M. Kirschner

Most-cited papers

Droplet barcoding for single cell transcriptomics applied to embryonic stem cells
Allon M. Klein, L. Mazutis, Ilke Akartuna, Naren P. Tallapragada +5 more
2015Cell3,194 citations Open access
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Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
Mohit Jain, R. Nilsson, Sonia Sharma, Nikhil Madhusudhan +6 more
2012Science1,393 citations Open access
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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
Huai-Xiang Hao, Yang Xie, Yue Zhang, O. Charlat +15 more
2012Nature924 citations
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Rescuing US biomedical research from its systemic flaws
B. Alberts, M. Kirschner, S. Tilghman, H. Varmus
2014Proceedings of the National Academy of Sciences of the United States of America739 citations Open access
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The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution
James A. Briggs, Caleb Weinreb, Daniel E. Wagner, Sean Gregory Megason +3 more
2018Science535 citations Open access
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On being the right (cell) size
M. Ginzberg, Ran Kafri, M. Kirschner
2015Science389 citations Open access
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Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
Pengda Liu, M. Begley, W. Michowski, H. Inuzuka +21 more
2014Nature365 citations Open access
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Multiple Phases of Chondrocyte Enlargement Underlie Differences in Skeletal Proportions
Kimberly L. Cooper, Seungeun Oh, Yong-Jin Sung, R. Dasari +2 more
2013Nature361 citations Open access
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A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis
T. Gujral, M. Chan, L. Peshkin, P. Sorger +2 more
2014Cell344 citations Open access
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Deep Proteomics of the Xenopus laevis Egg using an mRNA-derived Reference Database
Martin Wühr, R. Freeman, Marc Presler, Marko E. Horb +3 more
2014Current Biology253 citations Open access
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Hemichordate genomes and deuterostome origins
O. Simakov, T. Kawashima, Ferdinand Marlétaz, J. Jenkins +57 more
2015Nature234 citations Open access
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Direct observation of mammalian cell growth and size regulation
Sung-Min Son, Amit Tzur, Yaochung Weng, P. Jorgensen +3 more
2012Nature Methods226 citations Open access
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Cellular dynamics extracted from populations of fixed cells reveals a feedback between growth and progression through the cell cycle
Ran Kafri, Jason Levy, M. Ginzberg, Seungeun Oh +2 more
2013Nature224 citations Open access
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Substrate degradation by the proteasome: a single-molecule kinetic analysis
Ying Lu, Byung-Hoon Lee, R. King, D. Finley +1 more
2015Science223 citations Open access
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On the relationship of protein and mRNA dynamics in vertebrate embryonic development
L. Peshkin, Martin Wühr, Esther J. Pearl, W. Haas +6 more
2015Developmental Cell209 citations Open access
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Structural basis for dynamic regulation of the human 26S proteasome
Shuobing Chen, Jiayi Wu, Ying Lu, Yongbei Ma +6 more
2016Proceedings of the National Academy of Sciences of the United States of America173 citations Open access
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VHL Substrate Transcription Factor ZHX2 As An Oncogenic Driver In Clear Cell Renal Cell Carcinoma
Jing Zhang, Tao Wu, Jeremy M. Simon, M. Takada +29 more
2018Science170 citations Open access
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Non-canonical open reading frames encode functional proteins essential for cancer cell survival
J. Prensner, Oana M. Enache, V. Luria, Karsten Krug +22 more
2020Nature Biotechnology162 citations Open access
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Preprints for the life sciences
J. Berg, Needhi Bhalla, P. Bourne, M. Chalfie +21 more
2016Science154 citations
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Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C
N. Brown, R. Vanderlinden, E. R. Watson, Florian Weissmann +25 more
2016Cell148 citations Open access
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Kinetic Responses of β-Catenin Specify the Sites of Wnt Control
Ana Hernandez, Allon M. Klein, M. Kirschner
2012Science147 citations
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The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity
Erik R. Hanschen, T. Marriage, P. Ferris, Takashi Hamaji +18 more
2016Nature Communications146 citations Open access
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Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis
Sung-Min Son, J. Kang, Seungeun Oh, M. Kirschner +2 more
2015Journal of Cell Biology146 citations Open access
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APCCdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction
L. Wan, M. Tan, Jie Yang, H. Inuzuka +11 more
2014Developmental Cell138 citations Open access
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Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity
M. Ginzberg, Nancy Chang, Heather D'Souza, N. Patel +2 more
2018eLife125 citations Open access
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The Nuclear Proteome of a Vertebrate
Martin Wühr, Thomas Güttler, L. Peshkin, G. McAlister +8 more
2015Current Biology118 citations Open access
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Profiling of ubiquitin-like modifications reveals features of mitotic control
