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L. Coughlan · SciRah

Researcher profile · Semantic Scholar

L. Coughlan

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L. Coughlan — researcher profile on SciRah

h-index: 34
Works: 85
Citations: 3,829

Most-cited papers

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial
R. Nachbagauer, Jodi Feser, A. Naficy, D. Bernstein +29 more
2020Nature Medicine310 citations
Semantic Scholar
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
K. White, R. Rosales, S. Yıldız, Thomas Kehrer +22 more
2021Science290 citations Open access
Semantic Scholar
A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice.
Alec W. Freyn, Jamile Ramos da Silva, Victoria C. Rosado, C. Bliss +11 more
2020Molecular Therapy271 citations Open access
Semantic Scholar
Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection
Raveen Rathnasinghe, S. Strohmeier, Fatima Amanat, Virginia L. Gillespie +5 more
2020bioRxiv192 citations Open access
Semantic Scholar
Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens
R. Antrobus, L. Coughlan, T. Berthoud, Matthew D. J. Dicks +3 more
2013Molecular Therapy187 citations Open access
Semantic Scholar
Broadly neutralizing antibodies target a haemagglutinin anchor epitope
Jenna J. Guthmiller, Julianna Han, Henry A. Utset, Lei Li +29 more
2021Nature174 citations Open access
Semantic Scholar
ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome
A. Baker, R. Boyd, Daipayan Sarkar, Alicia Teijeira-Crespo +21 more
2021Science Advances156 citations Open access
Semantic Scholar
Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines
L. Coughlan
2020Frontiers in Immunology124 citations Open access
Semantic Scholar
Heterologous Two-Dose Vaccination with Simian Adenovirus and Poxvirus Vectors Elicits Long-Lasting Cellular Immunity to Influenza Virus A in Healthy Adults
L. Coughlan, S. Sridhar, R. Payne, M. Edmans +15 more
2018EBioMedicine123 citations Open access
Semantic Scholar
Tropism-Modification Strategies for Targeted Gene Delivery Using Adenoviral Vectors
L. Coughlan, R. Alba, A. Parker, A. Bradshaw +3 more
2010Viruses122 citations Open access
Semantic Scholar
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans
H. Dugan, Jenna J. Guthmiller, P. Arevalo, Min Huang +16 more
2020Science Translational Medicine116 citations Open access
Semantic Scholar
Coadministration of seasonal influenza vaccine and MVA-NP+M1 simultaneously achieves potent humoral and cell-mediated responses.
R. Antrobus, T. Berthoud, Caitlin E. Mullarkey, K. Hoschler +4 more
2014Molecular Therapy113 citations Open access
Semantic Scholar
Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors.
R. Alba, A. Bradshaw, L. Coughlan, L. Denby +12 more
2010Blood110 citations Open access
Semantic Scholar
A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses
Wei-Na Sun, Yonghong Liu, Fatima Amanat, I. González-Domínguez +21 more
2021Nature Communications106 citations Open access
Semantic Scholar
Requirements for Receptor Engagement during Infection by Adenovirus Complexed with Blood Coagulation Factor X
A. Bradshaw, A. Parker, M. Duffy, L. Coughlan +4 more
2010PLoS Pathogens89 citations Open access
Semantic Scholar
Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses
Jenna J. Guthmiller, L. Lan, M. Fernández-Quintero, Julianna Han +24 more
2020Immunity87 citations Open access
Semantic Scholar
Overcoming Barriers in the Path to a Universal Influenza Virus Vaccine.
L. Coughlan, P. Palese
2018Cell Host and Microbe85 citations Open access
Semantic Scholar
In Vivo Retargeting of Adenovirus Type 5 to αvβ6 Integrin Results in Reduced Hepatotoxicity and Improved Tumor Uptake following Systemic Delivery
