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K. Zettlitz · SciRah

Researcher profile · Semantic Scholar

K. Zettlitz

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K. Zettlitz — researcher profile on SciRah

h-index: 21
Works: 53
Citations: 1,538

Most-cited papers

An effective immuno-PET imaging method to monitor CD8-dependent responses to immunotherapy
Richard Tavaré, Helena Escuin-Ordinas, Stephen Mok, Melissa N. Mccracken +5 more
2015Cancer Research270 citations Open access
Semantic Scholar
Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo
Richard Tavaré, Melissa N. Mccracken, K. Zettlitz, Scott M. Knowles +4 more
2014Proceedings of the National Academy of Sciences of the United States of America165 citations Open access
Semantic Scholar
ImmunoPET of murine T cell reconstitution post-adoptive stem cell transplant using anti-CD4 and anti-CD8 cys-diabodies
Richard Tavaré, Melissa N. Mccracken, K. Zettlitz, Felix B Salazar +3 more
2015Journal of Nuclear Medicine110 citations Open access
Semantic Scholar
The effects of affinity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein.
Jonas Hopp, Nora Hornig, K. Zettlitz, A. Schwarz +3 more
2010Protein engineering, design & selection : PEDS97 citations
Semantic Scholar
N-Glycosylation as Novel Strategy to Improve Pharmacokinetic Properties of Bispecific Single-chain Diabodies*
R. Stork, K. Zettlitz, Dafne Müller, Miriam Rether +2 more
2008Journal of Biological Chemistry91 citations Open access
Semantic Scholar
ImmunoPET imaging of murine CD4+ T cells using anti-CD4 cys-diabody: Effects of protein dose on T cell function and imaging
Amanda C. Freise, K. Zettlitz, Felix B Salazar, Xiang Lu +2 more
2017Molecular Imaging and Biology67 citations Open access
Semantic Scholar
ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibody
K. Zettlitz, V. Lorenz, K. Landauer, Sabine Münkel +4 more
2010mAbs66 citations Open access
Semantic Scholar
Quantitative ImmunoPET of Prostate Cancer Xenografts with 89Zr- and 124I-Labeled Anti-PSCA A11 Minibody
Scott M. Knowles, K. Zettlitz, Richard Tavaré, M. Rochefort +5 more
2014Journal of Nuclear Medicine65 citations Open access
Semantic Scholar
Immuno-PET in Inflammatory Bowel Disease: Imaging CD4-Positive T Cells in a Murine Model of Colitis
Amanda C. Freise, K. Zettlitz, Felix B Salazar, Richard Tavaré +5 more
2018Journal of Nuclear Medicine63 citations Open access
Semantic Scholar
Dual-Modality Immuno-PET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer Using an Anti–Prostate Stem Cell Antigen Cys-Diabody
K. Zettlitz, Wen-Ting K. Tsai, Scott M. Knowles, N. Kobayashi +3 more
2018Journal of Nuclear Medicine45 citations Open access
Semantic Scholar
ImmunoPET of malignant and normal B cells with 89Zr- and 124I-labeled obinutuzumab antibody fragments reveals differential CD20 internalization in vivo
K. Zettlitz, Richard Tavaré, Scott M. Knowles, K. Steward +2 more
2017Clinical Cancer Research43 citations Open access
Semantic Scholar
Fluorescent Image-Guided Surgery with an Anti-Prostate Stem Cell Antigen (PSCA) Diabody Enables Targeted Resection of Mouse Prostate Cancer Xenografts in Real-Time
G. Sonn, Andrew S Behesnilian, Z. Jiang, K. Zettlitz +6 more
2015Clinical Cancer Research43 citations Open access
Semantic Scholar
Dual-Modality ImmunoPET/Fluorescence Imaging of Prostate Cancer with an Anti-PSCA Cys-Minibody
Wenting K Tsai, K. Zettlitz, Richard Tavaré, N. Kobayashi +2 more
2018Theranostics39 citations Open access
Semantic Scholar
A fully human scFv phage display library for rapid antibody fragment reformatting.
Keyu Li, K. Zettlitz, Julia Lipianskaya, Yu Zhou +4 more
2015Protein engineering, design & selection : PEDS31 citations Open access
Semantic Scholar
Enhanced immunoPET of ALCAM-positive colorectal carcinoma using site-specific ⁶⁴Cu-DOTA conjugation.
Richard Tavaré, Wei Wu, K. Zettlitz, Felix B Salazar +3 more
2014Protein engineering, design & selection : PEDS31 citations Open access
Semantic Scholar
Applications of immunoPET: using 124I-anti-PSCA A11 minibody for imaging disease progression and response to therapy in mouse xenograft models of prostate cancer
Scott M. Knowles, Richard Tavaré, K. Zettlitz, M. Rochefort +4 more
2014Clinical Cancer Research30 citations Open access
Semantic Scholar
