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W. Guan · SciRah

Researcher profile · Semantic Scholar

W. Guan

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W. Guan — researcher profile on SciRah

h-index: 8
Works: 29
Citations: 326

Most-cited papers

Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity.
W. Shakespeare, Michael G. Yang, R. Bohacek, F. Cerasoli +22 more
2000Proceedings of the National Academy of Sciences of the United States of America124 citations Open access
Semantic Scholar
A Src SH2 selective binding compound inhibits osteoclast-mediated resorption.
S. Violette, William C. Shakespeare, C. Bartlett, W. Guan +6 more
2000Chemistry and Biology52 citations Open access
Semantic Scholar
Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption.
S. Violette, W. Guan, C. Bartlett, Jeremy Smith +18 more
2001Bone40 citations
Semantic Scholar
A new fluorescent quantitative polymerase chain reaction technique.
Sheng-Qi Wang, Xiao-Hong Wang, Suhong Chen, W. Guan
2002Analytical Biochemistry28 citations
Semantic Scholar
Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents.
C. Vu, G. Luke, N. Kawahata, W. Shakespeare +19 more
2003Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain.
Noriyuki Kawahata, Michael G. Yang, G. Luke, William C. Shakespeare +14 more
2001Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Preparation and property analysis of a hepatocyte targeting pH-sensitive liposome.
Si-yuan Wen, Xiao-Hong Wang, Li Lin, W. Guan +1 more
2004World Journal of Gastroenterology15 citations Open access
Semantic Scholar
A novel mechanism-based mammalian cell assay for the identification of SH2-domain-specific protein-protein inhibitors.
R. Rickles, P. Henry, W. Guan, Mihai Dumitru Azimioara +3 more
1998Chemistry and Biology10 citations Open access
Semantic Scholar
Effect of antisense oligonucleotides targeting telomerase catalytic subunit on tumor cell proliferationin vitro
Shengqi Wang, Li Lin, Zhong-Bin Chen, Ruxian Lin +3 more
20026 citations
Semantic Scholar
[The inhibitory effects of hepatocyte targeting pH-sensitive liposome mediated phosphorothioate antisense oligonucleotide on gene expression controlled by HCV 5'NCR].
X.-H. Wang, S.-Q. Wang, S.-Y. Wen, W. Guan +1 more
2001Sheng wu gong cheng xue bao = Chinese journal of biotechnology4 citations
Semantic Scholar
[Preparation and analysis of oligonucleotide microarray for expression detection of mouse cytokine-associated gene].
Jian Huang, Suhong Chen, Li Tong, W. Guan +4 more
2002Sheng wu gong cheng xue bao = Chinese journal of biotechnology3 citations
Semantic Scholar
Structure-based design of a novel, osteoclast-selective, nonpeptide Src SH2 inhibitor with in vivo anti-resorptive activity
W. Shakespeare, Michael G. Yang, R. Bohacek, F. Cerasoli +21 more
20002 citations
Semantic Scholar
Specific regulatory inhibition of transfected HepG(2) with HCV 5'NCR by antisense phosphorothioate oligodeoxynucleotides.
Shengqi Wang, Xin Wang, W. Guan, Ming-Hui Li
2000Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology1 citations
Semantic Scholar
Deformable U-shaped microelectrodes made of carbon-PDMS for blood coagulation test
W. Guan, Fei Ma, Yuan Luo, Chengwu Han +2 more
2025Sensors and Actuators B: Chemical0 citations
Semantic Scholar
[Fabrication and property analysis of an oligochips for detecting hepatitis B virus mutant resistant to Lamivudine].
Zhong-Bin Chen, Wei-Lin Gao, W. Guan, Sheng-Qi Wang
2003Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology0 citations
Semantic Scholar
[Preliminary study on HLA-B genotyping by oligonucleotide chips].
Ke Lan, Shou-Wang Hu, Fan Zhang, Hui Wang +4 more
2003Zhongguo shi yan xue ye xue za zhi0 citations
Semantic Scholar
Preparation and use method of oligonucleotide chip for HLA typing
Sheng-Qi Wang, Ke Lan, Shou-Wang Hu, Fan Zhang +4 more
20020 citations
Semantic Scholar
Nonpeptide inhibitors of the pp60c-src (Src) SH2 domain: Discovery of a novel phosphotyrosine mimetic
N. Kawahata, Michael G. Yang, G. Luke, W. Shakespeare +14 more
20020 citations
Semantic Scholar
Bone-targeted, nonpeptide inhibitors of the Src SH2 domain: Structure-based design and structure-activity relationships
R. Bohacek, M. Weigele, Virginia A. Jacobsen, Karina J. Macek +30 more
20020 citations
Semantic Scholar
[5'NCR Incipient establishment of HCV 5'NCR transgenic mice model].
Xiao-Hong Wang, Peng Guo, W. Guan, Yong Cheng +1 more
2002Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology0 citations
Semantic Scholar
HCV5′NCR转基因细胞HepG2.9706的特性分析
Xiao-Hong Wang, Shengqi Wang, W. Guan, B. Mao
20020 citations
Semantic Scholar
HCV 5‘NCR转基因小鼠模型的初步建立
Xiao-Hong Wang, Peng Guo, W. Guan, Yong Cheng +1 more
20020 citations
Semantic Scholar
[Inhibitory effects of phosphorothioate antisense oligonucleotides on gene expression controlled by HCV 5'NCR in nude mice xenograft].
Xiao-Lin Wang, Shengqi Wang, W. Guan, B. Mao
2001Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology0 citations
Semantic Scholar
硫代反义寡核苷酸对裸鼠异植瘤HCV 5′NCR基因表达的抑制作用
Xiao-Hong Wang, Shengqi Wang, W. Guan, B. Mao
20010 citations
Semantic Scholar
丙型肝炎病毒特异性核酶对HepG2.9706细胞HCV 5′NCR基因表达的抑制作用
Xiao-Hong Wang, Shengqi Wang, W. Guan, Li-Zhong Liu +1 more
20010 citations
Semantic Scholar
Construction and expression of liver-specific expression plasmid of luciferase controlled by HCV5^NCR region
Xiao-Hong Wang, Shengqi Wang, W. Guan, B. Mao
20000 citations
Semantic Scholar
Albumen and gene detecting plate and its preparing method and use
Sheng-Qi Wang, Xiao-Hong Wang, Zong-Liang Zou, W. Guan +1 more
19990 citations
Semantic Scholar
Oligonucleotides antisens inhibant l'activite de la telomerase et leurs applications
Sheng-Qi Wang, Xiaofei Zheng, Bao-Zhen Zhu, Rui-Yun Xing +2 more
19990 citations
Semantic Scholar
Structure of antisense oligonucleotide to inhibit activity of telomerase and its application
Sheng-Qi Wang, Xiao-Fei Zheng, Bao-Zhen Zhu, Rui-Yun Xing +2 more
19980 citations
Semantic Scholar

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