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Mashito Sakai · SciRah

Researcher profile · Semantic Scholar

Mashito Sakai

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Mashito Sakai — researcher profile on SciRah

h-index: 21
Works: 41
Citations: 2,078

Most-cited papers

Niche-Specific Re-Programming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis
J. Seidman, T. Troutman, Mashito Sakai, Anita Gola +19 more
2020Immunity397 citations Open access
Semantic Scholar
Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity
Mashito Sakai, T. Troutman, J. Seidman, Zhengyu Ouyang +18 more
2019Immunity361 citations Open access
Semantic Scholar
Analysis of genetically diverse macrophages reveals local and domain-wide mechanisms that control transcription factor binding and function
Verena M. Link, Sascha H. Duttke, H. Chun, I. Holtman +17 more
2018Cell182 citations Open access
Semantic Scholar
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution
Masayuki Tsukasaki, Cong-Nhat Huynh Nam, Kazuo Okamoto, Ryunosuke Muro +14 more
2020Nature Metabolism122 citations
Semantic Scholar
Dok1 mediates high-fat diet–induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation
T. Hosooka, T. Noguchi, K. Kotani, Takehiro Nakamura +12 more
2008Nature Medicine107 citations
Semantic Scholar
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
Isidoro Cobo, Tiffany N. Tanaka, Kailash Chandra Mangalhara, Addison J. Lana +15 more
2022Immunity101 citations Open access
Semantic Scholar
p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress.
Daiki Karigane, Hiroshi Kobayashi, T. Morikawa, Yukako Ootomo +12 more
2016Cell Stem Cell83 citations Open access
Semantic Scholar
CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis
Mashito Sakai, M. Matsumoto, Tomoko Tujimura, Yong-Heng Cao +10 more
2012Nature Medicine81 citations
Semantic Scholar
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity
Bethany R. Fixsen, Claudia Z. Han, Yi Zhou, N. Spann +18 more
2023Nature Immunology78 citations Open access
Semantic Scholar
Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
G. Fonseca, Jen-Han Tao, Emma Westin, Sascha H. Duttke +8 more
2018Nature Communications67 citations Open access
Semantic Scholar
Epigenetic Regulation of Kupffer Cell Function in Health and Disease
Hunter R. Bennett, T. Troutman, Mashito Sakai, C. Glass
2021Frontiers in Immunology62 citations Open access
Semantic Scholar
Identification and characterization of an alternative promoter of the human PGC-1alpha gene.
Toyo Yoshioka, K. Inagaki, T. Noguchi, Mashito Sakai +7 more
2009Biochemical and Biophysical Research Communications - BBRC54 citations Open access
Semantic Scholar
The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch
Mashito Sakai, Tomoko Tujimura-Hayakawa, T. Yagi, Hiroyuki Yano +7 more
2016Nature Communications41 citations Open access
Semantic Scholar
Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models
Toshiya Matsukawa, Takashi Yagi, Tohru Uchida, Mashito Sakai +28 more
2023JCI Insight36 citations Open access
Semantic Scholar
Overexpression of KLF15 Transcription Factor in Adipocytes of Mice Results in Down-regulation of SCD1 Protein Expression in Adipocytes and Consequent Enhancement of Glucose-induced Insulin Secretion*
Tomoki Nagare, H. Sakaue, M. Matsumoto, Yong-Heng Cao +14 more
2011Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway
Hsu-Wen Chao, M. Doi, J. Fustin, Hua-Tao Chen +13 more
2017Nature Communications31 citations Open access
Semantic Scholar
Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivity.
Yasuhide Fukatsu, T. Noguchi, T. Hosooka, Takeshi Ogura +16 more
2009Endocrinology30 citations
Semantic Scholar
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression
Yohei Abe, Eric R Kofman, Maria Almeida, Zhengyu Ouyang +24 more
2023Molecules and Cells27 citations Open access
Semantic Scholar
An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells
Lorane Texari, N. Spann, T. Troutman, Mashito Sakai +2 more
2021STAR Protocols27 citations Open access
Semantic Scholar
PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes
Hiroyuki Yano, Mashito Sakai, Toshiya Matsukawa, T. Yagi +12 more
2018Scientific Reports24 citations Open access
Semantic Scholar
Overexpression of the transcriptional coregulator Cited2 protects against glucocorticoid-induced atrophy of C2C12 myotubes.
K. Tobimatsu, T. Noguchi, T. Hosooka, Mashito Sakai +4 more
