Researcher profile · Semantic Scholar

H. Kocinsky

h-index: 10
Works: 27
Citations: 468

Most-cited papers

Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sites.
H. Kocinsky, A. Girardi, D. Biemesderfer, Thao Nguyen +3 more
2005AJP - Renal Physiology111 citations
Semantic Scholar
NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity.
H. Kocinsky, D. Dynia, Tong Wang, P. Aronson
2007AJP - Renal Physiology80 citations
Semantic Scholar
Cyclic GMP Kinase II (cGKII) Inhibits NHE3 by Altering Its Trafficking and Phosphorylating NHE3 at Three Required Sites
Tiane Chen, H. Kocinsky, B. Cha, R. Murtazina +8 more
2014Journal of Biological Chemistry47 citations Open access
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Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron.
Mien T. X. Nguyen, Li E. Yang, Nicholas K. Fletcher, Donna H. Lee +4 more
2012AJP - Renal Physiology47 citations Open access
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NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.
R. Murtazina, O. Kovbasnjuk, Tian-E Chen, N. Zachos +6 more
2011American Journal of Physiology - Cell Physiology39 citations Open access
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Membrane Curvature Alters the Activation Kinetics of the Epithelial Na+/H+ Exchanger, NHE3*
R. T. Alexander, A. Malevanets, A. Durkan, H. Kocinsky +3 more
2007Journal of Biological Chemistry32 citations Open access
Semantic Scholar
NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase.
D. Dynia, A. Steinmetz, H. Kocinsky
2010AJP - Renal Physiology29 citations Open access
Semantic Scholar
Ezrin Is Required for the Functional Regulation of the Epithelial Sodium Proton Exchanger, NHE3
H. Hayashi, Atsushi Tamura, Devishree Krishnan, S. Tsukita +6 more
2013PLoS ONE19 citations Open access
Semantic Scholar
LP06 : Sustained virologic response after ACH-3102 and sofosbuvir treatment for 8 or 6 weeks: A phase 2 “proxy” study
E. Gane, C. Schwabe, M. Mader, V. Suri +7 more
201515 citations
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P3‐361: A randomized, double‐blind, sponsor‐unblinded, placebo‐ and positive‐controlled study to evaluate the effects of single oral administrations of PF‐04995274 on scopolamine‐induced deficits in cognitive function in healthy adults
C. Leurent, S. Duvvuri, D. Raunig, J. Antinew +7 more
201211 citations
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876 ACH-3102, A SECOND GENERATION NS5A INHIBITOR, DEMONSTRATES POTENT ANTIVIRAL ACTIVITY IN PATIENTS WITH GENOTYPE 1a HCV INFECTION DESPITE THE PRESENCE OF BASELINE NS5A-RESISTANT VARIANTS
A. Muir, J. Hill, E. Lawitz, T. Marbury +8 more
20139 citations
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NHE 3 phosphorylation at serines 552 and 605 does not directly affect NHE 3 activity
H. Kocinsky, D. Dynia, Tong Wang, P. Aronson
20077 citations
Semantic Scholar
POS-048 PHASE 3, RANDOMIZED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PEGCETACOPLAN IN TREATMENT OF C3G OR IC-MPGN
G. Remuzzi, B. Dixon, F. Fakhouri, M. Pickering +9 more
2022Kidney International Reports6 citations Open access
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847 ACH-2684 DEMONSTRATES POTENT VIRAL SUPPRESSION IN GENOTYPE 1 HEPATITIS C PATIENTS WITH AND WITHOUT CIRRHOSIS: SAFETY, PHARMACOKINETIC, AND VIRAL KINETIC ANALYSIS
E. Lawitz, J. Hill, B. Vince, A. Murillo +11 more
20135 citations Open access