L. Coughlan, S. Vallath, Antonio Saha, Magdalena B. Flak +5 more
2009Journal of Virology72 citations Open access
Semantic Scholar
Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model
Fatima Amanat, S. Strohmeier, Raveen Rathnasinghe, Michael Schotsaert +3 more
2021mBio69 citations Open access
Semantic Scholar
Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery
L. Coughlan, A. Bradshaw, A. Parker, H. Robinson +7 more
2012Molecular Therapy64 citations Open access
Semantic Scholar
Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine
S. Jangra, J. D. de Vrieze, Angela Choi, Raveen Rathnasinghe +18 more
2021Angewandte Chemie62 citations Open access
Semantic Scholar
Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions
A. Baker, Alexander Greenshields-Watson, L. Coughlan, James A. Davies +4 more
2018Nature Communications61 citations Open access
Semantic Scholar
Adenovirus-based vaccines—a platform for pandemic preparedness against emerging viral pathogens
L. Coughlan, E. Kremer, D. Shayakhmetov
2022Molecular Therapy53 citations Open access
Semantic Scholar
Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses
A. Bradshaw, L. Coughlan, A. Miller, R. Alba +3 more
2012Journal of Controlled Release42 citations Open access
Semantic Scholar
Targeting Antigen to the Surface of EVs Improves the In Vivo Immunogenicity of Human and Non-human Adenoviral Vaccines in Mice
C. Bliss, A. J. Parsons, R. Nachbagauer, Jennifer R. Hamilton +6 more
2019Molecular Therapy: Methods & Clinical Development41 citations Open access
Semantic Scholar
Chimeric hemagglutinin split vaccines elicit broadly cross-reactive antibodies and protection against group 2 influenza viruses in mice
E. Puente-Massaguer, K. Vasilev, A. Beyer, Madhumathi Loganathan +10 more
2023Science Advances38 citations Open access
Semantic Scholar
Adenoviral Vectors as Vaccines for Emerging Avian Influenza Viruses
Lucas J. Kerstetter, Stephen Buckley, C. Bliss, L. Coughlan
2021Frontiers in Immunology38 citations Open access
Semantic Scholar
The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells
Y. K. Stella Man, James A. Davies, L. Coughlan, Constantia Pantelidou +4 more
2018Molecular Cancer Therapeutics38 citations
Semantic Scholar
Pseudotyped αvβ6 integrin-targeted adenovirus vectors for ovarian cancer therapies
Hanni K. Uusi-Kerttula, James A. Davies, L. Coughlan, S. Hulin-Curtis +4 more
2016OncoTarget38 citations Open access
Semantic Scholar
Measuring Cellular Immunity to Influenza: Methods of Detection, Applications and Challenges
L. Coughlan, T. Lambe
2015Vaccines38 citations Open access
Semantic Scholar
Combined Fiber Modifications Both to Target αvβ6 and Detarget the Coxsackievirus–Adenovirus Receptor Improve Virus Toxicity Profiles In Vivo but Fail to Improve Antitumoral Efficacy Relative to Adenovirus Serotype 5
L. Coughlan, S. Vallath, A. Gros, M. Giménez-Alejandre +6 more
2012Human Gene Therapy38 citations Open access
Semantic Scholar
A single-shot adenoviral vaccine provides hemagglutinin stalk-mediated protection against heterosubtypic influenza challenge in mice
C. Bliss, Alec W. Freyn, Tom G. Caniels, V. Leyva-Grado +9 more
2022Molecular Therapy36 citations Open access
Semantic Scholar
Differential immunogenicity between HAdV-5 and chimpanzee adenovirus vector ChAdOx1 is independent of fiber and penton RGD loop sequences in mice
Matthew D. J. Dicks, Alexandra J. Spencer, L. Coughlan, K. Bauza +3 more
2015Scientific Reports36 citations Open access
Semantic Scholar
Gene delivery of a mutant TGFβ3 reduces markers of scar tissue formation after cutaneous wounding.
S. Waddington, Rachel A Crossley, V. Sheard, S. Howe +5 more
2010Molecular Therapy34 citations Open access
Semantic Scholar
