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R. Samstein · SciRah

Researcher profile · Semantic Scholar

R. Samstein

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R. Samstein — researcher profile on SciRah

h-index: 38
Works: 86
Citations: 16K

Most-cited papers

Tumor mutational load predicts survival after immunotherapy across multiple cancer types
R. Samstein, Chung-Han Lee, A. Shoushtari, M. Hellmann +53 more
2019Nature Genetics3,472 citations Open access
Semantic Scholar
A Comparative Encyclopedia of DNA Elements in the Mouse Genome
Feng Yue, Yong Cheng, A. Breschi, J. Vierstra +133 more
2014Nature1,636 citations Open access
Semantic Scholar
Immunology of COVID-19: Current State of the Science
N. Vabret, G. Britton, C. Gruber, Samarth Hegde +84 more
2020Immunity1,519 citations Open access
Semantic Scholar
CD4+ regulatory T cells control Th17 responses in a Stat3-dependent manner
A. Chaudhry, D. Rudra, P. Treuting, R. Samstein +3 more
2009Science1,050 citations Open access
Semantic Scholar
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
Diego Chowell, L. Morris, C. Grigg, J. Weber +16 more
2017Science1,031 citations Open access
Semantic Scholar
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation
A. Chaudhry, R. Samstein, P. Treuting, Yu-Qiong Liang +7 more
2011Immunity966 citations Open access
Semantic Scholar
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells
O. Kollet, Ayelet Dar, Shoham Shivtiel, A. Kalinkovich +8 more
2006Nature Medicine793 citations
Semantic Scholar
Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict
R. Samstein, Steven Z. Josefowicz, A. Arvey, P. Treuting +1 more
2012Cell618 citations Open access
Semantic Scholar
Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response
Rajarsi Mandal, R. Samstein, Ken-Wing Lee, J. Havel +20 more
2019Science490 citations Open access
Semantic Scholar
Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification
R. Samstein, A. Arvey, Steven Z. Josefowicz, Xiao P. Peng +10 more
2012Cell485 citations Open access
Semantic Scholar
Transcription factor Foxp3 and its protein partners form a complex regulatory network
D. Rudra, Paul C. Deroos, A. Chaudhry, R. Niec +6 more
2012Nature Immunology434 citations Open access
Semantic Scholar
Immunogenic neoantigens derived from gene fusions stimulate T cell responses
Wei Yang, Ken-Wing Lee, Raghvendra M. Srivastava, F. Kuo +30 more
2019Nature Medicine331 citations Open access
Semantic Scholar
Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification
A. Leader, J. Grout, B. Maier, B. Nabet +29 more
2021Cancer Cell318 citations Open access
Semantic Scholar
Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution
J. Vierstra, Eric Rynes, Richard S. Sandstrom, Miaohua Zhang +33 more
2014Science265 citations Open access
Semantic Scholar
Improved prediction of immune checkpoint blockade efficacy across multiple cancer types
Diego Chowell, Seong-Keun Yoo, C. Valero, A. Pastore +30 more
2021Nature Biotechnology240 citations Open access
Semantic Scholar
Inflammation-induced repression of Foxp3-bound chromatin in regulatory T cells
A. Arvey, J. van der Veeken, R. Samstein, Yongqiang Feng +2 more
2014Nature Immunology200 citations Open access
Semantic Scholar
Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting.
T. Fahmy, R. Samstein, C. C. Harness, W. Saltzman
2005Biomaterials200 citations
Semantic Scholar
Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy
R. Samstein, C. Krishna, Xiao-Xiao Ma, X. Pei +24 more
2020Nature Cancer189 citations Open access
Semantic Scholar
Shared immunogenic poly-epitope frameshift mutations in microsatellite unstable tumors
V. Roudko, C. C. Bozkus, T. Orfanelli, Christopher B. McClain +8 more
2020Cell171 citations Open access
Semantic Scholar
Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial
M. Galsky, S. Daneshmand, S. Izadmehr, Edgar Gonzalez-Kozlova +36 more
2023Nature Medicine145 citations Open access
Semantic Scholar
AN ANTI-TUMOR IMMUNE RESPONSE IS EVOKED BY PARTIAL-VOLUME SINGLE DOSE RADIATION IN TWO MURINE MODELS
Ela Markovsky, S. Budhu, R. Samstein, Hongyan Li +11 more
2018International Journal of Radiation Oncology, Biology, Physics89 citations Open access
Semantic Scholar
Localized Sinonasal Mucosal Melanoma: Outcomes and Associations with Stage, Radiotherapy and PET Response
R. Samstein, Richard D. Carvajal, M. Postow, M. Callahan +4 more
2016Head and Neck79 citations Open access
Semantic Scholar
Luteinizing Hormone-Releasing Hormone Enhances T Cell Recovery following Allogeneic Bone Marrow Transplantation
G. Goldberg, Christopher G. King, Rebecca A. Nejat, David Y. Suh +8 more
2009Journal of Immunology77 citations Open access
Semantic Scholar
The use of deoxycholic acid to enhance the oral bioavailability of biodegradable nanoparticles.
R. Samstein, Karlo Perica, F. Balderrama, M. Look +1 more
2008Biomaterials77 citations
Semantic Scholar
Lynch Syndrome and MSI-H Cancers: From Mechanisms to “Off-The-Shelf” Cancer Vaccines
V. Roudko, Cansu Cimen-Bozkus, B. Greenbaum, A. Lucas +2 more
2021Frontiers in Immunology75 citations Open access
Semantic Scholar
Functional Landscapes of POLE and POLD1 Mutations in Checkpoint Blockade-Dependent Anti-Tumor Immunity
Xiaoxiao Ma, N. Riaz, R. Samstein, Mark Lee +30 more
2022Nature Genetics70 citations Open access
Semantic Scholar
Leveraging Big Data of Immune Checkpoint Blockade Response Identifies Novel Potential Targets.
Y. Bareche, Deirdre Kelly, F. Abbas-Aghababazadeh, Minoru Nakano +9 more
2021Annals of Oncology67 citations Open access
Semantic Scholar
DNA Repair Gene Mutations as Predictors of Immune Checkpoint Inhibitor Response beyond Tumor Mutation Burden
D. Hsiehchen, Antony Hsieh, R. Samstein, Tian-Shi Lu +5 more
2020Cell Reports Medicine67 citations Open access
Semantic Scholar
Pathogenic ATM Mutations in Cancer and a Genetic Basis for Radiotherapeutic Efficacy.
K. Pitter, D. Casey, Yue Lu, M. Hannum +27 more
2020Journal of the National Cancer Institute64 citations Open access
Semantic Scholar
Tumor mutational burden as a predictive biomarker for checkpoint inhibitor immunotherapy
Mark Lee, R. Samstein, C. Valero, T. Chan +1 more
2019Human Vaccines & Immunotherapeutics61 citations Open access
Semantic Scholar
Advancing scientific knowledge in times of pandemics
N. Vabret, R. Samstein, Nicolas Fernandez, M. Merad +3 more
2020Nature reviews. Immunology56 citations Open access
Semantic Scholar
Combined Immune Checkpoint Blockade and Radiation Therapy: Timing and Dose Fractionation Associated with Greatest Survival Duration Among Over 750 Treated Patients
R. Samstein, A. Rimner, C. Barker, Y. Yamada
201753 citations Open access
Semantic Scholar
Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin
J. S. Lee, Patrick Han, Rabib Chaudhury, Shihan N Khan +13 more
2021Nature Biomedical Engineering51 citations
Semantic Scholar
Locally Advanced and Unresectable Cutaneous Squamous Cell Carcinoma: Outcomes of Concurrent Cetuximab and Radiotherapy
R. Samstein, A. Ho, N. Lee, C. Barker
2014Journal of Skin Cancer51 citations Open access
Semantic Scholar
Genomic Determinants of Clinical Outcomes in Rhabdomyosarcoma
D. Casey, L. Wexler, K. Pitter, R. Samstein +2 more
2019Clinical Cancer Research40 citations Open access
Semantic Scholar
Safety of combining thoracic radiation therapy with concurrent versus sequential immune checkpoint inhibition
D. von Reibnitz, J. Chaft, A. Wu, R. Samstein +8 more
2018Advances in Radiation Oncology39 citations Open access
Semantic Scholar
Immunogenetic Basis for Lung Cancer Risk
