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Kazuo Okamoto · SciRah

Researcher profile · Semantic Scholar

Kazuo Okamoto

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Kazuo Okamoto — researcher profile on SciRah

h-index: 28
Works: 57
Citations: 6,434

Most-cited papers

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
Kojiro Sato, Ayako Suematsu, Kazuo Okamoto, A. Yamaguchi +8 more
2006Journal of Experimental Medicine1,602 citations Open access
Semantic Scholar
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
N. Komatsu, Kazuo Okamoto, S. Sawa, T. Nakashima +5 more
2013Nature Medicine1,108 citations
Semantic Scholar
Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.
Kazuo Okamoto, T. Nakashima, M. Shinohara, Takako Negishi-Koga +5 more
2017Physiological Reviews504 citations
Semantic Scholar
IL-17-producing γδ T cells enhance bone regeneration
Takehito Ono, Kazuo Okamoto, T. Nakashima, T. Nitta +3 more
2016Nature Communications332 citations Open access
Semantic Scholar
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
M. Shinohara, Takako Koga, Kazuo Okamoto, S. Sakaguchi +10 more
2008Cell320 citations Open access
Semantic Scholar
Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis
M. Asagiri, T. Hirai, T. Kunigami, Shunya Kamano +13 more
2008Science299 citations
Semantic Scholar
Host defense against oral microbiota by bone-damaging T cells
Masayuki Tsukasaki, N. Komatsu, Kazuki Nagashima, T. Nitta +6 more
2018Nature Communications296 citations Open access
Semantic Scholar
IκBζ regulates TH17 development by cooperating with ROR nuclear receptors
Kazuo Okamoto, Yoshiko Iwai, M. Oh-hora, Masahiro Yamamoto +7 more
2010Nature254 citations
Semantic Scholar
Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging.
M. Hayashi, T. Nakashima, N. Yoshimura, Kazuo Okamoto +2 more
2019Cell Metabolism136 citations Open access
Semantic Scholar
Immune complexes regulate bone metabolism through FcRγ signalling
Takako Negishi-Koga, hans-Jürgen gober, Eriko Sumiya, N. Komatsu +7 more
2015Nature Communications133 citations Open access
Semantic Scholar
Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency.
Asuka Terashima, Kazuo Okamoto, T. Nakashima, S. Akira +2 more
2016Immunity131 citations Open access
Semantic Scholar
Critical role of p38 and GATA3 in natural helper cell function
J. Furusawa, K. Moro, Y. Motomura, Kazuo Okamoto +4 more
2013Journal of Immunology128 citations Open access
Semantic Scholar
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution
Masayuki Tsukasaki, Cong-Nhat Huynh Nam, Kazuo Okamoto, Ryunosuke Muro +14 more
2020Nature Metabolism122 citations
Semantic Scholar
Regulation of bone by the adaptive immune system in arthritis
Kazuo Okamoto, H. Takayanagi
2011Arthritis Research & Therapy109 citations Open access
Semantic Scholar
OPG Production Matters Where It Happened.
Masayuki Tsukasaki, Tatsuo Asano, Ryunosuke Muro, Cong-Nhat Huynh Nam +6 more
2020Cell Reports87 citations Open access
Semantic Scholar
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
M. Guerrini, Kazuo Okamoto, N. Komatsu, S. Sawa +4 more
2015Immunity84 citations Open access
Semantic Scholar
Osteoclasts in arthritis and Th17 cell development.
Kazuo Okamoto, H. Takayanagi
2011International Immunopharmacology70 citations
Semantic Scholar
The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis
Yutaro Ando, Masayuki Tsukasaki, Cong-Nhat Huynh Nam, Shizao Zang +11 more
2024International Journal of Oral Science69 citations Open access
Semantic Scholar
Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance
M. Inoue, Kazuo Okamoto, Asuka Terashima, T. Nitta +5 more
2018Nature Immunology68 citations
Semantic Scholar
