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L. A. Wheeler · SciRah

Researcher profile · Semantic Scholar

L. A. Wheeler

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L. A. Wheeler — researcher profile on SciRah

h-index: 8
Works: 23
Citations: 735

Most-cited papers

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras.
L. A. Wheeler, R. Trifonova, V. Vrbanac, E. Basar +12 more
2011Journal of Clinical Investigation226 citations Open access
Semantic Scholar
Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma.
L. A. Wheeler, A. Manzanera, S. Bell, R. Cavaliere +13 more
2015Neuro-Oncology161 citations Open access
Semantic Scholar
Gene Knockdown by EpCAM Aptamer–siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells
Adi Gilboa-Geffen, P. Hamar, Minh T. N. Le, L. A. Wheeler +4 more
2015Molecular Cancer Therapeutics77 citations Open access
Semantic Scholar
Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras.
L. A. Wheeler, V. Vrbanac, R. Trifonova, M. Brehm +6 more
2013Molecular Therapy73 citations Open access
Semantic Scholar
HIV DNA is heavily uracilated, which protects it from autointegration
Nan Yan, E. O'Day, L. A. Wheeler, A. Engelman +1 more
2011Proceedings of the National Academy of Sciences of the United States of America72 citations Open access
Semantic Scholar
Coiling Versus Microsurgical Clipping in the Treatment of Unruptured Middle Cerebral Artery Aneurysms: A Meta-Analysis
M. Alreshidi, David J. Cote, H. Dasenbrock, M. Acosta +11 more
2018Neurosurgery65 citations Open access
Semantic Scholar
TREX1 knockdown induces an interferon response to HIV that delays viral infection in humanized mice
L. A. Wheeler, R. Trifonova, V. Vrbanac, N. Barteneva +8 more
2016Cell Reports34 citations Open access
Semantic Scholar
Silencing Sexually Transmitted Infections: Topical siRNA-Based Interventions for the Prevention of HIV and HSV
L. A. Wheeler
2014Infectious Diseases in Obstetrics and Gynecology12 citations Open access
Semantic Scholar
Abstract LB-299: Gene knockdown by EpCAM aptamer-siRNA chimeras suppresses epithelial breast cancers and their tumor-initiating cells
Adi Gilboa-Geffen, P. Hamar, L. A. Wheeler, R. Trifonova +3 more
20157 citations
Semantic Scholar
Tension pneumocephalus mimicking septic shock: a case report
Caroline Miranda, Ali Mahta, L. A. Wheeler, A. Tsiouris +1 more
2017Radiology Case Reports2 citations Open access
Semantic Scholar
144 The Cytosolic Exonuclease TREX1 Digests HIV Reverse Transcripts to Avoid Triggering an Antiviral Interferon Response in T Cells and Macrophages
Nan Yan, L. A. Wheeler, Ashton D. Regalado-Magdos, Bart Stiggelbout +2 more
20122 citations
Semantic Scholar
BM-36MICROENVIRONMENT-DEPENDENT CHANGES TO THE MATURE microRNA EXPRESSION PROFILE OF BREAST CANCER CELLS METASTATIC TO THE BRAIN
L. A. Wheeler, A. Bronisz, Chiocca Ea
20141 citations Open access
Semantic Scholar
Inhibiting the Host Exonuclease TREX1 Induces a Localized and Protective Host Interferon Response against Acute HIV Infection In Vivo
L. A. Wheeler, Judy Lieberman
20141 citations
Semantic Scholar
P19-22. CD4-targeted delivery of HIV and CCR5 siRNAs by aptamer-siRNA chimeras suppresses HIV infection in primary cells and in human cervical explants
L. A. Wheeler, E. Basar, S. McKernan, Derek M. Dykxhoorn +1 more
2009Retrovirology1 citations Open access
Semantic Scholar
RNAi as a potential new therapy for HIV infection
L. A. Wheeler, Derek M. Dykxhoorn
20081 citations
Semantic Scholar
Abstract CT110: Phase II multicenter study of gene-mediated cytotoxic immunotherapy as an adjuvant to surgical resection for newly diagnosed malignant glioma: lessons learned from pseudo-progression and a nine-year survivor
D. Baskin, L. Aguilar, L. A. Wheeler, A. Manzanera +14 more
20160 citations
Semantic Scholar
Multicenter Phase IB/II Study of AdV-Tk, a Gene-Mediated Cytotoxic Immunotherapy, Adjuvant to Surgical Resection for Patients With Newly Diagnosed High Grade Glioma
L. A. Wheeler
20150 citations
Semantic Scholar
Phase II multicenter study of gene mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma.
L. Aguilar, L. A. Wheeler, A. Manzanera, S. Bell +12 more
20150 citations Open access
Semantic Scholar
Predicting outcomes: recursive partitioning analysis (RPA) prognostic algorithm for patients with metastatic sarcoma to the brain.
L. A. Wheeler, E. Chiocca
2014World Neurosurgery0 citations
Semantic Scholar
Developing an Effective Rectal Microbicide: Inhibiting HIV Transmission in Human Colorectal Tissue and Humanized Mice with CD4 Aptamer-siRNA Chimeras
L. A. Wheeler, Judy Lieberman
20140 citations Open access
Semantic Scholar
CD4 Aptamer-SiRNA Chimeras (CD4-AsiCs) Knockdown Gene Expression in CD4+ Cells and Inhibit HIV Transmission
L. A. Wheeler
20130 citations
Semantic Scholar
Abstract CN01-02: Targeting basal-like TNBCs and epithelial tumor-initiating cells with aptamer-siRNA chimeras.
Adi Gilboa-Geffen, L. A. Wheeler, Anders Wittrup, F. Petrocca +1 more
20130 citations
Semantic Scholar
T.19.5. Synthesis of a Bifunctional Chimera: Discriminate Delivery of siRNA to CD4+Cells by Fusion to RNA-based Aptamers
L. A. Wheeler, J. Lieberman
20090 citations
Semantic Scholar

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