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A. Lima · SciRah

Researcher profile · Semantic Scholar

A. Lima

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A. Lima — researcher profile on SciRah

h-index: 25
Works: 53
Citations: 1,847

Most-cited papers

Host Cell Invasion by TRYPANOSOMA cRUZI Is Potentiated by Activation of Bradykinin B2 Receptors
J. Scharfstein, V. Schmitz, V. Morandi, M. Capella +4 more
2000Journal of Experimental Medicine226 citations Open access
Semantic Scholar
Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi.
A. Monteiro, M. Abrahamson, A. Lima, M. A. Vannier-Santos +1 more
2001Journal of Cell Science129 citations
Semantic Scholar
Toll-Like Receptors in Leishmania Infections: Guardians or Promoters?
Marilia S. Faria, F. C. G. Reis, A. Lima
2012Journal of Parasitology Research128 citations Open access
Semantic Scholar
A New Cruzipain-Mediated Pathway of Human Cell Invasion by Trypanosoma cruzi Requires Trypomastigote Membranes
Isabela M. Aparicio, J. Scharfstein, A. Lima
2004Infection and Immunity105 citations Open access
Semantic Scholar
Heparan Sulfate Modulates Kinin Release by Trypanosoma cruzi through the Activity of Cruzipain*
A. Lima, P. C. Almeida, I. Tersariol, V. Schmitz +6 more
2002Journal of Biological Chemistry92 citations Open access
Semantic Scholar
Cooperative Activation of TLR2 and Bradykinin B2 Receptor Is Required for Induction of Type 1 Immunity in a Mouse Model of Subcutaneous Infection by Trypanosoma cruzi1
A. Monteiro, V. Schmitz, Erik Svensjö, R. Gazzinelli +11 more
2006Journal of Immunology90 citations
Semantic Scholar
Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.
A. Lima, Flavia C. G. dos Reis, Carole Serveau, Gilles Lalmanach +6 more
2001Molecular and biochemical parasitology (Print)78 citations
Semantic Scholar
Crovirin, a Snake Venom Cysteine-Rich Secretory Protein (CRISP) with Promising Activity against Trypanosomes and Leishmania
C. M. Adade, A.L.O. Carvalho, M. A. Tomaz, T. F. R. Costa +6 more
2014PLoS Neglected Tropical Diseases69 citations Open access
Semantic Scholar
Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy
Daniele Andrade, R. Serra, Erik Svensjö, A. Lima +7 more
2012British Journal of Pharmacology59 citations Open access
Semantic Scholar
Influence of parasite encoded inhibitors of serine peptidases in early infection of macrophages with Leishmania major
S. Eschenlauer, Marilia S. Faria, L. Morrison, Nicolas Bland +5 more
2009Cellular Microbiology57 citations Open access
Semantic Scholar
Leishmania inhibitor of serine peptidase prevents TLR4 activation by neutrophil elastase promoting parasite survival in murine macrophages
Marilia S. Faria, F. C. G. Reis, R. L. Azevedo-Pereira, L. Morrison +2 more
2010Journal of Immunology53 citations Open access
Semantic Scholar
Analysis and partial epitope mapping of human T cell responses to Trypanosoma cruzi cysteinyl proteinase.
A. Arnholdt, M. Piuvezam, D. Russo, A. Lima +3 more
1993Journal of Immunology48 citations
Semantic Scholar
Cruzipain Promotes Trypanosoma cruzi Adhesion to Rhodnius prolixus Midgut
L. A. Uehara, Otacílio da Cruz Moreira, A. Oliveira, P. Azambuja +5 more
2012PLoS Neglected Tropical Diseases44 citations Open access
Semantic Scholar
Temperature-dependent substrate inhibition of the cysteine proteinase (GP57/51) from Trypanosoma cruzi.
A. Lima, J. Scharfstein, Andrew C. Storer, Robert Ménard
1992Molecular and biochemical parasitology (Print)44 citations
Semantic Scholar
Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence
Camila C. Santos, G. Coombs, A. Lima, J. Mottram
2007Molecular Microbiology43 citations Open access
Semantic Scholar
Cysteine peptidases of kinetoplastid parasites.
C. Caffrey, A. Lima, D. Steverding
2011Advances in Experimental Medicine and Biology37 citations
Semantic Scholar
Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion
P. M. Ferrão, C. M. d'Avila-Levy, T. Araujo-Jorge, W. Degrave +7 more
