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H. Towle · SciRah

Researcher profile · Semantic Scholar

H. Towle

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H. Towle — researcher profile on SciRah

h-index: 52
Works: 120
Citations: 7,770

Most-cited papers

ChREBP•Mlx Is the Principal Mediator of Glucose-induced Gene Expression in the Liver*
Lin Ma, Luke N. Robinson, H. Towle
2006Journal of Biological Chemistry381 citations Open access
Semantic Scholar
Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain
J. B. Kim, G. D. Spotts, Y. Halvorsen, Hsiu-Ming Shih +3 more
1995Molecular and Cellular Biology343 citations Open access
Semantic Scholar
Regulation of the expression of lipogenic enzyme genes by carbohydrate.
H. Towle, E. N. Kaytor, Hsiu-Ming Shih
1997Annual review of nutrition315 citations
Semantic Scholar
Mlx Is the Functional Heteromeric Partner of the Carbohydrate Response Element-binding Protein in Glucose Regulation of Lipogenic Enzyme Genes*
Angela K Stoeckman, Lin Ma, H. Towle
2004Journal of Biological Chemistry224 citations Open access
Semantic Scholar
Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.
L. Olson, J. Redmon, H. Towle, R. Robertson
1993Journal of Clinical Investigation219 citations Open access
Semantic Scholar
Two CACGTG Motifs with Proper Spacing Dictate the Carbohydrate Regulation of Hepatic Gene Transcription (*)
Hsiu-Ming Shih, Zhe-Ru Liu, H. Towle
1995Journal of Biological Chemistry218 citations Open access
Semantic Scholar
Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors.
Megan Murray, N. D. Zilz, N. L. McCreary, M. J. MacDonald +1 more
1988Journal of Biological Chemistry210 citations Open access
Semantic Scholar
Direct Role of ChREBP·Mlx in Regulating Hepatic Glucose-responsive Genes*
Lin Ma, Nikolas G. Tsatsos, H. Towle
2005Journal of Biological Chemistry192 citations Open access
Semantic Scholar
The Role of SREBP-1c in Nutritional Regulation of Lipogenic Enzyme Gene Expression*
Angela K Stoeckman, H. Towle
2002Journal of Biological Chemistry182 citations Open access
Semantic Scholar
Identification of nuclear factors that enhance binding of the thyroid hormone receptor to a thyroid hormone response element.
M. B. Murray, H. Towle
1989Molecular Endocrinology176 citations Open access
Semantic Scholar
Glucose and Insulin Function through Two Distinct Transcription Factors to Stimulate Expression of Lipogenic Enzyme Genes in Liver*
Seung-Hoi Koo, Angela K. Dutcher, H. Towle
2001Journal of Biological Chemistry164 citations Open access
Semantic Scholar
Different Sterol Regulatory Element-binding Protein-1 Isoforms Utilize Distinct Co-regulatory Factors to Activate the Promoter for Fatty Acid Synthase*
Marisa M. Magaña, Seung-Hoi Koo, H. Towle, T. Osborne
2000Journal of Biological Chemistry163 citations Open access
Semantic Scholar
Metabolic Regulation of Gene Transcription in Mammals (*)
H. Towle
1995Journal of Biological Chemistry158 citations Open access
Semantic Scholar
Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression.
L. Olson, Arun J. Sharma, M. Peshavaria, C. Wright +3 more
1995Proceedings of the National Academy of Sciences of the United States of America154 citations Open access
Semantic Scholar
Glucose as a regulator of eukaryotic gene transcription.
H. Towle
2005Trends in endocrinology and metabolism153 citations
Semantic Scholar
Definition of the carbohydrate response element of the rat S14 gene. Evidence for a common factor required for carbohydrate regulation of hepatic genes.
Hsiu-Ming Shih, H. Towle
1992Journal of Biological Chemistry145 citations Open access
Semantic Scholar
Involvement of a Unique Carbohydrate-responsive Factor in the Glucose Regulation of Rat Liver Fatty-acid Synthase Gene Transcription*
C. Rufo, M. Téran-García, Manabu T. Nakamura, Seung-Hoi Koo +2 more
2001Journal of Biological Chemistry134 citations Open access
Semantic Scholar
