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Allen A. Thomas · SciRah

Researcher profile · Semantic Scholar

Allen A. Thomas

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Allen A. Thomas — researcher profile on SciRah

h-index: 17
Works: 31
Citations: 1,296

Most-cited papers

High-Precision Simultaneous Determination of Multiple Small Kinetic Isotope Effects at Natural Abundance
D. A. Singleton, Allen A. Thomas
1995294 citations
Semantic Scholar
Experimental and Theoretical Kinetic Isotope Effects for Asymmetric Dihydroxylation. Evidence Supporting a Rate-Limiting “(3 + 2)” Cycloaddition
A. DelMonte, J. Haller, K. Houk, K. Sharpless +3 more
1997154 citations
Semantic Scholar
Osmium-Catalyzed Dihydroxylation of Olefins in Acidic Media: Old Process, New Tricks
P. Dupau, R. Epple, Allen A. Thomas, V. Fokin +1 more
2002146 citations
Semantic Scholar
The Catalytic Asymmetric Aminohydroxylation of Unsaturated Phosphonates.
Allen A. Thomas, K. Sharpless
1999Journal of Organic Chemistry86 citations
Semantic Scholar
Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)
Huan-Chieh Chien, Claire Colas, Karissa Finke, Seth D. Springer +16 more
2018Journal of Medicinal Chemistry81 citations Open access
Semantic Scholar
Isotope effects and the distinction between synchronous, asynchronous, and stepwise Diels–Alder reactions
D. A. Singleton, Brian E. Schulmeier, C. Hang, Allen A. Thomas +2 more
200164 citations
Semantic Scholar
Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.
Allen A. Thomas, Y. Le Huerou, J. De Meese, I. Gunawardana +21 more
2008Bioorganic & Medicinal Chemistry Letters56 citations Open access
Semantic Scholar
Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species.
Kevin W. Hunt, A. Cook, R. Watts, Christopher T. Clark +22 more
2013Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
LAT-1 Activity of meta-Substituted Phenylalanine and Tyrosine Analogs
Evan Augustyn, Karissa Finke, A. Zur, Logan Hansen +7 more
2016Bioorganic & Medicinal Chemistry Letters46 citations Open access
Semantic Scholar
LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates
A. Zur, Huan-Chieh Chien, Evan Augustyn, A. Flint +10 more
2016Bioorganic & Medicinal Chemistry Letters43 citations Open access
Semantic Scholar
Non-charged thiamine analogs as inhibitors of enzyme transketolase.
Allen A. Thomas, J. De Meese, Y. Le Huerou, Steven A. Boyd +18 more
2008Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system.
Allen A. Thomas, Kevin W. Hunt, M. Volgraf, R. Watts +23 more
2014Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.
J. Blake, J. Gaudino, Jason De Meese, P. Mohr +21 more
2014Bioorganic & Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Prodrug thiamine analogs as inhibitors of the enzyme transketolase.
Yvan Le Huerou, I. Gunawardana, Allen A. Thomas, Steven A. Boyd +15 more
2008Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processing
Xing-Rong Liu, H. Wong, K. Scearce-Levie, R. Watts +14 more
2013Drug Metabolism And Disposition20 citations
Semantic Scholar
Oligo-α-hydroxy Ester Cross-Linkers: Impact of Cross-Linker Structure on Biodegradable Hydrogel Networks
Kenneth D. Eichenbaum, Allen A. Thomas, G. Eichenbaum, B. Gibney +2 more
200519 citations
Semantic Scholar
L-type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of L-histidine and L-tryptophan
Colton Hall, Hannah E. Wolfe, A. Wells, Huan-Chieh Chien +4 more
2019Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors.
Allen A. Thomas, Kevin W. Hunt, B. Newhouse, R. Watts +20 more
2014Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Symmetrical biodegradable crosslinkers for use in polymeric devices
Allen A. Thomas, In-Tae Kim, P. Kiser
200515 citations
Semantic Scholar
Rearrangement of methylenecamphor during electrophilic bromination: remarkably clean access to the unnatural fenchyl (1,3,3-trimethylbicyclo[2.2.1]heptane) system
Allen A. Thomas, K. Monk, Sonia Abraham, Stella Lee +1 more
200112 citations
Semantic Scholar
The effects of prodrug size and a carbonyl linker on L-type amino acid transporter 1-targeted cellular and brain uptake
Brooklynn Venteicher, Kasey Merklin, H. Ngo, Huan-Chieh Chien +9 more
2020ChemMedChem11 citations Open access
Semantic Scholar
Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.
M. Volgraf, Lina Chan, Malcolm P. Huestis, Hans E. Purkey +10 more
2014Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Allylic Metalation of Endo- and Exo-Cyclic Alkenes: Anomalous High Reactivity of .beta.-Pinene
C. Garner, Allen A. Thomas
19959 citations
Semantic Scholar
Cellular fatty acid level regulates the effect of tolylfluanid on mitochondrial dysfunction and insulin sensitivity in C2C12 skeletal myotubes.
A'Lexxus F Davis, Allen A. Thomas, Kimberly Shorter, Stephan L. Brown +1 more
2018Biochemical and Biophysical Research Communications - BBRC6 citations
Semantic Scholar
Stereochemical labeling at natural abundance. Stereochemistry, isotope effects, and mechanism of the Diels-Alder reaction of hexachlorocyclopentadiene with ethyl vinyl ether
D. A. Singleton, S. R. Merrigan, Allen A. Thomas
19996 citations
Semantic Scholar
Mitigation of opioid off-target effects and identification of structural drivers of opioid receptor engagement for BACE-1 small molecule inhibitors
D. Diaz, D. Dambach, Michael Siu, Kevin W. Hunt +6 more
2015Toxicology Mechanisms and Methods2 citations
Semantic Scholar
Osmium-Catalyzed Dihydroxylation of Olefins in Acidic Media: Old Process, New Tricks.
P. Dupau, R. Epple, Allen A. Thomas, V. Fokin +1 more
20022 citations
Semantic Scholar
Allylic Metalation of Endo‐ and Exo‐Cyclic Alkenes: Anomalous High Reactivity of β‐Pinene.
C. Garner, Allen A. Thomas
19961 citations
Semantic Scholar
Rearrangement of Methylenecamphor During Electrophilic Bromination: Remarkably Clean Access to the Unnatural Fenchyl (1,3,3-Trimethylbicyclo[2.2.1]heptane) System.
Allen A. Thomas, K. Monk, Sonia Abraham, Stella Lee +1 more
20010 citations
Semantic Scholar
Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters
P. Kiser, Allen A. Thomas, G. Eichenbaum, D. Needham +1 more
20000 citations
Semantic Scholar
Anti-tumor activity of a platinated polymer (AP5070) - Chemical optimization and confirmation of enhanaced therapeutic ratio
C. Luthy, Allen A. Thomas, E. H. Callahan, R. V. van Inwegen +4 more
19980 citations
Semantic Scholar

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