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Laura L. Perissinotti · SciRah

Researcher profile · Semantic Scholar

Laura L. Perissinotti

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Laura L. Perissinotti — researcher profile on SciRah

h-index: 19
Works: 33
Citations: 984

Most-cited papers

Effects of the donor acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction
V. Stojković, Laura L. Perissinotti, D. Willmer, S. Benkovic +1 more
2012Journal of the American Chemical Society111 citations Open access
Semantic Scholar
Yield of Carboxyl Anion Radicals in the Photocatalytic Degradation of Formate over TiO2 Particles
Laura L. Perissinotti, M. Brusa, M. A. Grela
2001106 citations
Semantic Scholar
Modeling heme proteins using atomistic simulations.
D. Bikiel, L. Boechi, L. Capece, A. Crespo +8 more
2006Physical Chemistry, Chemical Physics - PCCP68 citations
Semantic Scholar
A microscopic study of the deoxyhemoglobin-catalyzed generation of nitric oxide from nitrite anion.
Laura L. Perissinotti, M. Marti, F. Doctorovich, F. J. Luque +1 more
2008Biochemistry65 citations Open access
Semantic Scholar
Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.
J. Lees-Miller, Ji-Qing Guo, Yibo Wang, Laura L. Perissinotti +2 more
2015Journal of Molecular and Cellular Cardiology64 citations
Semantic Scholar
A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal‐induced arrhythmias
Pei-Chi Yang, Laura L. Perissinotti, F. López-Redondo, Yibo Wang +7 more
2017Journal of Physiology50 citations Open access
Semantic Scholar
Small ligand-globin interactions: reviewing lessons derived from computer simulation.
L. Capece, L. Boechi, Laura L. Perissinotti, Pau Arroyo-Mañez +4 more
2013Biochimica et Biophysica Acta44 citations Open access
Semantic Scholar
Addition and redox reactivity of hydrogen sulfides (H2S/HS⁻) with nitroprusside: new chemistry of nitrososulfide ligands.
S. L. Quiroga, Alejandra E. Almaraz, V. Amorebieta, Laura L. Perissinotti +1 more
2011Chemistry43 citations
Semantic Scholar
Transnitrosation of nitrosothiols: characterization of an elusive intermediate.
Laura L. Perissinotti, A. Turjanski, D. Estrin, F. Doctorovich
2005Journal of the American Chemical Society43 citations
Semantic Scholar
A surprisingly stable S-nitrosothiol complex.
Laura L. Perissinotti, D. Estrin, G. Leitus, F. Doctorovich
2006Journal of the American Chemical Society42 citations
Semantic Scholar
Folate binding site of flavin-dependent thymidylate synthase
Eric M Koehn, Laura L. Perissinotti, Salah Moghram, Arjun Prabhakar +3 more
2012Proceedings of the National Academy of Sciences of the United States of America41 citations Open access
Semantic Scholar
Thiol redox biochemistry: insights from computer simulations
A. Zeida, Carlos M. A. Guardia, Pablo Lichtig, Laura L. Perissinotti +5 more
2014Biophysical Reviews35 citations Open access
Semantic Scholar
NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
Ji-Qing Guo, Yen May Cheng, J. Lees-Miller, Laura L. Perissinotti +7 more
2015Biophysical Journal30 citations Open access
Semantic Scholar
The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer
V. Stojković, Laura L. Perissinotti, Jeeyeon Lee, S. Benkovic +1 more
2010Chemical Communications30 citations Open access
Semantic Scholar
Role of the pH in state-dependent blockade of hERG currents
Yibo Wang, Ji-Qing Guo, Laura L. Perissinotti, J. Lees-Miller +4 more
2016Scientific Reports29 citations Open access
Semantic Scholar
The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain
Laura L. Perissinotti, Ji-Qing Guo, Meruyert Kudaibergenova, J. Lees-Miller +7 more
2019Molecular Pharmacology26 citations Open access
