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Nan Yan · SciRah

Researcher profile · Semantic Scholar

Nan Yan

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Nan Yan — researcher profile on SciRah

h-index: 32
Works: 60
Citations: 8,060

Most-cited papers

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen
A. Brass, Derek M. Dykxhoorn, Yair Benita, Nan Yan +4 more
2008Science1,415 citations
Semantic Scholar
Cyclic GMP-AMP Synthase is an Innate Immune Sensor of HIV and Other Retroviruses
Daxing Gao, Jia-Xi Wu, You-Tong Wu, Feng-He Du +4 more
2013Science1,004 citations Open access
Semantic Scholar
miR-24 inhibits cell proliferation by suppressing expression of E2F2, MYC and other cell cycle regulatory genes by binding to “seedless” 3′UTR microRNA recognition elements
A. Lal, Francisco Navarro, C. Maher, L. Maliszewski +10 more
2009Molecules and Cells601 citations Open access
Semantic Scholar
STING activation by translocation from the ER is associated with infection and autoinflammatory disease
N. Dobbs, Nikolay Burnaevskiy, Didi Chen, Vijay K. Gonugunta +2 more
2015Cell Host and Microbe590 citations Open access
Semantic Scholar
Intrinsic Antiviral Immunity
Nan Yan, Zhi-Jian J. Chen
2012Nature Immunology530 citations Open access
Semantic Scholar
The cytosolic exonuclease TREX1 inhibits the innate immune response to HIV-1
Nan Yan, Ashton D. Regalado-Magdos, Bart Stiggelbout, Ae Lee-Kirsch Min +1 more
2010Nature Immunology416 citations Open access
Semantic Scholar
Interferon-independent activities of mammalian STING mediate antiviral response and tumor immune evasion
Jianjun Wu, N. Dobbs, Kun Yang, Nan Yan
2020Immunity327 citations Open access
Semantic Scholar
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death
Jianjun Wu, Yu-Ju Chen, N. Dobbs, Tomomi Sakai +3 more
2019Journal of Experimental Medicine305 citations Open access
Semantic Scholar
Trafficking-mediated STING degradation requires sorting to acidified endolysosomes and can be therapeutically targeted to enhance anti-tumor response
Vijay K. Gonugunta, Tomomi Sakai, Vladislav Pokatayev, Kun Yang +3 more
2017Cell Reports294 citations Open access
Semantic Scholar
RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice
Vladislav Pokatayev, Naushaba Hasin, H. Chon, S. Cerritelli +5 more
2016Journal of Experimental Medicine225 citations Open access
Semantic Scholar
Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
Ting-Ting Chu, Xintao Tu, Kun Yang, Jianjun Wu +2 more
2021Nature213 citations Open access
Semantic Scholar
STING-associated vasculopathy develops independently of IRF3 in mice
James D Warner, Ricardo A. Irizarry-Caro, Brock G. Bennion, Teresa L. Ai +8 more
2017Journal of Experimental Medicine185 citations Open access
Semantic Scholar
Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes
Maroof Hasan, J. Koch, D. Rakheja, Asit K. Pattnaik +6 more
2012Nature Immunology142 citations Open access
Semantic Scholar
STING Licensing of Type I Dendritic Cells Potentiates Antitumor Immunity
Jian Wang, Su-Xin Li, Maggie Wang, Xu Wang +8 more
2024Science immunology129 citations Open access
Semantic Scholar
Homeostatic regulation of STING protein at the resting-state by stabilizer TOLLIP
Vladislav Pokatayev, Kun Yang, Xintao Tu, N. Dobbs +3 more
2020Nature Immunology119 citations Open access
Semantic Scholar
N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1
Kun Yang, Ryan Huang, Haruhiko Fujihira, Tadashi Suzuki +1 more
2018Journal of Experimental Medicine108 citations Open access
Semantic Scholar
STING trafficking as a new dimension of immune signaling
Devon Jeltema, Kennady Abbott, Nan Yan
2023Journal of Experimental Medicine106 citations Open access
Semantic Scholar
Immune Diseases Associated with TREX1 and STING Dysfunction
Nan Yan