Soluble RANKL is physiologically dispensable but accelerates tumour metastasis to bone
Tatsuo Asano, Kazuo Okamoto, Y. Nakai, Masanori Tsutsumi +7 more
2019Nature Metabolism66 citations
Semantic Scholar
ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts
Minglu Yan, N. Komatsu, Ryunosuke Muro, Cong-Nhat Huynh Nam +18 more
2022Nature Immunology65 citations
Semantic Scholar
Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis
Y. Nakai, Kazuo Okamoto, Asuka Terashima, S. Ehata +4 more
2019Bone Research62 citations Open access
Semantic Scholar
Periosteal stem cells control growth plate stem cells during postnatal skeletal growth
Masayuki Tsukasaki, N. Komatsu, Takako Negishi-Koga, Cong-Nhat Huynh Nam +13 more
2022Nature Communications54 citations Open access
Semantic Scholar
LOX Fails to Substitute for RANKL in Osteoclastogenesis
Masayuki Tsukasaki, Koki Hamada, Kazuo Okamoto, Kazuki Nagashima +8 more
2017Journal of Bone and Mineral Research48 citations Open access
Semantic Scholar
Osteoimmunology.
Kazuo Okamoto, Hiroshi Takayanagi
2019Cold Spring Harbor Perspectives in Medicine41 citations Open access
Semantic Scholar
Crosstalk between bone and the immune system
Kazuo Okamoto
2024Journal of Bone and Mineral Metabolism39 citations Open access
Semantic Scholar
Effect of T cells on bone.
Kazuo Okamoto, H. Takayanagi
2023Bone37 citations Open access
Semantic Scholar
Genomewide Comprehensive Analysis Reveals Critical Cooperation Between Smad and c‐Fos in RANKL‐Induced Osteoclastogenesis
Y. Omata, T. Yasui, Jun Hirose, Naohiro Izawa +16 more
2015Journal of Bone and Mineral Research32 citations Open access
Semantic Scholar
The periosteum provides a stromal defence against cancer invasion into the bone
Kazutaka Nakamura, Masayuki Tsukasaki, Takaaki Tsunematsu, Minglu Yan +16 more
2024Nature31 citations
Semantic Scholar
The role of the BH3-only protein Noxa in bone homeostasis.
Erik Idrus, T. Nakashima, Ling Wang, M. Hayashi +5 more
2011Biochemical and Biophysical Research Communications - BBRC23 citations
Semantic Scholar
Identification of an intronic enhancer regulating RANKL expression in osteocytic cells
Minglu Yan, Masayuki Tsukasaki, Ryunosuke Muro, Yutaro Ando +6 more
2023Bone Research22 citations Open access
Semantic Scholar
Role of RANKL in cancer development and metastasis
Kazuo Okamoto
2021Journal of Bone and Mineral Metabolism21 citations
Semantic Scholar
Effect of JAK inhibitors on the three forms of bone damage in autoimmune arthritis: joint erosion, periarticular osteopenia, and systemic bone loss
M. Komagamine, N. Komatsu, Rui Ling, Kazuo Okamoto +5 more
2023Inflammation and Regeneration20 citations Open access
Semantic Scholar
Oncostatin M-driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis
Cong-Nhat Huynh Nam, Rui Ling, M. Komagamine, Tianshu Shi +12 more
2024Inflammation and Regeneration15 citations Open access
Semantic Scholar
Cytokine profile in patients with chronic non-bacterial osteomyelitis, juvenile idiopathic arthritis, and insulin-dependent diabetes mellitus.
M. Kostik, M. Makhova, A. Maletin, Shamai Magomedova +7 more
2021Cytokine15 citations
Semantic Scholar
Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1α signaling
Takehito Ono, Ryosuke Denda, Yuta Tsukahara, Takashi Nakamura +3 more
2022Bone Research12 citations Open access
Semantic Scholar
[Regulation of bone by IL-17-producing T cells].
Kazuo Okamoto
2017Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology11 citations Open access
Semantic Scholar
Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity
Ryunosuke Muro, T. Nitta, Sachiko Nitta, Masayuki Tsukasaki +6 more
2024Journal of Clinical Investigation6 citations Open access
Semantic Scholar
Disulfiram ameliorates bone loss in ovariectomized mice by suppressing osteoclastogenesis
