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R. Shaw · SciRah

Researcher profile · Semantic Scholar

R. Shaw

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R. Shaw — researcher profile on SciRah

h-index: 63
Works: 160
Citations: 47K

Most-cited papers

AMPK: guardian of metabolism and mitochondrial homeostasis
S. Herzig, R. Shaw
2017Nature reviews. Molecular cell biology3,751 citations Open access
Semantic Scholar
AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance
Daniel Garcia, R. Shaw
2017Molecules and Cells1,858 citations Open access
Semantic Scholar
AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
E. Q. Toyama, S. Herzig, J. Courchet, Tommy L. Lewis +7 more
2016Science1,019 citations Open access
Semantic Scholar
Small molecule inhibition of the autophagy kinase ULK1 and identification of ULK1 substrates
Daniel F. Egan, M. Chun, M. Vamos, Haixia Zou +11 more
2015Molecules and Cells667 citations Open access
Semantic Scholar
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin
D. Shackelford, Evan R. Abt, Laurie Gerken, Debbie S. Vasquez +7 more
2013Cancer Cell585 citations Open access
Semantic Scholar
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small cell lung cancer in preclinical models
R. Svensson, Seth J. Parker, L. Eichner, Matthew J. Kolar +16 more
2016Nature Medicine503 citations Open access
Semantic Scholar
AMPK: restoring metabolic homeostasis over space and time
Elijah Trefts, R. Shaw
2021Molecules and Cells413 citations Open access
Semantic Scholar
Autophagic cell death restricts chromosomal instability during replicative crisis
J. Nassour, R. Radford, A. Correia, Javier Miralles Fusté +4 more
2019Nature402 citations Open access
Semantic Scholar
mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc
Kenta Masui, Kazuhiro Tanaka, D. Akhavan, I. Babic +15 more
2013Cell Metabolism400 citations Open access
Semantic Scholar
Metformin inhibits hepatic mTORC1 signaling via dose-dependent mechanisms involving AMPK and the TSC complex
Jessica J. Howell, K. Hellberg, Marc Turner, G. Talbott +6 more
2017Cell Metabolism385 citations Open access
Semantic Scholar
Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity
Carsten Merkwirth, Virginija Jovaisaite, Jenni Durieux, O. Matilainen +11 more
2016Cell335 citations Open access
Semantic Scholar
Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD
Daniel Garcia, K. Hellberg, A. Chaix, M. Wallace +11 more
2019Cell Reports266 citations Open access
Semantic Scholar
Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α
B. Faubert, E. Vincent, Takla Griss, B. Samborska +7 more
2014Proceedings of the National Academy of Sciences of the United States of America259 citations Open access
Semantic Scholar
MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size
Tommy L. Jr Lewis, Seok-Kyu Kwon, Annie Lee, R. Shaw +1 more
2018Nature Communications256 citations Open access
Semantic Scholar
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer
L. Bar-Peled, Esther K. Kemper, R. Suciu, Ekaterina V. Vinogradova +16 more
2017Cell218 citations Open access
Semantic Scholar
Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1
Nazma Malik, Bibiana I. Ferreira, Pablo E. Hollstein, Stephanie D. Curtis +11 more
2023Science214 citations Open access
Semantic Scholar
Identification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large-scale substrate prediction
Bethany E. Schaffer, Rebecca S. Levin, Nicholas T. Hertz, T. Maures +7 more
2015Cell Metabolism175 citations Open access
Semantic Scholar
Genetic analysis reveals AMPK is required to support tumor growth in murine Kras-dependent lung cancer models
L. Eichner, Sonja N. Brun, S. Herzig, N. Young +9 more
2018Cell Metabolism173 citations Open access
Semantic Scholar
AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes
N. Young, A. Kamireddy, Jeanine L. Van Nostrand, L. Eichner +3 more
2016Genes & Development170 citations Open access
Semantic Scholar
AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy
Chien-Min Hung, P. S. Lombardo, Nazma Malik, Sonja N. Brun +7 more
2021Science Advances155 citations Open access
Semantic Scholar
Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a target in LKB1 Mutant Lung Cancer
Yan Liu, K. Marks, G. Cowley, J. Carretero +36 more
2013Cancer Discovery130 citations Open access
Semantic Scholar
The AMPK-related kinases SIK1 and SIK3 mediate key tumor suppressive effects of LKB1 in NSCLC.
Pablo E. Hollstein, L. Eichner, Sonja N. Brun, A. Kamireddy +11 more
2019Cancer Discovery128 citations Open access
Semantic Scholar
A novel AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential
Jonathan M. Goodwin, R. Svensson, H. Lou, M. Winslow +2 more
2014Molecules and Cells115 citations Open access
Semantic Scholar
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1
Tao Zhang, Dai-Chao Xu, Elijah Trefts, Ming-Ming Lv +36 more
2023Science110 citations Open access
Semantic Scholar
Transcriptional coregulators: fine-tuning metabolism
