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Okiru Komine · SciRah

Researcher profile · Semantic Scholar

Okiru Komine

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Okiru Komine — researcher profile on SciRah

h-index: 23
Works: 53
Citations: 2,703

Most-cited papers

SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses
Yoh-ichi Seki, H. Inoue, Naoko Nagata, K. Hayashi +13 more
2003Nature Medicine394 citations
Semantic Scholar
Mitochondria‐associated membrane collapse is a common pathomechanism in SIGMAR1‐ and SOD1‐linked ALS
S. Watanabe, Hristelina Ilieva, H. Tamada, H. Nomura +6 more
2016EMBO Molecular Medicine227 citations Open access
Semantic Scholar
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
Y. Nakazawa, Yuichiro Hara, Yasuyoshi Oka, Okiru Komine +22 more
2020Cell204 citations Open access
Semantic Scholar
Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease
A. Sobue, Okiru Komine, Yuichiro Hara, F. Endo +9 more
2021Acta Neuropathologica Communications200 citations Open access
Semantic Scholar
Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells.
F. Endo, Okiru Komine, N. Fujimori-Tonou, M. Katsuno +6 more
2015Cell Reports196 citations Open access
Semantic Scholar
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction
H. Konishi, Takayuki Okamoto, Yuichiro Hara, Okiru Komine +16 more
2020EMBO Journal157 citations Open access
Semantic Scholar
The Runx1 Transcription Factor Inhibits the Differentiation of Naive CD4+ T Cells into the Th2 Lineage by Repressing GATA3 Expression
Okiru Komine, Keitaro Hayashi, Waka Natsume, Toshio Watanabe +9 more
2003Journal of Experimental Medicine142 citations Open access
Semantic Scholar
Neuroinflammation in motor neuron disease
Okiru Komine, K. Yamanaka
2015Nagoya journal of medical science109 citations
Semantic Scholar
Neuroinflammation in Alzheimer’s disease: microglial signature and their relevance to disease
A. Sobue, Okiru Komine, K. Yamanaka
2023Inflammation and Regeneration104 citations Open access
Semantic Scholar
Differential Roles of Glial and Neuronal Glutamate Transporters in Purkinje Cell Synapses
Y. Takayasu, M. Iino, W. Kakegawa, H. Maeno +8 more
2005Journal of Neuroscience94 citations Open access
Semantic Scholar
SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system
S. Watanabe, N. Ageta-Ishihara, Shinji Nagatsu, K. Takao +7 more
2014Molecular Brain85 citations Open access
Semantic Scholar
Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype
T. Matsudaira, Sosuke Nakano, Y. Konishi, Shimpei Kawamoto +11 more
2023Communications Biology77 citations Open access
Semantic Scholar
Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
K. Oiwa, S. Watanabe, Kazunari Onodera, Y. Iguchi +6 more
2023Science Advances63 citations Open access
Semantic Scholar
Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes
Okiru Komine, Hirofumi Yamashita, N. Fujimori-Tonou, M. Koike +10 more
2018Cell Death and Differentiation59 citations Open access
Semantic Scholar
Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons
J. Lasiene, Okiru Komine, N. Fujimori-Tonou, Berit E. Powers +7 more
2016Acta Neuropathologica Communications53 citations Open access
Semantic Scholar
Aggresome formation and liquid–liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43
S. Watanabe, Hidekazu Inami, K. Oiwa, Yuri Murata +6 more
2020Cell Death and Disease52 citations Open access
Semantic Scholar
The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling.
Okiru Komine, Mai Nagaoka, K. Watase, D. Gutmann +6 more
2007Developmental Biology50 citations Open access
Semantic Scholar
Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease
Ting Wang, A. Sobue, Seiji Watanabe, Okiru Komine +3 more
2024Journal of Neuroinflammation45 citations Open access
Semantic Scholar
ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration
S. Watanabe, K. Oiwa, Yuri Murata, Okiru Komine +4 more
2020Molecular Brain45 citations Open access
Semantic Scholar
Imprinting modulates processing of visual information in the visual wulst of chicks
F. Maekawa, Okiru Komine, Katsushige Sato, T. Kanamatsu +3 more
2006BMC Neuroscience43 citations Open access
Semantic Scholar
Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer’s disease mice by controlling astrocyte activation
A. Sobue, Okiru Komine, F. Endo, Chihiro Kakimi +8 more
2024Cell Death and Disease34 citations Open access
Semantic Scholar
Novel reporters of mitochondria‐associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis
Shohei Sakai, S. Watanabe, Okiru Komine, A. Sobue +1 more
2021The FASEB Journal33 citations Open access
Semantic Scholar
Delta-like 1 regulates Bergmann glial monolayer formation during cerebellar development
Y. Hiraoka, Okiru Komine, Mai Nagaoka, Ning Bai +2 more
2013Molecular Brain30 citations Open access
Semantic Scholar
Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer’s disease
Md Ali Bin Saifullah, Okiru Komine, Yutao Dong, Kazuya Fukumoto +6 more
2020Molecular Brain23 citations Open access
Semantic Scholar
Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS
Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, K. Oiwa +7 more
2023Proceedings of the National Academy of Sciences of the United States of America21 citations Open access
Semantic Scholar
Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions.
Mariko Sugiyama, Ryoichi Banno, H. Yaginuma, Keigo Taki +11 more
2020Neurochemistry International21 citations
Semantic Scholar
ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice
Mai Horiuchi, Seiji Watanabe, Okiru Komine, Eiki Takahashi +5 more
2024Acta Neuropathologica Communications20 citations Open access
Semantic Scholar
Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.
S. Watanabe, Mai Horiuchi, Yuri Murata, Okiru Komine +3 more
2023Neurobiology of Disease20 citations Open access
Semantic Scholar
Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1‐linked amyotrophic lateral sclerosis mice
S. Watanabe, Okiru Komine, F. Endo, K. Wakasugi +1 more
2018Journal of Neurochemistry20 citations Open access
Semantic Scholar
Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway
Kohei Nishino, S. Watanabe, Shijie Jin, Yuri Murata +8 more
2019Acta Neuropathologica Communications19 citations Open access
Semantic Scholar
Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice
Okiru Komine, S. Ohnuma, Kunihiko Hinohara, Yuichiro Hara +7 more
2024iScience11 citations Open access
Semantic Scholar
Neuroinflammation in motor neuron disease
F. Endo, Okiru Komine, Koji Yamanaka
201610 citations Open access
Semantic Scholar
RBP-J promotes the maturation of neuronal progenitors.
Okiru Komine, Mai Nagaoka, Y. Hiraoka, M. Hoshino +3 more
2011Developmental Biology10 citations Open access
Semantic Scholar
Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders
Kazuya Fuma, Y. Iitani, K. Imai, T. Ushida +14 more
2025Communications Biology7 citations
Semantic Scholar
Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease
Hirofumi Yamashita, Okiru Komine, N. Fujimori-Tonou, K. Yamanaka
2023Frontiers in Cellular Neuroscience7 citations Open access
Semantic Scholar
The Runx 1 Transcription Factor Inhibits the Differentiation of Naive CD 4 T Cells into the Th 2 Lineage by Repressing GATA 3 Expression
Okiru Komine, Keitaro Hayashi, Waka Natsume, Toshio Watanabe +9 more
20037 citations
Semantic Scholar
Long-term systemic androgen deprivation partially modulates neuroinflammation in male AppNL−G−F/NL−G−F mice
Kasumi Maekawa, A. Sobue, Okiru Komine, Yuko Saito +4 more
2025Scientific Reports4 citations Open access
Semantic Scholar
Brain lipid profiles and oligodendrocyte gene expression show discordant responses to high-fat diet in Alzheimer’s disease mice