2017Journal of Interferon and Cytokine Research103 citations Open access
Semantic Scholar
DNA polymerase-α regulates type I interferon activation through cytosolic RNA:DNA synthesis
P. Starokadomskyy, T. Gemelli, Jonathan J. Rios, Chao Xing +27 more
2016Nature Immunology103 citations Open access
Semantic Scholar
Cytosolic nuclease TREX1 regulates oligosaccharyltransferase activity independent of nuclease activity to suppress immune activation
Maroof Hasan, C. Fermaintt, Ningguo Gao, Tomomi Sakai +7 more
2015Immunity101 citations Open access
Semantic Scholar
Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism
Maroof Hasan, Vijay K. Gonugunta, N. Dobbs, Aktar Ali +4 more
2017Proceedings of the National Academy of Sciences of the United States of America98 citations Open access
Semantic Scholar
The SET Complex Acts as a Barrier to Autointegration of HIV-1
Nan Yan, P. Cherepanov, Janet E Daigle, A. Engelman +1 more
2009PLoS Pathogens98 citations Open access
Semantic Scholar
Reactive oxygen species oxidize STING and suppress interferon production
L. Tao, Andrew Lemoff, Guo-Xun Wang, Christina M. Zarek +3 more
2020eLife96 citations Open access
Semantic Scholar
HIV DNA is heavily uracilated, which protects it from autointegration
Nan Yan, E. O'Day, L. A. Wheeler, A. Engelman +1 more
2011Proceedings of the National Academy of Sciences of the United States of America72 citations Open access
Semantic Scholar
Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies
Maroof Hasan, Nan Yan
2016Pharmacological Research71 citations Open access
Semantic Scholar
Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice
Maroof Hasan, N. Dobbs, Shaheen Khan, M. White +3 more
2015Journal of Immunology70 citations Open access
Semantic Scholar
STING controls energy stress-induced autophagy and energy metabolism via STX17
Yueguang Rong, Shenmin Zhang, N. Nandi, Zhe Wu +15 more
2022Journal of Cell Biology65 citations Open access
Semantic Scholar
Interruption of post-Golgi STING trafficking activates tonic interferon signaling
Xintao Tu, Ting-Ting Chu, Devon Jeltema, Kennady Abbott +5 more
2022Nature Communications56 citations Open access
Semantic Scholar
Innate immune activation by cGAMP-PC7A nanoparticles leads to potent and long-acting antiretroviral response against HIV-1
Chukwuemika Aroh, Zhao-Hui Wang, N. Dobbs, Min Luo +3 more
2017Journal of Immunology43 citations Open access
Semantic Scholar
Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis
Hua Lu, C. Fermaintt, N. Cherepanova, R. Gilmore +2 more
2018Proceedings of the National Academy of Sciences of the United States of America40 citations Open access
Semantic Scholar
Integrated pan-cancer analysis and experimental verification of the roles of tropomyosin 4 in gastric cancer
Qi-Jing Guo, Linglin Zhao, Nan Yan, Yan Li +5 more
2023Frontiers in Immunology39 citations Open access
Semantic Scholar
DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice
Tomomi Sakai, T. Miyazaki, Dong-Mi Shin, Yong-soo Kim +11 more
2017Journal of Autoimmunity35 citations Open access
Semantic Scholar
Safeguard against DNA sensing: the role of TREX1 in HIV-1 infection and autoimmune diseases
Maroof Hasan, Nan Yan
2014Frontiers in Microbiology32 citations Open access
Semantic Scholar
Gaining a Foothold: How HIV avoids innate immune recognition
Nan Yan, J. Lieberman
2010Current Opinion in Immunology32 citations Open access
Semantic Scholar
A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response
C. Fermaintt, Kanae Sano, Zhi-Da Liu, Nozomi Ishii +7 more
2019Nature Communications24 citations Open access
Semantic Scholar
No Longer A One-Trick Pony: STING Signaling Activity Beyond Interferon
Jianjun Wu, Nan Yan
2021Journal of Molecular Biology21 citations Open access
Semantic Scholar
Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex
M. Kucej, C. Fermaintt, Kun Yang, Ricardo A. Irizarry-Caro +1 more
2017Cell Reports21 citations Open access
Semantic Scholar
ATP13A2 Declines Zinc-Induced Accumulation of α-Synuclein in a Parkinson’s Disease Model
Hui-Ling Gao, Hehong Sun, Nan Yan, Pu Zhao +6 more
2022International Journal of Molecular Sciences19 citations Open access
Semantic Scholar
Aicardi-Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5.
H. Onizawa, H. Kato, H. Kimura, Tomoo Kudo +12 more
2020International Immunology19 citations
Semantic Scholar
The mammalian SKIV2L RNA exosome is essential for early B cell development
Kun Yang, Jie Han, Jennifer G. Gill, Jason Y. Park +6 more
2022Science immunology18 citations Open access
Semantic Scholar
STIM1 moonlights as an anchor for STING
Jianjun Wu, Nan Yan
2019Nature Immunology16 citations
Semantic Scholar
Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease
Kun Yang, Jie Han, Mayumi Asada, Jennifer G. Gill +8 more
2022Journal of Clinical Investigation12 citations Open access
Semantic Scholar
Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T-follicular helper cells and germinal center B cells
Rajkumar Venkatadri, V. Sabapathy, M. Doğan, Saleh Mohammad +6 more
2022European Journal of Immunology11 citations Open access
Semantic Scholar
Double-Stranded RNA Induces Mortality in an MDA5-Mediated Type I Interferonopathy Model.
Francine Lianne Emralino, Saya Satoh, N. Sakai, M. Takami +5 more
2022Journal of Immunology10 citations Open access
Semantic Scholar
SAMHD1 does it again, in resting T cells
Nan Yan, J. Lieberman
2012Nature Medicine10 citations Open access
Semantic Scholar
Metabolic Control of Viral Infection through PPAR-α Regulation of STING Signaling
L. Tao, Alexandria Lowe, Guo-Xun Wang, I. Dozmorov +3 more
2019bioRxiv9 citations Open access
Semantic Scholar
Bilayer STING goes head to head to stay put.
Kun Yang, Nan Yan
2023Molecules and Cells5 citations Open access
Semantic Scholar
Methods of Assessing STING Activation and Trafficking
Vladislav Pokatayev, Nan Yan
2017Methods in molecular biology4 citations Open access
Semantic Scholar
Response to Comment on “Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice”
Maroof Hasan, Nan Yan
2016Journal of Immunology4 citations
Semantic Scholar
Gain-of-function STING mutations induce T cell death in the SAVI mouse
Jianjun Wu, Nan Yan
2018Journal of Immunology2 citations
Semantic Scholar

Frequent co-authors

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N. Dobbs×9
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N. Dobbs — researcher profile on SciRah
Jianjun Wu×9
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Jianjun Wu — researcher profile on SciRah
Kun Yang×8
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Kun Yang — researcher profile on SciRah
J. Lieberman×7
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J. Lieberman — researcher profile on SciRah

×7

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Maroof Hasan — researcher profile on SciRah

Tomomi Sakai×5

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Tomomi Sakai — researcher profile on SciRah

Vladislav Pokatayev×5

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Vladislav Pokatayev — researcher profile on SciRah

C. Fermaintt×5

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C. Fermaintt — researcher profile on SciRah

Vijay K. Gonugunta×4

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Vijay K. Gonugunta — researcher profile on SciRah

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A. Engelman — researcher profile on SciRah

Zhi-Jian J. Chen×3

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Zhi-Jian J. Chen — researcher profile on SciRah

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Xintao Tu — researcher profile on SciRah