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J. Spinelli · SciRah

Researcher profile · Semantic Scholar

J. Spinelli

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J. Spinelli — researcher profile on SciRah

h-index: 21
Works: 39
Citations: 4,649

Most-cited papers

The Multifaceted Contributions of Mitochondria to Cellular Metabolism
J. Spinelli, M. Haigis
2018Nature Cell Biology1,641 citations Open access
Semantic Scholar
Accumulation of succinate controls activation of adipose tissue thermogenesis
E. Mills, K. Pierce, Mark P. Jedrychowski, Ryan Garrity +13 more
2018Nature489 citations Open access
Semantic Scholar
Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
J. Spinelli, H. Yoon, A. Ringel, Sarah Jeanfavre +2 more
2017Science412 citations Open access
Semantic Scholar
Mitochondrial biogenesis and proteome remodeling promotes one carbon metabolism for T cell activation
N. Ron-Harel, D. Santos, J. Ghergurovich, Peter T. Sage +10 more
2016Cell Metabolism395 citations Open access
Semantic Scholar
Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
S. McBrayer, Jared R. Mayers, G. Dinatale, Diana D. Shi +23 more
2018Cell319 citations Open access
Semantic Scholar
Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function
G. Notarangelo, J. Spinelli, Elizabeth M. Perez, G. Baker +20 more
2022Science250 citations Open access
Semantic Scholar
Fumarate is a terminal electron acceptor in the mammalian electron transport chain
J. Spinelli, Paul C. Rosen, Hans-Georg Sprenger, Anna M. Puszynska +10 more
2021Science197 citations Open access
Semantic Scholar
Adaptive Reprogramming of De Novo Pyrimidine Synthesis is a Metabolic Vulnerability in Triple-Negative Breast Cancer
Kristin K. Brown, J. Spinelli, J. Asara, A. Toker
2017Cancer Discovery171 citations Open access
Semantic Scholar
Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance
N. van Gastel, J. Spinelli, A. Sharda, A. Schajnovitz +13 more
2020Cell Metabolism121 citations Open access
Semantic Scholar
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
K. J. Condon, Jose M. Orozco, Charles H. Adelmann, J. Spinelli +4 more
2020Proceedings of the National Academy of Sciences of the United States of America112 citations Open access
Semantic Scholar
Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine
Andrew L. Cangelosi, Anna M. Puszynska, J. M. Roberts, Andrea Armani +10 more
2022Science64 citations Open access
Semantic Scholar
Selenium reduction of ubiquinone via SQOR suppresses ferroptosis
Namgyu Lee, Sung Jin Park, M. Lange, T. Tseyang +8 more
2023bioRxiv61 citations Open access
Semantic Scholar
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis
Grace Park, John A. Haley, Johnny Le, S. Jung +9 more
2023Nature Metabolism60 citations Open access
Semantic Scholar
SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis
Elma Zaganjor, H. Yoon, J. Spinelli, Elizabeth R. Nunn +12 more
2021Cell Reports56 citations Open access
Semantic Scholar
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance
Alessandra Dall’Agnese, J. Platt, M. M. Zheng, Max Friesen +16 more
2022Nature Communications50 citations Open access
Semantic Scholar
Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells
Mihir B Doshi, Namgyu Lee, T. Tseyang, Olga Ponomarova +11 more
2023Nature40 citations Open access
Semantic Scholar
PHD3 loss promotes exercise capacity and fat oxidation in skeletal muscle
H. Yoon, J. Spinelli, Elma Zaganjor, Samantha J. Wong +14 more
2020Cell Metabolism35 citations Open access
Semantic Scholar
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3
Karina N. Gonzalez Herrera, Elma Zaganjor, Y. Ishikawa, J. Spinelli +12 more
2018Cell Reports35 citations Open access
Semantic Scholar
Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition
Minwoo Nam, Wen-Xin Xia, Abdul Hannan Mir, Alexandra E. Jerrett +3 more
