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C. Ernest · SciRah

Researcher profile · Semantic Scholar

C. Ernest

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C. Ernest — researcher profile on SciRah

h-index: 22
Works: 40
Citations: 2,446

Most-cited papers

Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
J. Brandt, S. Close, S. Iturria, C. Payne +5 more
2007Journal of Thrombosis and Haemostasis779 citations Open access
Semantic Scholar
Cytochrome P450 3A Inhibition by Ketoconazole Affects Prasugrel and Clopidogrel Pharmacokinetics and Pharmacodynamics Differently
N. A. Farid, C. Payne, D. Small, K. Winters +5 more
2007Clinical pharmacology and therapy345 citations
Semantic Scholar
Increased Active Metabolite Formation Explains the Greater Platelet Inhibition With Prasugrel Compared to High-dose Clopidogrel
C. Payne, Y. Li, D. Small, C. Ernest +5 more
2007Journal of Cardiovascular Pharmacology179 citations Open access
Semantic Scholar
Effect of Potent CYP2D6 Inhibition by Paroxetine on Atomoxetine Pharmacokinetics
Donna J. Belle, C. Ernest, J. Sauer, Brian P. Smith +2 more
2002Journal of clinical pharmacology97 citations
Semantic Scholar
Effect of Atorvastatin on the Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel in Healthy Subjects
N. A. Farid, D. Small, C. Payne, J. Jakubowski +6 more
2008Pharmacotherapy96 citations
Semantic Scholar
Population Pharmacokinetic Analyses to Evaluate the Influence of Intrinsic and Extrinsic Factors on Exposure of Prasugrel Active Metabolite in TRITON‐TIMI 38
R. Wrishko, C. Ernest, D. Small, Y. Li +9 more
2009Journal of clinical pharmacology83 citations
Semantic Scholar
STOCHASTIC PREDICTION OF CYP3A-MEDIATED INHIBITION OF MIDAZOLAM CLEARANCE BY KETOCONAZOLE
J. Chien, A. Lucksiri, C. Ernest, J. Gorski +2 more
2006Drug Metabolism And Disposition79 citations
Semantic Scholar
Dose response of inhaled dry-powder insulin and dose equivalence to subcutaneous insulin lispro.
K. Rave, L. Nosek, A. de la Peña, M. Seger +4 more
2005Diabetes Care79 citations Open access
Semantic Scholar
Prasugrel pharmacokinetics and pharmacodynamics in subjects with moderate renal impairment and end‐stage renal disease
D. Small, R. Wrishko, C. Ernest, L. Ni +8 more
2009Journal of Clinical Pharmacy and Therapeutics75 citations Open access
Semantic Scholar
Donanemab Population Pharmacokinetics, Amyloid Plaque Reduction, and Safety in Participants with Alzheimer's Disease
I. Gueorguieva, B. Willis, L. Chua, K. Chow +5 more
2023Clinical pharmacology and therapy67 citations Open access
Semantic Scholar
Effect of ranitidine on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel
D. Small, N. A. Farid, Y. Li, C. Ernest +3 more
2008Current Medical Research and Opinion60 citations
Semantic Scholar
Inhibition of platelet aggregation with prasugrel and clopidogrel: An integrated analysis in 846 subjects
Y. Li, L. Ni, J. T. Brandt, D. Small +6 more
2009Platelets59 citations
Semantic Scholar
Prasugrel, a New Thienopyridine Antiplatelet Drug, Weakly Inhibits Cytochrome P450 2B6 in Humans
N. A. Farid, C. Payne, C. Ernest, Y. Li +3 more
2008Journal of clinical pharmacology58 citations
Semantic Scholar
Population pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in aspirin-treated patients with stable coronary artery disease
C. Ernest, D. Small, S. Rohatagi, D. E. Salazar +3 more
2008Journal of Pharmacokinetics and Pharmacodynamics54 citations
Semantic Scholar
Exenatide: effect of injection time on postprandial glucose in patients with Type 2 diabetes
H. Linnebjerg, P. Kothare, Z. Skrivanek, A. Peña +3 more
2006Diabetic Medicine54 citations
Semantic Scholar
Relationship Between Exposure to Prasugrel Active Metabolite and Clinical Outcomes in the TRITON‐TIMI 38 Substudy
Jeffrey S. Riesmeyer, D. E. Salazar, G. Weerakkody, L. Ni +7 more
2012Journal of clinical pharmacology50 citations
Semantic Scholar
Integrated Analysis of Pharmacokinetic Data Across Multiple Clinical Pharmacology Studies of Prasugrel, a New Thienopyridine Antiplatelet Agent
D. Small, Y. Li, C. Ernest, John H. April +5 more
2011Journal of clinical pharmacology36 citations
Semantic Scholar
Effect of rifampin on the pharmacokinetics and pharmacodynamics of prasugrel in healthy male subjects
N. A. Farid, J. Jakubowski, C. Payne, Y. Li +6 more
2009Current Medical Research and Opinion34 citations
Semantic Scholar
Dose/Exposure‐Response Modeling to Support Dosing Recommendation for Phase III Development of Baricitinib in Patients with Rheumatoid Arthritis
Xin Zhang, L. Chua, C. Ernest, W. Macias +2 more
2017CPT: Pharmacometrics & Systems Pharmacology32 citations Open access
Semantic Scholar
Inhaled micronized crystalline human insulin using a dry powder inhaler: dose‐response and time‐action profiles 1
K. Rave, L. Nosek, L. Heinemann, C. Gonzales +3 more
2004Diabetic Medicine30 citations
Semantic Scholar
Pharmacokinetics and pharmacodynamics of prasugrel in subjects with moderate liver disease
D. Small, N. A. Farid, Y.-G. Li, C. Ernest +3 more
2009Journal of Clinical Pharmacy and Therapeutics26 citations Open access
