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Laura J. Sharpe · SciRah

Researcher profile · Semantic Scholar

Laura J. Sharpe

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Laura J. Sharpe — researcher profile on SciRah

h-index: 30
Works: 72
Citations: 3,053

Most-cited papers

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)*
Laura J. Sharpe, Andrew J. Brown
2013Journal of Biological Chemistry373 citations Open access
Semantic Scholar
The Akt-SREBP nexus: cell signaling meets lipid metabolism.
J. Krycer, Laura J. Sharpe, Winnie Luu, Andrew J. Brown
2010Trends in endocrinology and metabolism344 citations
Semantic Scholar
The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway
N. Zelcer, Laura J. Sharpe, A. Loregger, Ika Kristiana +4 more
2014Molecular and Cellular Biology164 citations Open access
Semantic Scholar
DHCR7: A vital enzyme switch between cholesterol and vitamin D production.
A. V. Prabhu, Winnie Luu, Dianfan Li, Laura J. Sharpe +1 more
2016Progress in lipid research162 citations
Semantic Scholar
Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis.
Eser J. Zerenturk, Laura J. Sharpe, Elina Ikonen, Andrew J. Brown
2013Progress in lipid research154 citations
Semantic Scholar
Oxysterols: Old Tale, New Twists.
Winnie Luu, Laura J. Sharpe, Isabelle M. Capell-Hattam, I. Gelissen +1 more
2016Annual Review of Pharmacology and Toxicology144 citations Open access
Semantic Scholar
Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis*
Laura J. Sharpe, A. V. Prabhu, Winnie Luu, Andrew J. Brown
2016Journal of Biological Chemistry135 citations Open access
Semantic Scholar
The UPS and downs of cholesterol homeostasis.
Laura J. Sharpe, E. Cook, N. Zelcer, Andrew J. Brown
2014TIBS -Trends in Biochemical Sciences. Regular ed88 citations
Semantic Scholar
The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally[S]
Winnie Luu, Gene Hart-Smith, Laura J. Sharpe, Andrew J. Brown
2015Journal of Lipid Research86 citations Open access
Semantic Scholar
Oxysterols: From physiological tuners to pharmacological opportunities
Andrew J. Brown, Laura J. Sharpe, M. J. Rogers
2020British Journal of Pharmacology77 citations
Semantic Scholar
New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis.
Vicky Howe, Laura J. Sharpe, A. V. Prabhu, Andrew J. Brown
2017Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids77 citations
Semantic Scholar
Akt acutely activates the cholesterogenic transcription factor SREBP-2.
Winnie Luu, Laura J. Sharpe, J. Stevenson, Andrew J. Brown
2012Biochimica et Biophysica Acta75 citations Open access
Semantic Scholar
Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis[S]
Winnie Luu, Eser J. Zerenturk, Ika Kristiana, M. Bucknall +2 more
2014Journal of Lipid Research70 citations Open access
Semantic Scholar
Cholesterol homeostasis: How do cells sense sterol excess?
Vicky Howe, Laura J. Sharpe, Stephanie J. Alexopoulos, Sarah V Kunze +3 more
2016Chemistry and Physics of Lipids64 citations
Semantic Scholar
Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol
Ika Kristiana, Laura J. Sharpe, V. Catts, Louise Lutze-Mann +1 more
2010The Pharmacogenomics Journal63 citations Open access
Semantic Scholar
Akt Phosphorylates Sec24: New Clues into the Regulation of ER‐to‐Golgi Trafficking
Laura J. Sharpe, Winnie Luu, Andrew J. Brown
2011Traffic : the International Journal of Intracellular Transport59 citations Open access
Semantic Scholar
Cholesterol synthesis
Andrew J. Brown, H. Coates, Laura J. Sharpe
2021Biochemistry of Lipids, Lipoproteins and Membranes51 citations
Semantic Scholar
Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1
Hyeongsun Moon, Jayde E. Ruelcke, Eunju Choi, Laura J. Sharpe +10 more
2015OncoTarget51 citations Open access
Semantic Scholar
A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes
A. Loregger, E. Cook, J. Nelson, M. Moeton +6 more
2015Molecular and Cellular Biology49 citations Open access
Semantic Scholar
Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation
Laura J. Sharpe, Vicky Howe, Nicola A. Scott, Winnie Luu +4 more
2018Journal of Biological Chemistry46 citations Open access
Semantic Scholar
The role of signalling in cellular cholesterol homeostasis
Winnie Luu, Laura J. Sharpe, Ingrid C. Gelissen, Andrew J. Brown
2013IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology46 citations Open access
Semantic Scholar
The E3 Ubiquitin Ligases, HUWE1 and NEDD4-1, Are Involved in the Post-translational Regulation of the ABCG1 and ABCG4 Lipid Transporters*
Shereen M. Aleidi, Vicky Howe, Laura J. Sharpe, Alryel Yang +3 more
2015Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Post-translational control of the long and winding road to cholesterol.
Laura J. Sharpe, H. Coates, Andrew J. Brown
2020Journal of Biological Chemistry44 citations Open access
Semantic Scholar
The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis.
A. V. Prabhu, Laura J. Sharpe, Andrew J. Brown
2014Biochimica et Biophysica Acta40 citations
Semantic Scholar
Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory Element Binding Proteins.
Eser J. Zerenturk, Laura J. Sharpe, Andrew J. Brown
2012Biochimica et Biophysica Acta38 citations
Semantic Scholar
Cholesterol sensing by the ABCG1 lipid transporter: Requirement of a CRAC motif in the final transmembrane domain.
Laura J. Sharpe, G. Rao, Peter M. S. Jones, Elizabeth Glancey +4 more
