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A. Dominguez · SciRah

Researcher profile · Semantic Scholar

A. Dominguez

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A. Dominguez — researcher profile on SciRah

h-index: 21
Works: 43
Citations: 1,462

Most-cited papers

High Accumulation of T Regulatory Cells Prevents the Activation of Immune Responses in Aged Animals1
Sanjay Sharma, A. Dominguez, J. Lustgarten
2006Journal of Immunology245 citations Open access
Semantic Scholar
Flagellin Fusion Proteins as Adjuvants or Vaccines Induce Specific Immune Responses
C. Cuadros, F. López-Hernández, A. Dominguez, Michael McClelland +1 more
2004Infection and Immunity194 citations Open access
Semantic Scholar
Blockade of CCL1 Inhibits T Regulatory Cell Suppressive Function Enhancing Tumor Immunity without Affecting T Effector Responses
D. Hoelzinger, Shannon E. Smith, Noweeda N. Mirza, A. Dominguez +2 more
2010Journal of Immunology109 citations Open access
Semantic Scholar
Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti‐OX40 and anti‐4‐1BB monoclonal antibodies induces T cell–mediated protective immunity in Her‐2/neu transgenic mice
C. Cuadros, A. Dominguez, P. Lollini, M. Croft +3 more
2005International Journal of Cancer97 citations
Semantic Scholar
The CD8+ T cell repertoire against Her‐2/neu antigens in neu transgenic mice is of low avidity with antitumor activity
J. Lustgarten, A. Dominguez, C. Cuadros
2004European Journal of Immunology79 citations
Semantic Scholar
Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth
S. Z. Manrique, Maria Adelaida Duque Correa, D. Hoelzinger, A. Dominguez +5 more
2011Journal of Experimental Medicine74 citations Open access
Semantic Scholar
Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses
Shannon E. Smith, D. Hoelzinger, A. Dominguez, J. Van Snick +1 more
2011Cancer Immunology and Immunotherapy72 citations Open access
Semantic Scholar
Aged Mice Develop Protective Antitumor Immune Responses with Appropriate Costimulation1
J. Lustgarten, A. Dominguez, M. Thoman
2004Journal of Immunology65 citations Open access
Semantic Scholar
Aging affect the anti-tumor potential of dendritic cell vaccination, but it can be overcome by co-stimulation with anti-OX40 or anti-4-1BB.
Sanjay Sharma, A. Dominguez, J. Lustgarten
2006Experimental Gerontology61 citations
Semantic Scholar
Targeting the tumor microenvironment with anti-neu/anti-CD40 conjugated nanoparticles for the induction of antitumor immune responses
A. Dominguez, J. Lustgarten
2009Vaccine53 citations Open access
Semantic Scholar
Inhibition of adaptive immunity by IL-9 can be disrupted to achieve rapid T cell sensitization and rejection of progressive tumor challenges
D. Hoelzinger, A. Dominguez, P. Cohen, S. Gendler
2014Cancer Research48 citations Open access
Semantic Scholar
CpG-ODN but not other TLR-ligands restore the antitumor responses in old mice: the implications for vaccinations in the aged
Sanjay Sharma, A. Dominguez, D. Hoelzinger, J. Lustgarten
2008Cancer Immunology and Immunotherapy47 citations
Semantic Scholar
B7-H1 Expression on Old CD8+ T Cells Negatively Regulates the Activation of Immune Responses in Aged Animals
Noweeda N. Mirza, M. Duque, A. Dominguez, Adam G. Schrum +2 more
2010Journal of Immunology46 citations Open access
Semantic Scholar
CRISPR-mediated TGFBR2 knockout renders human ovarian cancer tumor-infiltrating lymphocytes resistant to TGF-β signaling
Samantha M. Fix, M. Forget, Donastas Sakellariou-Thompson, Yunfei Wang +11 more
2022Journal for ImmunoTherapy of Cancer40 citations Open access
Semantic Scholar
Systemic Targeting of CpG-ODN to the tumor microenvironment with anti-neu-CpG hybrid-molecule and T-reg depletion induces memory responses in BALB-neuT tolerant mice
Sanjay Sharma, A. Dominguez, S. Z. Manrique, F. Cavallo +2 more
2008Cancer Research39 citations Open access
Semantic Scholar
Comparative kinetic analyses of gene profiles of naïve CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations
Noweeda N. Mirza, K. Pollock, D. Hoelzinger, A. Dominguez +1 more
2011Aging Cell35 citations Open access
Semantic Scholar
Cooperative effect between immunotherapy and antiangiogenic therapy leads to effective tumor rejection in tolerant Her-2/neu mice.
C. Cuadros, A. Dominguez, G. Frost, P. Borgstrom +1 more
2003Cancer Research33 citations
Semantic Scholar
Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity
Simone Punt, Shruti Malu, Jodi A. McKenzie, S. Z. Manrique +25 more
2020Cancer Immunology and Immunotherapy28 citations Open access
Semantic Scholar
Implications of aging and self-tolerance on the generation of immune and antitumor immune responses.
A. Dominguez, J. Lustgarten
2008Cancer Research28 citations Open access
Semantic Scholar
Identification of Cross-Reactive Peptides Using Combinatorial Libraries Circumvents Tolerance against Her-2/neu-Immunodominant Epitope1
J. Lustgarten, A. Dominguez, C. Pinilla
