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A. Osmand · SciRah

Researcher profile · Semantic Scholar

A. Osmand

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A. Osmand — researcher profile on SciRah

h-index: 30
Works: 48
Citations: 3,888

Most-cited papers

Characterization of C-reactive protein and the complement subcomponent C1t as homologous proteins displaying cyclic pentameric symmetry (pentraxins).
A. Osmand, B. Friedenson, H. Gewurz, R. H. Painter +2 more
1977Proceedings of the National Academy of Sciences of the United States of America350 citations Open access
Semantic Scholar
Serines 13 and 16 Are Critical Determinants of Full-length Human Mutant Huntingtin-Induced Disease Pathogenesis in HD Mice
Xiao-Feng Gu, E. Greiner, R. Mishra, Ravindra B. Kodali +6 more
2009Neuron335 citations Open access
Semantic Scholar
Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease*
Christian Landles, Kirupa Sathasivam, A. Weiss, B. Woodman +10 more
2010Journal of Biological Chemistry326 citations Open access
Semantic Scholar
Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.
E. Slow, R. Graham, A. Osmand, R. S. Devon +8 more
2005Proceedings of the National Academy of Sciences of the United States of America304 citations Open access
Semantic Scholar
Radioimmunoassay of human C-reactive protein and levels in normal sera.
D. Claus, A. Osmand, H. Gewurz
1976Journal of Laboratory and Clinical Medicine239 citations
Semantic Scholar
Isolation of amyloid P component (protein AP) from normal serum as a calcium-dependent binding protein.
M. Pepys, A. Dash, E. Munn, A. Feinstein +5 more
1977The Lancet160 citations
Semantic Scholar
SUPPLEMENTARY INFORMATION Identifying polyglutamine protein species in situ that best predict neurodegeneration
Jason Miller, Montserrat Arrasate, Elizabeth Brooks, C. P. Libeu +22 more
2011157 citations
Semantic Scholar
Early autophagic response in a novel knock-in model of Huntington disease.
M. Heng, D. K. Duong, R. Albin, S. Tallaksen-Greene +5 more
2010Human Molecular Genetics140 citations Open access
Semantic Scholar
A Novel Antisense CAG Repeat Transcript at JPH3 Locus Mediating Expanded Polyglutamine Protein Toxicity in Huntington’s Disease-Like 2 (HDL2) Mice
B. Wilburn, Dobrila D. Rudnicki, Jing Zhao, T. Weitz +11 more
2011Neuron139 citations Open access
Semantic Scholar
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington’s disease
Xiao-Hong Lu, Virginia B. Mattis, Nan Wang, I. Al-Ramahi +19 more
2014Science Translational Medicine136 citations
Semantic Scholar
Interactions of alpha1-acid glycoprotein with the immune system. I. Purification and effects upon lymphocyte responsiveness.
K. M. Chiu, R. Mortensen, A. Osmand, H. Gewurz
1977Immunology129 citations
Semantic Scholar
Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease.
H. Nguyen, P. Kobbe, Henning Rahne, Till Wörpel +11 more
2006Human Molecular Genetics119 citations
Semantic Scholar
Interactions of C-reactive protein with the first component of human complement.
D. Claus, Joan N. Siegel, K. Petras, A. Osmand +1 more
1977Journal of Immunology119 citations Open access
Semantic Scholar
Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated Aβ Is Induced by Pyroglutamate–Aβ Formation
Anca Alexandru, W. Jagla, S. Graubner, A. Becker +15 more
2011Journal of Neuroscience105 citations Open access
Semantic Scholar
Interactions of C-reactive protein with the complement system. III. Complement-dependent passive hemolysis initiated by CRP
A. Osmand, R. Mortensen, J. Siegel, H. Gewurz
1975Journal of Experimental Medicine103 citations Open access
Semantic Scholar