2015PLoS ONE34 citations Open access
Semantic Scholar
The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites
V. Santos, A. E. R. Oliveira, Augusto César Broilo Campos, J. Reis-Cunha +4 more
2021Scientific Reports33 citations Open access
Semantic Scholar
Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNFα and IFNβ
Marilia S. Faria, Tereza C. Calegari-Silva, Áislan de Carvalho Vivarini, J. Mottram +2 more
2014The FASEB Journal32 citations Open access
Semantic Scholar
Toll-like receptor-2 and interleukin-6 mediate cardiomyocyte protection from apoptosis during Trypanosoma cruzi murine infection
N. Ponce, R. Cano, E. A. Carrera Silva, A. Lima +2 more
2012Medical Microbiology and Immmunology32 citations Open access
Semantic Scholar
Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex.
Erik Svensjö, Paulo R. Batista, C. Brodskyn, R. Silva +7 more
2006Microbes and infection31 citations Open access
Semantic Scholar
Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation
L. Morrison, A. Goundry, Marilia S. Faria, L. Tetley +7 more
2012Cellular Microbiology28 citations Open access
Semantic Scholar
Detection of matrix metallopeptidase-9-like proteins in Trypanosoma cruzi.
A. C. Nogueira de Melo, E. De Souza, C. G. R. Elias, A. L. Souza dos Santos +8 more
2010Experimental parasitology28 citations Open access
Semantic Scholar
Adipose Tissue-Derived Mesenchymal Stromal Cells Protect Mice Infected with Trypanosoma cruzi from Cardiac Damage through Modulation of Anti-parasite Immunity
D. B. Mello, I. P. Ramos, F. Mesquita, G. Brasil +6 more
2015PLoS Neglected Tropical Diseases27 citations Open access
Semantic Scholar
Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by Trypanosoma cruzi.
J. Scharfstein, A. Lima
2008Sub-cellular biochemistry27 citations
Semantic Scholar
The propeptide of cruzipain − a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F
F. C. G. Reis, T. F. R. Costa, T. Sulea, A. Mezzetti +4 more
2007The FEBS Journal25 citations Open access
Semantic Scholar
Trypanosoma cruzi, the causative agent of Chagas disease, modulates interleukin-6-induced STAT3 phosphorylation via gp130 cleavage in different host cells.
N. Ponce, E. A. Carrera Silva, A. Pellegrini, S. I. Cazorla +4 more
2013Biochimica et Biophysica Acta24 citations Open access
Semantic Scholar
THE ROLE OF CONSERVED RESIDUES OF CHAGASIN IN THE INHIBITION OF CYSTEINE PEPTIDASES
Flavia C. G. dos Reis, Brian O. Smith, Camila C. Santos, F. Tatiana +4 more
2008FEBS Letters22 citations Open access
Semantic Scholar
Sorting of phosphoglucomutase to glycosomes in Trypanosoma cruzi is mediated by an internal domain.
Luciana L. Penha, C. Sant'Anna, L. Mendonça-Previato, N. Cunha-e-Silva +2 more
2009Glycobiology21 citations Open access
Semantic Scholar
Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease (Journal of Clinical Investigation (2006) 116, (2739-2747) DOI: 10.1172/JCI27798)
O. Nikolskaia, A. Lima, Yuri V. Kim, J. Lonsdale-Eccles +3 more
200821 citations Open access
Semantic Scholar
Substrate inhibition and allosteric regulation by heparan sulfate of Trypanosoma brucei cathepsin L.
T. F. R. Costa, Flavia C. G. dos Reis, A. Lima
2012Biochimica et Biophysica Acta19 citations Open access
Semantic Scholar
Tissue Specific Dual RNA-Seq Defines Host–Parasite Interplay in Murine Visceral Leishmaniasis Caused by Leishmania donovani and Leishmania infantum
S. Forrester, A. Goundry, Bruna T. Dias, Thyago Leal-Calvo +4 more
2022bioRxiv17 citations Open access
Semantic Scholar
Venom alkaloids against Chagas disease parasite: search for effective therapies
R. C. M. Costa Silva, E. Fox, Fabio M. Gomes, D. Feijó +11 more
2020Scientific Reports14 citations Open access
Semantic Scholar
Neutrophil elastase promotes Leishmania donovani infection via interferon-β
Bruna T. Dias, Karina Dias-Teixeira, J. Godinho, Marilia S. Faria +5 more
2019The FASEB Journal13 citations Open access
Semantic Scholar