2024Nature Metabolism30 citations
Semantic Scholar
Brown Fat ATP-Citrate Lyase Links Carbohydrate Availability to Thermogenesis and Guards Against Metabolic Stress
Ekaterina D. Korobkina, C. M. Calejman, J. A. Haley, Miranda E. Kelly +23 more
2024Nature Metabolism28 citations Open access
Semantic Scholar
An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues
J. Spinelli, Liam P. Kelley, M. Haigis
2017Scientific Reports25 citations Open access
Semantic Scholar
S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress
A. Godbole, S. Gopalan, T. Nguyen, Alexander L. Munden +7 more
2023bioRxiv14 citations Open access
Semantic Scholar
Inhibition of nucleotide biosynthesis disrupts lipid accumulation and adipogenesis
A. Shinde, Elizabeth R. Nunn, Genesis A. Wilson, Mathew T. Chvasta +5 more
2023Journal of Biological Chemistry12 citations Open access
Semantic Scholar
Mitochondrial efficiency directs cell fate
J. Spinelli, Elma Zaganjor
2022Nature Cell Biology12 citations
Semantic Scholar
MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
Ayelén M Santamans, Beatriz Cicuéndez, A. Mora, M. Villalba-Orero +23 more
2024Science Advances9 citations Open access
Semantic Scholar
Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST
Hans-Georg Sprenger, Melanie J. Mittenbühler, Yizhi Sun, J. V. Van Vranken +22 more
2024bioRxiv7 citations Open access
Semantic Scholar
Strength in numbers: Phosphofructokinase polymerization prevails in the liver
Elma Zaganjor, J. Spinelli, M. Haigis
2017Journal of Cell Biology7 citations Open access
Semantic Scholar
p53 controls choice between apoptotic and non-apoptotic death following DNA damage
Megan E. Honeywell, M. Isidor, Nicholas W. Harper, Rachel E. Fontana +7 more
2023bioRxiv4 citations Open access
Semantic Scholar
Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice.
N. van Gastel, J. Spinelli, M. Haigis, D. Scadden
2021Bio-protocol4 citations Open access
Semantic Scholar
Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity
Tigist Y. Tamir, Shreya Chaudhary, Annie X Li, Sonia E. Trojan +13 more
2024bioRxiv3 citations Open access
Semantic Scholar
Oxygen-Independent Assays to Measure Mitochondrial Function in Mammals.
T. Tseyang, Jonathan Valeros, Paula Vo, J. Spinelli
2023Journal of Visualized Experiments3 citations
Semantic Scholar
An aneuploidy epistasis map reveals metabolic vulnerabilities associated with supernumerary chromosomes in cancer
R. Magesh, A. N. Kaur, F. Keller, A. Frederick +8 more
2024bioRxiv1 citations Open access
Semantic Scholar
PHD3 controls energy homeostasis and exercise capacity
H. Yoon, J. Spinelli, Elma Zaganjor, Samantha J. Wong +13 more
20191 citations Open access
Semantic Scholar
Investigating the Fate of Ammonia in Breast Cancer
J. Spinelli
20191 citations
Semantic Scholar
The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance
N. van Gastel, J. Spinelli, A. Sharda, A. Schajnovitz +9 more
2019Blood1 citations Open access
Semantic Scholar
An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues
J. Spinelli, Liam P. Kelley, M. Haigis
2017Scientific Reports1 citations Open access
Semantic Scholar
Small-Molecule Screen Identiﬁes De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3
Karina N. Gonzalez Herrera, Yoshinori Ishikawa ... Elma Zaganjor, P. Sorger, C. Clish +12 more
1 citations
Semantic Scholar
An improved method for high-purity isolation of oligodendrocytes from neonatal and adult mouse brain
Peiyi Guo, E. Mandon, Jie Wang, Morgan Mooney +7 more
2026iScience0 citations Open access
Semantic Scholar
The UTX Tumor Suppressor Directly Senses Oxygen to Control Chromatin and Cell Fate
Abhishek A. Chakraborty, Tuomas Laukka, M. Myllykoski, A. Ringel +16 more
2019bioRxiv0 citations Open access
Semantic Scholar

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