Chirag Krishna, A. Tervi, M. Saffern, Eric Wilson +15 more
2024Science38 citations Open access
Semantic Scholar
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors.
D. Khalil, N. Suek, L. Campesato, S. Budhu +17 more
2019Journal of Clinical Investigation38 citations Open access
Semantic Scholar
The DNA damage response in immunotherapy and radiation
R. Samstein, N. Riaz
2018Advances in Radiation Oncology28 citations Open access
Semantic Scholar
Prospective Cohort Study to Compare Long-term Lung Cancer-Specific and All-Cause Survival of Clinical Early Stage (T1a-b; ≤20mm) Non-Small-Cell Lung Cancer (NSCLC) Treated by Stereotactic Body Radiation Therapy (SBRT) and Surgery.
C. Henschke, R. Yip, Qi Sun, Pengfei Li +10 more
2023Journal of Thoracic Oncology20 citations Open access
Semantic Scholar
Radiotherapy and Immunotherapy in Lung Cancer
Kristin Hsieh, D. Dickstein, J. Runnels, E. Lehrer +3 more
2023Biomedicines18 citations Open access
Semantic Scholar
Where are we with proton beam therapy for thoracic malignancies? Current status and future perspectives.
S. Lazarev, K. Rosenzweig, R. Samstein, L. R. Salgado +6 more
2020Lung Cancer12 citations
Semantic Scholar
CITEseq analysis of non-small-cell lung cancer lesions reveals an axis of immune cell activation associated with tumor antigen load and TP53 mutations
A. Leader, J. Grout, Christie Chang, B. Maier +24 more
2020bioRxiv11 citations Open access
Semantic Scholar
Unilateral Suppression of Brown Fat on FDG PET/CT in Horner Syndrome.
G. Ulaner, R. Samstein, O. Cahlon, W. Weber +1 more
2016Clinical Nuclear Medicine8 citations
Semantic Scholar
Genomic Analyses for Predictors of Response to Chemoradiation in Stage III Non-Small Cell Lung Cancer
L. Luo, R. Samstein, R. Dick-Godfrey, B. Sidiqi +9 more
2020Advances in Radiation Oncology7 citations Open access
Semantic Scholar
Osteoclasts Are Involved in Stem Cell Mobilization: Cleavage of SDF-1 by Cathepsin K.
O. Kollet, R. Samstein, Asaf Spiegel, Shoham Shivtiel +4 more
20047 citations
Semantic Scholar
Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers
Roman M. Chabanon, Liudmila Shcherbakova, M. Lacroix-Triki, Marine Aglave +24 more
2025Nature Communications6 citations Open access
Semantic Scholar
Dissecting microsatellite instability in colorectal cancer: one size does not fit all
R. Samstein, T. Chan
2017Genome Medicine6 citations Open access
Semantic Scholar
Taking CAR T cells up a synthetic Notch
M. Saffern, R. Samstein
2021Nature reviews. Immunology5 citations
Semantic Scholar
Lung Cancer in Never Smokers: Genetics, Epidemiology, Environmental Exposures, and Distinct Immune Landscape.
Jia-Hua Lu, E. Shum, R. Samstein, Diddier Prada +1 more
2026Journal of Thoracic Oncology4 citations
Semantic Scholar

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T. Chan — researcher profile on SciRah
N. Riaz×9
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A. Rudensky×8
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A. Rudensky — researcher profile on SciRah
L. Morris×7
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L. Morris — researcher profile on SciRah

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V. Makarov — researcher profile on SciRah

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F. Kuo — researcher profile on SciRah

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A. Zehir — researcher profile on SciRah

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C. Barker — researcher profile on SciRah

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P. Treuting — researcher profile on SciRah

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Diego Chowell — researcher profile on SciRah

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C. Krishna — researcher profile on SciRah