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E. Stevens · SciRah

Researcher profile · Semantic Scholar

E. Stevens

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E. Stevens — researcher profile on SciRah

h-index: 22
Works: 48
Citations: 2,580

Most-cited papers

Combined small molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors
S. M. Chambers, Yu-Chen Qi, Yvonne Mica, Gabsang Lee +8 more
2012Nature Biotechnology581 citations Open access
Semantic Scholar
beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics.
K. Morgan, E. Stevens, B. Shah, P. J. Cox +7 more
2000Proceedings of the National Academy of Sciences of the United States of America328 citations Open access
Semantic Scholar
Ion channels as therapeutic targets: a drug discovery perspective.
S. Bagal, A. Brown, Peter J. Cox, Kiyoyuki Omoto +7 more
2013Journal of Medicinal Chemistry293 citations Open access
Semantic Scholar
Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia
Li-Shuang Cao, Aoibhinn McDonnell, A. Nitzsche, A. Alexandrou +17 more
2016Science Translational Medicine183 citations Open access
Semantic Scholar
Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release
A. Alexandrou, Adam R. Brown, Mark L. Chapman, M. Estacion +24 more
2016PLoS ONE176 citations Open access
Semantic Scholar
The role of sodium channels in neuropathic pain.
M. Rogers, Lam Tang, D. Madge, E. Stevens
2006Seminars in Cell and Developmental Biology149 citations
Semantic Scholar
Characterizing Human Stem Cell–derived Sensory Neurons at the Single-cell Level Reveals Their Ion Channel Expression and Utility in Pain Research
G. Young, Alex Gutteridge, Heather de Fox, Anna L. Wilbrey +10 more
2014Molecular Therapy138 citations Open access
Semantic Scholar
The biophysical and molecular basis of TRPV1 proton gating
Eduardo Aneiros, Li-Shuang Cao, M. Papakosta, E. Stevens +2 more
2011EMBO Journal122 citations Open access
Semantic Scholar
A novel selective and orally bioavailable Nav1.8 channel blocker, PF‐01247324, attenuates nociception and sensory neuron excitability
C. E. Payne, Adam R. Brown, Jonathon W. Theile, A. Loucif +20 more
2015British Journal of Pharmacology106 citations Open access
Semantic Scholar
Influence of the N Terminus on the Biophysical Properties and Pharmacology of TREK1 Potassium Channels
E. Veale, Ehab Al-Moubarak, Naina Bajaria, Kiyoyuki Omoto +4 more
2014Molecular Pharmacology57 citations
Semantic Scholar
GI‐530159, a novel, selective, mechanosensitive two‐pore‐domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability
A. Loucif, P. Saintot, Jia Liu, Brett M. Antonio +10 more
2017British Journal of Pharmacology53 citations Open access
Semantic Scholar
Recent advances in targeting ion channels to treat chronic pain
E. Stevens, Gary J. Stephens
2018British Journal of Pharmacology40 citations Open access
Semantic Scholar
Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain.
S. Bagal, P. Bungay, S. Denton, K. Gibson +13 more
2015ACS Medicinal Chemistry Letters37 citations Open access
Semantic Scholar
An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
L. T. Cho, A. Alexandrou, R. Torella, J. Knafels +12 more
2018Structure36 citations Open access
Semantic Scholar
CACHD1 is an α2δ-Like Protein That Modulates CaV3 Voltage-Gated Calcium Channel Activity
G. Cottrell, C. Soubrane, James A. Hounshell, Hong Lin +11 more
2018Journal of Neuroscience31 citations Open access
Semantic Scholar
Molecular Determinants for Assembly of G-protein-activated Inwardly Rectifying K+ Channels*
R. Woodward, E. Stevens, R. Murrell-Lagnado
1997Journal of Biological Chemistry30 citations Open access
Semantic Scholar
The Chimeric Approach Reveals That Differences in the TRPV1 Pore Domain Determine Species-specific Sensitivity to Block of Heat Activation*
M. Papakosta, C. Dalle, A. Haythornthwaite, Li-Shuang Cao +6 more
2011Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Tissue distribution and functional expression of the human voltage-gated sodium channel β3 subunit
E. Stevens, P. J. Cox, B. Shah, A. Dixon +3 more
2000Pflügers Archiv29 citations
Semantic Scholar
Spontaneous activity in peripheral sensory nerves: a systematic review
D. Choi, G. Goodwin, E. Stevens, N. Soliman +2 more
2023bioRxiv25 citations Open access
Semantic Scholar
The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain.
A. Brown, S. Bagal, P. Blackwell, D. Blakemore +16 more
2019Bioorganic & Medicinal Chemistry22 citations Open access
Semantic Scholar
Potassium channels: gene family, therapeutic relevance, high-throughput screening technologies and drug discovery.
J. Ford, E. Stevens, J. Mark Treherne, J. Packer +1 more
2002Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques22 citations
Semantic Scholar
beta3, a novel auxiliary subunit for the voltage-gated sodium channel, is expressed preferentially in sensory neurons and is upregulated in the chronic constriction injury model of neuropathic pain.
B. Shah, E. Stevens, M. I. Gonzalez, S. Bramwell +3 more
2000European Journal of Neuroscience22 citations
Semantic Scholar
A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR
Jia Liu, A. Berg, Yiting Wang, Walailak Jantarajit +5 more
2021British Journal of Pharmacology14 citations Open access
Semantic Scholar
Examination of the contribution of Nav1.7 to axonal propagation in nociceptors
G. Goodwin, S. McMurray, E. Stevens, F. Denk +1 more
2021bioRxiv14 citations Open access
Semantic Scholar
Discovery and optimisation of potent and highly subtype selective Nav1.8 inhibitors with reduced cardiovascular liabilities
