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K. Brameld · SciRah

Researcher profile · Semantic Scholar

K. Brameld

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K. Brameld — researcher profile on SciRah

h-index: 21
Works: 37
Citations: 2,187

Most-cited papers

Prolonged and tunable residence time using reversible covalent kinase inhibitors
J. Bradshaw, J. McFarland, Ville O. Paavilainen, A. Bisconte +19 more
2015Nature Chemical Biology385 citations Open access
Semantic Scholar
Small Molecule Conformational Preferences Derived from Crystal Structure Data. A Medicinal Chemistry Focused Analysis
K. Brameld, B. Kuhn, D. Reuter, M. Stahl
2008Journal of Chemical Information and Modeling321 citations Open access
Semantic Scholar
The pK(BHX) database: toward a better understanding of hydrogen-bond basicity for medicinal chemists.
C. Laurence, K. Brameld, J. Graton, J. Le Questel +1 more
2009Journal of Medicinal Chemistry316 citations
Semantic Scholar
Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease
C. Langrish, J. Bradshaw, M. Francesco, T. Owens +10 more
2021Journal of Immunology117 citations Open access
Semantic Scholar
The role of enzyme distortion in the single displacement mechanism of family 19 chitinases.
K. Brameld, William A. Goddard
1998Proceedings of the National Academy of Sciences of the United States of America112 citations Open access
Semantic Scholar
The chitinase PfCHT1 from the human malaria parasite Plasmodium falciparum lacks proenzyme and chitin-binding domains and displays unique substrate preferences.
Joseph M. Vinetz, S. K. Davé, Charles A. Specht, K. Brameld +3 more
1999Proceedings of the National Academy of Sciences of the United States of America105 citations Open access
Semantic Scholar
Substrate assistance in the mechanism of family 18 chitinases: theoretical studies of potential intermediates and inhibitors.
K. Brameld, W. Shrader, B. Imperiali, W. A. Goddard
1998Journal of Molecular Biology102 citations
Semantic Scholar
Substrate Distortion to a Boat Conformation at Subsite −1 Is Critical in the Mechanism of Family 18 Chitinases
K. Brameld, W. Goddard
199889 citations
Semantic Scholar
Discovery of Reversible Covalent Bruton's Tyrosine Kinase Inhibitors PRN473 and PRN1008 (Rilzabrutinib).
T. Owens, K. Brameld, E. Verner, T. Ton +20 more
2022Journal of Medicinal Chemistry83 citations Open access
Semantic Scholar
Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.
K. Brameld, T. Owens, E. Verner, E. Venetsanakos +12 more
2017Journal of Medicinal Chemistry82 citations Open access
Semantic Scholar
Distance Dependent Hydrogen Bond Potentials for Nucleic Acid Base Pairs from ab Initio Quantum Mechanical Calculations (LMP2/cc-pVTZ)
K. Brameld, S. Dasgupta, W. Goddard
199765 citations
Semantic Scholar
Ab Initio Quantum Mechanical Study of the Structures and Energies for the Pseudorotation of 5‘-Dehydroxy Analogues of 2‘-Deoxyribose and Ribose Sugars
K. Brameld, W. Goddard
199947 citations
Semantic Scholar
Targeting Interleukin-2-inducible T-cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694
Yiming Zhong, Shuai Dong, E. Strattan, L. Ren +13 more
2014Journal of Biological Chemistry46 citations Open access
Semantic Scholar
The proteome-wide potential for reversible covalency at cysteine
Kristine Senkane, E. Vinogradova, R. Suciu, Vincent M Crowley +4 more
2019Angewandte Chemie42 citations Open access
Semantic Scholar
Quinolones as HCV NS5B polymerase inhibitors.
D. V. Kumar, R. Rai, K. Brameld, J. Somoza +10 more
2011Bioorganic & Medicinal Chemistry Letters37 citations
Semantic Scholar
Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B
R. C. Schoenfeld, D. Bourdet, K. Brameld, Elbert Chin +15 more
2013Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Discovery of N-[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase
F. Talamas, Sarah C. Abbot, Shalini Anand, K. Brameld +26 more
2013Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
De novo fragment design: a medicinal chemistry approach to fragment-based lead generation.
F. Talamas, Gloria Ao-Ieong, K. Brameld, Elbert Chin +14 more
2013Journal of Medicinal Chemistry29 citations
