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E. Huizinga · SciRah

Researcher profile · Semantic Scholar

E. Huizinga

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E. Huizinga — researcher profile on SciRah

h-index: 40
Works: 108
Citations: 5,225

Most-cited papers

Structures of Glycoprotein Ibα and Its Complex with von Willebrand Factor A1 Domain
E. Huizinga, S. Tsuji, R. Romijn, Marion E. Schiphorst +3 more
2002Science567 citations Open access
Semantic Scholar
Structures of complement component C3 provide insights into the function and evolution of immunity
B. Janssen, E. Huizinga, H. Raaijmakers, A. Roos +4 more
2005Nature553 citations Open access
Semantic Scholar
Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A
R. J. Hulswit, Yifei Lang, M. Bakkers, Wen-Tao Li +8 more
2019Proceedings of the National Academy of Sciences of the United States of America390 citations Open access
Semantic Scholar
Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution
Q. Zeng, M. Langereis, A. V. van Vliet, E. Huizinga +1 more
2008Proceedings of the National Academy of Sciences of the United States of America270 citations Open access
Semantic Scholar
Platelet Adhesion to Collagen: an Update
J. Sixma, G. H. van Zanten, E. Huizinga, R. Martijn van der Plas +4 more
1997Thrombosis and Haemostasis193 citations
Semantic Scholar
von Willebrand factor proteolysis is deficient in classic, but not in bone marrow transplantation-associated, thrombotic thrombocytopenic purpura.
R. Martijn van der Plas, Marion E. Schiphorst, E. Huizinga, R. Hené +3 more
1999Blood189 citations
Semantic Scholar
Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding.
E. Huizinga, R. Martijn van der Plas, J. Kroon, J. Sixma +1 more
1997Structure162 citations Open access
Semantic Scholar
Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin*
Els F. Halff, C. A. Diebolder, Marian Versteeg, A. Schouten +2 more
2012Journal of Biological Chemistry156 citations Open access
Semantic Scholar
A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides.
T. Lisman, N. Raynal, D. Groeneveld, Ben Maddox +4 more
2006Blood129 citations Open access
Semantic Scholar
Factor B structure provides insights into activation of the central protease of the complement system
F. Milder, Lucio Gomes, A. Schouten, B. Janssen +6 more
2007Nature Structural &Molecular Biology117 citations Open access
Semantic Scholar
Mapping the Collagen-binding Site in the von Willebrand Factor-A3 Domain*
R. Romijn, E. Westein, B. Bouma, Marion E. Schiphorst +3 more
2003Journal of Biological Chemistry110 citations Open access
Semantic Scholar
Calcium modulates force sensing by the von Willebrand factor A2 domain
A. Jakobi, Alireza Mashaghi, S. Tans, E. Huizinga
2011Nature Communications106 citations Open access
Semantic Scholar
An Experimental Model to Study the in Vivo Survival of von Willebrand Factor
P. Lenting, E. Westein, Virginie Terraube, A. Ribba +4 more
2004Journal of Biological Chemistry104 citations Open access
Semantic Scholar
Identification of the Collagen-binding Site of the von Willebrand Factor A3-domain*
R. Romijn, B. Bouma, Winnifred Wuyster, P. Gros +3 more
2001Journal of Biological Chemistry100 citations Open access
Semantic Scholar
Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation.
C. A. Diebolder, Els F. Halff, A. Koster, E. Huizinga +1 more
2015Structure99 citations Open access
Semantic Scholar
Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity
M. Bakkers, Yifei Lang, L. Feitsma, R. J. Hulswit +8 more
2017Cell Host and Microbe96 citations Open access
Semantic Scholar
Evasion of Toll-like receptor 2 activation by staphylococcal superantigen-like protein 3
B. Bardoel, R. Vos, T. Bouman, P. Aerts +5 more
2012Journal of molecular medicine93 citations
Semantic Scholar
Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3)
Kirsten J. Koymans, L. Feitsma, T. H. Brondijk, P. Aerts +6 more
