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M. Huse · SciRah

Researcher profile · Semantic Scholar

M. Huse

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M. Huse — researcher profile on SciRah

h-index: 42
Works: 91
Citations: 9,872

Most-cited papers

The conformational plasticity of protein kinases.
M. Huse, J. Kuriyan
2002Cell1,716 citations Open access
Semantic Scholar
Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement
I. Moarefi, M. LaFevre-Bernt, F. Sicheri, M. Huse +3 more
1997Nature628 citations
Semantic Scholar
CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape
Mohamad Hamieh, A. Dobrin, Annalisa Cabriolu, S. V. D. van der Stegen +13 more
2019Nature616 citations Open access
Semantic Scholar
T cells use two directionally distinct pathways for cytokine secretion
M. Huse, B. Lillemeier, M. Kuhns, Daniel S. Chen +1 more
2006Nature Immunology460 citations
Semantic Scholar
Mechanical Forces in the Immune System
M. Huse
2017Nature reviews. Immunology416 citations Open access
Semantic Scholar
Novel Foxo1–dependent transcriptional programs control Treg cell function
W. Ouyang, W. Liao, Chong T Luo, Na Yin +12 more
2012Nature405 citations Open access
Semantic Scholar
Cytotoxic T cells use mechanical force to potentiate target cell killing
Roshni Basu, Benjamin Whitlock, J. Husson, A. Le Floc'h +9 more
2016Cell404 citations Open access
Semantic Scholar
Agonist/endogenous peptide–MHC heterodimers drive T cell activation and sensitivity
M. Krogsgaard, Qi-Jing Li, C. Sumen, J. Huppa +2 more
2005Nature368 citations
Semantic Scholar
Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.
Jia-Wei Wu, Min Hu, J. Chai, J. Seoane +8 more
2001Molecules and Cells333 citations Open access
Semantic Scholar
Cancer Immunosurveillance by Tissue-resident Innate Lymphoid Cells and Innate-like T Cells
Saïda Dadi, S. Chhangawala, Benjamin Whitlock, R. A. Franklin +7 more
2016Cell325 citations Open access
Semantic Scholar
Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells
E. Quann, Ernesto Merino, T. Furuta, M. Huse
2009Nature Immunology252 citations
Semantic Scholar
Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist.
M. Huse, L. Klein, A. T. Girvin, Joycelyn M. Faraj +3 more
2007Immunity247 citations Open access
Semantic Scholar
CD28 and CD3 have complementary roles in T-cell traction forces
Keenan T. Bashour, A. Gondarenko, Hao-Qian Chen, K. Shen +4 more
2014Proceedings of the National Academy of Sciences of the United States of America223 citations Open access
Semantic Scholar
IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
G. Gasteiger, S. Hemmers, M. Firth, A. Le Floc'h +3 more
2013Journal of Experimental Medicine214 citations Open access
Semantic Scholar
Shouts, whispers and the kiss of death: directional secretion in T cells
M. Huse, E. Quann, Mark M. Davis
2008Nature Immunology193 citations Open access
Semantic Scholar
A tunable diffusion-consumption mechanism of cytokine propagation enables plasticity in cell-to-cell communication in the immune system
Alon Oyler-Yaniv, Jennifer Oyler-Yaniv, Benjamin Whitlock, Zhiduo Liu +4 more
2017Immunity184 citations Open access
Semantic Scholar
HLA-independent T cell receptors for targeting tumors with low antigen density
J. Mansilla-Soto, Justin Eyquem, Sascha Haubner, Mohamad Hamieh +21 more
2022Nature Medicine175 citations Open access
Semantic Scholar
A Cascade of Protein Kinase C Isozymes Promotes Cytoskeletal Polarization in T Cells
E. Quann, Xin Liu, G. Altan-Bonnet, M. Huse
2011Nature Immunology165 citations Open access
Semantic Scholar
T cells as a self-referential, sensory organ.
Mark M. Davis, M. Krogsgaard, M. Huse, J. Huppa +2 more
2007Annual Review of Immunology147 citations Open access
Semantic Scholar
Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions
D. Vorselen, Yifan Wang, Miguel M. de Jesus, Pavak K. Shah +4 more
2020Nature Communications142 citations Open access
Semantic Scholar
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion
M. Shakiba, P. Zumbo, Gabriel Espinosa-Carrasco, Laura Menocal +18 more
2021Journal of Experimental Medicine139 citations Open access
Semantic Scholar
The T-cell-receptor signaling network
M. Huse
2009Journal of Cell Science139 citations Open access
Semantic Scholar
Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells
Fella Tamzalit, Mitchell S. Wang, Weiyang Jin, María Tello-Lafoz +5 more
2019Science immunology120 citations Open access
Semantic Scholar
Mechanical communication at the immunological synapse
Roshni Basu, M. Huse
2016Trends in Cell Biology120 citations Open access
Semantic Scholar
Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse
A. Le Floc'h, Yoshihiko Tanaka, Niels Bantilan, Guillaume Voisinne +3 more
2013Journal of Experimental Medicine118 citations Open access
Semantic Scholar
Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer
María Tello-Lafoz, Katja Srpan, Elisa E. Sanchez, Jing Hu +11 more
2021Immunity111 citations Open access
Semantic Scholar
Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II
Xin Liu, T. M. Kapoor, James K. Chen, M. Huse
