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R. Sanderson · SciRah

Researcher profile · Semantic Scholar

R. Sanderson

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R. Sanderson — researcher profile on SciRah

h-index: 60
Works: 149
Citations: 11K

Most-cited papers

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis
R. Iozzo, R. Sanderson
2011Journal of Cellular and Molecular Medicine546 citations Open access
Semantic Scholar
Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes*♦
Camilla A. Thompson, A. Purushothaman, V. Ramani, I. Vlodavsky +1 more
2013Journal of Biological Chemistry306 citations Open access
Semantic Scholar
Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.
Nikos Karamanos, Z. Piperigkou, A. Theocharis, Hideto Watanabe +10 more
2018Chemical Reviews305 citations Open access
Semantic Scholar
Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions*
A. Purushothaman, S. Bandari, Jian Liu, J. Mobley +2 more
2015Journal of Biological Chemistry264 citations Open access
Semantic Scholar
SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis
J. Ritchie, V. Ramani, Yong-Sheng Ren, A. Naggi +10 more
2011Clinical Cancer Research236 citations Open access
Semantic Scholar
Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.
A. Purushothaman, T. Uyama, F. Kobayashi, S. Yamada +3 more
2010Blood231 citations Open access
Semantic Scholar
Heparanase: from basic research to therapeutic applications in cancer and inflammation
I. Vlodavsky, Preeti Singh, I. Boyango, Lilach Gutter-Kapon +3 more
2016Drug resistance updates222 citations Open access
Semantic Scholar
Heparanase: Busy at the cell surface
L. Fux, N. Ilan, R. Sanderson, I. Vlodavsky
2009TIBS -Trends in Biochemical Sciences. Regular ed219 citations Open access
Semantic Scholar
Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior
S. Bandari, A. Purushothaman, V. Ramani, Garrett J. Brinkley +7 more
2017Matrix Biology211 citations Open access
Semantic Scholar
Heparanase regulation of cancer, autophagy and inflammation: New mechanisms and targets for therapy
R. Sanderson, M. Elkin, A. Rapraeger, N. Ilan +1 more
2016The FEBS Journal195 citations Open access
Semantic Scholar
Heparanase Stimulation of Protease Expression Implicates It as a Master Regulator of the Aggressive Tumor Phenotype in Myeloma*
A. Purushothaman, Ligong Chen, Yang Yang, R. Sanderson
2008Journal of Biological Chemistry193 citations Open access
Semantic Scholar
Non Anticoagulant Heparins and Inhibition of Cancer
B. Casu, I. Vlodavsky, R. Sanderson
2007Pathophysiology of Haemostasis and Thrombosis183 citations Open access
Semantic Scholar
The heparanase/syndecan-1 axis in cancer: mechanisms and therapies
V. Ramani, A. Purushothaman, M. D. Stewart, Camilla A. Thompson +3 more
2013The FEBS Journal182 citations Open access
Semantic Scholar
Proteoglycans in health and disease: New concepts for heparanase function in tumor progression and metastasis
Uri Barash, Victoria Cohen-Kaplan, Ilana Dowek, R. Sanderson +2 more
2010The FEBS Journal163 citations Open access
Semantic Scholar
Proteases and glycosidases on the surface of exosomes: Newly discovered mechanisms for extracellular remodeling
R. Sanderson, S. Bandari, I. Vlodavsky
2017Matrix Biology162 citations Open access
Semantic Scholar
Heparanase Enhances Syndecan-1 Shedding
Yang Yang, V. Macleod, Hua Miao, A. Theus +7 more
2007Journal of Biological Chemistry157 citations Open access
Semantic Scholar
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine
A. Theocharis, S. Skandalis, T. Neill, H. Multhaupt +12 more
2015Biochimica et Biophysica Acta150 citations Open access