Y. Merbl, Phillipe Refour, Hevan K. Patel, Michael Springer +1 more
2013Cell107 citations Open access
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Protein and lipid mass concentration measurement in tissues by stimulated Raman scattering microscopy
Seungeun Oh, Changhee Lee, Wenlong Yang, Ang Li +8 more
2019bioRxiv102 citations Open access
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Exploiting polypharmacology for drug target deconvolution
T. Gujral, L. Peshkin, M. Kirschner
2014Proceedings of the National Academy of Sciences of the United States of America100 citations Open access
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Size homeostasis in adherent cells studied by synthetic phase microscopy
Yong-Jin Sung, Amit Tzur, Seungeun Oh, W. Choi +4 more
2013Proceedings of the National Academy of Sciences of the United States of America96 citations Open access
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Molecular ties between the cell cycle and differentiation in embryonic stem cells
V. Li, M. Kirschner
2014Proceedings of the National Academy of Sciences of the United States of America93 citations Open access
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Hippo pathway mediates resistance to cytotoxic drugs
T. Gujral, M. Kirschner
2017Proceedings of the National Academy of Sciences of the United States of America87 citations Open access
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The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium
Wei-Ping Wang, Tao Wu, M. Kirschner
2014eLife82 citations Open access
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SCF-Mediated Cdh1 Degradation Defines a Negative Feedback System that Coordinates Cell-Cycle Progression
H. Fukushima, K. Ogura, L. Wan, Ying Lu +8 more
2013Cell Reports75 citations Open access
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Specificity of the Anaphase Promoting Complex: a single-molecule study
Ying Lu, Wei-Ping Wang, M. Kirschner
2015Science74 citations Open access
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Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length
Shi-Xuan Liu, M. Ginzberg, N. Patel, M. Hild +12 more
2017bioRxiv70 citations Open access
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Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation
Wen-Zhe Ma, Mao-Rong Chen, Hong Kang, Z. Steinhart +3 more
2019Proceedings of the National Academy of Sciences of the United States of America68 citations Open access
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Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase promoting complex
Wei-Ping Wang, M. Kirschner
2013Nature Cell Biology68 citations Open access
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The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function
L. Wan, Ming Chen, Juxiang Cao, Xiangpeng Dai +18 more
2017Cancer Discovery67 citations Open access
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Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development
Sébastien Darras, Jens H. Fritzenwanker, K. Uhlinger, E. Farrelly +10 more
2018PLoS Biology66 citations Open access
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Quantitative Lys-ϵ-Gly-Gly (diGly) Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-mediated Proteolysis of DNA Damage-inducible Transcript 4 (DDIT4) by the E3 Ligase HUWE1
Joel W. Thompson, Jane Nagel, S. Hoving, B. Gerrits +5 more
2014Journal of Biological Chemistry61 citations Open access
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Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9
J. Gallop, A. Walrant, L. Cantley, M. Kirschner
2013Proceedings of the National Academy of Sciences of the United States of America61 citations Open access
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Computationally enhanced quantitative phase microscopy reveals autonomous oscillations in mammalian cell growth
Xi-Li Liu, Seungeun Oh, L. Peshkin, M. Kirschner
2020Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
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Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss
Xi-Juan Liu, Jeremy M. Simon, Hai-Biao Xie, Lian-Xin Hu +13 more
2020Molecules and Cells55 citations Open access
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Opinion: Addressing systemic problems in the biomedical research enterprise
B. Alberts, M. Kirschner, S. Tilghman, H. Varmus
2015Proceedings of the National Academy of Sciences of the United States of America52 citations Open access
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The uniformity and stability of cellular mass density in mammalian cell culture
Xi-Li Liu, Seungeun Oh, M. Kirschner
2022Frontiers in Cell and Developmental Biology51 citations Open access
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The genome of the giant Nomura’s jellyfish sheds light on the early evolution of active predation
Hak-Min Kim, Jessica A. Weber, N. Lee, Seung Gu Park +19 more
2019BMC Biology47 citations Open access
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Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg
Marc Presler, Elizabeth S. Van Itallie, Allon M. Klein, Ryan C. Kunz +5 more
2017Proceedings of the National Academy of Sciences of the United States of America47 citations Open access
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Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy.
M. N. Aminake, A. Mahajan, Vipan Kumar, R. Hans +9 more
2012Bioorganic & Medicinal Chemistry46 citations
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YAP regulates cell size and growth dynamics via non-cell autonomous mediators
Douaa Mugahid, Marian Kalocsay, Xi-Li Liu, Jonathan Scott Gruver +2 more
2020eLife44 citations Open access
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