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Buwen Huang · SciRah

Researcher profile · Semantic Scholar

Buwen Huang

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Buwen Huang — researcher profile on SciRah

h-index: 14
Works: 25
Citations: 708

Most-cited papers

Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquin
Pei-Pei Kung, Patrick Bingham, A. Brooun, M. Collins +37 more
2017Journal of Medicinal Chemistry108 citations Open access
Semantic Scholar
Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
K. Freeman-Cook, R. Hoffman, D. Behenna, B. Boras +29 more
2021Journal of Medicinal Chemistry92 citations Open access
Semantic Scholar
Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone.
Pei-Pei Kung, Buwen Huang, Gang Zhang, J. Zhou +14 more
2010Journal of Medicinal Chemistry62 citations Open access
Semantic Scholar
Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer
Pei-Pei Kung, R. Martinez, Zhou Zhu, M. Zager +17 more
2014Molecular Cancer Therapeutics60 citations Open access
Semantic Scholar
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
Pei-Pei Kung, E. Rui, S. Bergqvist, Patrick Bingham +34 more
2016Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Discovery of novel disaccharide antibacterial agents using a combinatorial library approach.
Michael J Sofia, Nigel M. Allanson, N. Hatzenbuhler, R. Jain +22 more
1999Journal of Medicinal Chemistry54 citations
Semantic Scholar
Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone.
Pei-Pei Kung, P. Sinnema, P. Richardson, M. Hickey +9 more
2011Bioorganic & Medicinal Chemistry Letters44 citations Open access
Semantic Scholar
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
Heng-Miao Cheng, Suvi T. M. Orr, Simon Bailey, A. Brooun +35 more
2020Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyri
L. Zehnder, M. Bennett, J. Meng, Buwen Huang +22 more
2011Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Synthesis of aryl ethers via a sulfonyl transfer reaction.
N. Sach, D. Richter, S. Cripps, M. Tran-Dube +4 more
2012Organic Letters28 citations
Semantic Scholar
SAH derived potent and selective EZH2 inhibitors.
Pei-Pei Kung, Buwen Huang, L. Zehnder, J. Tatlock +6 more
2015Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK.
S. Tanis, M. Plewe, T. Johnson, S. Butler +18 more
2010Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Design and Characterization of a Pyridone-Containing EZH2 Inhibitor Phosphate Prodrug.
Pei-Pei Kung, C. Fan, H. Gukasyan, Buwen Huang +6 more
2021Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
A Pyropheophorbide Dimer with Single Pyrrole π Overlap and a Low-Energy Q Absorption
S. Knapp, Buwen Huang, T. Emge, S. Sheng +3 more
199918 citations
Semantic Scholar
Solution-phase parallel synthesis of Hsp90 inhibitors.
Sujin Cho-Schultz, M. Patten, Buwen Huang, Jeff Elleraas +8 more
2009Journal of combinatorial chemistry14 citations
Semantic Scholar
Design and Synthesis of Pyridone-Containing 3 , 4-Dihydroisoquinoline-1 ( 2 H ) ‐ ones as a Novel Class of Enhancer of Zeste Homolog 2 ( EZH 2 ) Inhibitors
Pei-Pei Kung, E. Rui, S. Bergqvist, Patrick Bingham +34 more
201612 citations
Semantic Scholar
Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
Pei-Pei Kung, E. Rui, S. Bergqvist, Patrick Bingham +34 more
2016Journal of Medicinal Chemistry5 citations Open access
Semantic Scholar
Synthesis of oxetane-3-carboxaldehyde and methyl oxetane-3-carboxylate via homologation of oxetane-3-one
Kephart Susan Elizabeth, Zehnder Luke Raymond, Buwen Huang, Sutton Scott Channing
20164 citations
Semantic Scholar
Structure-based and property-compliant library design of 11β-HSD1 adamantyl amide inhibitors.
G. Paderes, K. Dress, Buwen Huang, Jeff Elleraas +2 more
2011Methods in molecular biology2 citations
Semantic Scholar
Methyl 3-[3-(ethoxycarbonyl)thioureido]-1H-pyrazole-5-carboxylate
Buwen Huang, Pei-Pei Kung, A. Rheingold, A. DiPasquale +1 more
2009Acta Crystallographica Section E2 citations Open access
Semantic Scholar
A short asymmetric synthesis of methyl 2-((1S,3R)-3-((tert-butyldiphenylsilyl)oxy)cyclopentyl)acetate from norbornene
Buwen Huang, Jeff Elleraas, Jason Ewanicki, S. Sutton
20200 citations
Semantic Scholar
Synthesis of Oxetane‐3‐carboxaldehyde and Methyl Oxetane‐3‐carboxylate via Homologation of Oxetane‐3‐one.
Kephart Susan Elizabeth, Zehnder Luke Raymond, Buwen Huang, Sutton Scott Channing
20160 citations
Semantic Scholar
Companion Diagnostics and Cancer Biomarkers Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer
Pei-Pei Kung, R. Martinez, Zhou Zhu, M. Zager +17 more
20140 citations
Semantic Scholar
Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-6-methylpyrimidin-2-amine
Pei-Pei Kung, P. Sinnema, P. Richardson, M. Hickey +9 more
20110 citations
Semantic Scholar
2-(6-Bromo-3-pyridyl)-8-methylimidazo[1,2-a]pyrazine
Buwen Huang, E. Rui, Martin James Wythes, Pei-Pei Kung +3 more
2010Acta Crystallographica Section E0 citations Open access
Semantic Scholar

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