Carbohydrate regulation of the rat L-type pyruvate kinase gene requires two nuclear factors: LF-A1 and a member of the c-myc family.
Zhe-Ru Liu, K. Thompson, H. Towle
1993Journal of Biological Chemistry126 citations Open access
Semantic Scholar
Growth Hormone Induction of Hepatic Serine Protease Inhibitor 2.1 Transcription Is Mediated by a Stat5-related Factor Binding Synergistically to Two γ-Activated Sites (*)
P. L. Bergad, Hsiu-Ming Shih, H. Towle, S. Schwarzenberg +1 more
1995Journal of Biological Chemistry124 citations Open access
Semantic Scholar
Localization of the carbohydrate response element of the rat L-type pyruvate kinase gene.
K. Thompson, H. Towle
1991Journal of Biological Chemistry124 citations Open access
Semantic Scholar
Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes.
C. Arden, S. Tudhope, John L. Petrie, Z. Al-Oanzi +4 more
2012Biochemical Journal109 citations
Semantic Scholar
Definition of the carbohydrate response element of the rat S14 gene. Context of the CACGTG motif determines the specificity of carbohydrate regulation.
Hsiu-Ming Shih, H. Towle
1994Journal of Biological Chemistry105 citations Open access
Semantic Scholar
Glucose Activates ChREBP by Increasing Its Rate of Nuclear Entry and Relieving Repression of Its Transcriptional Activity*
Michael N. Davies, Brennon L. O'Callaghan, H. Towle
2008Journal of Biological Chemistry104 citations Open access
Semantic Scholar
An inducible nuclear factor binds to a growth hormone-regulated gene.
Jong-Bok Yoon, Susan A. Berry, S. Seelig, H. Towle
1990Journal of Biological Chemistry102 citations Open access
Semantic Scholar
Repression of rat kidney L-arginine:glycine amidinotransferase synthesis by creatine at a pretranslational level.
D. M. McGuire, Myron D. Gross, J. V. van Pilsum, H. Towle
1984Journal of Biological Chemistry99 citations
Semantic Scholar
Identification of multiple thyroid hormone response elements located far upstream from the rat S14 promoter.
N. Zilz, M. Murray, H. Towle
1990Journal of Biological Chemistry97 citations Open access
Semantic Scholar
Sequences within the 5'-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes.
D. Jacoby, N. Zilz, H. Towle
1989Journal of Biological Chemistry97 citations
Semantic Scholar
Glucose Regulation of the Acetyl-CoA Carboxylase Promoter PI in Rat Hepatocytes*
Brennon L. O'Callaghan, Seung-Hoi Koo, Yue Wu, H. Freake +1 more
2001Journal of Biological Chemistry94 citations Open access
Semantic Scholar
Carbohydrate Regulation of Hepatic Gene Expression
E. N. Kaytor, Hsiu-Ming Shih, H. Towle
1997Journal of Biological Chemistry94 citations Open access
Semantic Scholar
Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism.
Nikolas G. Tsatsos, H. Towle
2006Biochemical and Biophysical Research Communications - BBRC86 citations
Semantic Scholar
Growth hormone induces two mRNA species of the serine protease inhibitor gene family in rat liver.
Jong-Bok Yoon, H. Towle, S. Seelig
1987Journal of Biological Chemistry85 citations Open access
Semantic Scholar
Glucose regulation of mouse S(14) gene expression in hepatocytes. Involvement of a novel transcription factor complex.
Seung-Hoi Koo, H. Towle
2000Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Interactions of thyroid hormone, growth hormone, and high carbohydrate, fat-free diet in regulating several rat liver messenger ribonucleic acid species.
Chen Liaw, S. Seelig, C. Mariash, J. H. Oppenheimer +1 more
1983Biochemistry78 citations
Semantic Scholar
Stabilization of a specific nuclear mRNA precursor by thyroid hormone
P. Narayan, H. Towle
1985Molecular and Cellular Biology77 citations Open access
Semantic Scholar
Changes in the rates of synthesis and messenger RNA levels of hepatic glucose-6-phosphate and 6-phosphogluconate dehydrogenases following induction by diet or thyroid hormone.
Richard J. Miksicek, H. Towle
1982Journal of Biological Chemistry77 citations Open access
Semantic Scholar