2015Biochimica et Biophysica Acta36 citations
Semantic Scholar
Rapamycin down-regulates LDL-receptor expression independently of SREBP-2.
Laura J. Sharpe, Andrew J. Brown
2008Biochemical and Biophysical Research Communications - BBRC36 citations
Semantic Scholar
The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond.
Nicola A. Scott, Laura J. Sharpe, Andrew J. Brown
2020Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids33 citations
Semantic Scholar
Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis.
A. V. Prabhu, Winnie Luu, Laura J. Sharpe, Andrew J. Brown
2017Journal of Steroid Biochemistry and Molecular Biology32 citations
Semantic Scholar
The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages.
Shereen M. Aleidi, Alryel Yang, Laura J. Sharpe, G. Rao +5 more
2018Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids31 citations
Semantic Scholar
Norovirus RNA-Dependent RNA Polymerase Is Phosphorylated by an Important Survival Kinase, Akt
J. Eden, Laura J. Sharpe, P. White, Andrew J. Brown
2011Journal of Virology30 citations Open access
Semantic Scholar
The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6
Nicola A. Scott, Laura J. Sharpe, Isabelle M. Capell-Hattam, Samuel J. Gullo +2 more
2020Biochemical Journal29 citations Open access
Semantic Scholar
Is Seladin-1 Really a Selective Alzheimer's Disease Indicator?
Laura J. Sharpe, J. Wong, B. Garner, G. Halliday +1 more
2012Journal of Alzheimer's Disease28 citations Open access
Semantic Scholar
Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: studies of apolipoprotein E and VSVGt.
M. Kockx, D. Dinnes, Kuan-Yen Huang, Laura J. Sharpe +3 more
2012Biochemical Journal28 citations
Semantic Scholar
Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally
Isabelle M. Capell-Hattam, Laura J. Sharpe, Lydia Qian, Gene Hart-Smith +2 more
2020Journal of Biological Chemistry26 citations Open access
Semantic Scholar
Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6
Lydia Qian, Nicola A. Scott, Isabelle M. Capell-Hattam, Eliza Draper +4 more
2023Journal of Lipid Research22 citations Open access
Semantic Scholar
DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme
Eser J. Zerenturk, Laura J. Sharpe, Andrew J. Brown
2014Bioscience Reports22 citations Open access
Semantic Scholar
The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally
Isabelle M. Capell-Hattam, Nicole M. Fenton, H. Coates, Laura J. Sharpe +1 more
2022Journal of Lipid Research16 citations Open access
Semantic Scholar
Chapter 11 – Cholesterol Synthesis
Andrew J. Brown, Laura J. Sharpe
201616 citations
Semantic Scholar
Protein kinase A modulates the activity of a major human isoform of ABCG1[S]
I. Gelissen, Laura J. Sharpe, C. Sandoval, G. Rao +4 more
2012Journal of Lipid Research15 citations Open access
Semantic Scholar
Regulation of ABCG4 transporter expression by sterols and LXR ligands.
Alryel Yang, Amjad Z. Alrosan, Laura J. Sharpe, Andrew J. Brown +2 more
2020Biochimica et Biophysica Acta - General Subjects12 citations
Semantic Scholar
Balancing cholesterol metabolism in the liver and gut: perspectives in health and disease.
Yoshio Yamauchi, Laura J. Sharpe, Andrew J. Brown
2026Nature reviews: Gastroenterology & hepatology11 citations
Semantic Scholar
A lipidomic perspective on intermediates in cholesterol synthesis as indicators of disease status.
Laura J. Sharpe, Vicky Burns, Andrew J. Brown
2014Journal of genetics and genomics = Yi chuan xue bao10 citations
Semantic Scholar
Species variation in ABCG1 isoform expression: implications for the use of animal models in elucidating ABCG1 function.
Vicky Burns, Laura J. Sharpe, I. Gelissen, Andrew J. Brown
2013Atherosclerosis10 citations
Semantic Scholar
SC5D is the sixth enzyme in cholesterol biosynthesis targeted by the E3 ubiquitin ligase MARCHF6.
Nicole M. Fenton, Lydia Qian, Nicola A. Scott, Eloise G Paine +2 more
2024Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids9 citations Open access
Semantic Scholar
Neuronal growth regulator 1 (NEGR1) promotes the synaptic targeting of glutamic acid decarboxylase 65 (GAD65)
Fei-Fei Su, Grant Pfundstein, S. Sah, Shuyue Zhang +9 more
2024Journal of Neurochemistry8 citations
Semantic Scholar
Post-translational control of the long and winding road to cholesterol.
Laura J. Sharpe, H. Coates, Andrew J. Brown
2020Journal of Biological Chemistry8 citations Open access
Semantic Scholar
A paREDOX in the control of cholesterol biosynthesis
Nicole M. Fenton, Lydia Qian, Eloise G Paine, Laura J. Sharpe +1 more
2024Bioessays7 citations Open access
Semantic Scholar
Desmosterol in brain is elevated because DHCR24 needs REST for robust expression but REST is poorly expressed
G. Tint, Lu-xing Pan, Q. Shang, Laura J. Sharpe +3 more
2014Developmental Neuroscience6 citations Open access
Semantic Scholar
Refining sugar's involvement in cholesterol synthesis.
Nicole M. Fenton, Tina B Nguyen, Laura J. Sharpe, Andrew J. Brown
2022Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids5 citations
Semantic Scholar

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I. Gelissen×7
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A. V. Prabhu — researcher profile on SciRah

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Eser J. Zerenturk×4

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Vicky Howe — researcher profile on SciRah

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