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M. Volgraf · SciRah

Researcher profile · Semantic Scholar

M. Volgraf

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M. Volgraf — researcher profile on SciRah

h-index: 23
Works: 39
Citations: 2,508

Most-cited papers

Allosteric control of an ionotropic glutamate receptor with an optical switch
M. Volgraf, P. Gorostiza, R. Numano, R. Kramer +2 more
2006Nature Chemical Biology540 citations Open access
Semantic Scholar
Remote control of neuronal activity with a light-gated glutamate receptor.
S. Szobota, P. Gorostiza, Filippo Del Bene, Claire Wyart +12 more
2007Neuron348 citations Open access
Semantic Scholar
Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor
P. Gorostiza, M. Volgraf, R. Numano, S. Szobota +2 more
2007Proceedings of the National Academy of Sciences of the United States of America172 citations Open access
Semantic Scholar
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
David H. Hackos, P. Lupardus, T. Grand, Ye-Lin Chen +11 more
2016Neuron164 citations Open access
Semantic Scholar
Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors.
M. Volgraf, P. Gorostiza, S. Szobota, Max R Helix +2 more
2007Journal of the American Chemical Society148 citations
Semantic Scholar
Engineering light-gated ion channels.
M. Banghart, M. Volgraf, D. Trauner
2006Biochemistry121 citations
Semantic Scholar
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment
Alessia Balestrini, Victory Joseph, M. Dourado, Rebecca M. Reese +56 more
2021Journal of Experimental Medicine118 citations Open access
Semantic Scholar
Ligand binding at the protein–lipid interface: strategic considerations for drug design
J. Payandeh, M. Volgraf
2021Nature reviews. Drug discovery109 citations
Semantic Scholar
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
M. Volgraf, Benjamin D. Sellers, Yu Jiang, Guo-Sheng Wu +28 more
2016Journal of Medicinal Chemistry96 citations Open access
Semantic Scholar
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models
Jesse E. Hanson, K. Ma, J. Elstrott, Martin Weber +22 more
2020Cell Reports80 citations Open access
Semantic Scholar
A non-covalent ligand reveals biased agonism of the TRPA1 ion channel
Chang Liu, Rebecca M. Reese, S. Vu, L. Rougé +20 more
2020Neuron80 citations Open access
Semantic Scholar
Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR
R. Numano, S. Szobota, Albert Y. Lau, P. Gorostiza +4 more
2009Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
All optical interface for parallel, remote, and spatiotemporal control of neuronal activity.
Sheng Wang, S. Szobota, Yuan Wang, M. Volgraf +5 more
2007Nano letters (Print)68 citations
Semantic Scholar
Biomimetic synthesis of the IDO inhibitors exiguamine A and B.
M. Volgraf, Jean-Philip Lumb, H. Brastianos, G. Carr +5 more
2008Nature Chemical Biology53 citations Open access
Semantic Scholar
A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain.
Tzu-Ming Wang, B. Brown, L. Deng, Benjamin D. Sellers +8 more
2017Neuropharmacology41 citations Open access
Semantic Scholar
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
Elisia Villemure, M. Volgraf, Yu Jiang, Guo-Sheng Wu +18 more
2017ACS Medicinal Chemistry Letters37 citations Open access
Semantic Scholar
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
Jack A. Terrett, Hui-Fen Chen, D. Shore, Elisia Villemure +35 more
2021Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system.
Allen A. Thomas, Kevin W. Hunt, M. Volgraf, R. Watts +23 more
2014Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.
Hui-Fen Chen, M. Volgraf, S. Do, A. Kolesnikov +26 more
2018Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
Total synthesis of exiguamines A and B inspired by catecholamine chemistry.
V. Sofiyev, Jean-Philip Lumb, M. Volgraf, D. Trauner
2012Chemistry28 citations
Semantic Scholar
TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism
T. Chernov-Rogan, Eleonora Gianti, Chang Liu, Elisia Villemure +14 more
2019Proceedings of the National Academy of Sciences of the United States of America26 citations Open access
Semantic Scholar
Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.
Xiaojing Wang, A. Kolesnikov, Suzanne Tay, G. Chan +16 more
2017Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors
M. Kschonsak, C. Jao, C. Arthur, A. Rohou +13 more
2022bioRxiv24 citations Open access
Semantic Scholar
Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
Jack A. Terrett, J. Ly, Paula Katavolos, C. Hasselgren +52 more
2024Journal of Medicinal Chemistry16 citations
Semantic Scholar
A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists.
Elisia Villemure, Jack A. Terrett, R. Larouche-Gauthier, Martin Déry +6 more
2021ACS Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.
M. Volgraf, Lina Chan, Malcolm P. Huestis, Hans E. Purkey +10 more
2014Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.
Ruth Dorel, Da-Wei Sun, N. Carruthers, G. Castanedo +20 more
2024Journal of Medicinal Chemistry5 citations Open access
Semantic Scholar
Switchable Proteins and Channels
M. Volgraf, M. Banghart, D. Trauner
20115 citations
Semantic Scholar
I. Photocontrol of ionotropic glutamate receptors and II. Total synthesis of exiguamine A and B
M. Volgraf
20083 citations
Semantic Scholar
Oxadiazolones as transient receptor potential channel inhibitors
Francis Beaumier, Martin Déry, R. Larouche-Gauthier, Hui-Fen Chen +7 more
20171 citations
Semantic Scholar
All Optical Platform for Parallel and Spatiotemporal Control of Neuronal Activity
Sheng Wang, Yuan Wang, S. Szobota, M. Volgraf +5 more
20081 citations
Semantic Scholar
Taking away PAIN: enabling new structures of the Nav1.7 sodium channel by cryo-EM
C. Jao, C. Arthur, A. Rohou, M. Kschonsak +9 more
2021Acta Crystallographica Section A: Foundations and Advances0 citations Open access
Semantic Scholar
Structure of human TRPA1 in complex with inhibitor GDC-0334
A. Rohou, L. Rougé, C. Arthur, M. Volgraf +1 more
20210 citations
Semantic Scholar
P1-a15 Firing properties of medium spiny projection neu- ron in striatum could be modulated by the long-lasting spontaneous calcium rhythm
Makoto Osanai, Atsushi Tamura, I. Mori, Zhen-yong Wu +19 more
20180 citations
Semantic Scholar
Aminooxazoline inhibitor of BACE-1
Malcolm P. Huestis, Wendy Liu, M. Volgraf, Hans E. Purkey +7 more
20130 citations
Semantic Scholar
Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR
Rika Numano, Pau Gorostiza, M. Volgraf, S. Szobota +2 more
20100 citations
Semantic Scholar
Ligand-gated Channels: Glutamate Receptors
D. Logothetis, R. Numano, Claire Wyart, P. Gorostiza +7 more
20090 citations
Semantic Scholar
Synthesis of Exiguamine A
M. Volgraf, Jean-Philip Lumb, H. Brastianos, G. Carr +5 more
20090 citations Open access
Semantic Scholar
Engineering light-gated glutamate receptors
S. Szobota, R. Numano, Claire Wyart, P. Gorostiza +7 more
20090 citations Open access
Semantic Scholar

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