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L. Singh · SciRah

Researcher profile · Semantic Scholar

L. Singh

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L. Singh — researcher profile on SciRah

h-index: 33
Works: 62
Citations: 4,609

Most-cited papers

A summary of mechanistic hypotheses of gabapentin pharmacology.
C. Taylor, N. Gee, Ti-zhi Su, J. Kocsis +5 more
1998Epilepsy Research717 citations
Semantic Scholar
The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.
Mark D. Tricklebank, L. Singh, R. Oles, Cliff Preston +1 more
1989European Journal of Pharmacology431 citations
Semantic Scholar
Gabapentin (neurontin) and S‐(+)‐3‐isobutylgaba represent a novel class of selective antihyperalgesic agents
M. J. Field, R. Oles, A. S. Lewis, S. Mccleary +2 more
1997British Journal of Pharmacology357 citations Open access
Semantic Scholar
Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat.
M. J. Field, S. Mccleary, J. Hughes, L. Singh
1999Pain305 citations
Semantic Scholar
Evaluation of gabapentin and S-(+)-3-isobutylgaba in a rat model of postoperative pain.
M. J. Field, E. Holloman, S. Mccleary, J. Hughes +1 more
1997Journal of Pharmacology and Experimental Therapeutics281 citations
Semantic Scholar
Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones?
M. J. Field, S. Bramwell, J. Hughes, L. Singh
1999Pain213 citations
Semantic Scholar
Evidence for an involvement of the brain cholecystokinin B receptor in anxiety.
L. Singh, A. S. Lewis, M. J. Field, J. Hughes +1 more
1991Proceedings of the National Academy of Sciences of the United States of America201 citations Open access
Semantic Scholar
The behavioural properties of CI‐988, a selective cholecystokininB receptor antagonist
L. Singh, M. J. Field, J. Hughes, R. Menzies +3 more
1991British Journal of Pharmacology139 citations Open access
Semantic Scholar
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
L. Singh, A. E. Donald, A. Foster, P. Hutson +6 more
1990Proceedings of the National Academy of Sciences of the United States of America130 citations Open access
Semantic Scholar
Gabapentin, ineffective in normal rats, markedly reduces C‐fibre evoked responses after inflammation
Louise C. Stanfa, L. Singh, Richard G. Williams, A. Dickenson
1997NeuroReport118 citations
Semantic Scholar
Modulation of seizure susceptibility in the mouse by the strychnine‐insensitive glycine recognition site of the NMDA receptor/ion channel complex
L. Singh, R. Oles, M. Tricklebank
1990British Journal of Pharmacology115 citations Open access
Semantic Scholar
The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed byd-serine
L. Singh, M. J. Field, P. Ferris, J. Hunter +3 more
1996Psychopharmacology114 citations
Semantic Scholar
Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity
M. J. Field, R. Oles, L. Singh
2001British Journal of Pharmacology107 citations Open access
Semantic Scholar
Further evidence for the role of the α2δ subunit of voltage dependent calcium channels in models of neuropathic pain
M. J. Field, J. Hughes, L. Singh
2000107 citations Open access
Semantic Scholar
Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat.
J. Hunter, L. Singh
1994Neuroscience Letters100 citations
Semantic Scholar
Functional role of brain CCK receptors.
G. N. Woodruff, D. Hill, P. Boden, R. Pinnock +2 more
1991Neuropeptides95 citations
Semantic Scholar
Identification of Novel Ligands for the Gabapentin Binding Site on the α2δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents
J. Bryans, N. Davies, Nicolas S. Gee, V. U. Dissanayake +10 more
199886 citations
Semantic Scholar
Novel nonpeptide CCK-B antagonists: design and development of quinazolinone derivatives as potent, selective, and orally active CCK-B antagonists.
J. Padia, M. J. Field, J. Hinton, K. Meecham +7 more
1998Journal of Medicinal Chemistry78 citations Open access
Semantic Scholar
A role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine.
M. Tricklebank, L. Singh, R. Oles, E. Wong +1 more
1987European Journal of Pharmacology73 citations
Semantic Scholar
