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M. Brehm · SciRah

Researcher profile · Semantic Scholar

M. Brehm

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M. Brehm — researcher profile on SciRah

h-index: 58
Works: 203
Citations: 11K

Most-cited papers

Humanized mouse models of clinical disease
N. C. Walsh, L. Kenney, Sonal Jangalwe, Ken-Edwin Aryee +3 more
2016Annual Review of Pathology518 citations Open access
Semantic Scholar
Humanized mouse models for immuno-oncology research
Jane Chuprin, Hannah Buettner, Mina O. Seedhom, D. Greiner +4 more
2023Nature Reviews Clinical Oncology368 citations Open access
Semantic Scholar
Human ‘brite / beige’ adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice
S. Min, Jamie Kady, Minwoo Nam, Raziel Rojas-Rodriguez +8 more
2016Nature Medicine295 citations Open access
Semantic Scholar
Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy
Mi-Nan Wang, Li-chin Yao, M. Cheng, Danying Cai +13 more
2017The FASEB Journal292 citations Open access
Semantic Scholar
Humanized immune system mouse models: progress, challenges and opportunities
Todd M. Allen, M. Brehm, S. Bridges, Stacy E. Ferguson +8 more
2019Nature Immunology214 citations Open access
Semantic Scholar
Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection
Xaver Sewald, M. Ladinsky, P. Uchil, J. Beloor +11 more
2015Science169 citations Open access
Semantic Scholar
Lack of acute xenogeneic graft‐versus‐host disease, but retention of T‐cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression
M. Brehm, L. Kenney, Michael V. Wiles, B. Low +5 more
2018The FASEB Journal165 citations Open access
Semantic Scholar
In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery
R. Bahal, Nicole Ali McNeer, E. Quijano, Yan-Feng Liu +18 more
2016Nature Communications144 citations Open access
Semantic Scholar
Innovations, challenges, and minimal information for standardization of humanized mice
R. Stripecke, C. Münz, J. Schuringa, K. Bissig +19 more
2020EMBO Molecular Medicine117 citations Open access
Semantic Scholar
Improved B cell development in humanized NOD‐scid IL2Rγnull mice transgenically expressing human stem cell factor, granulocyte‐macrophage colony‐stimulating factor and interleukin‐3
Sonal Jangalwe, L. Shultz, A. Mathew, M. Brehm
2016Immunity, Inflammation and Disease107 citations Open access
Semantic Scholar
AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice
B. Youngblood, E. Brock, J. Leung, R. Falahati +8 more
2019International Archives of Allergy and Immunology93 citations Open access
Semantic Scholar
Humanized Mouse Models of Immunological Diseases and Precision Medicine
L. Shultz, J. Keck, Lisa M. Burzenski, Sonal Jangalwe +3 more
2019Mammalian Genome92 citations Open access
Semantic Scholar
Humanized Mouse Model of Mast Cell-Mediated Passive Cutaneous Anaphylaxis and Passive Systemic Anaphylaxis
P. Bryce, R. Falahati, L. Kenney, J. Leung +7 more
2016Journal of Allergy and Clinical Immunology92 citations Open access
Semantic Scholar
Humanized mice and tissue transplantation
Laurie L. Kenney, L. D. Shultz, Dale L. Greiner, M. Brehm
2015American Journal of Transplantation87 citations Open access
Semantic Scholar
Inflammation mediated by JNK in myeloid cells promotes the development of hepatitis and hepatocellular carcinoma
M. Han, T. Barrett, M. Brehm, R. Davis
2016Cell Reports74 citations Open access
Semantic Scholar
Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells
N. Leite, Elad Sintov, T. Meissner, M. Brehm +3 more
2020Cell Reports71 citations Open access
Semantic Scholar
Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency
F. Borel, Q. Tang, Gwladys Gernoux, Cynthia Greer +8 more
2017Molecular Therapy71 citations Open access
Semantic Scholar
γδ T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors
C. Harmon, A. Zaborowski, H. Moore, Pamela St Louis +13 more
2023Nature Cancer70 citations
Semantic Scholar
Enhanced development of functional human NK cells in NOD-scid-IL2rgnull mice expressing human IL15
Ken-Edwin Aryee, Lisa M. Burzenski, Li-chin Yao, J. Keck +3 more
2022The FASEB Journal55 citations Open access
Semantic Scholar
Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer
Mengdie Wang, C. Wisniewski, Choua Xiong, Peter Chhoy +12 more
2023Science Translational Medicine51 citations
Semantic Scholar
Creation of PDX-Bearing Humanized Mice to Study Immuno-oncology.
Li-chin Yao, Ken-Edwin Aryee, M. Cheng, Pali Kaur +2 more
2019Methods in molecular biology51 citations
Semantic Scholar
Genome-Wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features
J. Karlinsey, Taylor A Stepien, Matthew Mayho, Larissa A. Singletary +9 more
2019Cell Host and Microbe50 citations Open access
Semantic Scholar
A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic‐related cytokine release syndrome
Chun-Ting Ye, Hong-Yuan Yang, M. Cheng, L. Shultz +3 more
2020The FASEB Journal44 citations Open access
Semantic Scholar
A Novel Hemolytic Complement-Sufficient NSG Mouse Model Supports Studies of Complement-Mediated Antitumor Activity In Vivo
M. Verma, J. Clemens, Lisa M. Burzenski, S. Sampson +3 more
2017JIM - Journal of Immunological Methods39 citations Open access
Semantic Scholar
Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics
N. Kooreman, Patricia E. de Almeida, J. Stack, Raman V. Nelakanti +13 more
2017Cell Reports38 citations Open access
Semantic Scholar
Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells
Suheyla Hasgur, Ken-Edwin Aryee, L. Shultz, D. Greiner +1 more
2016Methods in molecular biology38 citations
Semantic Scholar
An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis
Batuhan Yenilmez, Nicole Wetoska, Mark Kelly, Dimas Echeverria +14 more
2021Molecular Therapy37 citations Open access
Semantic Scholar
Modeling human T1D-associated autoimmune processes
Mohsen Khosravi-Maharlooei, R. Madley, C. Borsotti, Leonardo M. R. Ferreira +7 more
2021Molecular Metabolism35 citations Open access
Semantic Scholar
In vivo correction of anaemia in beta-thalassemic mice by gammaPNA-mediated gene editing with nanoparticle delivery
R. Bahal, N. McNeer, E. Quijano, Yan-Feng Liu +18 more
201928 citations
Semantic Scholar
mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell–derived hematopoietic progenitors
Jungmin Lee, B. Dykstra, J. Spencer, L. Kenney +6 more
2017Journal of Clinical Investigation26 citations Open access
Semantic Scholar
Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response
J. Doloff, Minglin Ma, Atieh Sadraei, H. Tam +15 more
2023Science Advances23 citations Open access
Semantic Scholar
Kaposi Sarcoma-Associated Herpesvirus Glycoprotein H Is Indispensable for Infection of Epithelial, Endothelial, and Fibroblast Cell Types
M. Muniraju, Lorraine Z. Mutsvunguma, Joslyn Foley, Gabriela M. Escalante +9 more
2019Journal of Virology22 citations Open access
Semantic Scholar
Animal Models for Alopecia Areata: What and Where?
J. Sundberg, K. McElwee, M. Brehm, L. Su +1 more
2015Journal of Investigative Dermatology Symposium Proceedings20 citations Open access
Semantic Scholar
CDK4/6 inhibition sensitizes intracranial tumors to PD-1 blockade in preclinical models of brain metastasis
Naema Nayyar, Magali A. de Sauvage, Jane Chuprin, E. Sullivan +9 more
2023Clinical Cancer Research19 citations Open access
