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M. Estacion · SciRah

Researcher profile · Semantic Scholar

M. Estacion

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M. Estacion — researcher profile on SciRah

h-index: 41
Works: 93
Citations: 5,044

Most-cited papers

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy
Catharina G. Faber, J. Hoeijmakers, H. Ahn, Xiao-Yang Cheng +10 more
2012Annals of Neurology469 citations
Semantic Scholar
Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy.
Jian-Ying Huang, Chong-Yang Han, M. Estacion, D. Vasylyev +8 more
2014Brain : a journal of neurology272 citations Open access
Semantic Scholar
P2X7 Receptor-Dependent Blebbing and the Activation of Rho-Effector Kinases, Caspases, and IL-1β Release1
P. Verhoef, M. Estacion, W. Schilling, G. Dubyak
2003Journal of Immunology178 citations Open access
Semantic Scholar
NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders
M. Estacion, S. Dib-Hajj, P. Benke, R. Te Morsche +4 more
2008Journal of Neuroscience176 citations Open access
Semantic Scholar
Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release
A. Alexandrou, Adam R. Brown, Mark L. Chapman, M. Estacion +24 more
2016PLoS ONE175 citations Open access
Semantic Scholar
Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial.
J. Zakrzewska, J. Palmer, V. Morisset, G. Giblin +10 more
2017Lancet Neurology165 citations Open access
Semantic Scholar
Identification and localization of TRPC channels in the rat kidney.
Monu Goel, W. Sinkins, Cheng-Di Zuo, M. Estacion +1 more
2006AJP - Renal Physiology146 citations
Semantic Scholar
A Novel Nav1.7 Mutation Producing Carbamazepine-Responsive Erythromelalgia
Tanya Z. Fischer, E. Gilmore, M. Estacion, Emmanuella M. Eastman +4 more
2009Annals of Neurology141 citations Open access
Semantic Scholar
Regulation of Drosophila transient receptor potential‐like (TrpL) channels by phospholipase C‐dependent mechanisms
M. Estacion, William G. Sinkins, W. Schilling
2001Journal of Physiology138 citations Open access
Semantic Scholar
Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable
S. Dib-Hajj, M. Estacion, Brian W. Jarecki, L. Tyrrell +4 more
2008Molecular Pain133 citations Open access
Semantic Scholar
Voltage-clamp and current-clamp recordings from mammalian DRG neurons
T. Cummins, A. Rush, M. Estacion, S. Dib-Hajj +1 more
2009Nature Protocols118 citations
Semantic Scholar
Human Na(v)1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons.
Chong-Yang Han, M. Estacion, Jian-Ying Huang, D. Vasylyev +3 more
2015Journal of Neurophysiology117 citations Open access
Semantic Scholar
Functional expression of TrpC1: a human homologue of the Drosophila Trp channel.
W. Sinkins, M. Estacion, W. Schilling
1998Biochemical Journal115 citations Open access
Semantic Scholar
Human TRPC6 expressed in HEK 293 cells forms non‐selective cation channels with limited Ca2+ permeability
M. Estacion, William G. Sinkins, Stephen W. Jones, M. Applegate +1 more
2006Journal of Physiology113 citations Open access
Semantic Scholar
Intra- and interfamily phenotypic diversity in pain syndromes associated with a gain-of-function variant of NaV1.7
M. Estacion, Chong-Yang Han, Jin-Sung Choi, J. Hoeijmakers +7 more
2011Molecular Pain112 citations Open access
Semantic Scholar
A sodium channel gene SCN9A polymorphism that increases nociceptor excitability
M. Estacion, T. Harty, Jin-Sung Choi, L. Tyrrell +2 more
2009Annals of Neurology104 citations
Semantic Scholar
Association of Immunophilins with Mammalian TRPC Channels*
W. Sinkins, Monu Goel, M. Estacion, W. Schilling