Near-infrared-dye labeled anti-Prostate Stem Cell Antigen minibody enables real-time fluorescence imaging and targeted surgery in translational mouse models
Mo Zhang, N. Kobayashi, K. Zettlitz, Evelyn A. Kono +8 more
2018Clinical Cancer Research29 citations Open access
Semantic Scholar
A Dual-Modality Linker Enables Site-Specific Conjugation of Antibody Fragments for 18F-Immuno-PET and Fluorescence Imaging
K. Zettlitz, Christopher M. Waldmann, Wen-Ting K. Tsai, Richard Tavaré +3 more
2019Journal of Nuclear Medicine27 citations Open access
Semantic Scholar
Anti-MET immunoPET for non-small cell lung cancer using novel fully human antibody fragments
Keyu Li, Richard Tavaré, K. Zettlitz, S. Mumenthaler +4 more
2014Molecular Cancer Therapeutics27 citations Open access
Semantic Scholar
A novel expression and purification system for the production of enzymatic and biologically active human granzyme B.
M. Gehrmann, Brigitte T. Doß, M. Wagner, K. Zettlitz +4 more
2011JIM - Journal of Immunological Methods26 citations
Semantic Scholar
18F-labeled anti-human CD20 cys-diabody for same-day immunoPET in a model of aggressive B-cell lymphoma in human CD20 transgenic mice
K. Zettlitz, Richard Tavaré, Wen-Ting K. Tsai, R. Yamada +5 more
2018European Journal of Nuclear Medicine and Molecular Imaging25 citations Open access
Semantic Scholar
IBC’s 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics International Conferences and the 2012 Annual Meeting of The Antibody Society
P. Klöhn, U. Wuellner, N. Zizlsperger, Yu Zhou +7 more
2013mAbs21 citations Open access
Semantic Scholar
Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity
Fabian Richter, K. Zettlitz, O. Seifert, A. Herrmann +3 more
2018mAbs20 citations Open access
Semantic Scholar
Evaluation of [131I]I- and [177Lu]Lu-DTPA-A11 minibody for radioimmunotherapy in a preclinical model of PSCA-expressing prostate cancer
Wen-Ting K. Tsai, K. Zettlitz, Magnus Dahlbom, R. Reiter +1 more
2020Molecular Imaging and Biology15 citations Open access
Semantic Scholar
Murine endoglin-specific single-chain Fv fragments for the analysis of vascular targeting strategies in mice.
Dafne Müller, G. Trunk, A. Sichelstiel, K. Zettlitz +2 more
2008JIM - Journal of Immunological Methods15 citations Open access
Semantic Scholar
An anti-TNFR1 scFv-HSA fusion protein as selective antagonist of TNF action.
Verena Berger, Fabian Richter, K. Zettlitz, F. Unverdorben +4 more
2013Protein engineering, design & selection : PEDS14 citations
Semantic Scholar
Development and characterization of an αvβ6-specific diabody and a disulfide-stabilized αvβ6-specific cys-diabody.
Jason B White, David L. Boucher, K. Zettlitz, Anna M. Wu +1 more
2015Nuclear Medicine and Biology13 citations Open access
Semantic Scholar
[89Zr]A2cDb Immuno-PET of Prostate Cancer in a Human Prostate Stem Cell Antigen Knock-in (hPSCA KI) Syngeneic Model
K. Zettlitz, Wen-Ting K. Tsai, Scott M. Knowles, Felix B Salazar +3 more
2019Molecular Imaging and Biology10 citations Open access
Semantic Scholar
Humanization of a Mouse Monoclonal Antibody Directed Against a Cell Surface-Exposed Epitope of Membrane-Associated Heat Shock Protein 70 (Hsp70)
K. Zettlitz, Julia Seitter, Dafne Müller, R. Kontermann
2010Molecular Biotechnology9 citations
Semantic Scholar
Tri-functional platform for construction of modular antibody fragments for in vivo18F-PET or NIRF molecular imaging
Raymond F. Gamache, K. Zettlitz, Wen-Ting K. Tsai, J. Collins +2 more
2020Chemical Science7 citations Open access
Semantic Scholar
On-demand radiosynthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) on an electrowetting-on-dielectric microfluidic chip for 18F-labeling of protein
Hee-Kwon Kim, M. Javed, Su-Pin Chen, K. Zettlitz +5 more
2019RSC Advances6 citations Open access
Semantic Scholar
89Zr-ImmunoPET shows therapeutic efficacy of anti-CD20 interferon-α fusion protein in a murine B-cell lymphoma model
K. Zettlitz, Felix B Salazar, R. Yamada, K. R. Trinh +4 more
2022Molecular Cancer Therapeutics5 citations Open access
Semantic Scholar
89Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors.
Ann M Chan, T. Olafsen, Jessica Tsui, Felix B Salazar +12 more
2024Molecular Cancer Therapeutics4 citations
Semantic Scholar
Protein A/G Chromatography
K. Zettlitz
20103 citations
Semantic Scholar