Natural cysteine protease inhibitors in protozoa: Fifteen years of the chagasin family.
T. F. R. Costa, A. Lima
2016Biochimie13 citations
Semantic Scholar
Toll-Like Receptor- and Protein Kinase R-Induced Type I Interferon Sustains Infection of Leishmania donovani in Macrophages
Bruna T. Dias, A. Goundry, Á. C. Vivarini, T. F. R. Costa +3 more
2022Frontiers in Immunology12 citations Open access
Semantic Scholar
Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte-derived cells
A. Goundry, A. Romano, A. Lima, J. Mottram +1 more
2017The FASEB Journal12 citations Open access
Semantic Scholar
Cooperative Activation of TLR 2 and Bradykinin B 2 Receptor Is Required for Induction of Type 1 Immunity in a Mouse Model of Subcutaneous Infection by Trypanosoma cruzi 1
A. Monteiro, V. Schmitz, Erik Svensjö, R. Gazzinelli +11 more
200612 citations
Semantic Scholar
Trypanosomatid-Encoded Inhibitors of Peptidases: Unique Structural Features and Possible Roles as Virulence Factors
A. Lima, J. Mottram
201011 citations Open access
Semantic Scholar
Cysteine peptidase inhibitors in trypanosomatid parasites.
A. Lima, F. C. G. Reis, T. F. R. Costa
2013Current Medicinal Chemistry10 citations
Semantic Scholar
Cysteine Proteases in Differentiation of Embryonic Stem Cells into Neural Cells
Ricardo Luiz de Azevedo-Pereira, A. Lima, Deivid de Carvalho Rodrigues, E. Rondinelli +4 more
2011Stem Cells and Development8 citations
Semantic Scholar
Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi
T. Souto-Padrón, A. Lima, Rachel de Oliveira Ribeiro
2006Parasitology Research8 citations
Semantic Scholar
Toll-Like Receptor 3 (TLR3) Is Engaged in the Intracellular Survival of the Protozoan Parasite Leishmania (Leishmania) amazonensis
C. T. Rath, Á. C. Vivarini, J. V. dos Santos, J. M. Medina +6 more
2022Infection and Immunity6 citations Open access
Semantic Scholar
A promising pipeline of preclinical drug candidates for leishmaniasis and chronic Chagas' disease.
Manuel Saldivia, A. Lima, J. Mottram
2024Trends in Parasitology5 citations Open access
Semantic Scholar
Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host
D. Levy, A. Goundry, R. Laires, T. F. R. Costa +4 more
2021PLoS Neglected Tropical Diseases5 citations Open access
Semantic Scholar
Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response
T. F. R. Costa, A. Goundry, A. Morrot, D. Grab +2 more
2022International Journal of Molecular Sciences3 citations Open access
Semantic Scholar
Bone Marrow Granulocytes Downregulate IL-1β and TNF Production and the Microbicidal Activity of Inflammatory Macrophages.
Renata Novaes, T. F. R. Costa, A. Goundry, B. R. Verçoza +5 more
2022Biochemistry and cell biology = Biochimie et biologie cellulaire1 citations
Semantic Scholar
Tissue specific dual RNA-seq defines host-parasite interplay in 1 murine visceral leishmaniasis caused by Leishmania donovani and 2 Leishmania infantum 3 4
S. Forrester, A. Goundry, Bruna T. Dias, T. Leal +4 more
20221 citations
Semantic Scholar
Cathepsin G and neutrophil elastase control Leishmania infantum parasitism through TLRs-dependent induction of IFN-α and TNF-α
A. Goundry, Aislan C. Vivarini, Nathalia S. Rodrigues, U. Lopes +2 more
2026Communications Biology0 citations Open access
Semantic Scholar
The ecotin‐like peptidase inhibitor of Trypanosoma cruzi prevents TMPRSS2‐PAR2‐TLR4 crosstalk downmodulating infection and inflammation
T. F. R. Costa, C. M. Catta-Preta, A. Goundry, Danielle B. Carvalho +5 more
2024The FASEB Journal0 citations Open access
Semantic Scholar

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J. Mottram×16
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J. Scharfstein×14
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T. F. R. Costa×12
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A. Goundry×10
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Marilia S. Faria

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