2004Journal of Biological Chemistry104 citations Open access
Semantic Scholar
A novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy
M. Estacion, Janelle E. O'Brien, Allison Conravey, M. Hammer +3 more
2014Neurobiology of Disease103 citations Open access
Semantic Scholar
A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neurons.
M. Estacion, Andreas Gasser, S. Dib-Hajj, S. Waxman
2010Experimental Neurology98 citations
Semantic Scholar
Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy
C. de Kovel, M. Meisler, E. Brilstra, F. V. van Berkestijn +9 more
2014Epilepsy Research97 citations Open access
Semantic Scholar
Structural homology modeling and mutant cycle analysis predict pharmacoresponsiveness of a NaV1.7 mutant channel
Yang Yang, S. Dib-Hajj, Jian Zhang, Yang Zhang +3 more
2012Nature Communications92 citations Open access
Semantic Scholar
Activation of Human TRPC6 Channels by Receptor Stimulation*
M. Estacion, Su Li, W. Sinkins, M. Gosling +4 more
2004Journal of Biological Chemistry92 citations Open access
Semantic Scholar
Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling.
Paul Geha, Yang Yang, M. Estacion, Betsy R. Schulman +4 more
2016JAMA Neurology84 citations Open access
Semantic Scholar
Blockade of maitotoxin-induced endothelial cell lysis by glycine and L-alanine.
M. Estacion, J. S. Weinberg, W. Sinkins, W. Schilling
2003American Journal of Physiology - Cell Physiology81 citations
Semantic Scholar
Sodium Channels Contribute to Degeneration of Dorsal Root Ganglion Neurites Induced by Mitochondrial Dysfunction in an In Vitro Model of Axonal Injury
Anna‐Karin Persson, Insil Kim, P. Zhao, M. Estacion +2 more
2013Journal of Neuroscience70 citations Open access
Semantic Scholar
Characterization of ion channels seen in subconfluent human dermal fibroblasts.
M. Estacion
1991Journal of Physiology69 citations Open access
Semantic Scholar
Regulation of Drosophila TRPL Channels by Immunophilin FKBP59*
Monu Goel, R. Garcia, M. Estacion, W. Schilling
2001Journal of Biological Chemistry66 citations Open access
Semantic Scholar
Maitotoxin activates a nonselective cation channel and a P2Z/P2X7-like cytolytic pore in human skin fibroblasts.
W. Schilling, W. Sinkins, M. Estacion
1999American Journal of Physiology - Cell Physiology66 citations
Semantic Scholar
NaV1.7 as a Pharmacogenomic Target for Pain: Moving Toward Precision Medicine.
Yang Yang, Malgorzata A. Mis, M. Estacion, S. Dib-Hajj +1 more
2018TIPS - Trends in Pharmacological Sciences63 citations
Semantic Scholar
Maitotoxin induces biphasic interleukin-1beta secretion and membrane blebbing in murine macrophages.
P. Verhoef, S. Kertesy, M. Estacion, W. Schilling +1 more
2004Molecular Pharmacology63 citations
Semantic Scholar
Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli
Yang Yang, Jian-Ying Huang, Malgorzata A. Mis, M. Estacion +6 more
2016Journal of Neuroscience60 citations Open access
Semantic Scholar
Sodium Channels, Mitochondria, and Axonal Degeneration in Peripheral Neuropathy.
Anna‐Karin Persson, J. Hoeijmakers, M. Estacion, J. Black +1 more
2016Trends in Molecular Medicine54 citations
Semantic Scholar
Erratum: Maitotoxin induces biphasic interleukin-1β secretion and membrane blebbing in murine macrophages (Molecular Pharmacology (2004) 66 (909-920))
P. Verhoef, S. Kertesy, M. Estacion, W. Schilling +1 more
200454 citations
Semantic Scholar
Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation.
M. Estacion, B. Vohra, Shujun Liu, J. Hoeijmakers +5 more
2015Journal of Neurophysiology51 citations Open access
Semantic Scholar
Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability
M. Estacion, S. Waxman, S. Dib-Hajj
2010Molecular Pain50 citations Open access
Semantic Scholar
Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy
Julie I R Labau, M. Estacion, Brian S. Tanaka, B. D. de Greef +9 more
2020Brain : a journal of neurology48 citations Open access
Semantic Scholar
Competence induction by PDGF requires sustained calcium influx by a mechanism distinct from storage-dependent calcium influx.
M. Estacion, L. Mordan
1993Cell Calcium48 citations
Semantic Scholar
P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release.
Philip A. Verhoef, M. Estacion, W. Schilling, G. Dubyak
2003Journal of Immunology47 citations
Semantic Scholar
The response of Na(V)1.3 sodium channels to ramp stimuli: multiple components and mechanisms.
M. Estacion, S. Waxman
2013Journal of Neurophysiology43 citations
Semantic Scholar
A gain-of-function sodium channel β2-subunit mutation in painful diabetic neuropathy
Matthew Alsaloum, M. Estacion, R. Almomani, M. Gerrits +9 more
2019Molecular Pain42 citations Open access
Semantic Scholar
Can robots patch‐clamp as well as humans? Characterization of a novel sodium channel mutation
M. Estacion, Jin-Sung Choi, Emmanuella M. Eastman, Zhi-Miao Lin +5 more
2010Journal of Physiology41 citations Open access
Semantic Scholar
Contribution of sodium channels to lamellipodial protrusion and Rac1 and ERK1/2 activation in ATP‐stimulated microglia
Anna‐Karin Persson, M. Estacion, H. Ahn, Shujun Liu +3 more
2014Glia37 citations
Semantic Scholar
Maitotoxin-induced membrane blebbing and cell death in bovine aortic endothelial cells
M. Estacion, W. Schilling
2001BMC Physiology37 citations Open access
Semantic Scholar
Maitotoxin converts the plasmalemmal Ca(2+) pump into a Ca(2+)-permeable nonselective cation channel.
W. Sinkins, M. Estacion, V. Prasad, Monu Goel +3 more
2009American Journal of Physiology - Cell Physiology36 citations Open access
Semantic Scholar
Palytoxin-induced cell death cascade in bovine aortic endothelial cells.
W. Schilling, D. Snyder, W. Sinkins, M. Estacion
2006American Journal of Physiology - Cell Physiology36 citations
Semantic Scholar
Dexpramipexole blocks Nav1.8 sodium channels and provides analgesia in multiple nociceptive and neuropathic pain models.
Matteo Urru, Mirko Muzzi, E. Coppi, G. Ranieri +9 more
2019Pain34 citations
Semantic Scholar
Expression of voltage-gated calcium channels correlates with PDGF-stimulated calcium influx and depends upon cell density in C3H 10T1/2 mouse fibroblasts.
M. Estacion, L. Mordan
1993Cell Calcium34 citations
Semantic Scholar
The Novel Activity of Carbamazepine as an Activation Modulator Extends from NaV1.7 Mutations to the NaV1.8-S242T Mutant Channel from a Patient with Painful Diabetic Neuropathy
Chong-Yang Han, Andreas C. Themistocleous, M. Estacion, Fadia B. Dib-Hajj +6 more
2018Molecular Pharmacology31 citations Open access
Semantic Scholar
KCNQ variants and pain modulation: a missense variant in Kv7.3 contributes to pain resilience
Jun-Hui Yuan, M. Estacion, Malgorzata A. Mis, Brian S. Tanaka +6 more
2021Brain Communications30 citations Open access
Semantic Scholar
Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitability
Mohammad-Reza Ghovanloo, M. Estacion, Grant P. Higerd-Rusli, P. Zhao +2 more
2022British Journal of Pharmacology29 citations Open access
Semantic Scholar

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L. Tyrrell — researcher profile on SciRah

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C. Faber — researcher profile on SciRah