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K. Deshayes · SciRah

Researcher profile · Semantic Scholar

K. Deshayes

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K. Deshayes — researcher profile on SciRah

h-index: 35
Works: 80
Citations: 7,152

Most-cited papers

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.
E. Varfolomeev, J. Blankenship, S. Wayson, A. Fedorova +11 more
2007Cell957 citations Open access
Semantic Scholar
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
M. Lamkanfi, J. Mueller, Alberto C. Vitari, S. Misaghi +5 more
2009Journal of Cell Biology827 citations Open access
Semantic Scholar
c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation*
E. Varfolomeev, Tatiana Goncharov, A. Fedorova, Jasmin N. Dynek +4 more
2008Journal of Biological Chemistry510 citations Open access
Semantic Scholar
c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling
Jasmin N. Dynek, Tatiana Goncharov, E. Dueber, A. Fedorova +7 more
2010EMBO Journal365 citations Open access
Semantic Scholar
Structure-guided design of a selective BCL-X(L) inhibitor.
G. Lessene, P. Czabotar, B. Sleebs, K. Zobel +17 more
2013Nature Chemical Biology345 citations Open access
Semantic Scholar
cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production
N. Vanlangenakker, T. V. Berghe, P. Bogaert, B. Laukens +6 more
2011Cell Death and Differentiation341 citations Open access
Semantic Scholar
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
Zhi-Fu Tao, Lisa A. Hasvold, Le Wang, Xilu Wang +36 more
2014ACS Medicinal Chemistry Letters273 citations Open access
Semantic Scholar
The Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)
John A. Flygare, M. Beresini, N. Budha, H. Chan +38 more
2012Journal of Medicinal Chemistry244 citations Open access
Semantic Scholar
Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination
E. Dueber, A. Schoeffler, A. Lingel, J. Elliott +11 more
2011Science229 citations
Semantic Scholar
Cellular Inhibitors of Apoptosis Are Global Regulators of NF-κB and MAPK Activation by Members of the TNF Family of Receptors
E. Varfolomeev, Tatiana Goncharov, H. Maecker, K. Zobel +3 more
2012Science Signaling209 citations
Semantic Scholar
Exploring Protein–Protein Interactions with Phage Display
Sachdev S. Sidhu, W. Fairbrother, K. Deshayes
2003ChemBioChem196 citations
Semantic Scholar
Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
K. Zobel, Lan Wang, E. Varfolomeev, M. Franklin +7 more
2006ACS Chemical Biology179 citations Open access
Semantic Scholar
SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP)*
D. Vučić, K. Deshayes, H. Ackerly, M. Pisabarro +3 more
2002Journal of Biological Chemistry172 citations Open access
Semantic Scholar
The Erbin PDZ Domain Binds with High Affinity and Specificity to the Carboxyl Termini of δ-Catenin and ARVCF*
R. Laura, Andrea S. Witt, H. Held, R. Gerstner +5 more
2002Journal of Biological Chemistry153 citations Open access
Semantic Scholar
Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.
Toru Okamoto, K. Zobel, A. Fedorova, C. Quan +6 more
2013ACS Chemical Biology137 citations
Semantic Scholar
Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
D. Vučić, M. Franklin, H. Wallweber, K. Das +7 more
2005Biochemical Journal137 citations Open access
Semantic Scholar
Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).
J. Blankenship, E. Varfolomeev, Tatiana Goncharov, A. Fedorova +10 more
2009Biochemical Journal131 citations
Semantic Scholar
Improved Quantitative Mass Spectrometry Methods for Characterizing Complex Ubiquitin Signals
L. Phu, A. Izrael-Tomasevic, M. Matsumoto, D. Bustos +9 more
2010Molecular & Cellular Proteomics126 citations Open access
Semantic Scholar
OTUB1 modulates c‐IAP1 stability to regulate signalling pathways
Tatiana Goncharov, Kyle Niessen, M. C. de Almagro, A. Izrael-Tomasevic +6 more
2013EMBO Journal115 citations Open access
Semantic Scholar
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.
Tatiana Goncharov, Stefanie Hedayati, Melinda M. Mulvihill, A. Izrael-Tomasevic +11 more
2018Molecules and Cells112 citations Open access
Semantic Scholar
Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis.
B. Laukens, Claudia Jennewein, B. Schenk, N. Vanlangenakker +9 more
2011Neoplasia110 citations Open access
Semantic Scholar
Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.
C. Ndubaku, E. Varfolomeev, Lan Wang, K. Zobel +12 more
2009ACS Chemical Biology101 citations Open access
Semantic Scholar
Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP).
M. Franklin, S. Kadkhodayan, H. Ackerly, D. Alexandru +9 more
2003Biochemistry95 citations
Semantic Scholar
Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions.
F. Vajdos, M. Ultsch, M. Schaffer, K. Deshayes +3 more
2001Biochemistry95 citations
Semantic Scholar
Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner
L. Wagner, V. Marschall, S. Karl, S. Cristofanon +5 more
2013Oncogene94 citations
Semantic Scholar
Rapid identification of small binding motifs with high-throughput phage display: discovery of peptidic antagonists of IGF-1 function.