A Novel BACHD Transgenic Rat Exhibits Characteristic Neuropathological Features of Huntington Disease
L. Yu-Taeger, E. Petrasch‐Parwez, A. Osmand, A. Redensek +10 more
2012Journal of Neuroscience101 citations Open access
Semantic Scholar
Identifying polyglutamine protein species in situ that best predict neurodegeneration
Jason Miller, Montserrat Arrasate, Elizabeth Brooks, C. Peters-Libeu +22 more
2011Nature Chemical Biology74 citations Open access
Semantic Scholar
Microstructural changes observed with DKI in a transgenic Huntington rat model: Evidence for abnormal neurodevelopment
I. Blockx, G. Groof, M. Verhoye, J. Van Audekerke +6 more
2012NeuroImage69 citations
Semantic Scholar
Critical role of miR-155 in herpes simplex encephalitis
S. Bhela, S. Mulik, P. Reddy, Raphael L. Richardson +5 more
2014Journal of Immunology68 citations Open access
Semantic Scholar
Coexistence of Huntington’s disease and amyotrophic lateral sclerosis: a clinicopathologic study
M. Tada, E. Coon, A. Osmand, P. Kirby +11 more
2012Acta Neuropathologica67 citations Open access
Semantic Scholar
Posterior cortical atrophy in Alzheimer's disease: analysis of a new case and re-evaluation of a historical report
P. Hof, N. Archin, A. Osmand, J. H. Dougherty +3 more
1993Acta Neuropathologica67 citations
Semantic Scholar
Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition
F. Siebzehnrübl, K. Raber, Y. Urbach, Anja Schulze-Krebs +27 more
2018Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
Semantic Scholar
Imaging polyglutamine deposits in brain tissue.
A. Osmand, V. Berthelier, R. Wetzel
2006Methods in Enzymology54 citations
Semantic Scholar
Further Molecular Characterisation of the OVT73 Transgenic Sheep Model of Huntington's Disease Identifies Cortical Aggregates
S. Reid, Stefano Patassini, R. Handley, S. Rudiger +11 more
2013Journal of Huntington's Disease51 citations
Semantic Scholar
Complement activation by interaction of polyanions and polycations. III. Complement activation by interaction of multiple polyanious and polycations is the presence of C-reactive protein.
D. Claus, Joan N. Siegel, K. Petras, D. Skor +2 more
1977Journal of Immunology44 citations
Semantic Scholar
Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.
Genna M. Luciani, L. Magomedova, Rachel Puckrin, M. Urbanus +41 more
2011Nature Chemical Biology39 citations
Semantic Scholar
Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington’s disease mouse model
Terry Jo V. Bichell, M. Węgrzynowicz, K. G. Tipps, Emma M. Bradley +18 more
2017Biochimica et Biophysica Acta - Molecular Basis of Disease38 citations Open access
Semantic Scholar
Substance P augmentation of CSF-1-stimulated in vitro myelopoiesis. A two-signal progenitor restricted, tuftsin-like effect.
R. Moore, A. Osmand, J. A. Dunn, J. G. Joshi +1 more
1988Journal of Immunology37 citations
Semantic Scholar
αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease.
Ana Oliveira, A. Osmand, T. Outeiro, P. Muchowski +1 more
2016Human Molecular Genetics32 citations Open access
Semantic Scholar
IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes
A. Becker, Rico Eichentopf, R. Sedlmeier, A. Waniek +16 more
2016Biological chemistry32 citations Open access
Semantic Scholar
Partial amino-acid sequences of human and rabbit C-reactive proteins: homology with immunoglobulins and histocompatibility antigens.
A. Osmand, H. Gerwurz, B. Friedenson
1977Proceedings of the National Academy of Sciences of the United States of America27 citations Open access
Semantic Scholar
Expression and distribution of the dentatorubral-pallidoluysian atrophy gene product (atrophin-1/drplap) in neuronal and non-neuronal tissues.
