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J. Freskos · SciRah

Researcher profile · Semantic Scholar

J. Freskos

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J. Freskos — researcher profile on SciRah

h-index: 18
Works: 68
Citations: 914

Most-cited papers

Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
D. Becker, T. Barta, L. Bedell, T. Boehm +23 more
2010Journal of Medicinal Chemistry92 citations Open access
Semantic Scholar
Multicompartment Polymer Nanostructures with Ratiometric Dual-emission pH-Sensitivity
Guo-Rong Sun, H. Cui, Lily Yun Lin, N. S. Lee +6 more
2011Journal of the American Chemical Society74 citations Open access
Semantic Scholar
Synthesis of functionalized hydroxyphthalides and their conversion to 3-cyano-1(3H)-isobenzofuranones. The Diels-Alder reaction of methyl 4,4-diethoxybutynoate and cyclohexadienes
J. Freskos, G. W. Morrow, J. S. Swenton
198564 citations
Semantic Scholar
Synthesis and Structure−Activity Relationships of β- and α-Piperidine Sulfone Hydroxamic Acid Matrix Metalloproteinase Inhibitors with Oral Antitumor Efficacy
D. Becker, C. I. Villamil, T. Barta, L. Bedell +14 more
200558 citations Open access
Semantic Scholar
Hydrophilic pyrazine dyes as exogenous fluorescent tracer agents for real-time point-of-care measurement of glomerular filtration rate.
R. Rajagopalan, W. Neumann, A. Poreddy, R. Fitch +6 more
2011Journal of Medicinal Chemistry51 citations
Semantic Scholar
Design of potent inhibitors of human beta-secretase. Part 1.
J. Freskos, Y. M. Fobian, T. Benson, M. Bienkowski +13 more
2007Bioorganic & Medicinal Chemistry Letters43 citations
Semantic Scholar
A Facile Entry into Naphthopyran Quinones via an Annelation Reaction of Levoglucosenone. The Total Synthesis of (-)-Hongconin(1).
J. S. Swenton, J. Freskos, P. Dalidowicz, M. L. Kerns
1996Journal of Organic Chemistry39 citations
Semantic Scholar
Exogenous fluorescent tracer agents based on pegylated pyrazine dyes for real-time point-of-care measurement of glomerular filtration rate.
A. Poreddy, W. Neumann, J. Freskos, R. Rajagopalan +6 more
2012Bioorganic & Medicinal Chemistry35 citations
Semantic Scholar
Inhibitors of HIV-1 protease containing the novel and potent (R)-(hydroxyethyl)sulfonamide isostere.
M. L. Vazquez, M. Bryant, M. Clare, G. Decrescenzo +6 more
1995Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Synthesis of 2′-Deoxypyrimidine Nucleosides via Copper (I) Iodide Catalysis
J. Freskos
198931 citations
Semantic Scholar
A convergent synthesis of (+)-4-demethoxydaunomycinone and ( + )-daunomycinone
J. S. Swenton, J. Freskos, G. W. Morrow, A. Sercel
198430 citations
Semantic Scholar
A Convenient Synthesis of Pentafluoroethyl-Substituted Aromatics
J. Freskos
198826 citations
Semantic Scholar
Synthesis and identification of conformationally constrained selective MMP inhibitors.
J. Freskos, J. Mcdonald, B. Mischke, Patrick B. Mullins +3 more
1999Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Influence of nanostructure morphology on host capacity and kinetics of guest release.
N. S. Lee, Lily Yun Lin, W. Neumann, J. Freskos +4 more
2011Small24 citations
Semantic Scholar
A fundamental investigation of cross-linking efficiencies within discrete nanostructures, using the cross-linker as a reporting molecule
Guo-Rong Sun, N. S. Lee, W. Neumann, J. Freskos +3 more
200924 citations
Semantic Scholar
Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
D. Owen, John K. Walker, E. J. Jacobsen, J. Freskos +25 more
2009Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Photonic Shell-Crosslinked Nanoparticle Probes for Optical Imaging and Monitoring
N. S. Lee, Guo-Rong Sun, W. Neumann, J. Freskos +3 more
2009Advances in Materials22 citations Open access
Semantic Scholar
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
R. Hughes, John K. Walker, Jerry W. Cubbage, Y. M. Fobian +21 more
2009Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
R. Hughes, John K. Walker, D. J. Rogier, Steven E. Heasley +19 more
2009Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Synthesis of chiral succinates via Pd(0) catalyzed carbonylation/asymmetric hydrogenation sequence
J. Freskos, S. Laneman, Melissa L. Reilly, D. Ripin
199416 citations
Semantic Scholar
Non-destructive and Selective Imaging of the Functionally Active, Pro-invasive Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Enzyme in Cancer Cells*
A. Remacle, S. Shiryaev, V. Golubkov, J. Freskos +6 more
2013Journal of Biological Chemistry15 citations Open access
Semantic Scholar
Tunable dual-emitting shell-crosslinked nano-objects as single-component ratiometric pH-sensing materials
N. S. Lee, Guo-Rong Sun, Lily Yun Lin, W. Neumann +5 more
2011Journal of Materials Chemistry A15 citations Open access
Semantic Scholar
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
R. Hughes, D. J. Rogier, E. Jacobsen, John K. Walker +22 more
2010Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Design of potent inhibitors of human beta-secretase. Part 2.
