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C. L. Kline · SciRah

Researcher profile · Semantic Scholar

C. L. Kline

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C. L. Kline — researcher profile on SciRah

h-index: 19
Works: 50
Citations: 1,118

Most-cited papers

ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
C. L. Kline, A. V. D. van den Heuvel, J. Allen, V. Prabhu +2 more
2016Science Signaling195 citations Open access
Semantic Scholar
Discovery and clinical introduction of first-in-class imipridone ONC201
J. Allen, C. L. Kline, V. Prabhu, Jessica Wagner +28 more
2016OncoTarget147 citations Open access
Semantic Scholar
Role of Dopamine Receptors in the Anticancer Activity of ONC201
C. L. Kline, Marie D. Ralff, Amriti R. Lulla, Jessica Wagner +4 more
2017Neoplasia108 citations Open access
Semantic Scholar
Small molecule NSC59984 restores p53 pathway signaling and anti-tumor effects against colorectal cancer via p73 activation and degradation of mutant p53
Sheng-Liang Zhang, Lan-Lan Zhou, Bo Hong, A. V. D. van den Heuvel +6 more
2015Cancer Research101 citations Open access
Semantic Scholar
Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212
Jessica Wagner, C. L. Kline, M. Ralff, Avital Lev +10 more
2017Cell Cycle70 citations Open access
Semantic Scholar
Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism
V. Prabhu, N. Madhukar, C. Gilvary, C. L. Kline +19 more
2018Clinical Cancer Research54 citations Open access
Semantic Scholar
ONC201 demonstrates anti-tumor effects in both triple negative and non-triple negative breast cancers through TRAIL-dependent and TRAIL-independent mechanisms
M. Ralff, C. L. Kline, Ozan C Küçükkase, Jessica Wagner +5 more
2017Molecular Cancer Therapeutics46 citations Open access
Semantic Scholar
The Akt inhibitor ISC-4 activates Prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model
Arun K. Sharma, C. L. Kline, A. Berg, S. Amin +1 more
2011Clinical Cancer Research46 citations Open access
Semantic Scholar
Delivery of PAR-4 plasmid in vivo via nanoliposomes sensitizes colon tumor cells subcutaneously implanted into nude mice to 5-FU
C. L. Kline, S. Shanmugavelandy, M. Kester, R. Irby
2009Cancer Biology & Therapy43 citations Open access
Semantic Scholar
The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity
Jessica Wagner, C. L. Kline, R. Pottorf, B. R. Nallaganchu +4 more
2014OncoTarget42 citations Open access
Semantic Scholar
Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors
V. Prabhu, Amriti R. Lulla, N. Madhukar, M. Ralff +12 more
2017PLoS ONE39 citations Open access
Semantic Scholar
Primary cell lines: false representation or model system? a comparison of four human colorectal tumors and their coordinately established cell lines.
Danielle M. Pastor, L. Poritz, T. Olson, C. L. Kline +4 more
2010International Journal of Clinical and Experimental Medicine39 citations
Semantic Scholar
Personalized dosing via pharmacokinetic monitoring of 5-fluorouracil might reduce toxicity in early- or late-stage colorectal cancer patients treated with infusional 5-fluorouracil-based chemotherapy regimens.
C. L. Kline, Angelique Schiccitano, Jun-Jia Zhu, Cheryl Beachler +10 more
2014Clinical colorectal cancer38 citations
Semantic Scholar
Personalizing Colon Cancer Therapeutics: Targeting Old and New Mechanisms of Action
C. L. Kline, W. El-Deiry
2013Pharmaceuticals24 citations Open access
Semantic Scholar
Par-4 as a potential target for cancer therapy
R. Irby, C. L. Kline
2013Expert opinion on therapeutic targets22 citations
Semantic Scholar
The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU
C. L. Kline, R. Irby
2011Apoptosis20 citations
Semantic Scholar
Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients
C. L. Kline, H. Sheikh, Angelique Scicchitano, R. Gingrich +5 more
2011Cancer Biology & Therapy20 citations Open access
Semantic Scholar
Src kinase induces tumor formation in the c‐SRC C57BL/6 mouse
C. L. Kline, Rosalind J. Jackson, R. Engelman, W. Pledger +2 more
2008International Journal of Cancer20 citations Open access
Semantic Scholar
Glucosamine-induced phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 is mediated by the protein kinase R-like endoplasmic-reticulum associated kinase.
C. L. Kline, Tabitha L. Schrufer, L. S. Jefferson, S. Kimball
2006International Journal of Biochemistry and Cell Biology19 citations
Semantic Scholar
Src activity alters α3 integrin expression in colon tumor cells
C. L. Kline, T. Olson, R. Irby
2008Clinical and Experimental Metastasis13 citations
Semantic Scholar
Overexpression of Prostate Apoptosis Response Protein-4 in Colon Cancer Cells Can Inhibit Metastasis By Upregulating E-cadherin Expression
J. Nguyen, C. L. Kline, Natalia Caballero, R. Irby
20153 citations Open access
Semantic Scholar
Correction: Discovery and clinical introduction of first-in-class imipridone ONC201
J. Allen, C. L. Kline, V. Prabhu, Jessica Wagner +28 more
2021OncoTarget2 citations Open access
Semantic Scholar
Resistance to TRAIL Pathway-Targeted Therapeutics in Cancer
Jessica Wagner, C. L. Kline, W. El-Deiry
20172 citations
Semantic Scholar
Abstract 2942: TRAIL pathway inducer ONC201/TIC10 primes multiple myeloma cells (MM) for apoptosis by downregulating X-linked inhibitor of apoptosis
C. L. Kline, Amriti R. Lulla, D. Dicker, J. Allen +1 more
20152 citations
Semantic Scholar
Small Molecule ONC201/TIC10 Induces Caspase-Dependent Apoptosis in Acute Lymphoblastic Leukemia Cells Via Modulation of Bcl-2 and IAP Family Proteins
V. Prabhu, Amriti R. Lulla, Jessica Wagner, Liz J. Hernandez-Borrero +8 more
20142 citations Open access
Semantic Scholar
Abstract 124: Imipridone ONC201 promotes intra-tumoral accumulation of CD3+/NK+ cells that contribute to its anti-tumor efficacy
Jessica Wagner, C. L. Kline, Lan-Lan Zhou, A. Zloza +6 more
20171 citations
Semantic Scholar
Single Agent and Combinatorial Efficacy of First-in-Class Small Molecule ONC201 in Acute Leukemia and Multiple Myeloma
V. Prabhu, Amriti R. Lulla, C. L. Kline, Pieter van den Heuvel +12 more
20161 citations
Semantic Scholar
Dose-intensified ONC201 to exert anti-metastatic efficacy and to promote intra-tumoral recruitment of NK-cells in mice.
Jessica Wagner, C. L. Kline, W. El-Deiry
20161 citations
Semantic Scholar
Abstract 3000: Intra-tumoral accumulation of NK1.1/CD3+ cells and anti-metastasis effects of dose-intensified ONC201 in tumor-bearing mice
Jessica Wagner, C. L. Kline, M. Baumeister, W. El-Deiry
20161 citations
Semantic Scholar
Caspase-Dependent Anti-Tumor Effects of ONC201/TIC10 on Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM)
Amriti R. Lulla, C. L. Kline, Liz J. Hernandez-Borrero, V. Prabhu +8 more
20141 citations
Semantic Scholar
Editor's Note: Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53.
Sheng-Liang Zhang, Lan-Lan Zhou, Bo Hong, A. V. D. van den Heuvel +6 more
2026Cancer Research0 citations
Semantic Scholar
Regulation and Role of Par-4 in Gastrointestinal Tumors
R. Irby, C. L. Kline, ArunK. Sharma
2021Tumor Suppressor Par-40 citations
Semantic Scholar
Abstract A060: Targeting DRD2 dysregulation in recurrent glioblastoma with imipridone ONC201: predictive and pharmacodynamic clinical biomarker analyses
V. Prabhu, N. Madhukar, C. L. Kline, R. Tarapore +10 more
20180 citations
Semantic Scholar
DRES-10. DRD5 IS A MODULATOR OF GLIOMA SUSCEPTIBILITY TO DRD2 ANTAGONISM BY ONC201
Varun Vijay Prabhu, N. Madhukar, C. Gilvary, C. L. Kline +9 more
