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N. Cnubben · SciRah

Researcher profile · Semantic Scholar

N. Cnubben

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N. Cnubben — researcher profile on SciRah

h-index: 31
Works: 78
Citations: 4,210

Most-cited papers

The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids.
I. Rietjens, M. Boersma, L. D. de Haan, B. Spenkelink +6 more
2002Environmental Toxicology and Pharmacology402 citations Open access
Semantic Scholar
The interplay of glutathione-related processes in antioxidant defense.
N. Cnubben, I. Rietjens, H. Wortelboer, J. V. van Zanden +1 more
2001Environmental Toxicology and Pharmacology356 citations Open access
Semantic Scholar
Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis
R. Kleemann, L. Verschuren, M. V. van Erk, Y. Nikolsky +13 more
2007Genome Biology255 citations Open access
Semantic Scholar
An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach.
G. Bakker, M. V. van Erk, L. Pellis, S. Wopereis +5 more
2010American Journal of Clinical Nutrition253 citations Open access
Semantic Scholar
Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases.
M. Boersma, H. van der Woude, J. Bogaards, S. Boeren +5 more
2002Chemical Research in Toxicology244 citations Open access
Semantic Scholar
Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.
J. V. van Zanden, H. Wortelboer, S. Bijlsma, A. Punt +4 more
2005Biochemical Pharmacology178 citations Open access
Semantic Scholar
Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients.
W. Brand, M. E. Schutte, G. Williamson, J. V. van Zanden +4 more
2006Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie159 citations Open access
Semantic Scholar
Time-Resolved and Tissue-Specific Systems Analysis of the Pathogenesis of Insulin Resistance
R. Kleemann, M. V. van Erk, L. Verschuren, A. M. van den Hoek +12 more
2010PLoS ONE147 citations Open access
Semantic Scholar
A vegetable/fruit concentrate with high antioxidant capacity has no effect on biomarkers of antioxidant status in male smokers.
R. van den Berg, T. van Vliet, W. M. Broekmans, N. Cnubben +5 more
2001Journal of NutriLife146 citations Open access
Semantic Scholar
Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status
L. Pellis, M. V. van Erk, B. van Ommen, G. Bakker +7 more
2011Metabolomics137 citations Open access
Semantic Scholar
Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1
R. Evers, N. Cnubben, J. Wijnholds, L. van Deemter +2 more
1997FEBS Letters133 citations Open access
Semantic Scholar
Metabolic Profiling of the Response to an Oral Glucose Tolerance Test Detects Subtle Metabolic Changes
S. Wopereis, C. Rubingh, M. V. van Erk, E. Verheij +6 more
2009PLoS ONE128 citations Open access
Semantic Scholar
Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells.
J. V. van Zanden, L. Geraets, H. Wortelboer, P. van Bladeren +2 more
2004Biochemical Pharmacology112 citations Open access
Semantic Scholar
Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin.
H. Wortelboer, M. Usta, A. van der Velde, M. Boersma +5 more
2003Chemical Research in Toxicology111 citations Open access
Semantic Scholar
Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin.
J. V. van Zanden, Omar Ben Hamman, M. van Iersel, S. Boeren +5 more
2003Chemico-Biological Interactions101 citations Open access
Semantic Scholar
Human cytochrome p450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes.
S. Jeurissen, A. Punt, M. Boersma, J. Bogaards +5 more
2007Chemical Research in Toxicology84 citations Open access
Semantic Scholar
The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential.
J. V. van Zanden, H. van der Woude, Judith Vaessen, M. Usta +3 more
2007Biochemical Pharmacology82 citations Open access
Semantic Scholar
Comparative in vitro-in vivo percutaneous absorption of the pesticide propoxur.
J. V. D. van de Sandt, W. Meuling, G. Elliott, N. Cnubben +1 more
2000Toxicological Sciences79 citations Open access
Semantic Scholar
Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP
G. Zaman, N. Cnubben, P. van Bladeren, R. Evers +1 more
1996FEBS Letters78 citations Open access
Semantic Scholar
Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.
S. Jeurissen, J. Bogaards, M. Boersma, J. T. ter Horst +7 more
2006Chemical Research in Toxicology67 citations Open access
Semantic Scholar
Human cytochrome p450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1'-hydroxysafrole.
S. Jeurissen, J. Bogaards, H. Awad, M. Boersma +7 more
2004Chemical Research in Toxicology67 citations Open access
Semantic Scholar
Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in Caco-2 cells.
M. Usta, H. Wortelboer, J. Vervoort, M. Boersma +3 more
2007Chemical Research in Toxicology60 citations Open access
Semantic Scholar
Reversal of in vitro cellular MRP1 and MRP2 mediated vincristine resistance by the flavonoid myricetin.
J. V. van Zanden, A. de Mul, H. Wortelboer, M. Usta +3 more
2005Biochemical Pharmacology58 citations Open access
Semantic Scholar
Comparative in vitro-in vivo percutaneous penetration of the fungicide ortho-phenylphenol.
N. Cnubben, G. Elliott, B. Hakkert, W. Meuling +1 more
2002Regulatory toxicology and pharmacology : RTP52 citations
Semantic Scholar
Molecular orbital-based quantitative structure-activity relationship for the cytochrome P450-catalyzed 4-hydroxylation of halogenated anilines.
N. Cnubben, Sjaak Peelen, Jan-Willem Borst, J. Vervoort +2 more
1994Chemical Research in Toxicology51 citations Open access
Semantic Scholar
Assessment of inflammatory resilience in healthy subjects using dietary lipid and glucose challenges
S. Wopereis, D. Wolvers, M. V. van Erk, M. Gribnau +12 more
2013BMC Medical Genomics48 citations Open access
Semantic Scholar
Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of alpha,beta-unsaturated carbonyl compounds.
H. Wortelboer, M. Usta, J. V. van Zanden, P. van Bladeren +2 more
2005Biochemical Pharmacology48 citations Open access
Semantic Scholar
Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study
M. V. van Erk, S. Wopereis, C. Rubingh, T. van Vliet +8 more
2010BMC Medical Genomics47 citations Open access
Semantic Scholar
The effect of varying halogen substituent patterns on the cytochrome P450 catalysed dehalogenation of 4-halogenated anilines to 4-aminophenol metabolites.
N. Cnubben, J. Vervoort, M. Boersma, I. M. C. M. Rietjens
1995Biochemical Pharmacology47 citations Open access
Semantic Scholar
Towards harmonization of test methods for in vitro hepatic clearance studies.
J. Louisse, M. Alewijn, A. Peijnenburg, N. Cnubben +3 more
2019Toxicology in Vitro36 citations Open access
Semantic Scholar
Glutathione-dependent biotransformation of the alkylating drug thiotepa and transport of its metabolite monoglutathionylthiotepa in human MCF-7 breast cancer cells.
N. Cnubben, Angela J. M. Rommens, M. Oudshoorn, P. van Bladeren
1998Cancer Research34 citations
Semantic Scholar
Regulating human safety: How dose selection in toxicity studies impacts human health hazard assessment and subsequent risk management options.
M. Woutersen, A. Muller, M. Pronk, N. Cnubben +1 more
2020Regulatory toxicology and pharmacology : RTP29 citations Open access
Semantic Scholar
The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab
G. V. van Mierlo, N. Cnubben, D. Wouters, G. Wolbink +6 more
2014Journal of Immunotoxicology27 citations Open access
Semantic Scholar
Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system.
M. van Iersel, N. Cnubben, Natasja Smink, J. H. Koeman +1 more
1999Biochemical Pharmacology27 citations Open access
Semantic Scholar
Differential Effects of Drug Interventions and Dietary Lifestyle in Developing Type 2 Diabetes and Complications: A Systems Biology Analysis in LDLr−/− Mice
M. Radonjić, P. Wielinga, S. Wopereis, T. Kelder +10 more
2013PLoS ONE26 citations Open access
Semantic Scholar
Study on the regioselectivity and mechanism of the aromatic hydroxylation of monofluoroanilines.
N. Cnubben, J. Vervoort, C. Veeger, I. M. C. M. Rietjens