S. Knight, Matthew M Richardson, A. Osmand, Anna Stakkestad +1 more
1997Journal of Neurological Sciences25 citations
Semantic Scholar
Herpes simplex virus type 1-specific immunity induced by peptides corresponding to an antigenic site of glycoprotein B
J. Mester, S. Highlander, A. Osmand, J. Glorioso +1 more
1990Journal of Virology23 citations Open access
Semantic Scholar
Functional T cell recognition of synthetic peptides corresponding to continuous antibody epitopes of herpes simplex virus type 1 glycoprotein D.
J. Wyckoff, A. Osmand, R. Eisenberg, Gary H. Cohen +1 more
1988Immunobiology18 citations
Semantic Scholar
Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington’s Disease Knock-In Mouse Models
Nicholas R. Franich, M. Basso, Emily A André, Joseph Ochaba +11 more
2018Journal of Huntington's Disease16 citations Open access
Semantic Scholar
IgE myeloma presenting with classical myeloma features.
E. Weiner, R. Dicamelli, J. Showel, A. Osmand +2 more
1976Journal of Allergy and Clinical Immunology16 citations Open access
Semantic Scholar
Novel BAC mouse model of Huntington’s disease with 225 CAG repeats exhibits an early widespread and stable degenerative phenotype
M. Węgrzynowicz, T. J. Bichell, Barbara D. Soares, Meredith K. Loth +11 more
2015Journal of Huntington's Disease15 citations
Semantic Scholar
Neurotensin regulation of macrophage colony-stimulating factor-stimulated in vitro myelopoiesis.
Robert N. Moore, A. Osmand, J. A. Dunn, J. G. Joshi +2 more
1989Journal of Immunology15 citations Open access
Semantic Scholar
Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington’s Disease
A. Osmand, T. J. Bichell, A. Bowman, G. Bates
2016Journal of Huntington's Disease12 citations Open access
Semantic Scholar
Inhibition of Rabbit Platelet Aggregation and Clot Retraction by Rabbit and Human C-Reactive Proteins 1
R. Marder, B. Fiedel, A. Osmand, H. Gewurz
1977Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine8 citations
Semantic Scholar
Critical Role of MicroRNA-155 in Herpes
B. Rouse, Rajasagi, T. Veiga-Parga, A. Osmand +6 more
20145 citations
Semantic Scholar
Cytokine mediation of the suppressive effect of ferritin on colony-stimulating factor-1-dependent monocytopoiesis.
R. Kreisberg, M. S. Detrick, A. Osmand, Robert N. Moore
1993Journal of Immunology5 citations
Semantic Scholar
Inhibition of platelet aggregation by a myeloma protein with anti-phosphocholine specificity
B. Fiedel, A. Osmand, H. Gewurz
1976Nature5 citations
Semantic Scholar
Focal cortical hypermetabolism during transcranial magnetic stimulation
Michael Meyer, A. Osmand, Shannon E. Campbell, Guy Logan
1994Muscle and Nerve4 citations
Semantic Scholar
Luminescence energy transfer studies of C-reactive protein. Binding of terbium (III) ions in C-reactive protein.
M. Short, A. Osmand
1983Immunological Communications4 citations
Semantic Scholar
Characterization of C-reactive protein and the complement subcomponent Clt as homologous proteins displaying cyclic pentameric symmetry (pentraxins) (amino acid sequence/electron microscopy/amyloid P-component/evolution)
A. Osmand, H. Gewurz, Robert H. PAINTERt, E. Shelton
20161 citations
Semantic Scholar
Lactoferrin Immunoreactivity and Binding Sites in Neurons, Neuritic Plaques, and Neurofibrillary Tangles in Alzheimer’s Disease
A. Osmand, R. Switzer
19901 citations
Semantic Scholar
Complement Dependent Adherence, Phagocytosis and Hemolysis Initiated by C-Reactive Protein (CRP)
A. Osmand, R. Mortensen, H. Gewurz
1976Journal of Immunology1 citations Open access
Semantic Scholar

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