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H. Gukasyan · SciRah

Researcher profile · Semantic Scholar

H. Gukasyan

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H. Gukasyan — researcher profile on SciRah

h-index: 19
Works: 73
Citations: 1,804

Most-cited papers

PF-06463922, an ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical models
H. Zou, L. Friboulet, D. Kodack, Lars D. Engstrom +29 more
2015Cancer Cell463 citations Open access
Semantic Scholar
Eyes on Lipinski's Rule of Five: A New “Rule of Thumb” for Physicochemical Design Space of Ophthalmic Drugs
Thomas K. Karami, S. Hailu, Shao-Xin Feng, Richard Graham +1 more
2021Journal of Ocular Pharmacology and Therapeutics161 citations Open access
Semantic Scholar
Clathrin and caveolin-1 expression in primary pigmented rabbit conjunctival epithelial cells: role in PLGA nanoparticle endocytosis.
M. Qaddoumi, H. Gukasyan, J. Davda, V. Labhasetwar +2 more
2003Molecular Vision145 citations
Semantic Scholar
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquin
Pei-Pei Kung, Patrick Bingham, A. Brooun, M. Collins +37 more
2017Journal of Medicinal Chemistry108 citations Open access
Semantic Scholar
Ocular disposition, pharmacokinetics, efficacy and safety of nanoparticle-formulated ophthalmic drugs.
Hai-Zhi Bu, H. Gukasyan, L. Goulet, Xiaowei Lou +2 more
2007Current drug metabolism86 citations
Semantic Scholar
Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma.
G. Prasanna, S. Carreiro, Scott Anderson, H. Gukasyan +12 more
2011Experimental Eye Research63 citations
Semantic Scholar
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
Pei-Pei Kung, E. Rui, S. Bergqvist, Patrick Bingham +34 more
2016Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Axitinib inhibits retinal and choroidal neovascularization in in vitro and in vivo models.
A. Giddabasappa, Kush Lalwani, Rand Norberg, H. Gukasyan +6 more
2016Experimental Eye Research53 citations Open access
Semantic Scholar
Pharmacological modulation of fluid secretion in the pigmented rabbit conjunctiva.
M. Shiue, Ashutosh A. Kulkarni, H. Gukasyan, Jennifer B. Swisher +2 more
2000Life Science44 citations
Semantic Scholar
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
Heng-Miao Cheng, Suvi T. M. Orr, Simon Bailey, A. Brooun +35 more
2020Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Pharmacokinetic study of vitreous and serum concentrations of triamcinolone acetonide after posterior sub-tenon's injection.
Kyle D. Kovacs, Sushant Wagley, M. Quirk, O. Cerón +4 more
2010American journal of ophthalmology-glaucoma36 citations
Semantic Scholar
Transepithelial bioelectrical properties of rabbit acinar cell monolayers on polyester membrane scaffolds.
S. Selvam, P. Thomas, H. Gukasyan, Alan S. L. Yu +6 more
2007American Journal of Physiology - Cell Physiology32 citations Open access
Semantic Scholar
Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models.
G. Prasanna, J. Fortner, C. Xiang, Eric Zhang +12 more
2009Experimental Eye Research31 citations
Semantic Scholar
Correlation of In Vitro and In Vivo Kinetics of Nitric Oxide Donors in Ocular Tissues
S. Carreiro, Scott Anderson, H. Gukasyan, A. Krauss +1 more
2009Journal of Ocular Pharmacology and Therapeutics30 citations
Semantic Scholar
Regulation of L-cystine transport and intracellular GSH level by a nitric oxide donor in primary cultured rabbit conjunctival epithelial cell layers.
H. Gukasyan, R. Kannan, V. H. Lee, Kwang-Jin Kim
2003Investigative Ophthalmology and Visual Science30 citations
Semantic Scholar
Net glutathione secretion across primary cultured rabbit conjunctival epithelial cell layers.
H. Gukasyan, V. H. Lee, Kwang-Jin Kim, R. Kannan
2002Investigative Ophthalmology and Visual Science28 citations
Semantic Scholar
Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressure.
Qinhua Huang, E. Rui, Morena Cobbs, D. Dinh +7 more
2015Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
The Conjunctival Barrier in Ocular Drug Delivery
H. Gukasyan, Kwang-Jin Kim, V. H. Lee
200827 citations
Semantic Scholar
Glutathione and its transporters in ocular surface defense.
H. Gukasyan, Kwang-Jin Kim, V. H. Lee, R. Kannan
2007The ocular surface23 citations
Semantic Scholar
Evaluation of miR-216a and miR-217 as Potential Biomarkers of Acute Exocrine Pancreatic Toxicity in Rats
Jian-Ying Wang, Wen-Hu Huang, S. Thibault, Thomas P. Brown +6 more
2017Toxicologic pathology (Print)19 citations Open access
Semantic Scholar
Design and Characterization of a Pyridone-Containing EZH2 Inhibitor Phosphate Prodrug.
Pei-Pei Kung, C. Fan, H. Gukasyan, Buwen Huang +6 more
2021Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Abstract A277: PF-06463922, a novel ROS1/ALK inhibitor, demonstrates sub-nanomolar potency against oncogenic ROS1 fusions and capable of blocking the resistant ROS1G2032R mutant in preclinical tumor models.
H. Zou, Lars R. Engstrom, Qiuhua Li, M. Lu +12 more
201318 citations
Semantic Scholar
An Assessment of the Ocular Safety of Inactive Excipients Following Sub-Tenon Injection in Rabbits
H. Younis, M. Shawer, Kimberly Palacio, H. Gukasyan +2 more
2008Journal of Ocular Pharmacology and Therapeutics18 citations
Semantic Scholar
Characterization of cyclic AMP-regulated chloride conductance in the pigmented rabbit conjunctival epithelial cells.
M. Shiue, H. Gukasyan, Kwang-Jin Kim, D. Loo +1 more
2002Canadian Journal of Physiology and Pharmacology18 citations
Semantic Scholar
Ocular biopharmaceutics: impact of modeling and simulation on topical ophthalmic formulation development.
H. Gukasyan, S. Hailu, Thomas K. Karami, Richard Graham
2019Drug Discovery Today17 citations
Semantic Scholar
l‐Carnosine: multifunctional dipeptide buffer for sustained‐duration topical ophthalmic formulations
Swita R. Singh, S. Carreiro, Jessie Chu, G. Prasanna +5 more
2009The Journal of pharmacy and pharmacology16 citations
Semantic Scholar
Functional characterization and cloning of amino acid transporter B0,+ (ATB0,+) in primary cultured rat pneumocytes
T. Uchiyama, T. Fujita, H. Gukasyan, Kwang-Jin Kim +3 more
2008Journal of Cellular Physiology16 citations
Semantic Scholar
Safety Assessment of Formulation Vehicles Following Intravitreal Administration in Rabbits
S. Aguirre, H. Gukasyan, H. Younis, Wen-Hu Huang
2018Pharmaceutical Research14 citations Open access
Semantic Scholar
Tissue Distribution of Moxaverine–Hydrochloride in the Rabbit Eye and Plasma
Ulrich Becker, C. Ehrhardt, U. Schaefer, H. Gukasyan +3 more
2005Journal of Ocular Pharmacology and Therapeutics14 citations
Semantic Scholar
Design and Synthesis of Pyridone-Containing 3 , 4-Dihydroisoquinoline-1 ( 2 H ) ‐ ones as a Novel Class of Enhancer of Zeste Homolog 2 ( EZH 2 ) Inhibitors
Pei-Pei Kung, E. Rui, S. Bergqvist, Patrick Bingham +34 more
201612 citations
Semantic Scholar
Nucleotide-Induced Restoration of Conjunctival Chloride and Fluid Secretion in Adenovirus Type 5-Infected Pigmented Rabbit Eyes
Ashutosh A. Kulkarni, M. Trousdale, D. Stevenson, H. Gukasyan +4 more
2003Journal of Pharmacology and Experimental Therapeutics12 citations
Semantic Scholar
In Vivo Evaluation of 11β-Hydroxysteroid Dehydrogenase Activity in the Rabbit Eye
Scott Anderson, S. Carreiro, T. Quenzer, David C. Gale +6 more
2009Journal of Ocular Pharmacology and Therapeutics11 citations
Semantic Scholar
2nd Ophthalmic Drug Development and Delivery Summit
M. Marra, H. Gukasyan, S. Raghava, U. Kompella
2007Expert Opinion on Drug Delivery10 citations
Semantic Scholar