1992Chemico-Biological Interactions25 citations Open access
Semantic Scholar
Development of an on-line high performance liquid chromatography detection system for human cytochrome P450 1A2 inhibitors in extracts of natural products.
S. Jeurissen, F. W. Claassen, J. Havlík, E. Bouwmans +4 more
2007Journal of Chromatography A24 citations Open access
Semantic Scholar
Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2.
H. Wortelboer, M. Balvers, M. Usta, P. van Bladeren +1 more
2008Environmental Toxicology and Pharmacology22 citations Open access
Semantic Scholar
Identification of prognostic and diagnostic biomarkers of glucose intolerance in ApoE3Leiden mice.
S. Wopereis, M. Radonjić, C. Rubingh, M. V. van Erk +6 more
2012Physiological Genomics21 citations
Semantic Scholar
Use of the kinetically-derived maximum dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management.
M. Heringa, N. Cnubben, W. Slob, M. Pronk +3 more
2020Regulatory toxicology and pharmacology : RTP20 citations Open access
Semantic Scholar
Quantitative analysis of Tenecteplase in rat plasma samples using LC-MS/MS as an alternative for ELISA.
B. Büscher, H. Gerritsen, I. van Schöll, N. Cnubben +1 more
2007Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20 citations
Semantic Scholar
The Göttingen minipig® as an alternative non-rodent species for immunogenicity testing: A demonstrator study using the IL-1 receptor antagonist anakinra
G. V. van Mierlo, N. Cnubben, C. Kuper, J. Wolthoorn +5 more
2013Journal of Immunotoxicology19 citations Open access
Semantic Scholar
Different metabolic pathways of 2,5-difluoronitrobenzene and 2,5-difluoroaminobenzene compared to molecular orbital substrate characteristics.
I. M. C. M. Rietjens, N. Cnubben, M. V. van Haandel, Bozena Tyrakowska +2 more
1995Chemico-Biological Interactions19 citations
Semantic Scholar
Role of cytochromes P-450 and flavin-containing monooxygenase in the biotransformation of 4-fluoro-N-methylaniline.
M. Boersma, N. Cnubben, W. V. van Berkel, M. Blom +2 more
1993Drug Metabolism And Disposition19 citations
Semantic Scholar
Metabolism of ATP-binding cassette drug transporter inhibitors: complicating factor for multidrug resistance
N. Cnubben, H. Wortelboer, J. V. van Zanden, I. Rietjens +1 more
2005Expert Opinion on Drug Metabolism & Toxicology14 citations Open access
Semantic Scholar
Integration of efficacy, pharmacokinetic and safety assessment of interleukin-1 receptor antagonist in a preclinical model of arthritis.
A. Zuurmond, A. Koudijs, B. van El, R. Doornbos +6 more
2011Regulatory toxicology and pharmacology : RTP11 citations
Semantic Scholar
A single oral dose of a polyglucosamine influences the bioavailability of [9-14C]-Oleic acid in adult female Göttingen minipigs
N. Cnubben, Shanti L. Tel, M. A. Hemmes, Astrid Langenkamp-Brand +3 more
2016BMC Obesity10 citations Open access
Semantic Scholar
Comparative MO-QSAR studies in various species including man.
B. Tyrakowska, N. Cnubben, A. Soffers, Th. Wobbes +1 more
1996Chemico-Biological Interactions10 citations Open access
Semantic Scholar
Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status
L. Pellis, M. V. van Erk, B. van Ommen, G. Bakker +7 more
2011Metabolomics9 citations Open access
Semantic Scholar
The urinary metabolic profile of diethylene glycol methyl ether and triethylene glycol methyl ether in Sprague-Dawley rats and the role of the metabolite methoxyacetic acid in their toxicity.
J. Kelsey, N. Cnubben, J. Bogaards, R. Braakman +2 more
2019Regulatory toxicology and pharmacology : RTP7 citations Open access
Semantic Scholar

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I. Rietjens×18
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I. Rietjens — researcher profile on SciRah
P. van Bladeren×17
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J. V. van Zanden×11
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M. Usta — researcher profile on SciRah

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