D. Horwell

Most-cited papers

1. Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK(1) receptor antagonist.

   Valerie A. Ashwood, M. J. Field, D. Horwell, C. Julien-Larose +5 more

   2001Journal of Medicinal Chemistry68 citations Open access

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2. Cholecystokinin dipeptoid antagonists: design, synthesis, and anxiolytic profile of some novel CCK-A and CCK-B selective and "mixed" CCK-A/CCK-B antagonists.

   P. Boden, M. Higginbottom, D. Hill, D. Horwell +6 more

   1993Journal of Medicinal Chemistry63 citations Open access

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3. Generation of unnatural α,α-disubstituted amino acid derivatives from cyclic sulfamidates

   L. Boulton, H. Stock, J. Raphy, D. Horwell

   199939 citations

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4. A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging We gratefully acknowledge financial support from Pfizer Global Research and Development, the University of Ferrara (Italy, Postdoctoral Fellowship to A.M.), the EU (Marie C

   S. Ley, A. Massi, F. Rodríguez, D. Horwell +3 more

   2001Angewandte Chemie35 citations

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5. Syntheses of novel heterocycles as anticancer agents.

   P. M. S. Chauhan, Cristina Martins, D. Horwell

   2005Bioorganic & Medicinal Chemistry34 citations

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6. A Convenient and Versatile Method for the Synthesis of Protected Guanidines

   Zhao-Xia Guo, A. Cammidge, D. Horwell

   200032 citations

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7. PD 165929 — the first high affinity non-peptide neuromedin-B (NMB) receptor selective antagonist

   J. M. Eden, M. D. Hall, M. Higginbottom, D. Horwell +11 more

   199632 citations

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8. Synthesis of Conformationally Constrained Tryptophan Derivatives

   D. Horwell, Paul D. Nichols, G. Ratcliffe, E. Roberts

   199430 citations

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9. Synthesis of a non-peptide analogue of omega-conotoxin MVIIA

   S. Menzler, J. Bikker, D. Horwell

   199829 citations

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10. Rational design of high affinity tachykinin NK2 receptor antagonists.

    S. Boyle, S. Guard, J. Hodgson, D. Horwell +7 more

    1994Bioorganic & Medicinal Chemistry28 citations

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11. Regioselective nucleophilic ring opening reactions of 2,2-disubstituted aziridines — the asymmetric synthesis of α,α-disubstituted amino acids

    B. G. Burgaud, D. Horwell, Allessandro Padova, M. Pritchard

    199627 citations

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12. The development of a novel series of non-peptide tachykinin NK3 receptor selective antagonists

    P. Boden, J. M. Eden, J. Hodgson, D. Horwell +3 more

    199526 citations

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13. Evaluation of a Targeted Prodrug Strategy to Enhance Oral Absorption of Poorly Water-Soluble Compounds

    O. Chan, H. L. Schmid, L. A. Stilgenbauer, W. Howson +2 more

    1998Pharmaceutical Research25 citations

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14. The rational development of small molecule tachykinin NK3 receptor selective antagonists - the utilisation of a dipeptide chemical library in drug design

    P. Boden, J. M. Eden, J. Hodgson, D. Horwell +9 more

    199425 citations

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15. The design of a dipeptide library for screening at peptide receptor sites

    D. Horwell, W. Howson, G. Ratcliffe, D. Rees

    199323 citations

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16. Synthesis and biological evaluation of conformationally restricted Gabapentin analogues.

    J.-M. Receveur, J. Bryans, M. J. Field, L. Singh +1 more

    1999Bioorganic & Medicinal Chemistry Letters22 citations

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17. N- VS O-ALKYLATION IN 2(1H)-QUINOLINONE DERIVATIVES

    Zhao-Xia Guo, A. Cammidge, A. Mckillop, D. Horwell

    199921 citations

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18. Dendroid Peptide Structural Mimetics of ω-Conotoxin MVIIA based on a 2(1H)-Quinolinone Core

    Zhao-Xia Guo, A. Cammidge, D. Horwell

    200019 citations Open access

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19. Use of the chemical structure of peptides as the starting point to design nonpeptide agonists and antagonists at peptide receptors: examples with cholecystokinin and tachykinins.

    D. Horwell

    1996Bioorganic & Medicinal Chemistry18 citations

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20. Characterization of novel peptoid agonists for the CCK-A receptor.

    J. Hughes, G. Dockray, D. Hill, L. Garcia +5 more

    1996Regulatory Peptides18 citations

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21. Peptoid CCK receptor antagonists: pharmacological evaluation of CCKA, CCKB and mixed receptor antagonists

    L. Singh, M. J. Field, D. Hill, D. Horwell +4 more

    1995European Journal of Pharmacology18 citations

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22. The design of dipeptide helical mimetics, Part I: the synthesis of 1,6-disubstituted indanes

    D. Horwell, W. Howson, W. P. Nolan, G. Ratcliffe +2 more

    199516 citations

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23. Quantitative structure-activity relationships (QSARs) of N-terminus fragments of NK1 tachykinin antagonists: a comparison of classical QSARs and three-dimensional QSARs from similarity matrices.

    D. Horwell, W. Howson, M. Higginbottom, Dorica Naylor +2 more

    1995Journal of Medicinal Chemistry14 citations Open access

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24. Identification of novel ligands for the gabapentin binding site on the alpha2delta subunit of a calcium channel and their evaluation as anticonvulsant agents.