2015Proceedings of the National Academy of Sciences of the United States of America91 citations Open access
Semantic Scholar
Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation.
P. Marx, T. H. Brondijk, T. Plug, Roland A. Romijn +3 more
2008Blood89 citations Open access
Semantic Scholar
Implications for collagen I chain registry from the structure of the collagen von Willebrand factor A3 domain complex
T. H. Brondijk, D. Bihan, R. Farndale, E. Huizinga
2012Proceedings of the National Academy of Sciences of the United States of America86 citations Open access
Semantic Scholar
Crystal Structure of Quinohemoprotein Alcohol Dehydrogenase from Comamonas testosteroni
A. Oubrie, H. Rozeboom, K. Kalk, E. Huizinga +1 more
2002Journal of Biological Chemistry82 citations Open access
Semantic Scholar
Epitope mapping of inhibitory antibodies against platelet glycoprotein Ibalpha reveals interaction between the leucine-rich repeat N-terminal and C-terminal flanking domains of glycoprotein Ibalpha.
Nancy Cauwenberghs, K. Vanhoorelbeke, S. Vauterin, D. Westra +6 more
2001Blood82 citations Open access
Semantic Scholar
Coronavirus hemagglutinin-esterase and spike proteins coevolve for functional balance and optimal virion avidity
Yifei Lang, Wen-Tao Li, Zeshi Li, Danielle Koerhuis +8 more
2020Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI.
T. H. Brondijk, Talitha de Ruiter, J. Ballering, H. Wienk +6 more
2010Blood75 citations Open access
Semantic Scholar
Five novel mutations in the gene for human blood coagulation factor V associated with type I factor V deficiency.
R. van Wijk, Karel H. Nieuwenhuis, M. H. van den Berg, E. Huizinga +3 more
2001Blood75 citations Open access
Semantic Scholar
Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins
M. Langereis, M. Bakkers, Ling-Quan Deng, V. Padler-Karavani +16 more
2015Cell Reports69 citations Open access
Semantic Scholar
The Murine Coronavirus Hemagglutinin-esterase Receptor-binding Site: A Major Shift in Ligand Specificity through Modest Changes in Architecture
M. Langereis, Q. Zeng, B. Heesters, E. Huizinga +1 more
2012PLoS Pathogens55 citations Open access
Semantic Scholar
Structural basis for ligand and substrate recognition by torovirus hemagglutinin esterases
M. Langereis, Q. Zeng, G. Gerwig, Barbara Frey +4 more
2009Proceedings of the National Academy of Sciences of the United States of America51 citations Open access
Semantic Scholar
Structure of complement component C2A: implications for convertase formation and substrate binding.
F. Milder, H. Raaijmakers, M. Vandeputte, A. Schouten +6 more
2006Structure51 citations Open access
Semantic Scholar
Structural insights into collagen-binding by platelet receptor Glycoprotein VI.
L. Feitsma, Harma C Brondijk, G. Jarvis, D. Hagemans +5 more
2022Blood47 citations Open access
Semantic Scholar
Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia
S. Sivapalaratnam, S. Westbury, J. Stephens, D. Greene +21 more
2016Blood47 citations Open access
Semantic Scholar
Binding of von Willebrand Factor to Collagen Type III: Role of Specific Amino Acids in the Collagen Binding Domain of vWF and Effects of Neighboring Domains
R. M. van der Plas, Lucio Gomes, J. Marquart, T. Vink +4 more
2000Thrombosis and Haemostasis46 citations
Semantic Scholar
Fifteen novel mutations in PKLR associated with pyruvate kinase (PK) deficiency: Structural implications of amino acid substitutions in PK
R. van Wijk, E. Huizinga, A. V. van Wesel, B. V. van Oirschot +2 more
2009Human Mutation45 citations Open access
Semantic Scholar
HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia.
R. van Wijk, G. Rijksen, E. Huizinga, H. Nieuwenhuis +1 more
2003Blood44 citations Open access
Semantic Scholar
A Consensus Tetrapeptide Selected by Phage Display Adopts the Conformation of a Dominant Discontinuous Epitope of a Monoclonal Anti-VWF Antibody That Inhibits the von Willebrand Factor-Collagen Interaction*