2006Journal of Immunology26 citations Open access
Semantic Scholar
Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Toll-like receptor agonists
S. Z. Manrique, A. Dominguez, Noweeda N. Mirza, Christopher D. Spencer +6 more
2016OncoTarget23 citations Open access
Semantic Scholar
Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens
Latha B. Pathangey, Dustin McCurry, S. Gendler, A. Dominguez +6 more
2016OncoTarget17 citations Open access
Semantic Scholar
CCL1: a novel therapeutic target for the modulation of Treg function: Implications for immmunotherapy of cancer (40.10)
D. Hoelzinger, A. Dominguez, Shannon E. Smith, Soraya Zorro Manrique +1 more
2009Journal of Immunology2 citations
Semantic Scholar
172 Overcoming immunosuppressive TGF-β signaling in human ovarian cancer-derived tumor infiltrating lymphocytes via non-viral CRISPR engineering
Samantha M. Fix, M. Forget, Donastas Sakellariou-Thompson, Yunfei Wang +8 more
2021Journal for ImmunoTherapy of Cancer1 citations Open access
Semantic Scholar
Abstract A44: Checkpoint inhibition of adaptive immunity by IL-9 can be disrupted to achieve rapid T cell sensitization and rejection of progressive tumor challenges
D. Hoelzinger, A. Dominguez, P. Cohen, S. Gendler
20151 citations
Semantic Scholar
Global targeting of MDSC escape mechanisms cures advanced 4T1 breast tumors (P2062)
Soraya Zorro Manrique, Christopher D. Spencer, A. Dominguez, Judy M. Bradley +8 more
2013Journal of Immunology1 citations
Semantic Scholar
Identification and characterization of macrophage regulatory cells (Mac-regs) with immunoregulatory properties
S. Z. Manrique, M. Duque, A. Dominguez, Noweeda N. Mirza +3 more
20091 citations
Semantic Scholar
Nursing-led structured oral care programmes and their influence on ventilator-associated pneumonia rates in intensive care units
M. F. Gutierrez, Carlos Eduardo Ramírez, A. Dominguez
2026Journal of Medicine and Surgical Nursing0 citations
Semantic Scholar
CostimulationResponses with Appropriate Aged Mice Develop Protective Antitumor
J. Lustgarten, A. Dominguez
20170 citations
Semantic Scholar
Abstract 3640: IL-9 is involved in the establishment of a tolerogenic milieu that prevents anti-tumor immunity
D. Hoelzinger, A. Dominguez, P. Cohen, Sandra J. Gendker
20140 citations
Semantic Scholar
Aging subverts immune function by dictating alternative STAT responses to cytokine signaling (P5078)
Noweeda N. Mirza, Soraya Zorro Manrique, S. Cohen, A. Dominguez +2 more
2013Journal of Immunology0 citations
Semantic Scholar
IL-9 strategy to perturb Treg function and enhance anti-tumor immunity (P4273)
D. Hoelzinger, A. Dominguez, K. Pollock, J. Lustgarten +2 more
2013Journal of Immunology0 citations
Semantic Scholar
Contribution of an aging environment towards a proinflammatory tumor-like milieu (54.4)
Noweeda N. Mirza, D. Hoelzinger, Cheryl E. Myers, K. Pollock +4 more
2012Journal of Immunology0 citations
Semantic Scholar
Critical function of CCL1 in the maintenance of T regulatory cell’s suppressive role. (66.14)
D. Hoelzinger, A. Dominguez, J. Lustgarten
2011Journal of Immunology0 citations
Semantic Scholar
This information is current as Responses Immunity without Affecting T Effector Suppressive Function Enhancing Tumor Blockade of CCL 1 Inhibits T Regulatory Cell
D. Hoelzinger, Shannon E. Smith, Noweeda N. Mirza, A. Dominguez +2 more
20100 citations
Semantic Scholar
Identification and characterization of macrophage regulatory cells (Mac-regs) with immunoregulatory properties (89.38)
Soraya Zorro Manrique, M. Duque, A. Dominguez, Noweeda N. Mirza +3 more
2009Journal of Immunology0 citations
Semantic Scholar
Combination of CpG-ODN+anti-4-1BB but not CpG-ODN+anti-OX40 enhances antitumor immune responses in neu mice modulating the inhibitory function of Tregs (40.7)
Shannon E. Smith, D. Hoelzinger, A. Dominguez, J. Lustgarten
2009Journal of Immunology0 citations
Semantic Scholar
The immune function of aging T cells
Noweeda N. Mirza, D. Hoelzinger, A. Dominguez, J. Lustgarten
20090 citations
Semantic Scholar
The immune function of aging T cells (35.6)
Noweeda N. Mirza, D. Hoelzinger, A. Dominguez, J. Lustgarten
2009Journal of Immunology0 citations
Semantic Scholar
Her-2/neu-Immunodominant Epitope Tolerance against Using Combinatorial Libraries Circumvents Identification of Cross-Reactive Peptides
J. Lustgarten, A. Dominguez, C. Pinilla
20060 citations
Semantic Scholar
in Aged Animals Responses Prevents the Activation of Immune High Accumulation of T Regulatory Cells
Lustgarten Sanjay, Sharma, A. Dominguez, Joseph
20060 citations
Semantic Scholar
Aged Animals ResponsesPrevents the Activation of Immune High Accumulation of T Regulatory Cells
L. S. Sharma, A. Dominguez
20060 citations
Semantic Scholar
This information is current as Costimulation Immune Responses with Appropriate Aged Mice Develop Protective Antitumor
J. Lustgarten, A. Dominguez, M. Thoman
20040 citations
Semantic Scholar

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