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David J. Dowling · SciRah

Researcher profile · Semantic Scholar

David J. Dowling

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David J. Dowling — researcher profile on SciRah

h-index: 28
Works: 81
Citations: 2,748

Most-cited papers

Ontogeny of Early Life Immunity
David J. Dowling, O. Levy
2014Trends in immunology353 citations Open access
Semantic Scholar
Recent Advances in the Discovery and Delivery of TLR7/8 Agonists as Vaccine Adjuvants
David J. Dowling
2018ImmunoHorizons146 citations Open access
Semantic Scholar
Major Secretory Antigens of the Helminth Fasciola hepatica Activate a Suppressive Dendritic Cell Phenotype That Attenuates Th17 Cells but Fails To Activate Th2 Immune Responses
David J. Dowling, Clare M. Hamilton, S. Donnelly, James La Course +3 more
2009Infection and Immunity131 citations Open access
Semantic Scholar
Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses
David J. Dowling, E. Scott, A. Scheid, Ilana Bergelson +14 more
2017Journal of Allergy and Clinical Immunology123 citations Open access
Semantic Scholar
The Fasciola hepatica Tegumental Antigen Suppresses Dendritic Cell Maturation and Function
Clare M. Hamilton, David J. Dowling, C. Loscher, R. Morphew +2 more
2009Infection and Immunity116 citations Open access
Semantic Scholar
Imidazoquinoline TLR8 agonists activate human newborn monocytes and dendritic cells via adenosine-refractory and caspase-1-dependent pathways
V. Philbin, David J. Dowling, L. Gallington, Guadalupe Cortés +9 more
2012Journal of Allergy and Clinical Immunology112 citations Open access
Semantic Scholar
An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor-binding domain vaccine in aged mice
E. Nanishi, F. Borriello, Timothy R. O’Meara, M. McGrath +42 more
2021Science Translational Medicine104 citations Open access
Semantic Scholar
TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth.
David J. Dowling, S. V. van Haren, A. Scheid, Ilana Bergelson +18 more
2017JCI Insight100 citations Open access
Semantic Scholar
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity
F. Borriello, Valentina Poli, Ellen L. Shrock, R. Spreafico +30 more
2022Cell99 citations Open access
Semantic Scholar
Age-specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1-polarization
S. V. van Haren, David J. Dowling, Willemina Foppen, D. Christensen +5 more
2016Journal of Immunology94 citations Open access
Semantic Scholar
Toward precision adjuvants: optimizing science and safety
E. Nanishi, David J. Dowling, O. Levy
2020Current opinion in pediatrics87 citations Open access
Semantic Scholar
A comparative analysis of cytokine responses, cell surface marker expression and MAPKs in DCs matured with LPS compared with a panel of TLR ligands.
David J. Dowling, Clare M. Hamilton, S. O'Neill
2008Cytokine82 citations
Semantic Scholar
The Sigma Class Glutathione Transferase from the Liver Fluke Fasciola hepatica
E. J. LaCourse, S. Perally, R. Morphew, J. Moxon +10 more
2012PLoS Neglected Tropical Diseases74 citations Open access
Semantic Scholar
The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes
David J. Dowling, Zhen Tan, Z. Prokopowicz, C. Palmer +4 more
2013PLoS ONE72 citations Open access
Semantic Scholar
BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny
Asimenia Angelidou, J. Diray-Arce, M. Conti, K. Smolen +4 more
2020Frontiers in Microbiology63 citations Open access
Semantic Scholar
In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant
S. V. van Haren, Lakshmi Ganapathi, Ilana Bergelson, David J. Dowling +5 more
2016Cytokine58 citations Open access
Semantic Scholar
The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes
Lakshmi Ganapathi, S. V. van Haren, David J. Dowling, Ilana Bergelson +8 more
2015PLoS ONE49 citations Open access
Semantic Scholar
Pediatric vaccine adjuvants: Components of the modern vaccinologist's toolbox
David J. Dowling, O. Levy
2015The Pediatric Infectious Disease Journal45 citations Open access
Semantic Scholar
Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70
Byron Brook, Valerie Duval, S. Barman, Lauren Speciner +13 more
2024Science Translational Medicine43 citations
Semantic Scholar
Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization
F. Borriello, Carlo Pietrasanta, Jacqueline C. Y. Lai, L. Walsh +9 more
2017Frontiers in Immunology43 citations Open access
Semantic Scholar
Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns
E. Speer, David J. Dowling, Lukasz S. Ozog, Jian-Jin Xu +3 more
2017Pediatric Research42 citations
Semantic Scholar
Adjuvant Effect of Bacille Calmette–Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn
A. Scheid, F. Borriello, Carlo Pietrasanta, H. Christou +8 more
2018Frontiers in Immunology41 citations Open access
Semantic Scholar
The TLR5 Agonist Flagellin Shapes Phenotypical and Functional Activation of Lung Mucosal Antigen Presenting Cells in Neonatal Mice
Pankaj Sharma, O. Levy, David J. Dowling
2020Frontiers in Immunology35 citations Open access
Semantic Scholar
Distinct Toll-like receptor-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells
M. Pettengill, S. V. van Haren, Ning Li, David J. Dowling +4 more
2016Innate Immunity34 citations Open access
Semantic Scholar
Precision Vaccine Development: Cues From Natural Immunity
S. Barman, Dheeraj Soni, Byron Brook, E. Nanishi +1 more
2022Frontiers in Immunology33 citations Open access
Semantic Scholar
The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells.
C. Palmer, Jana Ninković, Z. Prokopowicz, C. Mancuso +4 more
2014Biomaterials33 citations
Semantic Scholar
Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum
Cariosa M. Noone, M. Parkinson, David J. Dowling, A. Aldridge +5 more
2013Malaria Journal33 citations Open access
Semantic Scholar
