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N. Zachos · SciRah

Researcher profile · Semantic Scholar

N. Zachos

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N. Zachos — researcher profile on SciRah

h-index: 39
Works: 164
Citations: 6,931

Most-cited papers

Gut Microbiota Produced Tryptamine Activates an Epithelial G-protein Coupled Receptor to Increase Colonic Secretion
Yogesh Bhattarai, B. B. Williams, E. Battaglioli, Weston R. Whitaker +11 more
2018Cell Host and Microbe388 citations Open access
Semantic Scholar
A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions
Gaelle Noel, N. Baetz, J. Staab, M. Donowitz +3 more
2017Scientific Reports388 citations Open access
Semantic Scholar
Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology
K. Saxena, S. Blutt, K. Ettayebi, Xi-Lei Zeng +15 more
2015Journal of Virology342 citations Open access
Semantic Scholar
Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology*
N. Zachos, O. Kovbasnjuk, Jennifer D. Foulke-Abel, Julie G. In +4 more
2015Journal of Biological Chemistry258 citations Open access
Semantic Scholar
Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle
Lawrence A. Vernetti, Albert Gough, N. Baetz, S. Blutt +18 more
2017Scientific Reports252 citations Open access
Semantic Scholar
Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids
Julie G. In, Jennifer D. Foulke-Abel, N. Zachos, Anne-Marie Hansen +7 more
2015Cellular and Molecular Gastroenterology and Hepatology225 citations Open access
Semantic Scholar
Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology
Jennifer D. Foulke-Abel, Julie G. In, Jian-Yi Yin, N. Zachos +4 more
2015Gastroenterology192 citations Open access
Semantic Scholar
Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis
Yong Tao, Byunghak Kang, Daniel Petkovich, Y. Bhandari +22 more
2019Cancer Cell147 citations Open access
Semantic Scholar
Intestinal in vitro and ex vivo Models to Study Host-Microbiome Interactions and Acute Stressors
S. Pearce, Heidi G. Coia, J. Karl, I. Pantoja-Feliciano +2 more
2018Frontiers in Physiology144 citations Open access
Semantic Scholar
Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections
Winnie Y. Zou, S. Blutt, S. Crawford, K. Ettayebi +6 more
2017Methods in molecular biology132 citations Open access
Semantic Scholar
Human mini-guts: new insights into intestinal physiology and host–pathogen interactions
Julie G. In, Jennifer D. Foulke-Abel, M. Estes, N. Zachos +2 more
2016Nature Reviews Gastroenterology &Hepatology123 citations Open access
Semantic Scholar
A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection
K. Saxena, L. Simon, Xi-Lei Zeng, S. Blutt +10 more
2017Proceedings of the National Academy of Sciences of the United States of America121 citations Open access
Semantic Scholar
Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea.
A. Janecke, P. Heinz-Erian, Jian-Yi Yin, B. Petersen +29 more
2015Human Molecular Genetics120 citations Open access
Semantic Scholar
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice
C. Bouffi, K. Wikenheiser-Brokamp, Praneet Chaturvedi, Nambirajan Sundaram +16 more
2023Nature Biotechnology113 citations Open access
Semantic Scholar
The Function of ATPase Copper Transporter ATP7B in Intestine
H. Pierson, A. Muchenditsi, Byung-Eun Kim, M. Ralle +3 more
2017Gastroenterology102 citations Open access
Semantic Scholar
Intestinal Stem Cells in GI Physiology and Disease Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function
C. Grant, S. Mojica, F. Sala, J. R. Hill +6 more
201598 citations
Semantic Scholar
Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model
S. Ranganathan, M. Doucet, Christen L. Grassel, BreOnna C. Delaine-Elias +2 more