Effect of gabapentin-like compounds on development and maintenance of morphine-induced conditioned place preference
N. Andrews, Sally Loomis, R. Blake, L. Ferrigan +2 more
2001Psychopharmacology66 citations
Semantic Scholar
Evaluation of selective NK(1) receptor antagonist CI-1021 in animal models of inflammatory and neuropathic pain.
M. I. González, M. J. Field, J. Hughes, L. Singh
2000Journal of Pharmacology and Experimental Therapeutics58 citations
Semantic Scholar
The tachykinin NK1 receptor antagonist PD 154075 blocks cisplatin-induced delayed emesis in the ferret.
L. Singh, M. J. Field, J. Hughes, B. Kuo +4 more
1997European Journal of Pharmacology47 citations
Semantic Scholar
Bombesin‐like peptides depolarize rat hippocampal interneurones through interaction with subtype 2 bombesin receptors
Kevin Lee, A. K. Dixon, I. González, E. B. Stevens +5 more
1999Journal of Physiology46 citations Open access
Semantic Scholar
Further evidence for the role of the alpha(2)delta subunit of voltage dependent calcium channels in models of neuropathic pain.
M. J. Field, J. Hughes, L. Singh
2000British Journal of Pharmacology45 citations
Semantic Scholar
Evidence that a proconvulsant action of lithium is mediated by inhibition of myo-inositol phosphatase in mouse brain.
Mark D. Tricklebank, L. Singh, A. Jackson, R. Oles
1991Brain Research43 citations
Semantic Scholar
Ovariohysterectomy in the rat: a model of surgical pain for evaluation of pre‐emptive analgesia?
M. I. González, M. J. Field, S. Bramwell, S. Mccleary +1 more
2000Pain40 citations
Semantic Scholar
The anticonvulsant and behavioural profile of L‐687,414, a partial agonist acting at the glycine modulatory site on the N‐methyl‐D‐aspartate (NMDA) receptor complex
M. Tricklebank, L. Bristow, P. Hutson, P. Leeson +6 more
1994British Journal of Pharmacology39 citations Open access
Semantic Scholar
Second generation "peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile.
B. K. Trivedi, J. Padia, A. Holmes, S. Rose +11 more
1998Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain.
M. J. Field, A. J. Carnell, M. I. Gonzalez, S. Mccleary +4 more
1999Pain37 citations
Semantic Scholar
Gabapentin and the Neurokinin1 Receptor Antagonist CI-1021 Act Synergistically in Two Rat Models of Neuropathic Pain
M. J. Field, M.Isabel Gonzalez, R. Tallarida, L. Singh
2002Journal of Pharmacology and Experimental Therapeutics36 citations
Semantic Scholar
The pharmacological properties of the imidazobenzodiazepine, FG 8205, a novel partial agonist at the benzodiazepine receptor
M. Tricklebank, T. Honoré, S. D. Iversen, John A. Kemp +7 more
1990British Journal of Pharmacology36 citations Open access
Semantic Scholar
The antagonism of benzodiazepine withdrawal effects by the selective cholecystokininB receptor antagonist CI‐988
L. Singh, M. J. Field, C. A. Vass, J. Hughes +1 more
1992British Journal of Pharmacology34 citations Open access
Semantic Scholar
Evidence against an involvement of the haloperidol‐sensitive σ recognition site in the discriminative stimulus properties of (+)‐N‐allylnormetazocine ((+)‐SKF 10,047)
L. Singh, E. Wong, A. C. Kesingland, M. Tricklebank
1990British Journal of Pharmacology34 citations Open access
Semantic Scholar
Effect of CCK receptor antagonists on the antinociceptive, reinforcing and gut motility properties of morphine
L. Singh, R. Oles, M. J. Field, P. Atwal +2 more
1996British Journal of Pharmacology30 citations Open access
Semantic Scholar
Evaluation of PD 154075, a tachykinin NK1 receptor antagonist, in a rat model of postoperative pain.
M.Isabel Gonzalez, M. J. Field, E. Holloman, J. Hughes +2 more
1998European Journal of Pharmacology27 citations
Semantic Scholar
Involvement of the central tachykinin NK1 receptor during maintenance of mechanical hypersensitivity induced by diabetes in the rat.
M. J. Field, S. Mccleary, P. Boden, N. Suman-Chauhan +2 more
1998Journal of Pharmacology and Experimental Therapeutics24 citations
Semantic Scholar
Modulation of 5‐hydroxytryptamine‐induced head‐twitch response by drugs acting at GABA and related receptors