2013Proceedings of the National Academy of Sciences of the United States of America106 citations Open access
Semantic Scholar
A Zn2+ Ion Links the Cytoplasmic Tail of CD4 and the N-terminal Region of Lck*
M. Huse, M. Eck, S. Harrison
1998Journal of Biological Chemistry105 citations Open access
Semantic Scholar
Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells
Thushara P. Abeyweera, Ernesto Merino, M. Huse
2011Journal of Cell Biology86 citations Open access
Semantic Scholar
T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces
Weiyang Jin, Fella Tamzalit, Parthiv Kant Chaudhuri, C. Black +2 more
2019Proceedings of the National Academy of Sciences of the United States of America82 citations Open access
Semantic Scholar
Retargeting T cells to GD2 pentasaccharide on human tumors using bispecific humanized antibody
Hong Xu, M. Cheng, Hong-Fen Guo, Yue-Dan Chen +2 more
2014Cancer immunology research79 citations Open access
Semantic Scholar
Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T-cell bispecific antibodies
B. Santich, Jeong A. Park, Hoa Tran, Hong-Fen Guo +2 more
2020Science Translational Medicine76 citations Open access
Semantic Scholar
Evidence for a functional sidedness to the αβTCR
M. Kuhns, A. T. Girvin, L. Klein, Rebecca Chen +8 more
2010Proceedings of the National Academy of Sciences of the United States of America73 citations Open access
Semantic Scholar
Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond
M. Huse
2012Front. Immun.67 citations Open access
Semantic Scholar
Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity
Mitchell S. Wang, Yue-Song Hu, Elisa E. Sanchez, Xi-He Xie +12 more
2022Nature Communications65 citations Open access
Semantic Scholar
Diacylglycerol kinase-α controls T cell polarity by shaping diacylglycerol accumulation at the immune synapse
Anne Chauveau, A. Le Floc'h, Niels Bantilan, G. Koretzky +1 more
2014Science Signaling65 citations Open access
Semantic Scholar
NK cell tolerance of self-specific activating receptor KIR2DS1 in individuals with cognate HLA-C2 ligand
G. Pittari, Xiao-rong Liu, A. Selvakumar, Ze-Guo Zhao +5 more
2013Journal of Immunology60 citations Open access
Semantic Scholar
Cytomegalovirus infection drives avidity selection of natural killer cells
Nicholas M. Adams, C. Geary, Endi K. Santosa, Dianne Lumaquin +10 more
2019Immunity56 citations Open access
Semantic Scholar
Semisynthesis of hyperphosphorylated type I TGFβ receptor: Addressing the mechanism of kinase activation [20]
M. Huse, Mandë Holford, J. Kuriyan, T. Muir
200054 citations
Semantic Scholar
Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse
A. Le Floc'h, M. Huse
2014Cellular and Molecular Life Sciences52 citations Open access
Semantic Scholar
From lipid second messengers to molecular motors: microtubule-organizing center reorientation in T cells
M. Huse, A. Le Floc'h, Xin Liu
2013Immunological Reviews49 citations Open access
Semantic Scholar
Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor.
R. Flavell, M. Huse, M. Goger, M. Trester-Zedlitz +2 more
2002Organic Letters46 citations
Semantic Scholar
Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase.
J. Ottesen, M. Huse, Matthew D. Sekedat, T. Muir
2004Biochemistry39 citations
Semantic Scholar
Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors
M. Cheng, B. Santich, Hong Xu, Mahiuddin Ahmed +2 more
2016Oncoimmunology37 citations Open access
Semantic Scholar
Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing
Fella Tamzalit, D. Tran, Weiyang Jin, Vitaly P. Boyko +5 more
2019Proceedings of the National Academy of Sciences of the United States of America34 citations Open access
Semantic Scholar
The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation
C. Rooney, A. Foster, D. Gabrilovich, E. Sotomayor +4 more
200733 citations
Semantic Scholar
Immunologically Active Autoantigens : The Role of Toll-Like Receptors in the Development of Chronic Inflammatory Disease
C. Rooney, A. Foster, D. Gabrilovich, E. Sotomayor +4 more
200927 citations
Semantic Scholar
Actin clearance promotes polarized dynein accumulation at the immunological synapse
Elisa E. Sanchez, Xin Liu, M. Huse
2018bioRxiv25 citations Open access
Semantic Scholar
Apoptotic contraction drives target cell release by cytotoxic T cells
Elisa E. Sanchez, María Tello-Lafoz, Aixuan J. Guo, Miguel M. de Jesus +11 more
2022bioRxiv22 citations Open access
Semantic Scholar
Mechanoregulation of Metastasis Beyond the Matrix
E. E. Er, María Tello-Lafoz, M. Huse
2022Cancer Research20 citations Open access
Semantic Scholar

Frequent co-authors

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Mark M. Davis×6
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Mark M. Davis — researcher profile on SciRah
A. Le Floc'h×6
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Weiyang Jin — researcher profile on SciRah

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Fella Tamzalit×5

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M. Krogsgaard×4

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