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R. Kontermann · SciRah

Researcher profile · Semantic Scholar

R. Kontermann

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R. Kontermann — researcher profile on SciRah

h-index: 52
Works: 199
Citations: 11K

Most-cited papers

The making of bispecific antibodies
U. Brinkmann, R. Kontermann
2017mAbs837 citations Open access
Semantic Scholar
The present and future of bispecific antibodies for cancer therapy
C. Klein, Ulrich Brinkmann, Janice M. Reichert, R. Kontermann
2024Nature reviews. Drug discovery427 citations
Semantic Scholar
Bispecific antibodies.
R. Kontermann, U. Brinkmann
2015Drug Discovery Today338 citations Open access
Semantic Scholar
Selective Targeting of TNF Receptors as a Novel Therapeutic Approach
R. Fischer, R. Kontermann, K. Pfizenmaier
2020Frontiers in Cell and Developmental Biology215 citations Open access
Semantic Scholar
Half-life extended biotherapeutics
R. Kontermann
2016Expert Opinion on Biological Therapy178 citations
Semantic Scholar
Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration
Yun Dong, R. Fischer, P. Naudé, O. Maier +10 more
2016Proceedings of the National Academy of Sciences of the United States of America153 citations Open access
Semantic Scholar
TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice
F. Wandrer, S. Liebig, S. Marhenke, A. Vogel +11 more
2020Cell Death and Disease137 citations Open access
Semantic Scholar
Pharmacokinetic properties of IgG and various Fc fusion proteins in mice
F. Unverdorben, Fabian Richter, Meike Hutt, O. Seifert +3 more
2016mAbs108 citations Open access
Semantic Scholar
Astrocyte‐specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor
R. Fischer, H. Wajant, R. Kontermann, K. Pfizenmaier +1 more
2014Glia106 citations
Semantic Scholar
Bispecific antibodies
U. Brinkmann, R. Kontermann
2021Science105 citations
Semantic Scholar
OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models
M. Fabre, C. Ferrer, S. Domínguez-Hormaetxe, B. Bockorny +13 more
2020Clinical Cancer Research88 citations Open access
Semantic Scholar
Targeting sTNF/TNFR1 Signaling as a New Therapeutic Strategy
R. Fischer, R. Kontermann, O. Maier
201585 citations Open access
Semantic Scholar
Tumor-antigen-binding bispecific antibodies for cancer treatment.
U. Weidle, R. Kontermann, U. Brinkmann
2014Seminars in Oncology79 citations Open access
Semantic Scholar
Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice
Irini Papazian, Eleni Tsoukala, Athena Boutou, Maria Karamita +8 more
2021Journal of Neuroinflammation70 citations Open access
Semantic Scholar
TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes
R. Fischer, Maksim Sendetski, T. Del Rivero, George F. Martinez +9 more
2019Proceedings of the National Academy of Sciences of the United States of America70 citations Open access
Semantic Scholar
Tailoring the stealth properties of biocompatible polysaccharide nanocontainers.
Biao Kang, Patricia Okwieka, Susanne Schöttler, O. Seifert +9 more
2015Biomaterials59 citations
Semantic Scholar
Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2
R. Fischer, J. Marsal, Cristiano Guttà, Stephan A. Eisler +4 more
2017Scientific Reports52 citations Open access
Semantic Scholar
In vivo near-infrared fluorescence imaging of FAP-expressing tumors with activatable FAP-targeted, single-chain Fv-immunoliposomes.
Ronny Rüger, F. Tansi, Markus Rabenhold, F. Steiniger +3 more
2014Journal of Controlled Release48 citations
Semantic Scholar
Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis
Sarah K. Williams, R. Fairless, O. Maier, P. Liermann +10 more
2018Scientific Reports46 citations Open access
Semantic Scholar
Selective Activation of Tumor Necrosis Factor Receptor II Induces Antiinflammatory Responses and Alleviates Experimental Arthritis
R. Fischer, Marcel Proske, M. Duffey, H. Stangl +7 more
2018Arthritis & Rheumatology42 citations
Semantic Scholar
Immuno-LipoTRAIL: Targeted delivery of TRAIL-functionalized liposomal nanoparticles.
O. Seifert, Nadine Pollak, Anja Nusser, F. Steiniger +3 more
2014Bioconjugate chemistry40 citations
Semantic Scholar
Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis
R. Fischer, Tanja Padutsch, V. Bracchi-Ricard, Kayla Murphy +10 more
2019Brain, behavior, and immunity38 citations Open access
Semantic Scholar
Corrigendum to "Bispecific antibodies" [Drug Discov. Today 20 (July (7)) (2015) 838-847].
R. Kontermann, U. Brinkmann
2018Drug Discovery Today38 citations
Semantic Scholar
EGFR-Targeted TRAIL and a Smac Mimetic Synergize to Overcome Apoptosis Resistance in KRAS Mutant Colorectal Cancer Cells
Yvonne Möller, M. Siegemund, Sven Beyes, Ricarda Herr +6 more
2014PLoS ONE38 citations Open access
Semantic Scholar
Preclinical efficacy of endoglin-targeting antibody-drug conjugates for the treatment of Ewing sarcoma.
P. Puerto-Camacho, A. T. Amaral, Salah-Eddine Lamhamedi-Cherradi, Brian A. Menegaz +22 more
2018Clinical Cancer Research37 citations Open access
Semantic Scholar
An optimized antibody-single-chain TRAIL fusion protein for cancer therapy
M. Siegemund, O. Seifert, Maria Zarani, T. Džinić +6 more
2016mAbs36 citations Open access
Semantic Scholar