K. Vanhoorelbeke, H. Depraetere, R. Romijn, E. Huizinga +2 more
2003Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Erythrocytosis associated with a novel missense mutation in the HIF2A gene
R. van Wijk, S. Sutherland, A. V. van Wesel, E. Huizinga +3 more
2010Haematologica41 citations Open access
Semantic Scholar
Coronavirus receptor switch explained from the stereochemistry of protein–carbohydrate interactions and a single mutation
M. Bakkers, Q. Zeng, L. Feitsma, R. J. Hulswit +7 more
2016Proceedings of the National Academy of Sciences of the United States of America40 citations Open access
Semantic Scholar
TLR Accessory Molecule RP105 (CD180) Is Involved in Post-Interventional Vascular Remodeling and Soluble RP105 Modulates Neointima Formation
J. Karper, M. Ewing, M. D. de Vries, S. D. de Jager +8 more
2013PLoS ONE38 citations Open access
Semantic Scholar
Paratope Determination of the Antithrombotic Antibody 82D6A3 Based on the Crystal Structure of Its Complex with the von Willebrand Factor A3-Domain*
S. Staelens, M. A. Hadders, S. Vauterin, C. Platteau +4 more
2006Journal of Biological Chemistry33 citations Open access
Semantic Scholar
The GPIbα–thrombin interaction: far from crystal clear
K. Vanhoorelbeke, H. Ulrichts, R. Romijn, E. Huizinga +1 more
200426 citations
Semantic Scholar
Evasion of Toll-like receptor 2 activation by staphylococcal superantigen-like protein 3
B. Bardoel, R. Vos, T. Bouman, P. Aerts +5 more
2012Journal of molecular medicine22 citations
Semantic Scholar
Distinct phenotypic expression of two de novo missense mutations affecting the dimer interface of glucose-6-phosphate dehydrogenase.
R. van Wijk, E. Huizinga, I. Prins, A. Kors +3 more
2004Blood Cells, Molecules & Diseases22 citations
Semantic Scholar
The structure of leech anti-platelet protein, an inhibitor of haemostasis.
E. Huizinga, A. Schouten, T. M. Connolly, Jan Kroon +2 more
2001Acta Crystallographica Section D: Biological Crystallography19 citations
Semantic Scholar
When less becomes more: optimization of protein expression in HEK293-EBNA1 cells using plasmid titration - a case study for NLRs.
Els F. Halff, Marian Versteeg, T. H. Brondijk, E. Huizinga
2014Protein Expression and Purification18 citations
Semantic Scholar
Adhesive Domains in the Collagen III Fragment α1(III)CB4 that Support α2β1- and von Willebrand Factor-mediated Platelet Adhesion under Flow Conditions
Marilyn W. Verkleij, M. Ijsseldijk, G. Heijnen-Snyder, E. Huizinga +5 more
1999Thrombosis and Haemostasis18 citations
Semantic Scholar
Characterization of bitiscetin‐2, a second form of bitiscetin from the venom of Bitis arietans : comparison of its binding site with the collagen‐binding site on the von Willebrand factor A3‐domain
B. Obert, Roland A. Romijn, A. Houllier, E. Huizinga +1 more
2006Journal of Thrombosis and Haemostasis15 citations Open access
Semantic Scholar
The GPIbalpha-thrombin interaction: far from crystal clear.
K. Vanhoorelbeke, H. Ulrichts, R. Romijn, E. Huizinga +1 more
2004Trends in Molecular Medicine13 citations
Semantic Scholar
Molecular basis determining species specificity for TLR2 inhibition by staphylococcal superantigen-like protein 3 (SSL3)
Kirsten J. Koymans, L. Feitsma, Adinda Bisschop, E. Huizinga +3 more
2018Veterinary Research12 citations Open access
Semantic Scholar
Correction: The Murine Coronavirus Hemagglutinin-esterase Receptor-binding Site: A Major Shift in Ligand Specificity through Modest Changes in Architecture
M. Langereis, Q. Zeng, B. Heesters, E. Huizinga +1 more
2012PLoS Pathogens11 citations Open access
Semantic Scholar
Isolated molecular Defects of von Willebrand Factor Binding to Collagen do not correlate with Bleeding Symptoms
R. Schneppenheim, T. Obser, E. Drewke, U. Gross-Wieltsch +6 more
20039 citations
Semantic Scholar

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