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Novel Complement Therapeutics in Development as Potential Treatment for Renal Disease.
C. Kelleher, H. Kocinsky
2020Advances in Chronic Kidney Disease4 citations
Semantic Scholar
POS-047 PHASE 2 STUDY TO EVALUATE EFFICACY AND SAFETY OF PEGCETACOPLAN IN THE TREATMENT OF PATIENTS WITH POSTTRANSPLANT RECURRENCE OF C3G OR IC MPGN
N. Palakow, M. Pickering, B. Dixon, P. Walker +6 more
2022Kidney International Reports2 citations Open access
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1199 FINDINGS FROM CLINICAL VIROLOGY STUDIES ON ACH-3102 ARE CONSISTENT WITH PRECLINICAL OBSERVATIONS ON ITS IMPROVED POTENCY AGAINST GENOTYPE-1a HCV AND RESISTANT VARIANTS
G. Yang, D. Patel, Y. Zhao, J. Fabrycki +7 more
20132 citations
Semantic Scholar
#4328 CHK-336, A FIRST-IN-CLASS ORALLY ADMINISTERED LDH INHIBITOR: SAFETY, PK AND TARGET ENGAGEMENT IN A FIRST-IN-HUMAN PHASE 1 HEALTHY VOLUNTEER STUDY
V. Tong, B. Schwartz, C. Lam, J. Knight +7 more
2023Nephrology, Dialysis and Transplantation1 citations Open access
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SaO018FACTOR D INHIBITION WITH ACH-4471 TO REDUCE COMPLEMENT ALTERNATIVE PATHWAY HYPERACTIVITY AND PROTEINURIA IN C3 GLOMERULOPATHY: PRELIMINARY PROOF OF CONCEPT DATA
H. Kocinsky, C. Kelleher, D. Apelian, Angela Bulawski +11 more
20181 citations Open access
Semantic Scholar
1200 FINDINGS FROM CLINICAL VIROLOGY STUDIES ON SOVAPREVIR, A PHASE 2 HCV NS3 PROTEASE INHIBITOR, INDICATE A HIGH PHARMACOLOGICAL BARRIER TO VIRAL RESISTANCE
J. Fabrycki, Y. Zhao, D. Patel, G. Yang +8 more
20131 citations Open access
Semantic Scholar
Corrigendum to PHASE 2 STUDY TO EVALUATE EFFICACY AND SAFETY OF PEGCETACOPLAN IN THE TREATMENT OF PATIENTS WITH POSTTRANSPLANT RECURRENCE OF C3G OR IC MPGN
M. Pickering, B. Dixon, P. Walker, F. Fakhowri +5 more
2022Kidney International Reports0 citations Open access
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Reviewers 2019
Aly Abdelrahman, R. Abi-Habib, S. Aifa, A. Allah +174 more
2020Journal of physiology and biochemistry0 citations Open access
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784 VIRAL KINETICS MODELING TO PREDICT cEVR AND AID IN DOSE SELECTION DECISIONS FOR PHASE-2/3 CLINICAL TRIALS
A. Agarwal, B. Zhang, H. Robison, L. Robarge +9 more
20130 citations Open access
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1201 NO CLINICALLY SIGNIFICANT PHARMACOKINETIC INTERACTION BETWEEN SOVAPREVIR AND ACH-3102 IN HEALTHY VOLUNTEERS
J. Hui, L. Robarge, H. Robison, H. Kocinsky +1 more
20130 citations Open access
Semantic Scholar
Abstract 763: A phase 1 open-label study to investigate the potential drug-drug interaction (DDI) between single-dose (SD) dacomitinib (PF-00299804; DC) and steady-state (SS) paroxetine (PX) in healthy volunteers (HVs)
Ana RuizαGarcia, N. Giri, R. Labadie, G. Ni +4 more
20120 citations
Semantic Scholar
abundance along the nephron O transporters' 2 , and H + , K + supplementation on Na -deficient diets with and without NaCl + Effects of K
S. Bachmann, E. Delpire, A. McDonough, Mien T. X. Nguyen +3 more
20120 citations
Semantic Scholar
Membrane Curvature Alters the Activation Kinetics of the Epithelial Na (cid:1) /H
Epithelial Na H Exchanger, R. Todd, A. Malevanets, AnneM.Durkan +4 more
0 citations
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P. Aronson

×4

Mingjun Huang×4

J. Orlowski×3

D. Dynia×3

A. Agarwal×3

M. Pickering×3

T. Cook×3

P. Walker×3