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Brett L. Hurst · SciRah

Researcher profile · Semantic Scholar

Brett L. Hurst

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Brett L. Hurst — researcher profile on SciRah

h-index: 29
Works: 84
Citations: 3,274

Most-cited papers

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease
Chun-Long Ma, M. Sacco, Brett L. Hurst, J. A. Townsend +7 more
2020Cell Research777 citations Open access
Semantic Scholar
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L
M. Sacco, Chun-Long Ma, Panagiotis Lagarias, A. Gao +13 more
2020Science Advances345 citations Open access
Semantic Scholar
Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity
Michael D. Swanson, Daniel M. Boudreaux, Loïc Salmon, J. Chugh +22 more
2015Cell111 citations Open access
Semantic Scholar
Effects of the Combination of Favipiravir (T-705) and Oseltamivir on Influenza A Virus Infections in Mice
D. Smee, Brett L. Hurst, M. Wong, K. Bailey +3 more
2009Antimicrobial Agents and Chemotherapy109 citations Open access
Semantic Scholar
Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells.
D. Smee, Brett L. Hurst, Hiroyuki Egawa, Kazumi Takahashi +2 more
2009Journal of Antimicrobial Chemotherapy104 citations Open access
Semantic Scholar
Consensus M2e peptide conjugated to gold nanoparticles confers protection against H1N1, H3N2 and H5N1 influenza A viruses
Wenqian Tao, Brett L. Hurst, A. Shakya, M. J. Uddin +7 more
2017Antiviral Research102 citations Open access
Semantic Scholar
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells
Drake M. Mellott, C. Tseng, A. Drelich, Pavla Fajtová +28 more
2021ACS Chemical Biology96 citations
Semantic Scholar
Effects of Double Combinations of Amantadine, Oseltamivir, and Ribavirin on Influenza A (H5N1) Virus Infections in Cell Culture and in Mice
D. Smee, Brett L. Hurst, M. Wong, K. Bailey +1 more
2009Antimicrobial Agents and Chemotherapy90 citations Open access
Semantic Scholar
Boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against coronaviruses
Yanmei Hu, Chun-Long Ma, Tommy Szeto, Brett L. Hurst +2 more
2021ACS Infectious Diseases81 citations Open access
Semantic Scholar
Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19
Hengrui Liu, S. Iketani, A. Zask, Nisha Khanizeman +28 more
2022Nature Communications77 citations Open access
Semantic Scholar
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19
C. Allerton, Joel T. Arcari, Lisa Aschenbrenner, Melissa Avery +43 more
2024Journal of Medicinal Chemistry76 citations Open access
Semantic Scholar
Evaluation of Cell Viability Dyes in Antiviral Assays with RNA Viruses that Exhibit Different Cytopathogenic Properties
D. Smee, Brett L. Hurst, W. J. Evans, Nathan R. Clyde +4 more
2017Journal of Virological Methods73 citations Open access
Semantic Scholar
Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2
Katie Heiser, Peter F. McLean, C. Davis, B. Fogelson +11 more
2020bioRxiv67 citations Open access
Semantic Scholar
Causation of Acute Flaccid Paralysis by Myelitis and Myositis in Enterovirus-D68 Infected Mice Deficient in Interferon αβ/γ Receptor Deficient Mice
J. Morrey, Hong Wang, Brett L. Hurst, Katherine Zukor +4 more
2018Viruses62 citations Open access
Semantic Scholar
Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis
Daman Reynolds, M. Huesemann, S. Edmundson, A. Sims +6 more
2021Algal Research59 citations Open access
Semantic Scholar
Trivalent Subunit Vaccine Candidates for COVID-19 and Their Delivery Devices
Oscar A. Ortega-Rivera, Matthew D. Shin, Angela Chen, V. Beiss +8 more
2021Journal of the American Chemical Society59 citations Open access
Semantic Scholar
IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro
Friedrich Hahn, Christina Wangen, Sigrun Häge, A. S. Peter +14 more
2020Viruses56 citations Open access
Semantic Scholar
Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms
A. C. Puhl, Ethan J. Fritch, T. Lane, Long-Ping V. Tse +21 more
2021ACS Omega53 citations Open access
Semantic Scholar
Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice
D. Smee, Brett L. Hurst, M. Wong, E. Tarbet +3 more
2010Antiviral Research53 citations Open access
Semantic Scholar
Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2
R. Hagey, M. Elazar, E. Pham, S. Tian +28 more
2022Nature Medicine50 citations Open access
Semantic Scholar
Antivirally Active Ribavirin Analogues – 4,5-disubstituted 1,2,3-triazole Nucleosides: Biological Evaluation against Certain Respiratory Viruses and Computational Modelling
A. Krajczyk, K. Kulińska, T. Kulinski, Brett L. Hurst +5 more
2014Antiviral Chemistry & Chemotherapy47 citations Open access
Semantic Scholar
Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L
M. Sacco, Chun-Long Ma, Panagiotis Lagarias, A. Gao +13 more
2020bioRxiv46 citations Open access
Semantic Scholar
High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity
Ryan Choi, Mowei Zhou, R. Shek, Jesse W. Wilson +15 more
2021bioRxiv42 citations Open access
Semantic Scholar
Enhancing influenza vaccine immunogenicity and efficacy through infection mimicry using silk microneedles
Jordan A. Stinson, Archana V. Boopathy, Brian Cieslewicz, Yi-Chen Zhang +7 more
2021Vaccine37 citations Open access
Semantic Scholar
Evaluation of antiviral therapies in respiratory and neurological disease models of Enterovirus D68 infection in mice.
Brett L. Hurst, W. J. Evans, D. Smee, A. V. Van Wettere +1 more
2018Virology37 citations Open access
Semantic Scholar
In vitro activity of favipiravir and neuraminidase inhibitor combinations against oseltamivir-sensitive and oseltamivir-resistant pandemic influenza A (H1N1) virus
E. Tarbet, A. Vollmer, Brett L. Hurst, D. Barnard +2 more
2014Archives of Virology36 citations Open access
Semantic Scholar
Development of a Respiratory Disease Model for Enterovirus D68 in 4-Week-Old Mice for Evaluation of Antiviral Therapies
Joseph Evans, Brett L. Hurst, C. Peterson, A. V. Van Wettere +3 more
2018Antiviral Research35 citations Open access
Semantic Scholar
D282, a Non-Nucleoside Inhibitor of Influenza Virus Infection that Interferes with de novo Pyrimidine Biosynthesis
D. Smee, Brett L. Hurst, C. Day
2012Antiviral Chemistry & Chemotherapy35 citations Open access
Semantic Scholar
Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus.
D. Smee, Brett L. Hurst, M. Wong, R. Glazer +2 more
2007Antiviral Research33 citations Open access
Semantic Scholar
Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms
A. C. Puhl, Ethan J. Fritch, T. Lane, Long-Ping V. Tse +20 more
2020bioRxiv27 citations Open access
Semantic Scholar
An intranasal nanoparticle STING agonist protects against respiratory viruses in animal models
Ankita Leekha, A. Saeedi, Monish Kumar, K. R. Sefat +14 more
2024Nature Communications26 citations Open access
Semantic Scholar
Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease.
J. Tuttle, Christophe Allais, C. Allerton, Annaliesa S. Anderson +55 more
2025Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Visible blue light inhibits infection and replication of SARS-CoV-2 at doses that are well-tolerated by human respiratory tissue
N. Stasko, Jacob F. Kocher, Abigail Annas, Ibrahim Henson +15 more
2021Scientific Reports23 citations Open access
Semantic Scholar
Epigallocatechin-3-Gallate (EGCG) Inhibits SARS-CoV-2 Infection in Primate Epithelial Cells
Brett L. Hurst, D. Dickinson, Stephen Hsu
2021Microbiology & Infectious Diseases22 citations Open access