A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity
David J. Dowling, H. Sanders, W. Cheng, S. Joshi +8 more
2016Frontiers in Immunology29 citations Open access
Semantic Scholar
Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference
Dheeraj Soni, S. V. van Haren, O. Idoko, Jay T. Evans +3 more
2020Frontiers in Immunology28 citations Open access
Semantic Scholar
Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro
E. Speer, David J. Dowling, Jian-Jin Xu, Lukasz S. Ozog +4 more
2018PLoS ONE28 citations Open access
Semantic Scholar
Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures
D. Oh, David J. Dowling, Saima Ahmed, Hyungwon Choi +9 more
2016Molecular & Cellular Proteomics28 citations Open access
Semantic Scholar
Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40
R. Morphew, Clare M. Hamilton, Hazel A. Wright, David J. Dowling +2 more
2012Veterinary parasitology24 citations Open access
Semantic Scholar
Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination
David J. Dowling, S. Barman, Alyson J. Smith, F. Borriello +13 more
2022Scientific Reports23 citations Open access
Semantic Scholar
Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen
Simon Doss-Gollin, Sanya Thomas, Byron Brook, Kimia Abedi +7 more
2023npj Vaccines21 citations Open access
Semantic Scholar
The effects of Fasciola hepatica tegumental antigens on mast cell function.
K. Vukman, Paul N. Adams, David J. Dowling, M. Metz +2 more
2013International Journal of Parasitology20 citations
Semantic Scholar
Ascaris lumbricoides pseudocoelomic body fluid induces a partially activated dendritic cell phenotype with Th2 promoting ability in vivo.
David J. Dowling, Cariosa M. Noone, Paul N. Adams, K. Vukman +4 more
2011International Journal of Parasitology20 citations
Semantic Scholar
The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems
Dheeraj Soni, Sharan Bobbala, Sophia Li, E. Scott +1 more
2020Pediatric Research19 citations Open access
Semantic Scholar
Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro
A. Queenan, David J. Dowling, W. Cheng, K. Faé +11 more
2018Vaccine18 citations Open access
Semantic Scholar
Nanomedicine and Spleen-Targeting Strategies for Precision Immunomodulation: Advances, Challenges, and Future Perspectives.
Chiwoo Oh, Han-Na Jung, Jiwoo Park, J. Awad +3 more
2025ACS Nano17 citations
Semantic Scholar
From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation
Dheeraj Soni, Francesco Borriello, David A. Scott, F. Feru +22 more
2024Science Advances17 citations Open access
Semantic Scholar
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
Timothy R. O’Meara, E. Nanishi, M. McGrath, S. Barman +9 more
2022bioRxiv16 citations Open access
Semantic Scholar
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
E. Nanishi, M. McGrath, Timothy R. O’Meara, S. Barman +17 more
2022Communications Biology16 citations Open access
Semantic Scholar
Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model
Guzmán Sanchez-Schmitz, Elena Morrocchi, Michael J. Cooney, Dheeraj Soni +4 more
2020Scientific Reports15 citations Open access
Semantic Scholar
Shaping neonatal immunization by tuning delivery of synergistic adjuvants via nanocarriers
S. Barman, F. Borriello, Byron Brook, Carlo Pietrasanta +12 more
2022bioRxiv13 citations Open access
Semantic Scholar
Immune profiling of age and adjuvant-specific activation of human blood mononuclear cells in vitro
Simone S. Schüller, S. Barman, Raúl Méndez-Giráldez, Dheeraj Soni +4 more
2024Communications Biology12 citations Open access
Semantic Scholar
Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice
E. Nanishi, F. Borriello, H. Seo, Timothy R. O’Meara +27 more
2023npj Vaccines12 citations Open access
Semantic Scholar
Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations
Branden Lee, E. Nanishi, O. Levy, David J. Dowling
2023Pharmaceutics11 citations Open access
Semantic Scholar
Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro
E. Speer, Elizabeth Diago-Navarro, Lukasz S. Ozog, David J. Dowling +4 more
2018Antimicrobial Agents and Chemotherapy11 citations Open access
Semantic Scholar
Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity
E. Nanishi, F. Borriello, Timothy R. O’Meara, M. McGrath +38 more
2021bioRxiv9 citations Open access
Semantic Scholar
Early life immune ontogeny – understanding how we build and sustain immunity to infection
David J. Dowling
2016Perspectives in Public Health9 citations
Semantic Scholar

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O. Levy×34
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O. Levy — researcher profile on SciRah
S. V. van Haren×14
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S. V. van Haren — researcher profile on SciRah
E. Nanishi×13
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E. Nanishi — researcher profile on SciRah
S. Barman×10
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S. Barman — researcher profile on SciRah

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F. Borriello — researcher profile on SciRah

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S. O'Neill — researcher profile on SciRah

Ilana Bergelson×8

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Ilana Bergelson — researcher profile on SciRah

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Byron Brook — researcher profile on SciRah

Manisha Menon×8

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Manisha Menon — researcher profile on SciRah

Dheeraj Soni×8

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Dheeraj Soni — researcher profile on SciRah

Spencer E. Brightman×7

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Spencer E. Brightman — researcher profile on SciRah

Timothy R. O’Meara×6

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Timothy R. O’Meara — researcher profile on SciRah