Detection of antibody therapy-induced anti-tumor immune responses using anti-CD8 immuno-pet
Richard Tavaré, Helena Escuin-Ordinas, Melissa N. Mccracken, K. Zettlitz +4 more
2015Journal of Immunotherapy for Cancer2 citations Open access
Semantic Scholar
Engineered antibodies for the therapy of cancer and inflammatory diseases
K. Zettlitz
20102 citations
Semantic Scholar
Abstract A088: Radiopharmaceutical therapy for pancreatic cancer: Engineered anti-prostate stem cell antigen (PSCA) antibody demonstrates targeted imaging and antitumor effects in a syngeneic mouse model of pancreatic ductal adenocarcinoma (PDAC)
Bao Y. Chen, Saad N. Ahmed, Felix B. Salazar, Sunidhi Jaiswal +8 more
2024Cancer Research1 citations
Semantic Scholar
89 Non-invasive imaging of tumor-infiltrating B lymphocytes in a triple negative breast cancer model using anti-CD20 immunoPET
Sunidhi Jaiswal, Saad N. Ahmed, Felix B. Salazar, Masoud Farshbaf +3 more
2023Regular and Young Investigator Award Abstracts1 citations Open access
Semantic Scholar
89Zr-anti-CD8 immunoPET visualizes heterogeneous intratumoral CD8+ immune responses to treatment with radiation and anti-CTLA4
E. Germino, K. Zettlitz, T. Watkins, Bao Y. Chen +7 more
2025npj Imaging0 citations Open access
Semantic Scholar
Reengineered Anti-CD4 Cys-diabody Variants for 89Zr-immunoPET of CD4+ T Cells in Immunocompetent Mice
Felix B. Salazar, Richard Tavaré, Arya B. Ökten, Maciej Kujawski +2 more
2025Molecular Imaging and Biology0 citations Open access
Semantic Scholar
Abstract 6021: Lutetium-177 (177Lu) radiolabeled engineered antibody fragment against human prostate stem cell antigen (hPSCA) demonstrates targeting and antitumor effects in a syngeneic mouse model of pancreatic ductal adenocarcinoma (PDAC)
Bao Y. Chen, Masoud Farshbaf, Felix B. Salazar, Saad N. Ahmed +8 more
2024Cancer Research0 citations
Semantic Scholar
Combined Radiation and Anti-CTLA4 Induces a CD8+ Immune Response in an Orthotopic Mouse Model of Breast Cancer Which is Detectable with CD8 ImmunoPET at an Early Timepoint after Treatment
E. Germino, K. Zettlitz, D. La Placa, S. Li +3 more
2022International Journal of Radiation Oncology, Biology, Physics0 citations
Semantic Scholar
Abstract 1775: Development of fully humanized N-cadherin monoclonal antibodies for treatment of castration resistant prostate cancer
Evelyn A. Kono, N. Kobayashi, K. Zettlitz, Keyu Li +4 more
2018Immunology0 citations
Semantic Scholar
Abstract A52: Efficacy of new developed N-cadherin monoclonal antibodies in combination with enzalutamide against castration-resistant prostate cancer
Evelyn A. Kono, N. Kobayashi, K. Zettlitz, J. Yamashiro +4 more
20180 citations
Semantic Scholar
Abstract 1856: Dual-modality immunoPET/fluorescence imaging of prostate cancer utilizing89Zr- or124I-Cy5.5-anti-PSCA cys-minibody
Wen-Ting K. Tsai, K. Zettlitz, Richard Tavaré, Felix B Salazar +2 more
20170 citations
Semantic Scholar
Title Immuno-PET of Murine T Cell Reconstitution Postadoptive Stem Cell Transplantation Using Anti-CD 4 and Anti-CD 8 Cys-Diabodies Permalink
Melissa N. Mccracken, K. Zettlitz, Felix B Salazar, T. Olafsen +2 more
20150 citations
Semantic Scholar
Preclinical evaluation of anti-{alpha}v{beta}6 diabodies and anti-{alpha}v{beta}6 cys-diabodies for imaging {alpha}v{beta}6-positive tumors with positron emission tomography
Jason B White, David L. Boucher, K. Zettlitz, Anna M. Wu +1 more
20140 citations
Semantic Scholar
Personalized Medicine and Imaging Applications of ImmunoPET : Using 124 I-Anti-PSCA A 11 Minibody for Imaging Disease Progression and Response to Therapy in Mouse Xenograft Models of Prostate Cancer
Scott M. Knowles, R. Tavar, K. Zettlitz, M. Rochefort +4 more
20140 citations
Semantic Scholar
Preclinical evaluation of anti-αvβ6 diabodies and anti-αvβ6 cys-diabodies for imaging αvβ6-positive tumors with positron emission tomography
Jason B White, David L. Boucher, K. Zettlitz, Anna M. Wu +1 more
20140 citations
Semantic Scholar
2027 DEVELOPMENT AND VALIDATION OF A FLUORESCENT LABELED ANTIBODY FRAGMENT FOR IMAGE-GUIDED PROSTATE CANCER SURGERY
G. Sonn, Eric J. M. Lepin, Scott M. Knowles, K. Zettlitz +2 more
20130 citations
Semantic Scholar

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Scott M. Knowles

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