Tatsuyuki Fukui, Asuka Terashima, Y. Omata, Ryota Chijimatsu +10 more
2024Journal of Bone and Mineral Metabolism4 citations Open access
Semantic Scholar
Effect of Dietary Nitrate on the Feed Digestibility in Ruminants
A. Miyazaki, Kazuo Okamoto, Eizo Tsuda, R. Kawashima +1 more
19743 citations Open access
Semantic Scholar
A distinct antigen presentation pathway drives potent T cell immunity in lipid nanoparticle–based mRNA vaccines
Ryunosuke Muro, Suqi Wang, Taku Ito-Kureha, H. Huynh +9 more
2026Science Advances2 citations Open access
Semantic Scholar
Bone voyage: OPN's path from skeleton to systemic immunosuppression.
Kyoko Hashimoto, Kazuo Okamoto, Hiroshi Takayanagi
2025Cancer Research2 citations
Semantic Scholar
Activin A secretion by muscle-repairing macrophages induces heterotopic ossification in mice
Wenqian Yin, Kazuo Okamoto, Asuka Terashima, W. Pluemsakunthai +10 more
2026Journal of Clinical Investigation1 citations Open access
Semantic Scholar
Correction: Crosstalk between bone and the immune system
Kazuo Okamoto
2024Journal of Bone and Mineral Metabolism1 citations Open access
Semantic Scholar
Title Pathogenic conversion of Foxp 3 + T cells into TH 17 cells in autoimmune arthritis
N. Komatsu, Kazuo Okamoto, S. Sawa, T. Nakashima +5 more
20131 citations
Semantic Scholar
Osteoclasts and Interleukin-17-Producing Helper T Cells in Rheumatoid
Kazuo Okamoto, H. Takayanagi
20111 citations
Semantic Scholar
Csf1r⁻ macrophages govern the second wave of neutrophils for bone repair
Yasuhiro Kobayashi, Zhifeng He, Linan Shi, Yuko Nakamichi +16 more
2025Research Square0 citations Open access
Semantic Scholar
Soluble RANKL is physiologically dispensable but accelerates tumour metastasis to bone
Tatsuo Asano, Kazuo Okamoto, Y. Nakai, Masanori Tsutsumi +7 more
2019Nature Metabolism0 citations
Semantic Scholar
PRMT5-mediated arginine methylation controls the strength of signaling via γc-family cytokines required for T cell maintenance
M. Inoue, Kazuo Okamoto, H. Takayanagi
2019Journal of Immunology0 citations
Semantic Scholar
Identification of an EF-hand motif protein for regulation of Jak-Stat signaling pathway
Kazuo Okamoto, I. Maia, Hiroshi Takayanagi
20170 citations
Semantic Scholar

Frequent co-authors

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H. Takayanagi×33
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H. Takayanagi — researcher profile on SciRah
N. Komatsu×15
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N. Komatsu — researcher profile on SciRah
T. Nitta×14
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T. Nitta — researcher profile on SciRah
T. Nakashima×13
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T. Nakashima — researcher profile on SciRah

Masayuki Tsukasaki

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Masayuki Tsukasaki — researcher profile on SciRah

Ryunosuke Muro×13

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Ryunosuke Muro — researcher profile on SciRah

Hiroshi Takayanagi×10

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Hiroshi Takayanagi — researcher profile on SciRah

Asuka Terashima×9

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Asuka Terashima — researcher profile on SciRah

Cong-Nhat Huynh Nam×7

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Cong-Nhat Huynh Nam — researcher profile on SciRah

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T. Okamura — researcher profile on SciRah

Sakae Tanaka×6

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Sakae Tanaka — researcher profile on SciRah

W. Pluemsakunthai×6

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W. Pluemsakunthai — researcher profile on SciRah