2019Infection and Immunity85 citations Open access
Semantic Scholar
Chronic Inflammation in Ulcerative Colitis Causes Long-Term Changes in Goblet Cell Function
Varsha Singh, Kelli F. Johnson, Jian-Yi Yin, Sun Lee +7 more
2021Cellular and Molecular Gastroenterology and Hepatology84 citations Open access
Semantic Scholar
Co-Culture System of Human Enteroids/Colonoids with Innate Immune Cells
Janet F. Staab, J. Lemme-Dumit, R. Latanich, M. Pasetti +1 more
2020Current Protocols in Immunology63 citations Open access
Semantic Scholar
Regenerative Intestinal Stem Cells Induced by Acute and Chronic Injury: The Saving Grace of the Epithelium?
W. D. Rees, Rene Tandun, Enoch Yau, N. Zachos +1 more
2020Frontiers in Cell and Developmental Biology62 citations Open access
Semantic Scholar
Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli
Lixia Liu, Waleska Saitz-Rojas, Rachel Smith, Laura A. Gonyar +6 more
2020Scientific Reports52 citations Open access
Semantic Scholar
Flagellin-specific human CAR Tregs for immune regulation in IBD
D. Boardman, May Q. Wong, W. Rees, Dan Wu +6 more
2022Journal of Autoimmunity50 citations Open access
Semantic Scholar
Benzopyrimido‐pyrrolo‐oxazine‐dione CFTR inhibitor (R)‐BPO‐27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins
Onur Cil, Puay-Wah Phuan, A. Gillespie, Su-Jin Lee +7 more
2017The FASEB Journal49 citations Open access
Semantic Scholar
The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology
Hui-Min Yu, Nesrin M. Hasan, Julie G. In, M. Estes +3 more
2017Annual Review of Physiology46 citations Open access
Semantic Scholar
Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids.
Byung-Ju Jin, Sailaja Battula, N. Zachos, O. Kovbasnjuk +4 more
2014Biomicrofluidics33 citations Open access
Semantic Scholar
Gastrointestinal microphysiological systems
S. Blutt, J. Broughman, Winnie Y. Zou, Xi-Lei Zeng +6 more
2017Experimental biology and medicine31 citations Open access
Semantic Scholar
Erratum: A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions
Gaelle Noel, N. Baetz, J. Staab, M. Donowitz +3 more
2017Scientific Reports31 citations Open access
Semantic Scholar
Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis
Nesrin M. Hasan, Kelli F. Johnson, Jian-Yi Yin, N. Baetz +7 more
2020Molecular Metabolism29 citations Open access
Semantic Scholar
Glucosylceramide production maintains colon integrity in response to Bacteroides fragilis toxin-induced colon epithelial cell signaling
L. Patterson, J. Allen, Isabella Posey, Jeremy J. P. Shaw +9 more
2020The FASEB Journal29 citations Open access
Semantic Scholar
Epithelial and Neutrophil Interactions and Coordinated Response to Shigella in a Human Intestinal Enteroid-Neutrophil Coculture Model
J. Lemme-Dumit, M. Doucet, N. Zachos, M. Pasetti
2020bioRxiv26 citations Open access
Semantic Scholar
Enterotoxigenic Escherichia coli is phagocytosed by macrophages underlying villus-like intestinal epithelial cells: modeling ex vivo innate immune defenses of the human gut
Gaelle Noel, M. Doucet, J. Nataro, J. Kaper +2 more
2017Gut microbes24 citations Open access
Semantic Scholar
Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis
K. Laky, Jessica Kinard, J. Li, Ian N. Moore +12 more
2023Science immunology23 citations Open access
Semantic Scholar
Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers
Alyssa C. Fasciano, Gaya S. Dasanayake, M. Estes, N. Zachos +4 more
2021bioRxiv23 citations Open access
Semantic Scholar
Aggregative Adherence Fimbriae II of Enteroaggregative Escherichia coli Are Required for Adherence and Barrier Disruption during Infection of Human Colonoids
Laura A. Gonyar, Rachel M Smith, J. Girón, N. Zachos +2 more