    J. Bryans, N. Davies, N. Gee, V. U. Dissanayake +10 more

    1998Journal of Medicinal Chemistry13 citations

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25. Conformationally constrained amino acids: Synthesis of novel 3,4-cyclised tryptophans

    D. Horwell, Paul D. Nichols, E. Roberts

    199413 citations

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26. Conformationally constrained amino-acids: Synthesis of novel β, β-, 2,3-, and 3,4-cyclised tryptophans

    D. Horwell, M. Mckiernan, Simon Osborne

    199812 citations

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27. Investigation into the preferred conformation of gabapentin for interaction with its binding site on the α2δ subunit of a calcium channel

    J. Bryans, N. Davies, N. Gee, D. Horwell +4 more

    199712 citations

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28. 2,3-Substituted 2-azanorbornanes as polar β-turn mimetics

    D. Horwell, D. Naylor, H. Willems

    199712 citations

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29. 'Targeted' molecular diversity: design and development of non-peptide antagonists for cholecystokinin and tachykinin receptors.

    D. Horwell, M. Pritchard, J. Raphy, G. Ratcliffe

    1996Immunopharmacology12 citations

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30. The design of polar β-turn dipeptide mimetics

    D. Horwell, W. Howson, D. Naylor, Henriëtte M.G. Wilems

    199510 citations

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31. The 'peptoid' approach to the design of non-peptide, small molecule agonists and antagonists of neuropeptides.

    D. Horwell

    1995Trends in Biotechnology10 citations

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32. The asymmetric synthesis of non-peptide CCK-A receptor agonists

    B. G. Burgaud, D. Horwell, M. Pritchard, N. Bernad +1 more

    199510 citations

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33. PD 165929 - The First High Affinity Non-Peptide Neuromedin-B (NMB) Receptor Selective Antagonist.

    J. M. Eden, M. D. Hall, M. Higginbottom, D. Horwell +11 more

    19979 citations

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34. Cholecystokinin B antagonists. Synthesis and quantitative structure-activity relationships of a series of C-terminal analogues of CI-988.

    C. Augelli-Szafran, D. Horwell, C. Kneen, D. Ortwine +7 more

    1996Bioorganic & Medicinal Chemistry9 citations

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35. The design and synthesis of the high efficacy, non-peptide CCK1 receptor agonist PD 170292

    N. Bernad, B. G. Burgaud, D. Horwell, R. A. Lewthwaite +2 more

    20008 citations Open access

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36. trans N -Methyl- N -[2-(1-pyrrolidinyl)cyclohexyl] cycloprop-2-ene-1-carboxamides: Novel lipophilic kappa opioid agonists

    V. Sabin, D. Horwell, A. Mcknight, P. Broqua

    19977 citations

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37. The design of dipeptide helical mimetics: the synthesis and biological activity of trisubstituted indanes

    D. Horwell, W. Howson, G. Ratcliffe, H. Willems

    19947 citations

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38. Synthesis of novel iodinated radioligands with high affinity and selectivity for CCK-B/gastrin receptors

    D. Horwell, J. Hunter, C. Kneen, M. Pritchard

    19956 citations

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39. Diastereoselective synthesis of cyclopropyl phenylalanines and their incorporation into dipeptides

    M. M. Campbell, D. Horwell, M. Mahon, Martyn C. Pritchard +1 more

    19936 citations

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40. Conformationally restricted analogues of the potent CCK-B antagonist CI-988.

    M. Higginbottom, D. Hill, D. Horwell, E. Mostafai +2 more

    1993Bioorganic & Medicinal Chemistry6 citations

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41. The design and synthesis of non-peptide ligands with affinity and selectivity for tachykinin receptors

    D. Horwell, I. MorrellAndrew, E. Roberts

    19965 citations

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42. Cyclobutylcarbinyl radical cleavage in the bicyclo[3.2.0]heptanone ring system

    D. Horwell, A. Morrell, E. Roberts

    19955 citations

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43. The rational design and synthesis of non-peptide ‘rhegnylogues” of CCK-26-33 - a novel series of CCK-A selective ligands

    Gregory T. Bourne, D. Horwell, M. Pritchard

    19935 citations

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44. Design and Biological Evaluation of Non‐Peptide Analogues of Omega‐Conotoxin MVIIA.

    S. Menzler, J. Bikker, Nirmala Suman-Chauhan, D. Horwell

    20004 citations

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45. 'Peptoid' design.

    D. Horwell, W. Howson, D. Rees

    1994Drug Design and Discovery4 citations

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46. Dendroids: a building block for the synthesis of polymodal dendritic structures

    J. V. Allen, D. Horwell, J. A. H. Lainton, J. A. O'Neill +1 more

    19983 citations

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47. The Rational Development of Small Molecule Tachykinin NK3 Receptor Selective Antagonists ‐ The Utilization of a Dipeptide Chemical Library in Drug Design.

    P. Boden, J. M. Eden, J. Hodgson, D. Horwell +9 more

    19953 citations

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48. Formation of the oxatricyclo[3.2.1.03,6]octane ring system via an intramolecular bromoetherification

    D. Horwell, A. Morrell, E. Roberts

    19943 citations

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49. Alternative strategies towards the identification of chemical lead compounds by rational design

    D. Horwell, I. Lennon, E. Roberts

    19943 citations

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50. The design and synthesis of the high efficacy, non-peptide CCK1 receptor agonist PD170292.

    N. Bernad, B. G. Burgaud, D. Horwell, R. A. Lewthwaite +2 more

    2000Bioorganic & Medicinal Chemistry Letters2 citations

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