Adenoviral vectors as novel vaccines for influenza
L. Coughlan, Caitlin E. Mullarkey, S. Gilbert
2015The Journal of pharmacy and pharmacology31 citations
Semantic Scholar
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models
P. Maisonnasse, Y. Aldon, Aurélien Marc, R. Marlin +47 more
2021Nature Communications29 citations Open access
Semantic Scholar
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models
R. Grand, P. Maisonnasse, Y. Aldon, Aurélien Marc +46 more
2021Research Square29 citations Open access
Semantic Scholar
Trivalent NDV-HXP-S Vaccine Protects against Phylogenetically Distant SARS-CoV-2 Variants of Concern in Mice
I. González-Domínguez, J. Martinez, S. Slamanig, Nicholas Lemus +12 more
2022Microbiology spectrum27 citations Open access
Semantic Scholar
The antibody landscapes following AS03 and MF59 adjuvanted H5N1 vaccination
J. Goll, A. Jain, T. L. Jensen, R. Assis +13 more
2022npj Vaccines24 citations Open access
Semantic Scholar
Introduction of two prolines and removal of the polybasic cleavage site leads to optimal efficacy of a recombinant spike based SARS-CoV-2 vaccine in the mouse model
Fatima Amanat, S. Strohmeier, Raveen Rathnasinghe, Michael Schotsaert +3 more
2020bioRxiv23 citations Open access
Semantic Scholar
RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine
S. Jangra, Gabriel Laghlali, Angela Choi, Raveen Rathnasinghe +6 more
2022Frontiers in Immunology22 citations Open access
Semantic Scholar
Vaccination with SARS-CoV-2 variants of concern protects mice from challenge with wild-type virus
Fatima Amanat, S. Strohmeier, P. Meade, Nicholas Dambrauskas +6 more
2021PLoS Biology21 citations Open access
Semantic Scholar
Immunity to Seasonal Coronavirus Spike Proteins Does Not Protect from SARS-CoV-2 Challenge in a Mouse Model but Has No Detrimental Effect on Protection Mediated by COVID-19 mRNA Vaccination
Fatima Amanat, J. Clark, J. Carreño, S. Strohmeier +8 more
2022bioRxiv17 citations Open access
Semantic Scholar
A chimeric haemagglutinin-based universal influenza virus vaccine boosts human cellular immune responses directed towards the conserved haemagglutinin stalk domain and the viral nucleoprotein
Carly M. Bliss, R. Nachbagauer, C. Mariottini, Frans Cuevas +11 more
2024EBioMedicine15 citations Open access
Semantic Scholar
Retargeting Adenovirus Serotype 48 Fiber Knob Domain by Peptide Incorporation
L. Coughlan, Hanni K. Uusi-Kerttula, Jiang-Tao Ma, B. Degg +2 more
2014Human Gene Therapy15 citations
Semantic Scholar
Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum
Estrella Lopez-Gordo, A. Doszpoly, M. Duffy, L. Coughlan +5 more
2017Journal of Virology14 citations Open access
Semantic Scholar
Long-lasting B cell convergence to distinct broadly reactive epitopes following vaccination with chimeric influenza virus hemagglutinins
Jenna J. Guthmiller, Linda Yu-Ling Lan, Lei Li, Yan-Bin Fu +33 more
2025Immunity13 citations Open access
Semantic Scholar
Enhancing the protection of influenza virus vaccines with BECC TLR4 adjuvant in aged mice
Robert E. Haupt, L. Baracco, Erin M. Harberts, Madhumathi Loganathan +5 more
2023Scientific Reports12 citations Open access
Semantic Scholar
Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies
J. Carreño, Jacqueline U. McDonald, Tara Hurst, P. Rigsby +22 more
2020Vaccines12 citations Open access
Semantic Scholar
Murine Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Neutralize Authentic Wild-Type SARS-CoV-2 as Well as B.1.1.7 and B.1.351 Viruses and Protect In Vivo in a Mouse Model in a Neutralization-Dependent Manner
Fatima Amanat, S. Strohmeier, W. Lee, S. Bangaru +3 more
2021mBio8 citations Open access
Semantic Scholar

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