2020Infection and Immunity22 citations Open access
Semantic Scholar
Enterohemorrhagic E. coli (EHEC)—Secreted Serine Protease EspP Stimulates Electrogenic Ion Transport in Human Colonoid Monolayers
Chung-Ming Tse, Julie G. In, Jian-Yi Yin, M. Donowitz +7 more
2018Toxins20 citations Open access
Semantic Scholar
Optimizing Human Intestinal Enteroids for Environmental Monitoring of Human Norovirus
Katie N Overbey, N. Zachos, Caroline Coulter, K. Schwab
2021Food and Environmnetal Virology19 citations Open access
Semantic Scholar
Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation
Onur Cil, Puay-Wah Phuan, J. Son, Jie S. Zhu +10 more
2016Translational Research: The Journal of Laboratory and Clinical Medicine19 citations Open access
Semantic Scholar
Current and potential future applications of human stem cell models in drug development.
M. Donowitz, J. Turner, A. Verkman, N. Zachos
2020Journal of Clinical Investigation17 citations Open access
Semantic Scholar
NHERF2/NHERF3 Protein Heterodimerization and Macrocomplex Formation Are Required for the Inhibition of NHE3 Activity by Carbachol*
Jian-bo Yang, Varsha Singh, Tian-E Chen, Rafiquel I. Sarker +7 more
2014Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Epithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury
Julie G. In, Jian-Yi Yin, Roger Atanga, M. Doucet +7 more
2018bioRxiv15 citations Open access
Semantic Scholar
An in vitro chronic damage model impairs inflammatory and regenerative responses in human colonoid monolayers.
W. Rees, N. Telkar, David T. S. Lin, May Q. Wong +5 more
2022Cell Reports11 citations Open access
Semantic Scholar
Improved 223Ra Therapy with Combination Epithelial Sodium Channel Blockade
Diane S Abou, Amanda Fears, Lucy Summer, M. Longtine +10 more
2021Journal of Nuclear Medicine10 citations Open access
Semantic Scholar
Defining a ‘cells to society’ research framework for appendiceal tumours
A. Holowatyj, M. Overman, Konstantinos I. Votanopoulos, A. Lowy +12 more
2025Nature Reviews. Cancer9 citations
Semantic Scholar
PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs
B. Cha, Jian-bo Yang, Varsha Singh, N. Zachos +5 more
2017Journal of Biological Chemistry9 citations Open access
Semantic Scholar
Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces
K. Maeda, N. Zachos, M. Orzalli, Stefanie S. Schmieder +10 more
2022Cell Host and Microbe8 citations Open access
Semantic Scholar
Recovery of Infectious Human Norovirus GII.4 Sydney From Fomites via Replication in Human Intestinal Enteroids
Katie N Overbey, N. Zachos, Caroline Coulter, J. Jacangelo +1 more
2021Frontiers in Cellular and Infection Microbiology7 citations Open access
Semantic Scholar
An in vitro Chronic Damage Model Impairs Inflammatory and Regenerative Responses in Human Colonoid Monolayers
W. Rees, N. Telkar, David Li, C. Poloni +4 more
2021Social Science Research Network6 citations Open access
Semantic Scholar
SARS-COV-2 induced Diarrhea is inflammatory, Ca2+ Dependent and involves activation of calcium activated Cl channels
M. Donowitz, C. Tse, K. Dokladny, Manmeet Rawat +13 more
2021bioRxiv4 citations Open access
Semantic Scholar
COVID-19 Diarrhea is Inflammatory, Caused by Direct Viral Effects Plus Major Role of Virus-induced Cytokines
Mark Donowitz, Chung-Ming Tse, R. Sarker, R. Lin +19 more
2024Cellular and Molecular Gastroenterology and Hepatology3 citations Open access
Semantic Scholar
Using Enteroendocrine Cell–Enriched Human Enteroids to Evaluate Responses to Gut Stimuli
N. Zachos
2019Cellular and Molecular Gastroenterology and Hepatology3 citations Open access
Semantic Scholar

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