Semantic Scholar
Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells
Julia Schanin, W. Korver, E. Brock, J. Leung +9 more
2022Communications Biology18 citations Open access
Semantic Scholar
Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV‐1 pathogenesis
Yetao Wang, Lawrence M. Lifshitz, Noah J. Silverstein, Esther Mintzer +6 more
2023EMBO Journal16 citations Open access
Semantic Scholar
Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice
Philip A. Durost, Ken-Edwin Aryee, Fatima Manzoor, R. Tisch +4 more
2017Human Gene Therapy16 citations Open access
Semantic Scholar
Humanized Mice in Translational Immunology
M. Brehm, R. Bortell, M. Verma, L. Shultz +1 more
201616 citations
Semantic Scholar
Nuclear factor kappa B-dependent persistence of Salmonella Typhi and Paratyphi in human macrophages
Taylor A Stepien, Larissa A. Singletary, Fermin E. Guerra, J. Karlinsey +9 more
2024mBio15 citations Open access
Semantic Scholar
Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model
Jiwon Yang, Jing Jiao, K. Draheim, Guoxiang Yang +12 more
2023The FASEB Journal14 citations Open access
Semantic Scholar
The presence and preferential activation of Tregs diminishes adoptive transfer of autoimmune diabetes by polyclonal NOD T cell effectors into NSG versus NOD-scid mice
Maximiliano Presa, Yi-Guang Chen, A. Grier, E. Leiter +4 more
2015Journal of Immunology14 citations Open access
Semantic Scholar
Transgenic expression of human IL15 in NOD-scid IL2rg null (NSG) mice enhances the development and survival of functional human NK cells
M. Brehm, Ken-Edwin Aryee, Lisa Bruzenksi, D. Greiner +2 more
2018Journal of Immunology12 citations
Semantic Scholar
NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity
Ken-Edwin Aryee, L. Shultz, Lisa M. Burzenski, D. Greiner +1 more
2023Journal of Leukocyte Biology11 citations Open access
Semantic Scholar
Proteomic and Transcriptional Profiles of Human Stem Cell-Derived β Cells Following Enteroviral Challenge
J. Nyalwidhe, Agata Jurczyk, Basanthi Satish, Sambra D. Redick +10 more
2020Microorganisms11 citations Open access
Semantic Scholar
Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells
Le-Yuan Ma, Magnolia L. Pak, Jian-Hong Ou, Jun Yu +7 more
2019Proceedings of the National Academy of Sciences of the United States of America11 citations Open access
Semantic Scholar
I-Ag7 β56/57 polymorphisms regulate non-cognate negative selection to CD4 T cell orchestrators of type-1 diabetes
Brian D. Stadinski, Sarah B. Cleveland, M. Brehm, D. Greiner +2 more
2023Nature Immunology10 citations Open access
Semantic Scholar
The Role of IFNγ-Producing Th1 Cells in a Type I IFN-Independent Murine Model of Autoinflammation Resulting from DNase II-Deficiency
Sudesh Pawaria, K. Nundel, K. M. Gao, S. Moses +8 more
2019Arthritis & Rheumatology10 citations Open access
Semantic Scholar
Generation of the NeoThy mouse model for human immune system studies
Natalia M. Del Rio, Liupei Huang, Lydia Murphy, Jayalaxmi Suresh Babu +6 more
2023Lab animal8 citations Open access
Semantic Scholar
Human anti-HIV-1 gp120 monoclonal antibodies with neutralizing activity cloned from humanized mice infected with HIV-1
Melissa Gawron, M. Duval, C. Carbone, S. Jaiswal +8 more
2018Journal of Immunology7 citations Open access
Semantic Scholar
862 Targeting PSGL-1, a novel macrophage checkpoint, repolarizes suppressive macrophages, induces an inflammatory tumor microenvironment, and suppresses tumor growth
Phuong Nguyen, R. Phennicie, Kevin J. Kauffman, D. Nowakowska +9 more
20206 citations Open access
Semantic Scholar

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