Semantic Scholar
Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: Growth regulation and the prospect of new cancer therapies
R. Sanderson, Yang Yang, T. Kelly, V. Macleod +2 more
2005Journal of Cellular Biochemistry150 citations Open access
Semantic Scholar
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.
Yang Yang, V. Macleod, Yuemeng Dai, Yekaterina Khotskaya-Sample +13 more
2007Blood142 citations Open access
Semantic Scholar
Heparanase is a Host Enzyme Required for Herpes Simplex Virus-1 Release from Cells
Satvik R. Hadigal, A. Agelidis, Ghadah A. Karasneh, Thessicar E Antoine +5 more
2015Nature Communications140 citations Open access
Semantic Scholar
Syndecan-1: a dynamic regulator of the myeloma microenvironment
R. Sanderson, Yang Yang
2007Clinical and Experimental Metastasis131 citations Open access
Semantic Scholar
Opposing functions of heparanase-1 and heparanase-2 in cancer progression
I. Vlodavsky, Miriam Gross-Cohen, Marina Weissmann, N. Ilan +1 more
2017TIBS -Trends in Biochemical Sciences. Regular ed123 citations Open access
Semantic Scholar
Heparan Sulfate Chains of Syndecan-1 Regulate Ectodomain Shedding*
V. Ramani, P. Pruett, Camilla A. Thompson, Lawrence D. DeLucas +1 more
2012Journal of Biological Chemistry116 citations Open access
Semantic Scholar
Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity*♦
V. Ramani, Yang Yang, Yong-Sheng Ren, Li Nan +1 more
2010Journal of Biological Chemistry116 citations Open access
Semantic Scholar
Phase I study of the heparanase inhibitor roneparstat: an innovative approach for ultiple myeloma therapy
M. Galli, M. Chatterjee, M. Grasso, G. Specchia +9 more
2018Haematologica113 citations Open access
Semantic Scholar
Heparanase-mediated Loss of Nuclear Syndecan-1 Enhances Histone Acetyltransferase (HAT) Activity to Promote Expression of Genes That Drive an Aggressive Tumor Phenotype*
A. Purushothaman, Douglas R. Hurst, C. Pisano, S. Mizumoto +2 more
2011Journal of Biological Chemistry113 citations Open access
Semantic Scholar
Heparanase Regulates Levels of Syndecan-1 in the Nucleus
Ligong Chen, R. Sanderson
2009PLoS ONE108 citations Open access
Semantic Scholar
Syndecan-1 Is Required for Robust Growth, Vascularization, and Metastasis of Myeloma Tumors in Vivo*
Y. Khotskaya, Yuemeng Dai, J. Ritchie, V. Macleod +3 more
2009Journal of Biological Chemistry107 citations Open access
Semantic Scholar
Heparan Sulfate in the Nucleus and its Control of Cellular Functions
M. D. Stewart, R. Sanderson
2013Matrix Biology102 citations Open access
Semantic Scholar
Fibronectin on the Surface of Extracellular Vesicles Mediates Fibroblast Invasion
Diptiman Chanda, E. Otoupalova, Kenneth P. Hough, Morgan L. Locy +5 more
2019American Journal of Respiratory Cell and Molecular Biology87 citations Open access
Semantic Scholar
Targeting heparanase overcomes chemoresistance and diminishes relapse in myeloma
V. Ramani, F. Zhan, Jian-Bo He, P. Barbieri +3 more
2015OncoTarget85 citations Open access
Semantic Scholar
Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype
V. Ramani, I. Vlodavsky, M. Ng, Yi Zhang +3 more
2016Matrix Biology81 citations Open access
Semantic Scholar
Heparanase-enhanced Shedding of Syndecan-1 and Its Role in Driving Disease Pathogenesis and Progression
Sunil Rangarajan, J. R. Richter, R. Richter, S. Bandari +3 more
2020Journal of Histochemistry and Cytochemistry75 citations Open access
Semantic Scholar
Chemotherapy stimulates syndecan-1 shedding: A potentially negative effect of treatment that may promote tumor relapse
V. Ramani, R. Sanderson
2013Matrix Biology66 citations Open access
Semantic Scholar