Glucose and triiodothyronine both induce malic enzyme in the rat hepatocyte culture: evidence that triiodothyronine multiplies a primary glucose-generated signal.
C. Mariash, C. McSwigan, H. Towle, Harold L. Schwartz +1 more
1981Journal of Clinical Investigation75 citations Open access
Semantic Scholar
Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARα-mediated pathway
M. Armstrong, H. Towle
200172 citations
Semantic Scholar
A critical role for the loop region of the basic helix–loop–helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription
Lin Ma, Y. Sham, K. Walters, H. Towle
2006Nucleic Acids Research70 citations Open access
Semantic Scholar
Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α
E. Hanse, Douglas G. Mashek, Jennifer R. Becker, Ashley Solmonson +5 more
2012Cell Cycle69 citations Open access
Semantic Scholar
Characterization of a thyroid hormone-responsive gene from rat.
C. Liaw, H. Towle
1984Journal of Biological Chemistry69 citations Open access
Semantic Scholar
Upstream stimulatory factor regulates Pdx-1 gene expression in differentiated pancreatic beta-cells.
Jin Qian, E. N. Kaytor, H. Towle, L. Olson
1999Biochemical Journal68 citations Open access
Semantic Scholar
Inhibition of growth hormone action in models of inflammation.
P. L. Bergad, S. Schwarzenberg, J. T. Humbert, M. Morrison +3 more
2000American Journal of Physiology - Cell Physiology67 citations
Semantic Scholar
Regulator of G Protein Signaling (RGS16) Inhibits Hepatic Fatty Acid Oxidation in a Carbohydrate Response Element-binding Protein (ChREBP)-dependent Manner*
V. Pashkov, Jie Huang, Vinay K. Parameswara, W. Kedzierski +7 more
2011Journal of Biological Chemistry65 citations Open access
Semantic Scholar
Elevated Glucose Represses Liver Glucokinase and Induces Its Regulatory Protein to Safeguard Hepatic Phosphate Homeostasis
C. Arden, John L. Petrie, S. Tudhope, Z. Al-Oanzi +4 more
2011Diabetes64 citations Open access
Semantic Scholar
Functional synergism between multiple thyroid hormone response elements regulates hepatic expression of the rat S14 gene.
Hsien-Ching Liu, H. Towle
1994Molecular Endocrinology55 citations Open access
Semantic Scholar
Paradoxical effects of cycloheximide on the ultra-rapid induction of two hepatic mRNA sequences by triiodothyronine (T3).
S. Seelig, D. Jump, H. Towle, C. Liaw +3 more
1982Endocrinology53 citations
Semantic Scholar
Glucose and cAMP: Adversaries in the regulation of hepatic gene expression
H. Towle
2001Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.
Chao-Dong Wu, D. Okar, Angela K Stoeckman, Li-Jen Peng +4 more
2004Endocrinology48 citations
Semantic Scholar
Rapid induction of a specific nuclear mRNA precursor by thyroid hormone.
P. Narayan, Chen Liaw, H. Towle
1984Proceedings of the National Academy of Sciences of the United States of America46 citations Open access
Semantic Scholar
Glucose regulates leucine-induced insulin release and the expression of the branched chain ketoacid dehydrogenase E1 alpha subunit gene in pancreatic islets.
M. J. MacDonald, D. McKenzie, J. H. Kaysen, T. Walker +3 more
1991Journal of Biological Chemistry43 citations
Semantic Scholar

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Hsiu-Ming Shih×7
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Seung-Hoi Koo×5
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Lin Ma×4
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S. Seelig×4
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E. N. Kaytor — researcher profile on SciRah

Angela K Stoeckman×3

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L. Olson — researcher profile on SciRah

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Zhe-Ru Liu — researcher profile on SciRah

Nikolas G. Tsatsos×2

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P. L. Bergad×2

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P. L. Bergad — researcher profile on SciRah