Semantic Scholar
Characterization of RO5126946, a Novel α7 Nicotinic Acetylcholine Receptor–Positive Allosteric Modulator
Sunil Sahdeo, T. Wallace, Ryoko Hirakawa, F. Knoflach +8 more
2014Journal of Pharmacology and Experimental Therapeutics26 citations Open access
Semantic Scholar
Conformational Equilibria of β-Alanine and Related Compounds as Studied by NMR Spectroscopy
Françoise Gregoire, Sindy H. Wei, E. Streed, K. Brameld +5 more
199826 citations
Semantic Scholar
The Irreversible Covalent Fibroblast Growth Factor Receptor Inhibitor PRN1371 Exhibits Sustained Inhibition of FGFR after Drug Clearance
E. Venetsanakos, K. Brameld, V. Phan, E. Verner +11 more
2017Molecular Cancer Therapeutics22 citations Open access
Semantic Scholar
DNA Interstrand Crosslinking by 2,5-Bis(1-aziridinyl)-1,4-benzoquinone: Nucleotide Sequence Preferences and Covalent Structure of the dG-to-dG Cross-Links at 5'-d(GNnC) in Synthetic Oligonucleotide Duplexes
S. Alley, K. Brameld, P. B. Hopkins
199419 citations
Semantic Scholar
3-heterocyclyl quinolone inhibitors of the HCV NS5B polymerase.
D. V. Kumar, R. Rai, K. Brameld, J. Riggs +11 more
2012Bioorganic & Medicinal Chemistry Letters16 citations
Semantic Scholar
Conformational analysis of aqueous pullulan oligomers: an effective computational approach☆
J. Liu, K. Brameld, D. Brant, W. Goddard
200214 citations
Semantic Scholar
Ab initio derived spectroscopic quality force fields for molecular modeling and dynamics
S. Dasgupta, K. Brameld, Cun F. Fan, W. Goddard
199714 citations
Semantic Scholar
THU0068 Preclinical Characterization of PRN1008, a Novel Reversible Covalent Inhibitor of BTK that Shows Efficacy in a RAT Model of Collagen-Induced Arthritis
R. Hill, J. Bradshaw, Angelina Bisconte, D. Tam +6 more
20157 citations
Semantic Scholar
Efficacy in collagen induced arthritis models with a selective, reversible covalent Bruton’s tyrosine kinase inhibitor PRN473 is driven by durable target occupancy rather than extended plasma exposure (THER5P.904)
A. Bisconte, R. Hill, M. Bradshaw, E. Verner +5 more
2015Journal of Immunology6 citations
Semantic Scholar
Abstract SY30-01: Discovery of the highly selective covalent FGFR1-4 inhibitor PRN1371, currently in development for the treatment of solid tumors
K. Brameld
20161 citations
Semantic Scholar
483 Irreversible covalent pan-FGFR inhibitors are highly efficacious against FGFR-dependent cancers
V. Phan, E. Verner, M. E. Gerritsen, J. Bradshaw +9 more
20141 citations
Semantic Scholar
Characterization of RO 5126946 , a Novel a 7 Nicotinic Acetylcholine Receptor – Positive Allosteric Modulator s
Sunil Sahdeo, T. Wallace, Ryoko Hirakawa, F. Knoflach +8 more
20141 citations
Semantic Scholar
Title page
Sunil Sahdeo, T. Wallace, Ryoko Hirakawa, F. Knoflach +8 more
2021Gigantism and Acromegaly0 citations
Semantic Scholar
Abstract A19: A phase 1, multicenter, dose-escalation study of PRN1371, an irreversible covalent FGFR1-4 kinase inhibitor, in patients with advanced solid tumors including metastatic urothelial carcinoma (mUC)
S. Piha-Paul, C. Hierro, I. Matos, V. Boni +15 more
20200 citations
Semantic Scholar
Title Page
Sunil Sahdeo, T. Wallace, Ryoko Hirakawa, F. Knoflach +8 more
2018Public Health Genomics0 citations Open access
Semantic Scholar
Abstract 2091: PRN1371, an irreversible, covalent inhibitor of FGFR1-4 exhibits sustained pathway inhibition in cancer cell lines
E. Venetsanakos, Y. Xing, Natalie Loewenstein, J. Bradshaw +10 more
20170 citations
Semantic Scholar
Abstract 1249: PRN1371, an irreversible, covalent inhibitor of FGFR1, 2, 3 and 4 is highly efficacious in preclinical tumor models
E. Venetsanakos, M. Bradshaw, D. Goldstein, Kwan Leung +9 more
20160 citations
Semantic Scholar
94 A Covalent Inhibitor of ITK and RLK Inhibits Th1 and Th17 Cell Differentiation and Prevents Disease Manifestation in an Adoptive Transfer Model of Colitis
Hyoung-Soo Cho, James M. Conley, H. Shin, H. Haberstock-Debić +6 more
20150 citations Open access
Semantic Scholar
Molecular modeling of biological systems : from chitinase A to Z-DNA
K. Brameld
19990 citations
Semantic Scholar

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