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C. Kielkopf · SciRah

Researcher profile · Semantic Scholar

C. Kielkopf

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C. Kielkopf — researcher profile on SciRah

h-index: 33
Works: 133
Citations: 3,771

Most-cited papers

Bradford Assay for Determining Protein Concentration.
C. Kielkopf, William J. Bauer, I. Urbatsch
2020Cold Spring Harbor Protocols557 citations
Semantic Scholar
U2AF1 Mutations Alter Sequence Specificity of pre-mRNA Binding and Splicing
Theresa Okeyo-Owuor, B. S. White, Rakesh Chatrikhi, D. Mohan +10 more
2014Leukemia135 citations Open access
Semantic Scholar
Structural basis for NADH/NAD+ redox sensing by a Rex family repressor.
K. McLaughlin, C. Strain-Damerell, K. Xie, D. Brekasis +3 more
2010Molecules and Cells101 citations Open access
Semantic Scholar
Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival
D. Fei, Hayley Motowski, Rakesh Chatrikhi, S. Prasad +5 more
2016bioRxiv95 citations Open access
Semantic Scholar
Staufen1 dimerizes via a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay
M. Gleghorn, Chenguang Gong, C. Kielkopf, L. Maquat
2013Nature Structural &Molecular Biology71 citations Open access
Semantic Scholar
An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal
A. Agrawal, E. Salsi, Rakesh Chatrikhi, Steven Henderson +4 more
2016Nature Communications67 citations Open access
Semantic Scholar
Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures
J. Jenkins, C. Kielkopf
2017Trends in Genetics62 citations Open access
Semantic Scholar
Cancer-relevant Splicing Factor CAPERα Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex*
S. Loerch, Alexandre Maucuer, V. Manceau, Michael R. Green +1 more
2014Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Unmasking the U2AF homology motif family: a bona fide protein–protein interaction motif in disguise
S. Loerch, C. Kielkopf
2016RNA: A publication of the RNA Society59 citations Open access
Semantic Scholar
Methods for Measuring the Concentrations of Proteins.
C. Kielkopf, William J. Bauer, I. Urbatsch
2020Cold Spring Harbor Protocols56 citations
Semantic Scholar
U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs
J. Jenkins, A. Agrawal, Ankit Gupta, Michael R. Green +1 more
2013Nucleic Acids Research47 citations Open access
Semantic Scholar
Structure of phosphorylated SF1 bound to U2AF65 in an essential splicing factor complex
Wenhua Wang, Alexandre Maucuer, Ankit Gupta, V. Manceau +6 more
2012Structure43 citations Open access
Semantic Scholar
Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal
Eliezra Glasser, Debanjana Maji, Giulia Biancon, Anees Mohammed Keedakkatt Puthenpeedikakkal +7 more
2021bioRxiv40 citations Open access
Semantic Scholar
Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis of Proteins.
C. Kielkopf, William J. Bauer, I. Urbatsch
2021Cold Spring Harbor Protocols40 citations
Semantic Scholar
The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface
S. Loerch, J. Leach, S. Horner, Debanjana Maji +3 more
2018Journal of Biological Chemistry39 citations Open access
Semantic Scholar
Three RNA recognition motifs participate in RNA recognition and structural organization by the pro-apoptotic factor TIA-1
William J. Bauer, J. Heath, J. Jenkins, C. Kielkopf
2011Journal of Molecular Biology39 citations Open access
Semantic Scholar
Different requirements of the kinase and UHM domains of KIS for its nuclear localization and binding to splicing factors.
V. Manceau, C. Kielkopf, A. Sobel, Alexandre Maucuer
2008Journal of Molecular Biology37 citations Open access
Semantic Scholar
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2–RNA complex
Rakesh Chatrikhi, Callen F. Feeney, Mary J. Pulvino, Georgios Alachouzos +11 more
2020bioRxiv36 citations Open access
Semantic Scholar
A splice site-sensing conformational switch in U2AF2 is modulated by U2AF1 and its recurrent myelodysplasia-associated mutation
Chandani Warnasooriya, Eliezra Glasser, Callen F. Feeney, Kholiswa M. Laird +3 more
2019bioRxiv34 citations Open access
Semantic Scholar
Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing
Debanjana Maji, Eliezra Glasser, Steven Henderson, Justin W. Galardi +3 more
2020Journal of Biological Chemistry33 citations Open access
Semantic Scholar
Solution Conformation and Thermodynamic Characteristics of RNA Binding by the Splicing Factor U2AF65*
J. Jenkins, Haihong Shen, Michael R. Green, C. Kielkopf
2008Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Expressing Cloned Genes for Protein Production, Purification, and Analysis.
C. Kielkopf, William J. Bauer, I. Urbatsch
2020Cold Spring Harbor Protocols30 citations Open access
Semantic Scholar
Cancer-associated mutations mapped on high resolution structures of the U2AF2 RNA recognition motifs
Eliezra Glasser, A. Agrawal, J. Jenkins, C. Kielkopf
2017Biochemistry29 citations Open access
Semantic Scholar
Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM–ULM interaction
Jason Talkish, Haller Igel, Oarteze Hunter, S. Horner +5 more
2019RNA: A publication of the RNA Society27 citations Open access
Semantic Scholar
Structures of SF3b1 Reveal a Dynamic Achilles Heel of Spliceosome Assembly: Implications for cancer-associated abnormalities and drug discovery