S. Bagal, M. Kemp, P. Bungay, Tan-Ya L. Hay +9 more
201611 citations Open access
Semantic Scholar
Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K2P18.1.
Aymeric Monteillier, A. Loucif, Kiyoyuki Omoto, E. Stevens +4 more
2016Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Differential aging‐related changes in neurophysiology and gene expression in IB4‐positive and IB4‐negative nociceptive neurons
Malgorzata A. Mis, M. Rogers, A. Jeffries, Anna L. Wilbrey +6 more
2018Aging Cell7 citations Open access
Semantic Scholar
Tissue distribution and functional expression of the human voltage-gated sodium channel beta3 subunit.
E. Stevens, P. J. Cox, B. Shah, A. Dixon +3 more
2001Pflügers Archiv: European Journal of Physiology7 citations
Semantic Scholar
Ion Channels
B. Barker, G. T. Young, C. Soubrane, G. Stephens +2 more
2001Journal of Physiology7 citations
Semantic Scholar
Expression and functional studies of the novel CNS protein CACHD1
C. Soubrane, E. Stevens, G. Stephens
20123 citations
Semantic Scholar
Influence of the N-terminus on the Biophysical Properties and Pharmacology of TREK1 Potassium Channels By
E. Veale, Ehab Al-Moubarak, Naina Bajaria, Kiyoyuki Omoto +4 more
20142 citations
Semantic Scholar
High‐Throughput Screening Technologies in Ion Channel Drug Discovery
E. Stevens, A. Whyment, J. M. Treherne
20081 citations
Semantic Scholar
Automated patch clamp screening of hERG and other cardiac channels using QPatch16
E. Stevens
20081 citations
Semantic Scholar
GI-530159, a novel, selective, mechano-sensitive K2P channel opener, reduces rat dorsal root ganglion (DRG) neuron excitability.
A. Loucif, P. Saintot, Jia Liu, Brett M. Antonio +11 more
1 citations
Semantic Scholar
Regulation of Kv2.1 Channels by Kv9.1 Variants
H. Choudhury, Muruj Barri, K. Osborn, M. Rajasekaran +4 more
2025Biomedicines0 citations Open access
Semantic Scholar
Development of a QPatch current-clamp assay as a physiologically relevant screen for Kv1.3 inhibitors
S. Stabilini, A. Loucif, N. Secomandi, E. Stevens
2022Biophysical Journal0 citations Open access
Semantic Scholar
Ion channel discovery – partnering to access specialized expertise
E. Stevens, P. Wright
20200 citations Open access
Semantic Scholar
Corrigendum to "Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K2P18.1" [Bioorg. Med. Chem. Lett. 26 (2016) 4919-4924].
Aymeric Monteillier, A. Loucif, Kiyoyuki Omoto, E. Stevens +4 more
2017Bioorganic & Medicinal Chemistry Letters0 citations
Semantic Scholar
Application of induced pluripotent stem cell technology for disease modelling and drug discovery in peripheral sensory neurons
James G. Bilsland, M. Bictash, A. Nitzsche, Li-Shuang Cao +4 more
20170 citations
Semantic Scholar
Functional investigation of nociceptor-like neurons derived from human pluripotent stem cells
Malgorzata A. Mis, A. Nitzsche, Lishuang Cao, James G. Bilsland +3 more
20150 citations
Semantic Scholar
CHAPTER 4:Ion Channel Modulators
K. Gibson, P. J. Cox, E. Stevens, W. Winchester +3 more
20130 citations
Semantic Scholar
Presynaptic Calcium Channels as Drug Targets for Pain
P. J. Cox, E. Stevens
20130 citations
Semantic Scholar
Biophysical and Pharmacological Characterisation of Native Human NaV1.8 Channels from Isolated Dorsal Root Ganglia (DRG)
L. Payne, V. Panchenko, A. Ghetti, Paul E. Miller +1 more
20120 citations Open access
Semantic Scholar
Assay Development And Screening For Modulators Of The Human Two-pore Domain Potassium Channel, TASK-3, Using Automated Electrophysiology
Gary S. Clark, M. Gardener, Scott A. Maidment, Tristana von Will +5 more
20090 citations Open access
Semantic Scholar
Thienopyrimidinderivater as kaliumkanalinhibitorer
J. Ford, N. Palmer, J. Atherall, D. Madge +3 more
20040 citations
Semantic Scholar
Progress in Drug Research
J. Glasel, V. Kolb, P. Skatrud, J. Ford +7 more
2002Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques0 citations
Semantic Scholar
In vitro slice preparation and intracellular microelectrode investigation of thymic cell physiology
E. Stevens, J. E. Downing
19910 citations
Semantic Scholar
to in KAR
A. Loucif, P. Saintot, Jia Liu, Brett M. Antonio +10 more
0 citations
Semantic Scholar

Frequent co-authors

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Li-Shuang Cao×14
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Li-Shuang Cao — researcher profile on SciRah
Kiyoyuki Omoto×9
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Kiyoyuki Omoto — researcher profile on SciRah
A. Loucif×9
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A. Loucif — researcher profile on SciRah
P. J. Cox×7
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P. J. Cox — researcher profile on SciRah

×6

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P. Saintot — researcher profile on SciRah

Alex Gutteridge×6

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Alex Gutteridge — researcher profile on SciRah

Anna L. Wilbrey×6

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Anna L. Wilbrey — researcher profile on SciRah

James G. Bilsland×5

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James G. Bilsland — researcher profile on SciRah

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S. Bagal — researcher profile on SciRah

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E. Veale — researcher profile on SciRah

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A. Mathie — researcher profile on SciRah

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