J. Freskos, Y. M. Fobian, T. Benson, Joseph B. Moon +13 more
2007Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
alpha-Alkyl-alpha-amino-beta-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1.
D. Becker, G. Decrescenzo, J. Freskos, D. Getman +5 more
2001Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Regioselective N-methyl carbon lithiation of N-boc-methylalkylamines. Expedient synthesis of unsymmetrical amines
V. Snieckus, M. Rogers-Evans, P. Beak, W. Lee +2 more
199413 citations
Semantic Scholar
Annelation reaction of levoglucosenone. Chiral intermediates for the synthesis of naphtho[2.3-c]pyran-5,10-quinone antibiotics
J. Freskos, J. S. Swenton
198511 citations
Semantic Scholar
Synthesis and structure-activity relationships of beta- and alpha-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy.
D. Becker, C. I. Villamil, T. Barta, L. Bedell +14 more
2005Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar
MMP-13 selective alpha-sulfone hydroxamates: identification of selective P1' amides.
Y. M. Fobian, J. Freskos, T. Barta, L. Bedell +8 more
2011Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes.
J. Freskos, B. Asmelash, Kimberly R. Gaston, A. Karwa +6 more
2013Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
(Hydroxyethyl) sulfonamide HIV-1 Protease inhibitors: Identification of the 2-methylbenzoyl moiety at P-2
J. Freskos, Deborah E. Bertenshaw, D. Getman, R. Heintz +8 more
19968 citations
Semantic Scholar
Use of R-Pantolactone in the Synthesis of L-Tert Leucine Derivatives
J. Freskos
19947 citations
Semantic Scholar
New optical probes for the continuous monitoring of renal function
R. Dorshow, B. Asmelash, L. Chinen, M. Debreczeny +9 more
2008SPIE BiOS5 citations
Semantic Scholar
Synthesis of succinate containing dipeptide isosteres via carbonylation of enol triflates.
J. Freskos, D. Ripin, Melissa L. Reilly
19935 citations
Semantic Scholar
Photonic Shell-Crosslinked Nanoparticle Probes for Optical Imaging and Monitoring
N. S. Lee, W. Neumann, J. Freskos, Tim Marzan +3 more
20084 citations
Semantic Scholar
A Facile Entry into Naphthopyran Quinones via an Annelation Reaction of Levoglucosenone. The Total Synthesis of (-)-Hongconin.
J. S. Swenton, J. Freskos, P. Dalidowicz, M. L. Kerns
19964 citations
Semantic Scholar
Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols.
J. Freskos, B. Mischke, G. Decrescenzo, R. Heintz +9 more
1999Bioorganic & Medicinal Chemistry Letters3 citations
Semantic Scholar
Real-time point-of-care measurement of impaired renal function in a rat acute injury model employing exogenous fluorescent tracer agents
R. Dorshow, R. Fitch, K. Galen, J. Wojdyla +5 more
2013Biomedical optics2 citations
Semantic Scholar
Discovery of a Novel Series of Selective MMP Inhibitors: Identification of the γ-Sulfone-thiols.
J. Freskos
20101 citations
Semantic Scholar
N-alkylated aminopyrazines for use as hydrophilic optical agents
A. Poreddy, B. Asmelash, K. Galen, R. Fitch +13 more
2009BiOS1 citations
Semantic Scholar
alpha-Amino-beta-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1.
D. Becker, T. Barta, L. Bedell, G. Decrescenzo +9 more
2001Bioorganic & Medicinal Chemistry Letters1 citations
Semantic Scholar
Sulfonylalkanoylaminohydroxyethylaminosulfonamide useful as retroviral protease inhibitors
M. L. Vazquez, R. Mueller, J. Talley, D. Getman +2 more
19931 citations
Semantic Scholar
A convenient synthesis of hydroxyphthalides
J. Freskos, T. Cynkowski, J. S. Swenton
19841 citations
Semantic Scholar
Development of fluorescent tracers for the real-time monitoring of renal function
A. Poreddy, B. Asmelash, M. Debreczeny, R. Fitch +13 more
2011BiOS0 citations
Semantic Scholar
Graphical contents list
T. Barta, D. Becker, L. Bedell, A. Easton +23 more
2011Bioorganic & Medicinal Chemistry Letters0 citations Open access
Semantic Scholar
Synthesis of Chiral Succinates via Pd(0)-Catalyzed Carbonylation/ Asymmetric Hydrogenation Sequence.
J. Freskos, S. Laneman, Melissa L. Reilly, D. Ripin
20100 citations
Semantic Scholar
ChemInform Abstract: α-Alkyl-α-amino-β-sulfone Hydroxamates as Potent MMP Inhibitors that Spare MMP-1.
D. Becker, G. Decrescenzo, J. Freskos, D. Getman +5 more
20020 citations
Semantic Scholar
Process for the preparation of retroviral protease inhibitors useful in hydroksietyyliaminosulfoniamidien
J. Talley, M. L. Vazquez, G. Decrescenzo, R. Mueller +2 more
20010 citations
Semantic Scholar
Inhibiteur de metalloprotease a base d'acide hydroxamique aromatique sulfone
T. Barta, D. Becker, T. Boehm, G. A. De Crescenzo +4 more
19980 citations
Semantic Scholar
Composes aromatiques d'acide sulfonyle alpha-hydroxy hydroxamique
J. Freskos, T. Boehm, B. Mischke, R. Heintz +3 more
19980 citations
Semantic Scholar

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B. Mischke — researcher profile on SciRah
J. Shieh×12
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R. Heintz — researcher profile on SciRah

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