L. Mouchiroud, L. Eichner, R. Shaw, J. Auwerx
2014Cell Metabolism110 citations Open access
Semantic Scholar
Leptin-Mediated Increases in Catecholamine Signaling Reduce Adipose Tissue Inflammation via Activation of Macrophage HDAC4
B. Luan, M. Goodarzi, Naomi G Phillips, Xiu-Qing Guo +6 more
2014Cell Metabolism108 citations Open access
Semantic Scholar
Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy
Annie Lee, Chandana Kondapalli, D. Virga, Tommy L. Lewis +9 more
2022Nature Communications101 citations Open access
Semantic Scholar
Autophagy in Cancer: Regulation by Small Molecules
A. Limpert, L. J. Lambert, N. A. Bakas, N. Bata +3 more
2018TIPS - Trends in Pharmacological Sciences97 citations Open access
Semantic Scholar
AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation
Jeanine L. Van Nostrand, K. Hellberg, E. Luo, Eric L. Van Nostrand +6 more
2020Genes & Development91 citations Open access
Semantic Scholar
Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter
Danielle L. Schmitt, Stephanie D. Curtis, Anne Lyons, Jin-Fan Zhang +5 more
2022Nature Communications77 citations Open access
Semantic Scholar
Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice
Daniel B. McClatchy, Yuan-Hui Ma, Chao Liu, Benjamin D. Stein +5 more
2015Journal of Proteome Research77 citations Open access
Semantic Scholar
HDAC3 is critical in tumor development and therapeutic resistance in Kras-mutant non–small cell lung cancer
L. Eichner, Stephanie D. Curtis, Sonja N. Brun, Caroline K McGuire +6 more
2023Science Advances70 citations Open access
Semantic Scholar
The AMP-activated protein kinase ( AMPK ) signaling pathway coordinates cell growth , autophagy , & metabolism
M. Mihaylova, R. Shaw
201266 citations
Semantic Scholar
Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
Huiyu Ren, N. A. Bakas, M. Vamos, A. Chaikuad +10 more
2020Journal of Medicinal Chemistry61 citations Open access
Semantic Scholar
Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress
Ramya S. Kuna, Avi Kumar, Karl A. Wessendorf-Rodriguez, Hector M Galvez +6 more
2023bioRxiv58 citations Open access
Semantic Scholar
Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer
M. Pariollaud, Lara Ibrahim, E. Irizarry, Rebecca M. Mello +6 more
2022bioRxiv57 citations Open access
Semantic Scholar
Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling
Chenchu Lin, A. Blessing, T. Pulliam, Yan Shi +9 more
2020bioRxiv51 citations Open access
Semantic Scholar
LKB1 promotes metabolic flexibility in response to energy stress
Seth J. Parker, R. Svensson, Ajit S. Divakaruni, Austin E Y T Lefebvre +3 more
2016Metabolic Engineering51 citations Open access
Semantic Scholar
The AMPK Pathway: Molecular Rejuvenation of Metabolism and Mitochondria
Nazma Malik, R. Shaw
2025Annual Review of Cell and Developmental Biology48 citations Open access
Semantic Scholar
Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
Benjamin D. Stein, Diego Calzolari, K. Hellberg, Ying S. Hu +8 more
2019Cell Reports46 citations Open access
Semantic Scholar
The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non–small cell lung cancer
L. Rodón, R. Svensson, E. Wiater, M. Chun +4 more
2019Science Advances44 citations Open access
Semantic Scholar
EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth
Alexandra Kuhlmann-Hogan, Thekla Cordes, Zi-Yan Xu, Ramya S. Kuna +14 more
2024Cancer Discovery42 citations
Semantic Scholar
Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer.
R. Svensson, R. Shaw
2016Cold Spring Harbor Symposia on Quantitative Biology38 citations Open access
Semantic Scholar
LKB1-dependent regulation of TPI1 creates a divergent metabolic liability between human and mouse lung adenocarcinoma
Benjamin D. Stein, J. Ferrarone, E. E. Gardner, J. W. Chang +15 more
2023Cancer Discovery35 citations Open access
Semantic Scholar
PHD3 loss promotes exercise capacity and fat oxidation in skeletal muscle
H. Yoon, J. Spinelli, Elma Zaganjor, Samantha J. Wong +14 more
2020Cell Metabolism35 citations Open access
Semantic Scholar
Metformin trims fats to restore insulin sensitivity
R. Shaw
2013Nature Medicine34 citations
Semantic Scholar
Corrigendum: Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model
Yi-Feng Xia, Narayana Yeddula, Mathias Leblanc, Eugene Ke +4 more
2015Nature Cell Biology20 citations Open access
Semantic Scholar
Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in PolgD257A mice
Esther W. Lim, Michal K. Handzlik, Elijah Trefts, Jivani M. Gengatharan +3 more
2021Science Advances19 citations Open access
Semantic Scholar
Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy
Annie Lee, Chandana Kondapalli, D. Virga, Tommy L. Lewis +7 more
2019bioRxiv18 citations Open access
Semantic Scholar
AMPK Regulates the Epigenome through Phosphorylation of TET2.
Eleanor R. C. Fiedler, R. Shaw
2018Cell Metabolism18 citations Open access
Semantic Scholar

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