semantic Scholar
Characterisation of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major
R. Williams, Kerry Woods, L. Juliano, J. Mottram +1 more
2009Autophagy103 citations Open access
Semantic Scholar
Morphological Events during the Cell Cycle of Leishmania major
A. Ambit, Kerry Woods, B. Cull, G. Coombs +1 more
2011Eukaryotic Cell97 citations Open access
Semantic Scholar
Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation
A. Tomlins, F. Ben-Rached, Roderick A. M. Williams, William R. Proto +7 more
2013Autophagy96 citations Open access
Semantic Scholar
Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background
Saskia Decuypere, M. Vanaerschot, K. Brunker, H. Imamura +5 more
2012PLoS Neglected Tropical Diseases96 citations Open access
Semantic Scholar
Metacaspase 2 of Trypanosoma brucei is a calcium‐dependent cysteine peptidase active without processing
C. Moss, Gareth D. Westrop, L. Juliano, G. Coombs +1 more
2007FEBS Letters96 citations Open access
Semantic Scholar
ATG5 Is Essential for ATG8-Dependent Autophagy and Mitochondrial Homeostasis in Leishmania major
R. Williams, Terry K. Smith, B. Cull, J. Mottram +1 more
2012PLoS Pathogens88 citations Open access
Semantic Scholar
Evaluation of mobile phase characteristics on three zwitterionic columns in hydrophilic interaction liquid chromatography mode for liquid chromatography-high resolution mass spectrometry based untargeted metabolite profiling of Leishmania parasites.
Rong Zhang, D. Watson, Lijie Wang, Gareth D. Westrop +2 more
2014Journal of Chromatography A86 citations Open access
Semantic Scholar
Crystal structure of a Trypanosoma brucei metacaspase
K. McLuskey, J. Rudolf, William R. Proto, N. Isaacs +3 more
2012Proceedings of the National Academy of Sciences of the United States of America84 citations Open access
Semantic Scholar
Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry.
Liang Zheng, Ruben T'Kind, Saskia Decuypere, Simona John von Freyend +2 more
2010Rapid Communications in Mass Spectrometry79 citations
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Trypanosoma brucei Metacaspase 4 Is a Pseudopeptidase and a Virulence Factor
William R. Proto, E. Castanys-Muñoz, Alana Black, L. Tetley +4 more
2011Journal of Biological Chemistry73 citations Open access
Semantic Scholar
Two pathways for cysteine biosynthesis in Leishmania major.
R. Williams, Gareth D. Westrop, G. Coombs
2009Biochemical Journal73 citations Open access
Semantic Scholar
In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization
C. Shaw, J. Lonchamp, Tim Downing, H. Imamura +10 more
2016Molecular Microbiology72 citations Open access
Semantic Scholar
Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis
R. T'kindt, A. Jankevics, Richard A. Scheltema, Liang Zheng +5 more
2010Analytical and Bioanalytical Chemistry64 citations Open access
Semantic Scholar
The AP3 adaptor is involved in the transport of membrane proteins to acidocalcisomes of Leishmania
Sébastien Besteiro, D. Tonn, L. Tetley, G. Coombs +1 more
2008Journal of Cell Science64 citations
Semantic Scholar
Oligopeptidase B deficient mutants of Leishmania major
Jane C. Munday, K. McLuskey, E. Brown, G. Coombs +1 more
2010Molecular and biochemical parasitology (Print)57 citations Open access
Semantic Scholar
Influence of parasite encoded inhibitors of serine peptidases in early infection of macrophages with Leishmania major
S. Eschenlauer, Marilia S. Faria, L. Morrison, Nicolas Bland +5 more
2009Cellular Microbiology57 citations Open access
Semantic Scholar
Leishmania mexicana metacaspase is a negative regulator of amastigote proliferation in mammalian cells
E. Castanys-Muñoz, E. Brown, G. Coombs, J. Mottram
2012Cell Death and Disease56 citations Open access
Semantic Scholar
The potential of metabolomics for Leishmania research in the post-genomics era
Richard A. Scheltema, Saskia Decuypere, R. T'kindt, J. Dujardin +2 more
2010Parasitology55 citations Open access
Semantic Scholar
Phosphoenolpyruvate Carboxylase Identified as a Key Enzyme in Erythrocytic Plasmodium falciparum Carbon Metabolism
J. Storm, Sonal Sethia, G. Blackburn, Achuthanunni Chokkathukalam +4 more
2014PLoS Pathogens54 citations Open access
Semantic Scholar
Metabolomic Analyses of Leishmania Reveal Multiple Species Differences and Large Differences in Amino Acid Metabolism
Gareth D. Westrop, R. Williams, Lijie Wang, Tong Zhang +3 more
2015PLoS ONE53 citations Open access
Semantic Scholar
Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5
H. Denise, J. Poot, M. Jiménez, A. Ambit +4 more
2006BMC Molecular Biology53 citations Open access
Semantic Scholar
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
D. Klionsky, K. Abdelmohsen, A. Abe, J. Abedin +496 more
201650 citations Open access
Semantic Scholar
Identification of Semicarbazones, Thiosemicarbazones and Triazine Nitriles as Inhibitors of Leishmania mexicana Cysteine Protease CPB
J. Schröder, S. Noack, Richard J. Marhöfer, J. Mottram +2 more
2013PLoS ONE49 citations Open access
Semantic Scholar
Leishmania donovani: differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays.
