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J. Bertino · SciRah

Researcher profile · Semantic Scholar

J. Bertino

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J. Bertino — researcher profile on SciRah

h-index: 87
Works: 808
Citations: 34K

Most-cited papers

Abstract C151: Contribution of serine, folate, and glycine metabolism to the ATP, NADPH, and purine requirements of cancer cells.
Philip M. Tedeschi, E. Markert, M. Gounder, Hongxia Lin +8 more
2013243 citations
Semantic Scholar
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates
S. Dolfi, L. Chan, Jean Qiu, Philip M. Tedeschi +4 more
2013Cancer & Metabolism173 citations Open access
Semantic Scholar
In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs
A. Tefferi, H. Kantarjian, S. Rajkumar, L. Baker +111 more
2015Mayo Clinic proceedings150 citations Open access
Semantic Scholar
Discovery and clinical introduction of first-in-class imipridone ONC201
J. Allen, C. L. Kline, V. Prabhu, Jessica Wagner +28 more
2016OncoTarget147 citations Open access
Semantic Scholar
First-in-human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors
M. Stein, J. Bertino, H. Kaufman, T. Mayer +23 more
2017Clinical Cancer Research136 citations Open access
Semantic Scholar
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
C. Baer, Rainer Claus, Christoph Plass, Alexei Vazquez +60 more
2013Cancer Research103 citations Open access
Semantic Scholar
Exploiting methionine restriction for cancer treatment.
Sushma Chaturvedi, R. Hoffman, J. Bertino
2018Biochemical Pharmacology84 citations
Semantic Scholar
NAD+ Kinase as a Therapeutic Target in Cancer
Philip M. Tedeschi, Nitu Bansal, J. Kerrigan, E. Abali +2 more
2016Clinical Cancer Research84 citations Open access
Semantic Scholar
NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview
A. A. Pramono, G. Rather, Herry Herman, K. Lestari +1 more
2020Biomolecules82 citations Open access
Semantic Scholar
Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers
K. Hirshfield, Denis Tolkunov, H. Zhong, Siraj M. Ali +26 more
2016The Oncologist80 citations Open access
Semantic Scholar
Functional annotation of rare gene aberration drivers of pancreatic cancer
Y. Tsang, Turgut Dogruluk, Philip M. Tedeschi, Joanna Wardwell-Ozgo +20 more
2016Nature Communications80 citations Open access
Semantic Scholar
Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma
K. Capaccione, Xue-Hui Hong, Katherine M Morgan, Wenyu Liu +8 more
2014OncoTarget80 citations Open access
Semantic Scholar
In cancer, all roads lead to NADPH.
G. Rather, A. A. Pramono, Z. Székely, J. Bertino +1 more
2021Pharmacology and Therapeutics77 citations
Semantic Scholar
ABT-199, a BH3 mimetic that specifically targets Bcl-2, enhances the antitumor activity of chemotherapy, bortezomib and JQ1 in “double hit” lymphoma cells
N. Johnson-Farley, Jonny Veliz, S. Bhagavathi, J. Bertino
2015Leukemia and Lymphoma75 citations
Semantic Scholar
Small Molecule Inhibitors that Disrupt the MTDH-SND1 Complex Suppress Breast Cancer Progression and Metastasis
Minhong Shen, Yong Wei, Hahn Kim, L. Wan +17 more
2021Nature Cancer70 citations Open access
Semantic Scholar
Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment
Jessica Wagner, C. Kline, Lan-Lan Zhou, K. Campbell +13 more
2018Journal of Clinical Investigation68 citations Open access
Semantic Scholar
Mitochondrial Methylene Tetrahydrofolate Dehydrogenase (MTHFD2) Overexpression is Associated with Tumor Cell Proliferation and is a Novel Target for Drug Development
Philip M. Tedeschi, A. Vazquez, J. Kerrigan, J. Bertino
2015Molecular Cancer Research65 citations Open access
Semantic Scholar
Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration
M. Stein, J. Malhotra, R. Tarapore, U. Malhotra +30 more
2019Journal of Immunotherapy for Cancer63 citations Open access
Semantic Scholar
Toward point-of-care assessment of patient response: a portable tool for rapidly assessing cancer drug efficacy using multifrequency impedance cytometry and supervised machine learning
Karan Ahuja, G. Rather, Zhongtian Lin, Jianye Sui +4 more
2019Microsystems & Nanoengineering63 citations Open access
Semantic Scholar
Gamma secretase inhibition by BMS-906024 enhances efficacy of paclitaxel in lung adenocarcinoma
Katherine M Morgan, B. Fischer, F. Lee, Jamie J. Shah +5 more
2017Molecular Cancer Therapeutics57 citations Open access
Semantic Scholar
BMI-1 targeting interferes with patient-derived tumor-initiating cell survival and tumor growth in prostate cancer
Nitu Bansal, M. Bartucci, S. Yusuff, Stephani A. Davis +16 more
2016Clinical Cancer Research54 citations Open access
Semantic Scholar
Enrichment of human prostate cancer cells with tumor initiating properties in mouse and zebrafish xenografts by differential adhesion
Nitu Bansal, Stephani A. Davis, I. Tereshchenko, T. Budak-Alpdogan +6 more
2013The Prostate54 citations Open access
Semantic Scholar
Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity
S. Kimani, Sushil Kumar, Nitu Bansal, Kamalendra Singh +8 more
2017Scientific Reports50 citations Open access
Semantic Scholar
Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy
Philip M. Tedeschi, Hongxia Lin, M. Gounder, J. Kerrigan +3 more
2015Molecular Pharmacology41 citations Open access
Semantic Scholar
Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells
Nitu Bansal, P. Mishra, M. Stein, R. DiPaola +1 more
2015OncoTarget38 citations Open access
Semantic Scholar
Zinc Metallochaperones Reactivate Mutant p53 Using an ON/OFF Switch Mechanism
Xin Yu, Samuel Kogan, Ying Chen, Ashley T. Tsang +10 more
2018Clinical Cancer Research36 citations Open access
Semantic Scholar
A phase I trial of MK-2206 and hydroxychloroquine in patients with advanced solid tumors
J. Mehnert, A. Kaveney, J. Malhotra, K. Spencer +11 more
2019Cancer Chemotherapy and Pharmacology29 citations
Semantic Scholar
Darinaparsin Inhibits Prostate Tumor–Initiating Cells and Du145 Xenografts and Is an Inhibitor of Hedgehog Signaling
Nitu Bansal, Nadine Johnson Farley, Lisa Y. Wu, Jonathan J. Lewis +2 more
2014Molecular Cancer Therapeutics28 citations Open access
Semantic Scholar
Rapid Assessment of Surface Markers on Cancer Cells Using Immuno-Magnetic Separation and Multi-frequency Impedance Cytometry for Targeted Therapy
Zhongtian Lin, Siang-Yo Lin, Pengfei Xie, Chen-Yong Lin +3 more
2020Scientific Reports27 citations Open access
Semantic Scholar
LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes*
K. DiFranco, N. Johnson-Farley, J. Bertino, D. Elson +3 more
2015Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis21 citations Open access
Semantic Scholar
Quantification of folate metabolism using transient metabolic flux analysis
Philip M. Tedeschi, N. Johnson-Farley, Hongxia Lin, Laura M. Shelton +5 more
2015Cancer & Metabolism21 citations Open access
Semantic Scholar
Antitumor and modeling studies of a penetratin-peptide that targets E2F-1 in small cell lung cancer
Xiaoqi Xie, J. Kerrigan, T. Minko, O. Garbuzenko +8 more
2013Cancer Biology & Therapy19 citations Open access
Semantic Scholar
6-thioguanine: a drug with unrealized potential for cancer therapy.
P. Munshi, M. Lubin, J. Bertino
2014The Oncologist16 citations Open access
Semantic Scholar
Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts
Philip M. Tedeschi, Yamini K. Kathari, I. Farooqi, J. Bertino
2014Cancer Chemotherapy and Pharmacology16 citations Open access
Semantic Scholar
Activated matriptase as a target to treat breast cancer with a drug conjugate
G. Rather, Siang-Yo Lin, Hongxia Lin, Whitney A. Banach-Petrosky +5 more
2018OncoTarget13 citations Open access
Semantic Scholar
A novel peptide that inhibits E2F transcription and regresses prostate tumor xenografts
Xiaoqi Xie, Nitu Bansal, Tazeem Shaik, J. Kerrigan +7 more
2014OncoTarget13 citations Open access
Semantic Scholar
2D Magnetic Sensor Array for Real-time Cell Tracking and Multi-site Detection with Increased Robustness and Flow-rate
Hao Tang, S. Venkatesh, Zhongtian Lin, Xuyang Lu +6 more
2019IEEE Custom Integrated Circuits Conference10 citations
Semantic Scholar
Modeling and antitumor studies of a modified L–penetratin peptide targeting E2F in lung cancer and prostate cancer
Tazeem Shaik, G. Rather, Nitu Bansal, T. Minko +7 more
2018OncoTarget10 citations Open access
Semantic Scholar
Translational Research of PT-112, a Clinical Agent in Advanced Phase I Development: Evident Bone Tropism, Synergy In Vitro with Bortezomib and Lenalidomide , and Potent Efficacy in the Vk*MYC Mouse Model of Multiple Myeloma
T. Ames, Meaghen E. Sharik, G. Rather, G. Hochart +9 more
20178 citations
Semantic Scholar
Landmark Study: The Relation of Solar Radiation to Cancer Mortality in North America.
J. Bertino
2016Cancer Research7 citations Open access
Semantic Scholar
Checking in on Lenalidomide in Diffuse Large B Cell Lymphoma.
M. Goldfinger, Mi-Na L. Xu, J. Bertino, D. Cooper
2019Clinical Lymphoma, Myeloma & Leukemia6 citations
Semantic Scholar
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells
Philip M. Tedeschi, E. Markert, M. Gounder, Hongxia Lin +10 more
2013Cell Death and Disease6 citations Open access
Semantic Scholar
Anti-Tumor Effects of a Penetratin Peptide Targeting Transcription of E2F-1, 2 and 3a Is Enhanced When Used in Combination with Pemetrexed or Cisplatin
G. Rather, Michael Anyanwu, T. Minko, O. Garbuzenko +2 more
2021Cancers5 citations Open access
Semantic Scholar
A Novel Antibody-Toxin Conjugate to Treat Mantle Cell Lymphoma
G. Rather, Siang-Yo Lin, Hongxia Lin, Z. Székely +1 more
2019Frontiers in Oncology5 citations Open access
Semantic Scholar
A sensitive liquid chromatography–mass spectrometry bioanalytical assay for a novel anticancer candidate – ZMC1
Hongxia Lin, Xin Yu, Oliver S. Eng, B. Buckley +4 more
2015Biomedical chromotography5 citations Open access
Semantic Scholar
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates
S. Dolfi, L. Chan, Jean Qiu, Philip M. Tedeschi +4 more
2013Cancer & Metabolism5 citations Open access
Semantic Scholar
Abstract LB-209: D2-like dopamine receptor antagonism by ONC201 identified by confluence of computational, receptor binding, and clinical studies
N. Madhukar, O. Elemento, C. Benes, M. Garnett +11 more
20164 citations
Semantic Scholar
Impact of Empirically Eliminating 5-Fluorouracil Bolus and Leucovorin in Patients with Metastatic Colorectal Cancer Receiving First-Line Treatment with mFOLFOX6
Alexa J. Basilio, Anand B. Shah, K. Sommerer, S. Chehab +29 more
2021British Journal of Cancer Research3 citations Open access
Semantic Scholar
Methods to Study the Role of Methionine-Restricted Diet and Methioninase in Cancer Growth Control.
S. Chaturvedi, J. Bertino
2019Methods in molecular biology3 citations
Semantic Scholar
Safety and pharmacodynamics of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration.
M. Stein, J. Malhotra, U. Malhotra, A. Silk +16 more
20183 citations
Semantic Scholar

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