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J. Funk · SciRah

Researcher profile · Semantic Scholar

J. Funk

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J. Funk — researcher profile on SciRah

h-index: 24
Works: 52
Citations: 3,123

Most-cited papers

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein.
J. Funk, Wa-Ga Shou, J. Harry, E. Espling +2 more
1997Genes & Development565 citations Open access
Semantic Scholar
Prolonged and tunable residence time using reversible covalent kinase inhibitors
J. Bradshaw, J. McFarland, Ville O. Paavilainen, A. Bisconte +19 more
2015Nature Chemical Biology385 citations Open access
Semantic Scholar
Artesunate in the treatment of metastatic uveal melanoma--first experiences.
Thomas G. Berger, D. Dieckmann, T. Efferth, E. Schultz +3 more
2005Oncology Report193 citations
Semantic Scholar
Ultraviolet B and H2O2 Are Potent Inducers of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes*
M. Brauchle, J. Funk, P. Kind, S. Werner
1996Journal of Biological Chemistry185 citations Open access
Semantic Scholar
Neuronal cell cycle re-entry mediates Alzheimer disease-type changes.
A. Mcshea, Hyoung-Gon Lee, R. Petersen, G. Casadesus +5 more
2007Biochimica et Biophysica Acta173 citations Open access
Semantic Scholar
The G2/M Regulator 14-3-3ς Prevents Apoptosis through Sequestration of Bax*
T. Samuel, H. Weber, P. Rauch, B. Verdoodt +4 more
2001Journal of Biological Chemistry149 citations Open access
Semantic Scholar
Inactivation of both the Retinoblastoma Tumor Suppressor and p21 by the Human Papillomavirus Type 16 E7 Oncoprotein Is Necessary To Inhibit Cell Cycle Arrest in Human Epithelial Cells
A. Helt, J. Funk, D. Galloway
2002Journal of Virology115 citations Open access
Semantic Scholar
Ultraviolet B irradiation-induced G2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase.
T. Herzinger, J. Funk, K. Hillmer, D. Eick +2 more
1995Oncogene103 citations
Semantic Scholar
A phase I trial of PRN1008, a novel reversible covalent inhibitor of Bruton's tyrosine kinase, in healthy volunteers
Patrick F. Smith, J. Krishnarajah, P. Nunn, R. Hill +5 more
2017British Journal of Clinical Pharmacology99 citations Open access
Semantic Scholar
p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanoma
J. Funk, P. I. Schiller, M. Barrett, David J. Wong +2 more
1998Journal of cutaneous pathology98 citations
Semantic Scholar
Cytokine production after helium-neon laser irradiation in cultures of human peripheral blood mononuclear cells.
J. Funk, Andrea Kruse, Holger Kirchner
1992Journal of Photochemistry and Photobiology. B: Biology96 citations
Semantic Scholar
Abrogation of p53-induced cell cycle arrest by c-Myc: evidence for an inhibitor of p21WAF1/CIP1/SDI1.
H. Hermeking, J. Funk, M. Reichert, J. W. Ellwart +1 more
1995Oncogene95 citations
Semantic Scholar
The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax.
T. Samuel, H. Weber, P. Rauch, B. Verdoodt +4 more
2001Journal of Biological Chemistry84 citations
Semantic Scholar
Linking DNA Damage to Cell Cycle Checkpoints
T. Samuel, H. Weber, J. Funk
2002Cell Cycle83 citations Open access
Semantic Scholar
Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.
K. Brameld, T. Owens, E. Verner, E. Venetsanakos +12 more
2017Journal of Medicinal Chemistry82 citations Open access
Semantic Scholar
EGFR kinase domain mutations – functional impact and relevance for lung cancer therapy
D. Irmer, J. Funk, A. Blaukat
2007Oncogene80 citations Open access
Semantic Scholar
Human p14ARF-mediated cell cycle arrest strictly depends on intact p53 signaling pathways
H. Weber, T. Samuel, P. Rauch, J. Funk
2002Oncogene74 citations Open access
Semantic Scholar
Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP‐1‐associated regulator of cyclin B, in Alzheimer's disease
Xiong-Wei Zhu, A. Mcshea, Peggy L. R. Harris, A. Raina +9 more
2004Journal of Neuroscience Research69 citations
Semantic Scholar
The Chromatin Structure of the Dual c-myc Promoter P1/P2 Is Regulated by Separate Elements*
T. Albert, Julie Wells, J. Funk, A. Pullner +5 more
2001Journal of Biological Chemistry67 citations Open access
Semantic Scholar
Helium‐neon laser irradiation induces effects on cytokine production at the protein and the mRNA level
J. Funk, A. Kruse, P. Neustock, H. Kirchner
1993Experimental Dermatology57 citations
Semantic Scholar
Targeting Interleukin-2-inducible T-cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694
Yiming Zhong, Shuai Dong, E. Strattan, L. Ren +13 more
2014Journal of Biological Chemistry46 citations Open access
Semantic Scholar
Cutting Edge: Resistance to Apoptosis and Continuous Proliferation of Dendritic Cells Deficient for TNF Receptor-11
J. Funk, H. Walczak, Constanze Voigtländer, S. Berchtold +6 more
2000Journal of Immunology38 citations
Semantic Scholar
Identification of CIP-1-associated Regulator of Cyclin B (CARB), a Novel p21-binding Protein Acting in the G2 Phase of the Cell Cycle*
A. Mcshea, T. Samuel, J. Eppel, D. Galloway +1 more
2000Journal of Biological Chemistry36 citations Open access
Semantic Scholar
A small molecule inhibitor of ITK and RLK impairs TH1 differentiation and prevents colitis disease progression
Hyoung-Soo Cho, H. Shin, H. Haberstock-Debić, Y. Xing +5 more
2015Journal of Immunology34 citations Open access
Semantic Scholar
Multiple disseminated large-cell acanthomas of the skin associated with human papillomavirus type 6.
Thomas G. Berger, E. Stockfleth, T. Meyer, F. Kiesewetter +1 more
2005Journal of American Academy of Dermatology24 citations
Semantic Scholar
The Irreversible Covalent Fibroblast Growth Factor Receptor Inhibitor PRN1371 Exhibits Sustained Inhibition of FGFR after Drug Clearance
E. Venetsanakos, K. Brameld, V. Phan, E. Verner +11 more
2017Molecular Cancer Therapeutics22 citations Open access
Semantic Scholar
ITK and RLK Inhibitor PRN694 Improves Skin Disease in Two Mouse Models of Psoriasis.
Jessica M. Fuhriman, M. Winge, H. Haberstock-Debić, J. Funk +2 more
2017Journal of Investigative Dermatology18 citations Open access
Semantic Scholar
Cell Cycle Checkpoint Genes and Cancer
J. Funk
200617 citations
Semantic Scholar
[Cell cycle control, genetic instability and cancer].
J. Funk, P. Kind
1997Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete9 citations
Semantic Scholar
THU0068 Preclinical Characterization of PRN1008, a Novel Reversible Covalent Inhibitor of BTK that Shows Efficacy in a RAT Model of Collagen-Induced Arthritis
R. Hill, J. Bradshaw, Angelina Bisconte, D. Tam +6 more
20157 citations
Semantic Scholar
Protein Kinase C Activation is Involved in Ultraviolet B Irradiation‐Induced Endothelial Cell ICAM‐1 Up‐Regulation and Lymphocyte–Endothelium Interaction In Vitro
J. Funk, E. Holler, F. Kohlhuber, M. Ueffing +3 more
1996Scandinavian Journal of Immunology7 citations
Semantic Scholar
Efficacy in collagen induced arthritis models with a selective, reversible covalent Bruton’s tyrosine kinase inhibitor PRN473 is driven by durable target occupancy rather than extended plasma exposure (THER5P.904)
A. Bisconte, R. Hill, M. Bradshaw, E. Verner +5 more
2015Journal of Immunology6 citations
Semantic Scholar
Human Epithelial Cells Necessary To Inhibit Cell Cycle Arrest in Papillomavirus Type 16 E 7 Oncoprotein Is Tumor Suppressor and p 21 by the Human Inactivation of both the Retinoblastoma
A. Helt, J. Funk, D. Galloway
20023 citations