2018Neuro-Oncology0 citations Open access
Semantic Scholar
Abstract 3857: Selective targeting of dopamine receptor dysregulation in high grade gliomas with imipridone ONC201
V. Prabhu, N. Madhukar, C. L. Kline, R. Tarapore +15 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
From TRAIL to ONC201: Case Study on the Safety Benefit of Developing Targeted Agents Against Cancer-selective Pathways
C. L. Kline, Jessica Wagner, Amriti R. Lulla, M. Ralff +8 more
2018Early Drug Development0 citations
Semantic Scholar
DDIS-08. THE SMALL MOLECULE IMIPRIDONE ONC201 IS ACTIVE IN GLIOBLASTOMA WITH DRD2 PATHWAY DYSREGULATION
V. Prabhu, N. Madhukar, C. L. Kline, R. Tarapore +11 more
20170 citations Open access
Semantic Scholar
Abstract 3245: Preclinical evaluation of the imipridone family of small molecules, including analogues of clinical-stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212
Jessica Wagner, C. L. Kline, G. L. Olson, B. R. Nallaganchu +5 more
20170 citations
Semantic Scholar
Abstract 3213: Antagonism of D2-like dopamine receptors plays a role in Onc201’s anticancer effects
C. L. Kline, Amriti R. Lulla, Jessica Wagner, D. Dicker +3 more
20170 citations
Semantic Scholar
Selective antagonism of the G protein-coupled receptor DRD2 contributes to the antitumor efficacy of small molecule ONC201
N. Madhukar, C. L. Kline, V. Prabhu, O. Elemento +5 more
20160 citations
Semantic Scholar
Abstract 3014: ONC201 anti-cancer effects against solid tumors are mediated through eIF2α kinases HRI and PKR but are PERK-independent
C. L. Kline, W. El-Deiry
20160 citations
Semantic Scholar
Abstract 2497: ONC201 targets cancer stem cells in colorectal, prostate and glioblastoma multiforme tumors via modulation of stem cell-related gene expression
V. Prabhu, J. Allen, Dan Zhao, Amriti R. Lulla +7 more
20160 citations
Semantic Scholar
Preclinical activity of new investigational drug ONC201 in triple-negative and non-triple negative and BRCA1-deficient breast cancer cells.
M. Baumeister, Jessica Wagner, V. Prabhu, C. L. Kline +3 more
20160 citations
Semantic Scholar
Abstract LB-A16: Novel Small Molecule ONC201 Induces Cell Death in Triple Negative and Non-triple Negative Breast Cancer Cells
M. Baumeister, Jessica Wagner, C. L. Kline, J. Allen +2 more
20150 citations
Semantic Scholar
Abstract 4499: Cytotoxicity, biochemical activity, and structural analysis of ONC201 and comparisons to a biologically inactive isomer
Jessica Wagner, C. L. Kline, R. Pottorf, B. R. Nallaganchu +4 more
20150 citations
Semantic Scholar
Abstract 674: Early integrated stress response induction of ATF4 is required for the anticancer effects of the dual Akt/ERK inhibitor and TRAIL pathway inducer ONC201/TIC10
C. L. Kline, Pieter van den Heuvel, J. Allen, D. Dicker +1 more
20150 citations
Semantic Scholar
Abstract 1802: Small molecule compound NCI-8 induces mutant p53 degradation via inhibition of the MDM2-Hsp90 axis
Sheng-Liang Zhang, Lan-Lan Zhou, C. L. Kline, D. Dicker +1 more
20140 citations
Semantic Scholar
Abstract 1176: Pharmacokinetic monitoring of 5-FU appears beneficial in stage II-IV colorectal cancer patients treated with different 5-FU-based chemotherapeutic regimens.
C. L. Kline, Angelique Schiccitano, Jay Zhu, Cheryl Beachler +10 more
20130 citations
Semantic Scholar
Potential of Prostate Apoptosis Response protein-4 (Par-4) in colon cancer therapy
C. L. Kline
20110 citations
Semantic Scholar
ISC-4 and Par-4 inhibit colon tumor growth 1 The Akt inhibitor ISC-4 activates Prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model
C. L. Kline, A. Berg, S. Amin, R. Irby
20110 citations
Semantic Scholar

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