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Garrick K. Packard · SciRah

Researcher profile · Semantic Scholar

Garrick K. Packard

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Garrick K. Packard — researcher profile on SciRah

h-index: 11
Works: 28
Citations: 495

Most-cited papers

Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
J. Ernst, P. A. Thompson, C. Nilewski, P. Sprengeler +19 more
2020Journal of Medicinal Chemistry122 citations Open access
Semantic Scholar
Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115.
D. Mortensen, Sophie M Perrin-Ninkovic, G. Shevlin, J. Elsner +28 more
2015Journal of Medicinal Chemistry68 citations Open access
Semantic Scholar
CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization
D. Mortensen, K. E. Fultz, Shui-Chan Xu, Wei-Ming Xu +23 more
2015Molecular Cancer Therapeutics50 citations Open access
Semantic Scholar
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A
P. A. Thompson, B. Eam, N. Young, S. Fish +21 more
2020Molecular Cancer Therapeutics41 citations
Semantic Scholar
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Qun Li, K. Woods, Sheela A. Thomas, Gui-Dong Zhu +18 more
2006Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223.
D. Mortensen, Sophie M Perrin-Ninkovic, G. Shevlin, Jingjing Zhao +28 more
2015Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Beta-selective glycosylations with masked D-mycosamine precursors.
Garrick K. Packard, S. Rychnovsky
2001Organic Letters28 citations
Semantic Scholar
A unified approach to polyene macrolides: synthesis of candidin and nystatin polyols.
I. Kadota, Yue-Qing Hu, Garrick K. Packard, S. Rychnovsky
2004Proceedings of the National Academy of Sciences of the United States of America23 citations Open access
Semantic Scholar
Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase.
Sheela A. Thomas, Tongmei Li, K. Woods, Xiaohong Song +16 more
2006Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors.
Garrick K. Packard, Patrick W. Papa, J. Riggs, Paul E. Erdman +18 more
2012Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Synthesis of rimocidinolide methyl ester, the aglycone of (+)-rimocidin.
Garrick K. Packard, Yue-Qing Hu, A. Vescovi, S. Rychnovsky
2004Angewandte Chemie16 citations
Semantic Scholar
Preclinical Evaluation of eFT226, a Novel, Potent and Selective eIF4A Inhibitor with Anti-Tumor Activity in B-Cell Malignancies
P. A. Thompson, B. Eam, N. Young, S. Fish +22 more
201711 citations
Semantic Scholar
Strategic Diastereoselective C1 Functionalization in the Aza-Rocaglamide Scaffold toward Natural Product-Inspired eIF4A Inhibitors.
C. Nilewski, Theo D. Michels, A. Xiang, Garrick K. Packard +7 more
2020Organic Letters10 citations
Semantic Scholar
A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation
Gregory D. Ferguson, M. Delgado, V. Plantevin-Krenitsky, K. Jensen-Pergakes +23 more
2016PLoS ONE8 citations Open access
Semantic Scholar
1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties.
C. Nilewski, Theo D. Michels, Garrick K. Packard, A. Xiang +10 more
2021Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
Abstract 2698: eFT226, a potent and selective inhibitor of eIF4A, is efficacious in preclinical models of lymphoma
P. A. Thompson, B. Eam, N. Young, S. Fish +20 more
2019Experimental and Molecular Therapeutics5 citations
Semantic Scholar
Synthesis of cyclic hydropyran oligolides with convergent amine, amide, phosphonate and furan appendages
S. D. Burke, Christopher J. O'Donnell, J. Hans, C. W. Moon +3 more
19974 citations
Semantic Scholar
Abstract B33: Targeting PI3K/mTOR signaling with potent, selective and orally-available small-molecule inhibitors of eIF4E
G. Parker, I. Hung, J. Staunton, M. Barrera +20 more
20201 citations
Semantic Scholar
Abstract 1302: Targeting hormone receptor-dependent cancers with potent, selective and orally-available small molecule inhibitors of eIF4E
Gary G. Chiang, G. Parker, I. Hung, V. Goel +22 more
2019Experimental and Molecular Therapeutics1 citations
Semantic Scholar
Abstract DDT02-05: eFT226: A selective and highly potent inhibitor of eukaryotic initiation factor 4A (eIF4A), a novel approach for the treatment of cancer
S. Reich, P. A. Thompson, J. Ernst, B. Eam +22 more
2018Cancer Chemistry1 citations
Semantic Scholar
Synthesis and purification procedures of heteroaryl compounds
Roy L. Harris, John Sapienza, G. Shevlin, Patrick W. Papa +15 more
20100 citations
Semantic Scholar
Compounds 3,4-dihydropyrazino [2,3-b] pyrazin-2 (1H) -one as mTOR kinase inhibitors for oncology indications associated with mTOR / PI3K / Akt pathway diseases
J. Elsner, Roy L. Harris, Branden Lee, D. Mortensen +14 more
20090 citations
Semantic Scholar
Heteroaryl compounds, their compositions and methods of treatment with them
R. Albers, Roy L. Harris, Dehua Huang, Branden Lee +11 more
20070 citations
Semantic Scholar
heteroaryl compounds, their compositions and their use as inhibitors of protein kinases
D. Mortensen, M. Mederos, John Sapienza, R. Albers +11 more
20070 citations
Semantic Scholar
Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine
Qun Li, K. Woods, Sheela A. Thomas, Gui-Dong Zhu +17 more
20060 citations
Semantic Scholar
Preclinical antitumor activity of benzopyranones
R. Narla, Alice Collette, B. Stein, D. Giegel +12 more
20050 citations
Semantic Scholar
Synthesis of Rimocidinolide Methyl Ester (I), the Aglycone of (+)‐Rimocidin.
Garrick K. Packard, Yue-Qing Hu, A. Vescovi, S. Rychnovsky
20040 citations
Semantic Scholar
β‐Selective Glycosylations with Masked D‐Mycosamine Precursors.
Garrick K. Packard, S. Rychnovsky
20020 citations
Semantic Scholar

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Theo D. Michels

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