Semantic Scholar
Donanemab exposure and efficacy relationship using modeling in Alzheimer's disease
I. Gueorguieva, B. Willis, L. Chua, K. Chow +5 more
2023Alzheimer's & Dementia22 citations Open access
Semantic Scholar
Mechanism-Based Inactivation of CYP 3 A by HIV Protease Inhibitors
C. Ernest, S. Hall, David R. Jones
200518 citations
Semantic Scholar
Effect of Age on the Pharmacokinetics and Pharmacodynamics of Prasugrel during Multiple Dosing
D. Small, R. Wrishko, C. Ernest, L. Ni +5 more
2009Drugs & Aging14 citations
Semantic Scholar
Exposure-response relationship for ramucirumab (RAM) from the randomized, double-blind, phase III REVEL trial (docetaxel [DOC] vs DOC plus RAM) in second-line treatment of metastatic non-small cell lung cancer (NSCLC).
E. Smit, M. Pérol, M. Reck, F. Cappuzzo +10 more
20157 citations
Semantic Scholar
Abstract 4001: Relationship between Exposure to the Prasugrel Active Metabolite with TIMI Major/Minor Bleeding in TRITON-TIMI 38
D. Salazar, C. Ernest, R. Wrishko, G. Weerakkody +9 more
20084 citations
Semantic Scholar
Prediction of Prasugrel Active Metabolite Concentrations From 2 Downstream Inactive Metabolite Concentrations Using Multilinear Regression Analysis
C. Ernest, Michael A. Heathman, R. Wrishko
2009Journal of clinical pharmacology3 citations
Semantic Scholar
Optimal clinical trial design based on a dichotomous Markov-chain mixed-effect sleep model
C. Ernest, J. Nyberg, M. Karlsson, A. Hooker
2014Journal of Pharmacokinetics and Pharmacodynamics2 citations Open access
Semantic Scholar
Methodological Comparison of In Vitro Binding Parameter Estimation: Sequential vs. Simultaneous Non-linear Regression
C. Ernest, A. Hooker, M. Karlsson
2010Pharmaceutical Research2 citations
Semantic Scholar
CORRIGENDUM: Abstract PI-57: Pharmacokinetic/Pharmacodynamic Modeling of Inhibition of Serotonin and Norepinephrine Uptake by Duloxetine and -Escitalopram in Healthy Subjects
E. Lobo, C. Ernest, M. Detke, B. Pangallo +4 more
20092 citations
Semantic Scholar
Donanemab exposure‐efficacy relationship in patients with early symptomatic Alzheimer’s disease
I. Gueorguieva, L. Chua, K. Chow, C. Ernest +4 more
2023Alzheimer's & Dementia1 citations Open access
Semantic Scholar
PK/PD modeling links accelerated resolution of COVID‐19‐related clinical symptoms to SARS‐CoV‐2 viral load reduction in patients following treatment with Bamlanivimab alone or Bamlanivimab and Etesevimab together
C. Ernest, J. Chien, D. R. Patel, E. Chigutsa
2022CPT: Pharmacometrics & Systems Pharmacology1 citations Open access
Semantic Scholar
A REVIEW ON PROTEASE
A. Purohit, Dhwani Upadhyay, Ijbpas, Rodney Brown +32 more
2021International Journal of Biology Pharmacy and Allied Sciences1 citations Open access
Semantic Scholar
Optimal clinical trial design based on a dichotomous Markov-chain mixed-effect sleep model
C. Ernest, J. Nyberg, M. O. Karlsson, A. Hooker
2014Journal of Pharmacokinetics and Pharmacodynamics0 citations Open access
Semantic Scholar
Simultaneous optimal experimental design for in vitro binding parameter estimation
C. Ernest, M. Karlsson, A. Hooker
2013Journal of Pharmacokinetics and Pharmacodynamics0 citations
Semantic Scholar
Multinomial Markov-chain model of sleep architecture in Phase Advanced Subjects
C. Ernest, R. Bizzotto, D. DeBrota, L. Ni +3 more
20130 citations
Semantic Scholar
Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications
C. Ernest
20130 citations
Semantic Scholar
Simultaneous optimal experimental design for in vitro binding parameter estimation
C. Ernest, M. O. Karlsson, A. Hooker
2013Journal of Pharmacokinetics and Pharmacodynamics0 citations
Semantic Scholar
CORRIGENDUM: Abstract PI‐57: Pharmacokinetic/Pharmacodynamic Modeling of Inhibition of Serotonin and Norepinephrine Uptake by Duloxetine and Escitalopram in Healthy Subjects
E. Lobo, C. Ernest, MP Knadler, J. Chappell
20090 citations
Semantic Scholar
BASED INACTIVATION OF CYTOCHROME P 450 3 A ( CYP 3 A ) BY HIV PROTEASE INHIBITORSa
C. Ernest, S. Hall, David R. Jones
20040 citations
Semantic Scholar

Frequent co-authors

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D. Small×15
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D. Small — researcher profile on SciRah
K. Winters×13
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C. Payne×12
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C. Payne — researcher profile on SciRah
N. A. Farid×12
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D. E. Salazar — researcher profile on SciRah

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Y. Li — researcher profile on SciRah

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L. Ni — researcher profile on SciRah

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R. Wrishko — researcher profile on SciRah

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A. Hooker — researcher profile on SciRah

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S. Rohatagi — researcher profile on SciRah

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J. Jakubowski — researcher profile on SciRah