Semantic Scholar
Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases
Michael Westberg, Yi-Chi Su, Xinzhi Zou, L. Ning +3 more
2020bioRxiv22 citations Open access
Semantic Scholar
Anti-SARS-CoV-2 Activity of Targeted Kinase Inhibitors: Repurposing Clinically Available Drugs for COVID-19 Therapy
RuthMabel Boytz, M. Słabicki, Sita Ramaswamy, J. J. Patten +13 more
2022Journal of Medical Virology21 citations Open access
Semantic Scholar
Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice
Jonna L. B. Westover, Brady T. Hickerson, A. V. Van Wettere, Brett L. Hurst +7 more
2019Pathogens21 citations Open access
Semantic Scholar
Calcium Phosphate Nanoparticle (CaPNP) for Dose-Sparing of Inactivated Whole Virus Pandemic Influenza A (H1N1) 2009 Vaccine in Mice
Tülin Morçӧl, Brett L. Hurst, E. Tarbet
2017Vaccine21 citations Open access
Semantic Scholar
A zanamivir dimer with prophylactic and enhanced therapeutic activity against influenza viruses.
E. Tarbet, Stephanie M. Hamilton, A. Vollmer, Angela Luttick +6 more
2014Journal of Antimicrobial Chemotherapy19 citations Open access
Semantic Scholar
Boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against coronaviruses in cell culture
Yanmei Hu, Chun-Long Ma, Tommy Szeto, Brett L. Hurst +2 more
2020bioRxiv17 citations Open access
Semantic Scholar
Full-Length Recombinant hSP-D Binds and Inhibits SARS-CoV-2
Raquel Arroyo, Shawn N. Grant, M. Colombo, L. Salvioni +7 more
2021Biomolecules15 citations Open access
Semantic Scholar
Vandetanib Blocks the Cytokine Storm in SARS-CoV-2-Infected Mice
A. C. Puhl, G. F. Gomes, Samara Damasceno, Ethan J. Fritch +18 more
2022ACS Omega14 citations Open access
Semantic Scholar
TEMPOL inhibits SARS-CoV-2 replication and development of lung disease in the Syrian hamster model
N. Maio, Sara Cherry, D. Schultz, Brett L. Hurst +2 more
2022iScience14 citations Open access
Semantic Scholar
A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells
Drake M. Mellott, C. Tseng, A. Drelich, Pavla Fajtová +25 more
2020bioRxiv13 citations Open access
Semantic Scholar
An Advax-CpG adjuvanted recombinant H5 hemagglutinin vaccine protects mice against lethal influenza infection.
Yoshikazu Honda-Okubo, E. Tarbet, Brett L. Hurst, N. Petrovsky
2023Vaccine11 citations Open access
Semantic Scholar
Influenza Virus H1N1 inhibition by serine protease inhibitor (serpin) antithrombin III
D. Smee, Brett L. Hurst, C. Day, Ralf Geiben-Lynn
2014International Trends in Immunity11 citations
Semantic Scholar
Antiviral Activities and Phosphorylation of 5-halo-2'-Deoxyuridines and N-Methanocarbathymidine in Cells Infected with Vaccinia Virus
D. Smee, Daniel E Humphreys, Brett L. Hurst, D. Barnard
2008Antiviral Chemistry & Chemotherapy11 citations Open access
Semantic Scholar
Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5
Thomas R. Lane, Jia-Ning Fu, B. Sherry, B. Tarbet +16 more
2023Antiviral Research10 citations Open access
Semantic Scholar
Phrenic nerve deficits and neurological immunopathology associated with acute West Nile virus infection in mice and hamsters
Katherine Zukor, Hong Wang, Brett L. Hurst, V. Siddharthan +3 more
2016Journal of Neurovirology9 citations Open access
Semantic Scholar
An Isomer of Galidesivir That Potently Inhibits Influenza Viruses and Members of the Bunyavirales Order.
K. Sparrow, Rinu Shrestha, James M. Wood, K. Clinch +9 more
2023ACS Medicinal Chemistry Letters8 citations Open access
Semantic Scholar

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D. Smee — researcher profile on SciRah
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Yanmei Hu — researcher profile on SciRah

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