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Spencer E. Brightman · SciRah

Researcher profile · Semantic Scholar

Spencer E. Brightman

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Spencer E. Brightman — researcher profile on SciRah

h-index: 13
Works: 23
Citations: 515

Most-cited papers

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses
David J. Dowling, E. Scott, A. Scheid, Ilana Bergelson +14 more
2017Journal of Allergy and Clinical Immunology123 citations Open access
Semantic Scholar
Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors
Spencer E. Brightman, Angelica Becker, Rukman R. Thota, Martin S Naradikian +9 more
2023Nature Immunology68 citations Open access
Semantic Scholar
Harnessing neoantigen specific CD4 T cells for cancer immunotherapy
Spencer E. Brightman, Martin S Naradikian, Aaron Miller, S. Schoenberger
2020Journal of Leukocyte Biology46 citations Open access
Semantic Scholar
Linked CD4+/CD8+ T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
Joseph S. Dolina, Joey Lee, Spencer E. Brightman, Sara McArdle +8 more
2023bioRxiv45 citations Open access
Semantic Scholar
Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization
F. Borriello, Carlo Pietrasanta, Jacqueline C. Y. Lai, L. Walsh +9 more
2017Frontiers in Immunology43 citations Open access
Semantic Scholar
Linked CD4+/CD8+ T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
Joseph S. Dolina, Joey Lee, Spencer E. Brightman, Sara McArdle +9 more
2023Journal of Clinical Investigation29 citations Open access
Semantic Scholar
A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity
David J. Dowling, H. Sanders, W. Cheng, S. Joshi +8 more
2016Frontiers in Immunology29 citations Open access
Semantic Scholar
Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures
D. Oh, David J. Dowling, Saima Ahmed, Hyungwon Choi +9 more
2016Molecular & Cellular Proteomics28 citations Open access
Semantic Scholar
Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination
David J. Dowling, S. Barman, Alyson J. Smith, F. Borriello +13 more
2022Scientific Reports23 citations Open access
Semantic Scholar
A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancer
A. Miller, Z. Koşaloğlu-Yalçın, Luise Westernberg, L. Montero +16 more
2024Science Translational Medicine21 citations
Semantic Scholar
Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro
A. Queenan, David J. Dowling, W. Cheng, K. Faé +11 more
2018Vaccine18 citations Open access
Semantic Scholar
From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation
Dheeraj Soni, Francesco Borriello, David A. Scott, F. Feru +22 more
2024Science Advances17 citations Open access
Semantic Scholar
Tumor cells fail to present MHC-II–restricted epitopes derived from oncogenes to CD4+ T cells
Spencer E. Brightman, Martin S Naradikian, Rukman R. Thota, Angelica Becker +8 more
2022JCI Insight16 citations Open access
Semantic Scholar
Discovery of a small molecule TLR3 agonist adjuvant
Branden Lee, Danica Dong, E. Nanishi, J. Awad +30 more
2025Nature Communications5 citations Open access
Semantic Scholar
Age-specific TLR7/8 adjuvant formulation overcomes hyporesponsiveness to neonatal acellular pertussis vaccination in a mouse model
David J. Dowling, Alyson J. Smith, F. Borriello, Spencer E. Brightman +5 more
2018Journal of Immunology2 citations
Semantic Scholar
Pilot experience with opebacan/rBPI 21 in myeloablative hematopoietic cell transplantation
E. Guinan, D. Avigan, R. Soiffer, N. Bunin +6 more
2015F1000Research2 citations Open access
Semantic Scholar
The spontaneous neoantigen-specific CD4+ T cell response to a growing tumor is functionally and phenotypically diverse
Ryan Q Griswold, Spencer E. Brightman, K. S. Zavala, Manuel Azaid Ordaz-Arias +10 more
2025bioRxiv1 citations Open access
Semantic Scholar
Precision immunology for discovery and development of the Precision Vaccines Program (PVP)-037 small molecule series: imidazopyrimidine adjuvants identified via age-specific human in vitro modeling
Dheeraj Soni, F. Borriello, David A. Scott, A. Ozonoff +10 more
2020Journal of Immunology1 citations
Semantic Scholar
The spontaneous neoantigen-specific CD4+ T-cell response to a growing tumor is functionally and phenotypically diverse
Ryan Q Griswold, Spencer E. Brightman, Karla Soria Zavala, Manuel Azaid Ordaz-Arias +10 more
2025Journal for ImmunoTherapy of Cancer0 citations Open access
Semantic Scholar
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors
Spencer E. Brightman, Angelica Becker, Rukman R. Thota, Martin S Naradikian +9 more
2023Nature Immunology0 citations Open access
Semantic Scholar
Abstract C021: Targeted delivery of neoantigens to pancreatic cancer to enable immunotherapy
Siming Sun, J. Patel, Alexis Wascher, E. Mose +5 more
2022Cancer Research0 citations
Semantic Scholar
Kiyokazu Kakugawa DYNAMIC TRANSLOCATION OF THEMIS FROM THE CYTOPLASM TO THE NUCLEUS IS ESSENTIAL FOR ITS FUNCTION IN T CELLS
Spencer E. Brightman, Angelica Becker, Rukman R. Thota, Martin S Naradikian +4 more
20220 citations
Semantic Scholar
TCR-engineered neoantigen-specific CD4+ T cells mediate immunotherapy of a class II-negative murine squamous cell carcinoma
Spencer E. Brightman, Angelica Becker, Rukman R. Thota, Martin S Naradikian +3 more
2022Journal of Immunology0 citations
Semantic Scholar

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S. Schoenberger×12
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S. Schoenberger — researcher profile on SciRah
David J. Dowling×10
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Martin S Naradikian

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Joseph S. Dolina×6

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S. V. van Haren×5

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Angelica Becker×5

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Angelica Becker — researcher profile on SciRah

Ryan Q Griswold×5

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Ezra E. W. Cohen×5

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Ezra E. W. Cohen — researcher profile on SciRah

Bjoern Peters×5

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Bjoern Peters — researcher profile on SciRah