Abstract C253: PF-06463922, a novel brain-penetrating small molecule inhibitor of ALK/ROS1 with potent activity against a broad spectrum of ALK resistant mutations in preclinical models in vitro and in vivo.
H. Zou, Lars R. Engstrom, Qiuhua Li, M. Lu +18 more
20139 citations
Semantic Scholar
Solution Formulation Development of a VEGF Inhibitor for Intravitreal Injection
M. Marra, P. Khamphavong, Peter Wisniecki, H. Gukasyan +1 more
2011AAPS PharmSciTech9 citations Open access
Semantic Scholar
An Assessment of the Ocular Safety of Excipient Maleic Acid Following Intravitreal Injection in Rabbits
S. Aguirre, Walter Collette, H. Gukasyan, Wen-Hu Huang
2012Toxicologic pathology (Print)8 citations Open access
Semantic Scholar
Thermodynamic stoichiometry of Na+-coupled glutathione transport.
H. Gukasyan, V. H. Lee, Hagop Simityan, Kwang-Jin Kim +1 more
2006Canadian Journal of Physiology and Pharmacology8 citations
Semantic Scholar
Impairment of conjunctival glutathione secretion and ion transport by oxidative stress in an adenovirus type 5 ocular infection model of pigmented rabbits.
R. Kannan, H. Gukasyan, Wen-Zheng Zhang, M. Trousdale +2 more
2004Free Radical Biology & Medicine8 citations
Semantic Scholar
Metabolism and transport of purinergic receptor agonists in rabbit conjunctival epithelial cells.
H. Gukasyan, B. Yerxa, W. Pendergast, V. H. Lee
2000Advances in Experimental Medicine and Biology8 citations
Semantic Scholar
Ophthalmic Product Development: From Bench to Bedside
Seshadri Neervannan, U. Kompella, P. Hughes, Jie Shen +62 more
2021AAPS Advances in the Pharmaceutical Sciences Series6 citations
Semantic Scholar
Specialized protective role of mucosal glutathione in pigmented rabbit conjunctiva.
H. Gukasyan, Kwang-Jin Kim, R. Kannan, R. Farley +1 more
2003Investigative Ophthalmology and Visual Science6 citations
Semantic Scholar
Translational Pharmacokinetic-Pharmacodynamic Modeling for an Orally Available Novel Inhibitor of Epigenetic Regulator Enhancer of Zeste Homolog 2
S. Yamazaki, H. Gukasyan, Hui Wang, S. Uryu +1 more
2020Journal of Pharmacology and Experimental Therapeutics5 citations Open access
Semantic Scholar
Ophthalmic Drug Discovery and Development
H. Gukasyan, S. Hailu, Thomas K. Karami
2019Pharmaceutical Research5 citations Open access
Semantic Scholar
Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2
H. Gukasyan, T. Uchiyama, Kwang-Jin Kim, C. Ehrhardt +4 more
2017Pharmaceutical Research5 citations
Semantic Scholar
Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
Pei-Pei Kung, E. Rui, S. Bergqvist, Patrick Bingham +34 more
2016Journal of Medicinal Chemistry5 citations Open access
Semantic Scholar
Metabolism and Transport of Purinergic Receptor Agonists in Rabbit Conjunctival Epithelial Cells
H. Gukasyan, B. Yerxa, W. Pendergast, V. H. Lee
20025 citations
Semantic Scholar
Abstract LB-390: Antitumor efficacy of crizotinib (PF-02341066), a potent and selective ALK and c-Met RTK inhibitor, in EML4-ALK driven NSCLC tumors in vitro and in vivo
H. Zou, Qiuhua Li, Joseph H. Lee, Lars D. Engstrom +17 more
20114 citations
Semantic Scholar
Improving the solubility of pseudo-hydrophobic chemicals through co-crystal formulation
Isis Janilkarn-Urena, A. Tse, Jie-Ye Lin, Bliss Tafolla-Aguirre +16 more
2025PNAS Nexus3 citations Open access
Semantic Scholar
In vitro and in vivo studies on the effect of a mitochondrial fusion promoter on Leydig cell integrity and function
Samuel Garza, Chantal Sottas, H. Gukasyan, Vassilios Papadopoulos
2024Frontiers in Toxicology3 citations Open access
Semantic Scholar
Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats
D. B. Martinez-Arguelles, Jennifer W. Nedow, H. Gukasyan, V. Papadopoulos
2023Frontiers in Endocrinology3 citations Open access
Semantic Scholar

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