Debanjana Maji, Alan Grossfield, C. Kielkopf
2019Biochimica et Biophysica Acta. Gene Regulatory Mechanisms25 citations Open access
Semantic Scholar
Purification of Polyhistidine-Tagged Proteins by Immobilized Metal Affinity Chromatography.
C. Kielkopf, William J. Bauer, I. Urbatsch
2020Cold Spring Harbor Protocols23 citations
Semantic Scholar
Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA
A. Agrawal, K. McLaughlin, J. Jenkins, C. Kielkopf
2014Proceedings of the National Academy of Sciences of the United States of America20 citations Open access
Semantic Scholar
SF1 Phosphorylation Enhances Specific Binding to U2AF65 and Reduces Binding to 3'-Splice-Site RNA.
Rakesh Chatrikhi, Wenhua Wang, Ankit Gupta, S. Loerch +2 more
2016Biophysical Journal19 citations Open access
Semantic Scholar
Large Favorable Enthalpy Changes Drive Specific RNA Recognition by RNA Recognition Motif Proteins
K. McLaughlin, J. Jenkins, C. Kielkopf
2011Biochemistry19 citations Open access
Semantic Scholar
A UHM–ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing
Justin W. Galardi, Victoria N. Bela, Nazish Jeffery, Xueyang He +6 more
2022Journal of Biological Chemistry17 citations Open access
Semantic Scholar
A Broad Range of Conformations Contribute to the Solution Ensemble of the Essential Splicing Factor U2AF65
J. Jenkins, Kholiswa M. Laird, C. Kielkopf
2012Biochemistry17 citations Open access
Semantic Scholar
Insights from Structures of Cancer-Relevant Pre-mRNA Splicing Factors
C. Kielkopf
2017Current Opinion in Genetics and Development15 citations Open access
Semantic Scholar
Dynamic Stacking of an Expected Branch Point Adenosine in Duplexes containing Pseudouridine-Modified or Unmodified U2 snRNA Sites
S. Kennedy, William J. Bauer, Wenhua Wang, C. Kielkopf
2019Biochemical and Biophysical Research Communications - BBRC13 citations Open access
Semantic Scholar
RNA Induces Conformational Changes in the SF1/U2AF65 Splicing Factor Complex
Ankit Gupta, J. Jenkins, C. Kielkopf
2010Journal of Molecular Biology13 citations Open access
Semantic Scholar
Analysis of Proteins by Immunoblotting.
C. Kielkopf, William J. Bauer, I. Urbatsch
2021Cold Spring Harbor Protocols11 citations
Semantic Scholar
Expression of Cloned Genes in Pichia pastoris Using the Methanol-Inducible Promoter AOX1.
C. Kielkopf, William J. Bauer, I. Urbatsch
2021Cold Spring Harbor Protocols11 citations
Semantic Scholar
Dividing and Conquering the RNA Recognition Motif Family: A Representative Case Based on hnRNP L
S. Loerch, C. Kielkopf
2015Journal of Molecular Biology11 citations Open access
Semantic Scholar
Purification of Fusion Proteins by Affinity Chromatography on Glutathione Resin.
C. Kielkopf, William J. Bauer, I. Urbatsch
2020Cold Spring Harbor Protocols10 citations
Semantic Scholar
Expression of Cloned Genes in E. coli Using IPTG-Inducible Promoters.
C. Kielkopf, William J. Bauer, I. Urbatsch
2021Cold Spring Harbor Protocols9 citations
Semantic Scholar
Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State)
S. Loerch, J. Jenkins, C. Kielkopf
20197 citations
Semantic Scholar
Preparation of Cell Extracts for Purification of Proteins Expressed in Pichia pastoris.
C. Kielkopf, William J. Bauer, I. Urbatsch
2021Cold Spring Harbor Protocols4 citations
Semantic Scholar
Subcellular Localization of Signal Peptide Fusion Proteins Expressed in E. coli.
C. Kielkopf, William J. Bauer, I. Urbatsch
2021Cold Spring Harbor Protocols4 citations
Semantic Scholar
Purification, crystallization and preliminary X-ray crystallographic analysis of a central domain of human splicing factor 1.
Ankit Gupta, C. Kielkopf
2011Acta Crystallographica. Section F : Structural Biology and Crystallization Communications4 citations Open access
Semantic Scholar
Solubilization of Expressed Proteins from Inclusion Bodies.
C. Kielkopf, William J. Bauer, I. Urbatsch
2021Cold Spring Harbor Protocols3 citations
Semantic Scholar
Preparation of Cell Extracts for Purification of Soluble Proteins Expressed in E. coli.
C. Kielkopf, William J. Bauer, I. Urbatsch
2021Cold Spring Harbor Protocols3 citations
Semantic Scholar
Considerations for Membrane Protein Purification.
C. Kielkopf, William J. Bauer, I. Urbatsch
2021Cold Spring Harbor Protocols3 citations
Semantic Scholar
Recurrent Neurodevelopmentally Associated Variants of the Pre-mRNA Splicing Factor U2AF2 Alter RNA Binding Affinities and Interactions
Debanjana Maji, J. Jenkins, Paul L. Boutz, C. Kielkopf
2024Biochemistry2 citations Open access
Semantic Scholar
Variations of Staining Sodium Dodecyl Sulfate-Polyacrylamide Gels with Coomassie Brilliant Blue.
C. Kielkopf, William J. Bauer, I. Urbatsch
2021Cold Spring Harbor Protocols2 citations
Semantic Scholar
Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
Debanjana Maji, Eliezra Glasser, Steven Henderson, Justin W. Galardi +3 more
2020Journal of Biological Chemistry2 citations Open access
Semantic Scholar
Expression of Cloned Genes Using the Baculovirus Expression System.
C. Kielkopf, William J. Bauer, I. Urbatsch
2020Cold Spring Harbor Protocols2 citations Open access
Semantic Scholar

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