S. Handley, L. Singh
1985British Journal of Pharmacology23 citations Open access
Semantic Scholar
Synthesis and biological evaluation of conformationally restricted Gabapentin analogues.
J.-M. Receveur, J. Bryans, M. J. Field, L. Singh +1 more
1999Bioorganic & Medicinal Chemistry Letters22 citations
Semantic Scholar
Effect of gastrin-releasing peptide on rat hippocampal extracellular GABA levels and seizures in the audiogenic seizure-prone DBA/2 mouse.
N. Andrews, Ben Davis, M.Isabel Gonzalez, R. Oles +2 more
2000Brain Research21 citations
Semantic Scholar
Peptoid CCK receptor antagonists: pharmacological evaluation of CCKA, CCKB and mixed receptor antagonists
L. Singh, M. J. Field, D. Hill, D. Horwell +4 more
1995European Journal of Pharmacology18 citations
Semantic Scholar
Modulation of the in vivo actions of morphine by the mixed CCKA/B receptor antagonist PD 142898.
L. Singh, M. J. Field, J. Hunter, R. Oles +1 more
1996European Journal of Pharmacology14 citations
Semantic Scholar
Identification of novel ligands for the gabapentin binding site on the alpha2delta subunit of a calcium channel and their evaluation as anticonvulsant agents.
J. Bryans, N. Davies, N. Gee, V. U. Dissanayake +10 more
1998Journal of Medicinal Chemistry13 citations
Semantic Scholar
Anticonvulsant activity of glycine-site NMDA antagonists: 1. 2-Carboxyl prodrugs of 5,7-dichlorokynurenic acid
K. Moore, P. Leeson, R. Carling, Mark D. Ticklebank +1 more
199312 citations
Semantic Scholar
The modulation of head-twitch behaviour by drugs acting on beta-adrenoceptors: evidence for the involvement of both beta1- and beta2-adrenoceptors
S. Handley, L. Singh
2004Psychopharmacology10 citations
Semantic Scholar
Chronic antidepressant treatment reduces central β-adrenoceptor sensitivity in a behavioral test
S. Handley, L. Singh
19866 citations
Semantic Scholar
Further evidence for the role of the a 2 d subunit of voltage dependent calcium channels in models of neuropathic pain
M. J. Field, J. Hughes, L. Singh
6 citations
Semantic Scholar
Involvement of noradrenaline in potentiation of the head-twitch response by GABA-related drugs
L. Singh, J. C. Patrick Heaton, Penny J. Rea, S. Handley
2004Psychopharmacology3 citations
Semantic Scholar
NMDA)receptor complex
M. Tricklebank, L. Bristow, P. Hutson, P. Leeson +6 more
19943 citations
Semantic Scholar
Differential modulation of kappa and mu opioid antinociception by the glycine/NMDA receptor agonist D-serine.
J. Hunter, P. Atwal, G. N. Woodruff, L. Singh
1994British Journal of Pharmacology3 citations
Semantic Scholar
Behavioural evidence for an interdependence between GABAA receptors and β2-adrenoceptors
L. Singh, S. Handley
19873 citations
Semantic Scholar

Frequent co-authors

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M. J. Field×25
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M. J. Field — researcher profile on SciRah
R. Oles×17
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R. Oles — researcher profile on SciRah
J. Hughes×15
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J. Hughes — researcher profile on SciRah
G. N. Woodruff×8
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G. N. Woodruff — researcher profile on SciRah

×6

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S. Mccleary — researcher profile on SciRah

M. Tricklebank×6

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M. Tricklebank — researcher profile on SciRah

N. Suman-Chauhan×6

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N. Suman-Chauhan — researcher profile on SciRah

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S. Handley — researcher profile on SciRah

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P. Leeson — researcher profile on SciRah

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J. Hunter — researcher profile on SciRah

S. D. Iversen×3

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S. D. Iversen — researcher profile on SciRah

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P. Hutson — researcher profile on SciRah