Researcher profile · Semantic Scholar

T. Barta

h-index: 14
Works: 32
Citations: 723

Most-cited papers

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.
J. Rice, J. Veal, R. Fadden, A. Barabasz +8 more
2008Arthritis & Rheumatism142 citations
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Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
D. Becker, T. Barta, L. Bedell, T. Boehm +23 more
2010Journal of Medicinal Chemistry92 citations Open access
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Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.
P. Fadden, K. Huang, J. Veal, P. Steed +25 more
2010Chemistry and Biology86 citations Open access
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Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90.
T. Barta, J. Veal, J. Rice, Jeffrey M. Partridge +10 more
2008Bioorganic & Medicinal Chemistry Letters70 citations
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Synthesis and Structure−Activity Relationships of β- and α-Piperidine Sulfone Hydroxamic Acid Matrix Metalloproteinase Inhibitors with Oral Antitumor Efficacy
D. Becker, C. I. Villamil, T. Barta, L. Bedell +14 more
200558 citations Open access
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Stereocontrol in the intramolecular Diels-Alder reaction. 7. Use of the trimethylsilyl group as a removable stereocontrol element to provide greatly enhanced levels of diastereoselection
R. K. Boeckman, T. Barta
198557 citations
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Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor
David A. Carlson, Aaron S. Franke, D. Weitzel, B. L. Speer +12 more
2013ACS Chemical Biology51 citations Open access
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C-phosphorylation of enolates: an alternate route to complex carbonyl-activated phosphonates
R. K. Boeckman, Theodore M. Kamenecka, S. G. Nelson, J. Pruitt +1 more
199120 citations Open access
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Novel carbazole and acyl-indole antimitotics.
T. Barta, A. Barabasz, Briana E. Foley, L. Geng +6 more
2009Bioorganic & Medicinal Chemistry Letters19 citations
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4-[(tert-Butyldiphenylsilyl)oxy]-2-(tributylstannyl)-(E)-2-buten-1-ol: a useful precursor for tetrahydrofuran synthesis
A. Barrett, T. Barta, J. Flygare
198917 citations
Semantic Scholar
α-Amino-β-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1
Daniel P. Becker, T. Barta, L. Bedell, G. Decrescenzo +9 more
200116 citations Open access
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Selective, orally active MMP inhibitors with an aryl backbone.
T. Barta, D. Becker, L. Bedell, G. A. De Crescenzo +4 more
2001Bioorganic & Medicinal Chemistry Letters16 citations Open access
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Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.
K. Huang, T. Barta, J. Rice, E. D. Smith +13 more
2012Bioorganic & Medicinal Chemistry Letters14 citations Open access
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Studies directed toward the total synthesis of tetronolide 1. An enantioselective synthesis of the octahydronaphthalene unit
R. K. Boeckman, T. Barta, S. G. Nelson
199114 citations Open access
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Approaches to avermectin assembly: a concise stereospecific synthesis of the hexahydrobenzofuran entity.
A. Barrett, T. Barta, J. Flygare, M. Sabat +1 more
199012 citations
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Synthesis and structure-activity relationships of beta- and alpha-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy.
D. Becker, C. I. Villamil, T. Barta, L. Bedell +14 more
2005Journal of Medicinal Chemistry10 citations Open access
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MMP-13 selective alpha-sulfone hydroxamates: identification of selective P1' amides.
Y. M. Fobian, J. Freskos, T. Barta, L. Bedell +8 more
2011Bioorganic & Medicinal Chemistry Letters9 citations Open access
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MMP-13 selective α-sulfone hydroxamates: a survey of P1' heterocyclic amide isosteres.
T. Barta, D. Becker, L. Bedell, A. Easton +8 more
2011Bioorganic & Medicinal Chemistry Letters9 citations Open access
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Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations.
Ian S. Cloudsdale, John K. Dickson, T. Barta, B. Grella +3 more
2017Bioorganic & Medicinal Chemistry6 citations Open access
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Protection of immobilized sulfhydryl groups against autooxidation by alterations in their microenvironment
A. Klibanov, T. Barta
1981Applied Biochemistry and Biotechnology3 citations
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Agonist-induced Ca 2 +-sensitization in smooth muscle : redundancy of RhoGEFs and response kinetics ; a caged compound study
J. Stull, K. Kamm, Min-Sheng Zhu, Ning Gao +20 more
20131 citations
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A novel, orally active, small molecule Hsp90 inhibitor.
P. Fadden, A. Barabasz, T. Barta, J. Eaves +9 more
20061 citations
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alpha-Amino-beta-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1.
D. Becker, T. Barta, L. Bedell, G. Decrescenzo +9 more
2001Bioorganic & Medicinal Chemistry Letters1 citations
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Graphical contents list
T. Barta, D. Becker, L. Bedell, A. Easton +23 more
2011Bioorganic & Medicinal Chemistry Letters0 citations Open access
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MMP-13 in complex with selective tetrazole core inhibitor
J. Kiefer, T. Barta, D. Becker, K. J. Mathis +1 more
20110 citations
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Slow, tight binding inhibition of Hsp90 isoforms correlates with potent anti-proliferative activity in cancer cell lines
Jeffrey M. Partridge, A. Barabasz, T. Barta, P. Fadden +15 more
20080 citations
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Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90
T. Barta, J. Veal, J. Rice, Jeffrey M. Partridge +10 more
20080 citations
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Derives de carbazole
G. Hanson, T. Barta, L. Geng, K. Huang +1 more
20060 citations
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Tetrahydroindolon- and tetrahydroindazolonderivater
J. Veal, T. Barta, L. Geng, G. Hanson +3 more
20060 citations
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Inhibiteur de metalloprotease a base d'acide hydroxamique aromatique sulfone
T. Barta, D. Becker, T. Boehm, G. A. De Crescenzo +4 more
19980 citations
Semantic Scholar
C-Phosphorylation of Enolates: An Alternate Route to Complex Carbonylactivated Phosphonates.
R. Jun, Theodore M. Kamenecka, S. G. Nelson, J. Pruitt +1 more
19920 citations
Semantic Scholar
4-((tert-Butyldiphenylsilyl)oxy)-2-(tributylstannyl)-2E-buten-1-ol: A Useful Precursor for Tetrahydrofuran Synthesis.
A. Barrett, T. Barta, J. Flygare
19900 citations
Semantic Scholar

C. I. Villamil

×9

A. Barabasz×8

S. Hall×8

G. Hanson×8

K. Huang×7

J. Freskos×7

S. Hockerman×7

Briana E. Foley×7