The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation
Fabian Richter, Sarah K. Williams, K. John, Carina Huber +14 more
2021Frontiers in Immunology35 citations Open access
Semantic Scholar
Bispecific single-chain diabody-immunoliposomes targeting endoglin (CD105) and fibroblast activation protein (FAP) simultaneously.
Markus Rabenhold, F. Steiniger, A. Fahr, R. Kontermann +1 more
2015Journal of Controlled Release35 citations
Semantic Scholar
Superior Properties of Fc-comprising scTRAIL Fusion Proteins
Meike Hutt, L. Marquardt, O. Seifert, M. Siegemund +4 more
2017Molecular Cancer Therapeutics33 citations Open access
Semantic Scholar
Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single-chain format
Sina Fellermeier, Nadine Beha, Jan-Erik Meyer, Sarah Ring +3 more
2016Oncoimmunology32 citations Open access
Semantic Scholar
Potential of activatable FAP-targeting immunoliposomes in intraoperative imaging of spontaneous metastases.
F. Tansi, Ronny Rüger, Claudia Böhm, R. Kontermann +3 more
2016Biomaterials31 citations Open access
Semantic Scholar
Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis
Timon Fiedler, R. Fairless, Kira Pichi, Roman Fischer +5 more
2023Journal of Neuroinflammation29 citations Open access
Semantic Scholar
Inhibition of Tumor Cell Growth and Cancer Stem Cell Expansion by a Bispecific Antibody Targeting EGFR and HER3
Alexander Rau, W. S. Lieb, O. Seifert, Jonas Honer +5 more
2020Molecular Cancer Therapeutics29 citations Open access
Semantic Scholar
IgG-single-chain TRAIL fusion proteins for tumour therapy
M. Siegemund, Felix Schneider, Meike Hutt, O. Seifert +4 more
2018Scientific Reports28 citations Open access
Semantic Scholar
A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells
F. Hartung, Thomas Krüwel, Xiaoyi Shi, K. Pfizenmaier +4 more
2020Frontiers in Pharmacology27 citations Open access
Semantic Scholar
Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids
D. Stöhr, Jens O. Schmid, Tobias B. Beigl, A. Mack +11 more
2020Cell Death and Differentiation27 citations Open access
Semantic Scholar
Activatable bispecific liposomes bearing fibroblast activation protein directed single chain fragment/Trastuzumab deliver encapsulated cargo into the nuclei of tumor cells and the tumor microenvironment simultaneously.
F. Tansi, Ronny Rüger, Claudia Böhm, F. Steiniger +4 more
2017Acta Biomaterialia27 citations Open access
Semantic Scholar
A Fab-Selective Immunoglobulin-Binding Domain from Streptococcal Protein G with Improved Half-Life Extension Properties
F. Unverdorben, Meike Hutt, O. Seifert, R. Kontermann
2015PLoS ONE25 citations Open access
Semantic Scholar
Immunoliposomes for Targeted Delivery of an Antifibrotic Drug.
Liane Schuster, O. Seifert, Stefanie Vollmer, R. Kontermann +2 more
2015Molecular Pharmaceutics23 citations
Semantic Scholar
Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV
Lisa C Schmitt, Alexander Rau, O. Seifert, Jonas Honer +7 more
2017mAbs22 citations Open access
Semantic Scholar
Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS
V. Pegoretti, J. Bauer, Roman Fischer, Iskra Paro +9 more
2023Journal of Neuroinflammation20 citations Open access
Semantic Scholar
The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration
Natalia Ortí-Casañ, A. Boerema, K. Köpke, Amber Ebskamp +9 more
2023Scientific Reports20 citations Open access
Semantic Scholar
Proteolysis-Targeting Chimeras Enhance T Cell Bispecific Antibody-Driven T Cell Activation and Effector Function through Increased MHC Class I Antigen Presentation in Cancer Cells
V. Massafra, Sofia Tundo, Aline Dietzig, A. Ducret +7 more
2021Journal of Immunology20 citations Open access
Semantic Scholar
Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules
O. Seifert, Alexander Rau, Nadine Beha, Fabian Richter +1 more
2019mAbs20 citations Open access
Semantic Scholar
Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity
Fabian Richter, K. Zettlitz, O. Seifert, A. Herrmann +3 more
2018mAbs20 citations Open access
Semantic Scholar
Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism
Frank A. Lincoln, Dirke Imig, Chiara Boccellato, Viktorija Juric +5 more
2018Cell Death and Disease20 citations Open access
Semantic Scholar
Characterization of the biological anti-staphylococcal functionality of hUK-66 IgG1, a humanized monoclonal antibody as substantial component for an immunotherapeutic approach
B. Oesterreich, Birgit Lorenz, Tim Schmitter, R. Kontermann +5 more
2014Human Vaccines & Immunotherapeutics20 citations Open access
Semantic Scholar
Genetic delivery of an immunoRNase by an oncolytic adenovirus enhances anticancer activity
Inés Fernández-Ulibarri, Katharina Hammer, Michaela Arndt, Johanna K. Kaufmann +7 more
2015International Journal of Cancer19 citations Open access
Semantic Scholar
Improved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc
Fabian Richter, O. Seifert, A. Herrmann, K. Pfizenmaier +1 more
2019mAbs18 citations Open access
Semantic Scholar
Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism
Vesna Vetma, Cristiano Guttà, N. Peters, C. Praetorius +6 more
2020Cell Death and Differentiation17 citations Open access
Semantic Scholar

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