2009Biochemical and Biophysical Research Communications - BBRC22 citations
Semantic Scholar
Induced pluripotent stem cell-derived mesenchymal stem cells attenuate cerebral ischemia-reperfusion injury via anti-inflammation and anti-oxidative stress in rats
Masafumi Arakawa, Y. Sakamoto, Yoshitaka Miyagawa, C. Nito +7 more
2023Molecular Therapy21 citations Open access
Semantic Scholar
Purification of mouse hepatic non-parenchymal cells or nuclei for use in ChIP-seq and other next-generation sequencing approaches
T. Troutman, Hunter R. Bennett, Mashito Sakai, J. Seidman +2 more
2021STAR Protocols20 citations Open access
Semantic Scholar
Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure
S. Toma-Fukai, R. Hibi, T. Naganuma, Mashito Sakai +4 more
2020Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes
Hunter R. Bennett, T. Troutman, Enchen Zhou, N. Spann +11 more
2023Nature Immunology15 citations Open access
Semantic Scholar
The Lung Microenvironment Instructs Gene Transcription in Neonatal and Adult Alveolar Macrophages
Asami Honda, M. Hoeksema, Mashito Sakai, Sean J Lund +9 more
2022Journal of Immunology14 citations Open access
Semantic Scholar
Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs
Ze-Yang Shen, Rick Z. Li, T. Prohaska, M. Hoeksema +8 more
2020bioRxiv11 citations Open access
Semantic Scholar
Drinking hydrogen water improves photoreceptor structure and function in retinal degeneration 6 mice
T. Igarashi, I. Ohsawa, Maika Kobayashi, Kai Miyazaki +9 more
2022Scientific Reports10 citations Open access
Semantic Scholar
Glucose Production Assay in Primary Mouse Hepatocytes
M. Matsumoto, Mashito Sakai
20125 citations Open access
Semantic Scholar
Exploring the signal-dependent transcriptional regulation involved in the liver pathology of type 2 diabetes
Mashito Sakai
2022Diabetology International2 citations Open access
Semantic Scholar
Niche-Specific Re-Programming of Epigenetic Landscapes Drives Myeloid Cell Diversity in NASH
J. Seidman, T. Troutman, Mashito Sakai, Anita Gola +19 more
2020Social Science Research Network1 citations
Semantic Scholar
Systematic analysis of transcriptional and epigenetic effects of genetic variation in Kupffer cells enables discrimination of cell intrinsic and environment-dependent mechanisms
Hunter R. Bennett, T. Troutman, E. Zhou, N. Spann +11 more
2022bioRxiv0 citations Open access
Semantic Scholar
Crystal structure of atypical ubiquitin ligase PCAF_N
S. Toma-Fukai, R. Hibi, T. Naganuma, Mashito Sakai +4 more
2021Acta Crystallographica Section A: Foundations and Advances0 citations Open access
Semantic Scholar
Distinct Changes in the Chromatin Landscape Regulate Maturation of the Alveolar Macrophage Immune Response In Vivo
A. Yamamura, M. Hoeksema, Mashito Sakai, Sean J Lund +6 more
2020Journal of Immunology0 citations
Semantic Scholar
264 Interrogating altered enhancer landscapes to decode pathogenic changes in macrophages during chronic inflammatory disease
J. Seidman, T. Troutman, Mashito Sakai, R. Li +10 more
20200 citations Open access
Semantic Scholar
Exploiting altered enhancer landscapes to decode pathogenic changes in gene expression of diverse hepatic macrophages
T. Troutman, J. Seidman, Mashito Sakai, Anita Gola +11 more
2019Journal of Immunology0 citations
Semantic Scholar
Deciphering liver environmental signaling pathways for Kupffer cell identity
Mashito Sakai, T. Troutman, J. Seidman, Zhengyu Ouyang +14 more
2019Journal of Immunology0 citations
Semantic Scholar
Developmental and Environmental Regulation of Lung Macrophage Immune Response
A. Yamamura, Sean J Lund, O. Lakhdari, Mashito Sakai +2 more
2019Journal of Immunology0 citations
Semantic Scholar
Hepatic Myeloid Cell Diversity During Fibrosis and Nonalcoholic Steatohepatitis
T. Troutman, J. Seidman, Verena M. Link, M. Hosseini +5 more
2018Journal of Immunology0 citations
Semantic Scholar
DYRK1B regulates hepatic gluconeogenesis through GCN5-CITED2-PKA module and PGC-1α
Masaru Mitsushima, Mashito Sakai, M. Matsumoto, S. Iida +6 more
20170 citations
Semantic Scholar
Dual functions of Dyrk1 to regulate hepatic gluconeogenesis through PGC-1α and GCN5-CITED2-PKA module
Masaru Mitsushima, Mashito Sakai, Tomoko Tsujimura-Hayakawa, T. Yagi +6 more
20160 citations
Semantic Scholar

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T. Troutman×13
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