Semantic Scholar
A phase 1, multicenter, dose-escalation study of PRN1371, an irreversible covalent FGFR1-4 kinase inhibitor, in patients with advanced solid tumors, followed by expansion cohorts in patients with FGFR genetic alterations.
S. Piha-Paul, C. Hierro, J. Funk, S. Gourlay +4 more
20162 citations
Semantic Scholar
483 Irreversible covalent pan-FGFR inhibitors are highly efficacious against FGFR-dependent cancers
V. Phan, E. Verner, M. E. Gerritsen, J. Bradshaw +9 more
20141 citations
Semantic Scholar
[Light in the confusion of ectodermal dysplasia syndrome. Mutations in p63 gene induce different phenotype expressions].
J. Krutmann, J. Funk, B. Korge
2001Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete1 citations
Semantic Scholar
HPV-16 E 7 ? oncoprotein Inhibition of CDK activity and PCNA-dependent DNA replication
J. Funk, Wa-Ga Shou, J. Harry, E. Espling +2 more
19971 citations
Semantic Scholar
Abstract 2091: PRN1371, an irreversible, covalent inhibitor of FGFR1-4 exhibits sustained pathway inhibition in cancer cell lines
E. Venetsanakos, Y. Xing, Natalie Loewenstein, J. Bradshaw +10 more
20170 citations
Semantic Scholar
700 ITK and RLK inhibitor improves skin disease in a psoriatic mouse model
J. Fuhriman, M. Winge, H. Haberstock-Debić, J. Funk +2 more
20170 citations Open access
Semantic Scholar
Abstract 1249: PRN1371, an irreversible, covalent inhibitor of FGFR1, 2, 3 and 4 is highly efficacious in preclinical tumor models
E. Venetsanakos, M. Bradshaw, D. Goldstein, Kwan Leung +9 more
20160 citations
Semantic Scholar
94 A Covalent Inhibitor of ITK and RLK Inhibits Th1 and Th17 Cell Differentiation and Prevents Disease Manifestation in an Adoptive Transfer Model of Colitis
Hyoung-Soo Cho, James M. Conley, H. Shin, H. Haberstock-Debić +6 more
20150 citations Open access
Semantic Scholar
Mechanisms of G2/M-checkpoint control in ultraviolet B-irradiated keratinocytes
J. Funk, T. Herzinger, K. Hillmer, D. Wolf +2 more
2007Journal of Cancer Research and Clinical Oncology0 citations Open access
Semantic Scholar
S5-01-05 PATHOLOGICAL CORRELATES OF DEMENTIA IN A LARGE POPULATION-BASED COHORT
Hyoung-Gon Lee, I. Vincent, Nancy J. Linford, J. Funk +2 more
20060 citations
Semantic Scholar
Discovery, synthesis and characterization of hexahydropyranoquinolines as a novel class of selective inhibitors of the mitotic kinesin Eg5.
D. Finsinger, F. Zenke, C. Amendt, K. Schiemann +8 more
20060 citations
Semantic Scholar
[Aspirin against cylindromatosis? Molecular functions of the CYLD tumor suppressor].
J. Funk
2004Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete0 citations
Semantic Scholar
O2-04-07 Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1 associated regulator of cyclin B, in Alzheimer disease
Xiong-Wei Zhu, A. Mcshea, Peggy L. R. Harris, A. Raina +9 more
20040 citations
Semantic Scholar
[Vaccination with human "papillomavirus-like particles"].
J. Funk
2003Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete0 citations
Semantic Scholar
[Defective gap junctions: variability of the phenotype exemplified by connexin 26 mutations].
J. Krutmann, J. Funk, B. Korge
2002Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete0 citations
Semantic Scholar
[Phenotypic variations of the genotype: retrotransposons as epigenetic mediators?].
J. Krutmann, J. Funk, B. Korge
2001Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete0 citations
Semantic Scholar
Deficient for TNF Receptor-1 Continuous Proliferation of Dendritic Cells Cutting Edge: Resistance to Apoptosis and
J. Funk, H. Walczak, Constanze Voigtländer, S. Berchtold +6 more
20000 citations
Semantic Scholar

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