Noe Kawade, Okiru Komine, A. Sobue, Chihiro Kakimi +9 more
2026Scientific Reports3 citations Open access
Semantic Scholar
Immune checkpoint LAG-3 governs stage-dependent and disease-associated microglial modules in ALS model mice
Yuta Morisaki, Nanaka Nomura, Motoki Ohshima, Miruto Matsuda +4 more
2026Journal of Neuroinflammation1 citations Open access
Semantic Scholar
Author Correction: Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype
T. Matsudaira, Sosuke Nakano, Yusuke Konishi, Shimpei Kawamoto +11 more
2025Communications Biology1 citations Open access
Semantic Scholar
Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia.
Haruki Fujisawa, Takashi Watanabe, Okiru Komine, Sachiho Fuse +9 more
2024Free Radical Biology & Medicine1 citations Open access
Semantic Scholar
Corrigendum: Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease
Hirofumi Yamashita, Okiru Komine, N. Fujimori-Tonou, K. Yamanaka
2023Frontiers in Cellular Neuroscience1 citations Open access
Semantic Scholar
TBK1 eliminates aggregation-prone monomeric TDP-43 through an IFNβ-immunoproteasome pathway in ALS models.
Shohei Sakai, K. Oiwa, Y. Iguchi, Izzet Mehmet Akcay +7 more
2026EMBO Reports0 citations Open access
Semantic Scholar
Anti-LAG-3 antibody treatment initiated after symptom onset extends survival in ALS model mice.
Yuta Morisaki, Nanaka Nomura, Miruto Matsuda, Motoki Ohshima +5 more
2026Neurosciences research0 citations Open access
Semantic Scholar
TBK1 eliminates aggregation-prone monomeric TDP-43 through the IFNβ-immunoproteasome pathway
Shohei Sakai, K. Oiwa, Y. Iguchi, Seiji Watanabe +4 more
2025bioRxiv0 citations Open access
Semantic Scholar
Correction: Long-term systemic androgen deprivation partially modulates neuroinflammation in male AppNL−G−F/NL−G−F mice
Kasumi Maekawa, A. Sobue, Okiru Komine, Yuko Saito +4 more
2025Scientific Reports0 citations Open access
Semantic Scholar
Monitoring DNA lesions and progress of nucleotide excision repair by ChIP-seq data
Yuichiro Hara, Y. Nakazawa, Yasuyoshi Oka, Okiru Komine +22 more
20190 citations
Semantic Scholar
Behavioral characterization of APP knock-in mice model in touchscreen-based tests aiming early detection of Alzheimer's disease.
Md Ali Bin Saifullah, Okiru Komine, A. Sobue, K. Yamanaka +1 more
2019Proceedings for Annual Meeting of The Japanese Pharmacological Society0 citations Open access
Semantic Scholar
Collapse of mitochondria-associated membrane as common pathomechanism for amyotrophic lateral sclerosis
S. Watanabe, Hristelina Ilieva, H. Tamada, H. Nomura +6 more
20170 citations
Semantic Scholar
Roles of ganglioside GD3 in the regulation of microenvironment of gliomas
Pu Zhang, Yuki Ohkawa, Akira Kato, Okiru Komine +8 more
20170 citations
Semantic Scholar

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K. Yamanaka×25
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K. Yamanaka — researcher profile on SciRah
A. Sobue×18
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A. Sobue — researcher profile on SciRah
S. Watanabe×14
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S. Watanabe — researcher profile on SciRah
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Koji Yamanaka — researcher profile on SciRah

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Seiji Watanabe×8

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Seiji Watanabe — researcher profile on SciRah

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K. Oiwa — researcher profile on SciRah

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T. Saido — researcher profile on SciRah

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M. Katsuno — researcher profile on SciRah

Mayuko Shimada×5

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Mayuko Shimada — researcher profile on SciRah

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N. Fujimori-Tonou — researcher profile on SciRah