Valerie Jean-Moreno, R. Rojas, Diego Goyeneche, G. Coombs +1 more
2006Experimental parasitology46 citations
Semantic Scholar
Glycosome turnover in Leishmania major is mediated by autophagy
B. Cull, Joseane Lima Prado Godinho, J. C. Fernandes Rodrigues, B. Frank +4 more
2014Autophagy45 citations Open access
Semantic Scholar
The Mercaptopyruvate Sulfurtransferase of Trichomonas vaginalis Links Cysteine Catabolism to the Production of Thioredoxin Persulfide
Gareth D. Westrop, I. Georg, G. Coombs
2009Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence
Camila C. Santos, G. Coombs, A. Lima, J. Mottram
2007Molecular Microbiology43 citations Open access
Semantic Scholar
Leishmania panamensis: comparative inhibition of nuclear DNA topoisomerase II enzymes from promastigotes and human macrophages reveals anti-parasite selectivity of fluoroquinolones, flavonoids and pentamidine.
T. Cortázar, G. Coombs, John E. Walker
2007Experimental parasitology43 citations
Semantic Scholar
The efficacy of aerosol treatment with non-ionic surfactant vesicles containing amphotericin B in rodent models of leishmaniasis and pulmonary aspergillosis infection.
Manal M. Alsaadi, J. Italia, A. Mullen, M. Ravi Kumar +13 more
2012Journal of Controlled Release42 citations
Semantic Scholar
Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation
P. Fyfe, Gareth D. Westrop, A. Silva, G. Coombs +1 more
2012Proceedings of the National Academy of Sciences of the United States of America42 citations Open access
Semantic Scholar
Molecular detection of Hematodinium spp. in Norway lobster Nephrops norvegicus and other crustaceans.
H. J. Small, Douglas M. Neil, A. C. Taylor, R. Atkinson +1 more
2006Diseases of Aquatic Organisms42 citations Open access
Semantic Scholar
Distinct Roles in Autophagy and Importance in Infectivity of the Two ATG4 Cysteine Peptidases of Leishmania major
R. Williams, J. Mottram, G. Coombs
2012Journal of Biological Chemistry34 citations Open access
Semantic Scholar
α-Ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB
Koen Steert, Maya Berg, J. Mottram, Gareth D. Westrop +7 more
2010ChemMedChem34 citations Open access
Semantic Scholar
The influence of defined ante-mortem stressors on the early post-mortem biochemical processes in the abdominal muscle of the Norway lobster, Nephrops norvegicus (Linnaeus, 1758)
Sebastian G. Gornik, A. Albalat, R. Atkinson, G. Coombs +1 more
201033 citations Open access
Semantic Scholar
Overexpression of the Natural Inhibitor of Cysteine Peptidases in Leishmania mexicana Leads to Reduced Virulence and a Th1 Response
K. Bryson, Sébastien Besteiro, H. Mcgachy, G. Coombs +2 more
2009Infection and Immunity31 citations Open access
Semantic Scholar
Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation
L. Morrison, A. Goundry, Marilia S. Faria, L. Tetley +7 more
2012Cellular Microbiology28 citations Open access
Semantic Scholar
Design and evaluation of Trypanosoma brucei metacaspase inhibitors
Maya Berg, P. Van der Veken, J. Joossens, V. Muthusamy +9 more
2010Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar

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