K. Deshayes, M. Schaffer, N. Skelton, G. Nakamura +2 more
2002Chemistry and Biology64 citations Open access
Semantic Scholar
Photodynamic transport of metal ions
J. Winkler, K. Deshayes, Bin Shao
198963 citations
Semantic Scholar
Synthesis of the helicopodands: novel shapes for chiral clefts
K. Deshayes, Richard D. Broene, I. Chao, C. Knobler +1 more
199156 citations
Semantic Scholar
Hybrid photoactive assemblies: electron injection from host-guest complexes into semiconductor nanoparticles.
C. Pagba, Giovanni Zordan, E. Galoppini, Eugene L Piatnitski +3 more
2004Journal of the American Chemical Society53 citations
Semantic Scholar
A Negative Activation Energy for Luminescence Decay: Specific Solvation Effects on the Emission Properties of Bis(2,2‘-bipyridine)(3,5-dicarboxy-2,2‘-bipyridine)ruthenium(II) Chloride
S. Fernando, U. Maharoof, K. Deshayes, T. Kinstle +1 more
199646 citations
Semantic Scholar
The development of peptide-based tools for the analysis of angiogenesis.
A. Fedorova, K. Zobel, H. Gill, A. Ogasawara +10 more
2011Chemistry and Biology43 citations Open access
Semantic Scholar
Remote intermolecular "heavy-atom effect": spin-orbit coupling across the wall of a hemicarcerand.
Z. S. Romanova, K. Deshayes, P. Piotrowiak
2001Journal of the American Chemical Society42 citations
Semantic Scholar
Host-guest complexation. 65. Hemicarcerands that encapsulate hydrocarbons with molecular weights greater than two hundred
D. Cram, R. Jaeger, K. Deshayes
199341 citations
Semantic Scholar
Requirement of nuclear factor κB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis.
Dominic Stadel, S. Cristofanon, B. A. Abhari, K. Deshayes +4 more
2011Neoplasia40 citations Open access
Semantic Scholar
Triplet Energy Transfer through the Walls of Hemicarcerands: Temperature Dependence and the Role of Internal Reorganization Energy
I. Place, Á. Farrán, K. Deshayes, P. Piotrowiak
199837 citations
Semantic Scholar
Complex with a phage display-derived peptide provides insight into the function of insulin-like growth factor I.
M. Schaffer, K. Deshayes, G. Nakamura, S. Sidhu +1 more
2003Biochemistry35 citations
Semantic Scholar
c-IAP 1 and UbcH 5 promote K 11-linked polyubiquitination of RIP 1 in TNF signaling
Jasmin N. Dynek, E. Dueber, A. Fedorova, A. Izrael-Tomasevic +7 more
201032 citations
Semantic Scholar
Novel Bcl-2 Homology-3 Domain-like Sequences Identified from Screening Randomized Peptide Libraries for Inhibitors of the Pro-survival Bcl-2 Proteins*
Erinna F. Lee, A. Fedorova, K. Zobel, M. Boyle +6 more
2009Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Hemicarceplexes That Release Guests upon Irradiation.
Evgueni L. Piatnitski, K. Deshayes
1998Angewandte Chemie29 citations
Semantic Scholar
Further insights into the effects of pre-organizing the BimBH3 helix.
Toru Okamoto, D. Segal, K. Zobel, A. Fedorova +6 more
2014ACS Chemical Biology27 citations
Semantic Scholar
A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.
P. Marinec, K. Landgraf, M. Uppalapati, Gang Chen +8 more
2021ACS Chemical Biology26 citations
Semantic Scholar
"Through Space" Triplet Energy Transfer: Movement of Electrons through the Hemicarcerand Skeleton
Á. Farrán, K. Deshayes, C. Matthews, I. Balanescu
199523 citations
Semantic Scholar
Electrostatic docking of a supramolecular host-guest assembly to cytochrome c probed by bidirectional photoinduced electron transfer.
Katarzyna I. Jankowska, C. Pagba, Eugene L. Piatnitski Chekler, K. Deshayes +1 more
2010Journal of the American Chemical Society22 citations
Semantic Scholar
Free Energy Dependence of Intermolecular Triplet Energy Transfer: Observation of the Inverted Region
Á. Farrán, K. Deshayes
199622 citations
Semantic Scholar
Characterization of ML-IAP protein stability and physiological role in vivo.
E. Varfolomeev, E. Moradi, Jasmin N. Dynek, J. Zha +6 more
2012Biochemical Journal20 citations
Semantic Scholar
Electron and excitation transfer in hetero-supramolecular assemblies and at moleculenanoparticle interfaces
P. Piotrowiak, K. Deshayes, Z. S. Romanova, C. Pagba +4 more
200320 citations Open access
Semantic Scholar
The SARS-CoV-2 Spike Protein D614G Mutation Shows Increasing Dominance and May Confer a Structural Advantage to the Furin Cleavage Domain
Le-Yan Tang, Allison Schulkins, Chun-Nan Chen, K. Deshayes +1 more
202017 citations Open access
Semantic Scholar
Evaluation of Assay Technologies for the Identification of Protein–Peptide Interaction Antagonists
S. Kadkhodayan, L. Elliott, Grace Mausisa, H. Wallweber +3 more
2007Assay and drug development technologies17 citations
Semantic Scholar
A new water soluble cyclophane host that is organized by calcium binding
K. L. Cole, M. Farrán, K. Deshayes
199217 citations
Semantic Scholar
Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers
Sonja C. Lueck, A. Russ, U. Botzenhardt, R. Schlenk +7 more
2016OncoTarget16 citations Open access
Semantic Scholar

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