Shed Syndecan-1 Translocates to the Nucleus of Cells Delivering Growth Factors and Inhibiting Histone Acetylation
M. D. Stewart, V. Ramani, R. Sanderson
2014Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Involvement of heparanase in atherosclerosis and other vessel wall pathologies
I. Vlodavsky, M. Blich, Jin-Ping Li, R. Sanderson +1 more
2013Matrix Biology61 citations Open access
Semantic Scholar
Syndecan-1 (CD138) suppresses apoptosis in multiple myeloma by activating IGF1 receptor: prevention by synstatinIGF1R inhibits tumor growth
DeannaLee M Beauvais, O. Jung, Yang Yang, R. Sanderson +1 more
2016Cancer Research57 citations Open access
Semantic Scholar
Cancer esearch oenvironment and Immunology aranase Enhances Local and Systemic Osteolysis in tiple Myeloma by Upregulating the Expression and R retion of RANKL
Yang, Yong-Sheng Ren, V. Ramani, Nan Li +2 more
201057 citations
Semantic Scholar
Heparanase: multiple functions in inflammation, diabetes and atherosclerosis.
I. Vlodavsky, R. Iozzo, R. Sanderson
2013Matrix Biology54 citations Open access
Semantic Scholar
Forty Years of Basic and Translational Heparanase Research
I. Vlodavsky, N. Ilan, R. Sanderson
2020Advances in Experimental Medicine and Biology50 citations Open access
Semantic Scholar
Heparanase inhibits osteoblastogenesis and shifts bone marrow progenitor cell fate in myeloma bone disease
J. Ruan, T. Trotter, Li Nan, R. Luo +4 more
2013Bone47 citations Open access
Semantic Scholar
Heparanase Enhances the Insulin Receptor Signaling Pathway to Activate Extracellular Signal-regulated Kinase in Multiple Myeloma*
A. Purushothaman, Stephen K. Babitz, R. Sanderson
2012Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Glycocalyx heparan sulfate cleavage promotes endothelial cell angiopoietin-2 expression by impairing shear stress–related AMPK/FoxO1 signaling
R. Richter, Amit R. Ashtekar, Lei Zheng, Danielle Pretorius +4 more
2022JCI Insight44 citations Open access
Semantic Scholar
Family history of hematologic malignancies and risk of multiple myeloma: differences by race and clinical features
M. V. VanValkenburg, Gwendolyn I. Pruitt, I. Brill, L. Costa +13 more
2015Cancer Causes and Control41 citations Open access
Semantic Scholar
Recent Insights into Cell Surface Heparan Sulphate Proteoglycans and Cancer
J. Couchman, H. Multhaupt, R. Sanderson
2016F1000Research40 citations Open access
Semantic Scholar
Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis
T. Kelly, L. Suva, Kristy M. Nicks, V. Macleod +1 more
2010Journal of Bone and Mineral Research39 citations Open access
Semantic Scholar
Heparanase and chemotherapy synergize to drive macrophage activation and enhance tumor growth
U. Bhattacharya, Lilach Gutter-Kapon, T. Kan, I. Boyango +8 more
2019Cancer Research35 citations Open access
Semantic Scholar
Heparanase promotes myeloma stemness and in vivo tumorigenesis
K. Tripathi, V. Ramani, S. Bandari, Rada Amin +4 more
2019Matrix Biology35 citations Open access
Semantic Scholar
NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma
M. Hao, R. Franqui-Machin, H. Xu, J. Shaughnessy +10 more
2017Leukemia30 citations Open access
Semantic Scholar
Heparanase—A single protein with multiple enzymatic and nonenzymatic functions
I. Vlodavsky, Yasmin Kayal, Maram Hilwi, Soaad Soboh +2 more
2023Proteoglycan Research28 citations Open access
Semantic Scholar

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I. Vlodavsky — researcher profile on SciRah
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Yang Yang×10
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A. Purushothaman

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