Semantic Scholar
Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study
Laura L. Perissinotti, Pablo M. De Biase, Ji-Qing Guo, Pei-Chi Yang +4 more
2018Frontiers in Physiology26 citations Open access
Semantic Scholar
Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.
Laura L. Perissinotti, Ji-Qing Guo, Pablo M. De Biase, Colleen E. Clancy +2 more
2015Biophysical Journal24 citations Open access
Semantic Scholar
A unique family of stable and water-soluble S-nitrosothiol complexes.
Laura L. Perissinotti, G. Leitus, L. Shimon, D. Estrin +1 more
2008Inorganic Chemistry23 citations Open access
Semantic Scholar
Lipid roles in hERG function and interactions with drugs.
Meruyert Kudaibergenova, Laura L. Perissinotti, S. Noskov
2019Neuroscience Letters19 citations
Semantic Scholar
Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators
Ji-Qing Guo, S. Durdağı, Mohamed M. Changalov, Laura L. Perissinotti +4 more
2014PLoS ONE18 citations Open access
Semantic Scholar
Computational Membrane Biophysics: From Ion Channels Interactions with Drugs to Cellular Function
Williams E. Miranda, Van A. Ngo, Laura L. Perissinotti, S. Noskov
2017Biochimica et Biophysica Acta - Proteins and Proteomics14 citations Open access
Semantic Scholar
Solvent effects on peroxynitrite structure and properties from QM/MM simulations.
M. C. González Lebrero, Laura L. Perissinotti, D. Estrin
2005Journal of Physical Chemistry A14 citations
Semantic Scholar
Computational Models for Understanding of Structure, Function and Pharmacology of the Cardiac Potassium Channel Kv11.1 (hERG).
Sören J. Wacker, S. Noskov, Laura L. Perissinotti
2017Current Topics in Medicinal Chemistry12 citations
Semantic Scholar
Electrospray ionization mass spectrometry of a novel family of complexes in which various nitroso compounds are stabilized via coordination to [IrCl5]2-.
Natalia Escola, F. Di Salvo, R. Haddad, Laura L. Perissinotti +2 more
2007Inorganic Chemistry4 citations Open access
Semantic Scholar
Coordinated nitroxyl anion is produced and released as nitrous oxide by the decomposition of iridium-coordinated nitrosothiols
Daniel Kazhdan, Laura L. Perissinotti, B. Watanabe, M. Eberlin +4 more
20113 citations Open access
Semantic Scholar
Understanding the Binding Mechanism of Ryanodine to the Open- and Closed States of the Ryanodine Receptor Pore
Williams E. Miranda, Van A. Ngo, Laura L. Perissinotti, S. R. Wayne Chen +1 more
20171 citations Open access
Semantic Scholar
Molecular Mechanisms of hERG Potassium Channel Interactions with Ivabradine: Importance of the Lipophilic Route
S. Noskov, H. Duff, Laura L. Perissinotti, Ji-Qing Guo +1 more
20180 citations Open access
Semantic Scholar
An in Silico Study of Female Susceptibility to Arousal-Induced Arrhythmias
Pei-Chi Yang, Yibo Wang, Laura L. Perissinotti, J. Kurokawa +4 more
20160 citations Open access
Semantic Scholar
In response to Melgari et al. "hERG potassium channel inhibition by ivabradine requires channel gating".
J. Lees-Miller, Ji-Qing Guo, Yibo Wang, Laura L. Perissinotti +2 more
2015Journal of Molecular and Cellular Cardiology0 citations
Semantic Scholar
Molecular Origins of State-Dependent Herg1 Blockade by Dofetilide
Yibo Wang, Laura L. Perissinotti, Ji-Qing Guo, H. Duff +1 more
20150 citations Open access
Semantic Scholar
Thiol redox biochemistry: insights from computer simulations
A. Zeida, Carlos M. A. Guardia, Pablo Lichtig, Laura L. Perissinotti +5 more
2014Biophysical Reviews0 citations Open access
Semantic Scholar
Modeling heme proteins using atomistic simulations w
D. Bikiel, L. Boechi, L. Capece, A. Crespo +7 more
20060 citations
Semantic Scholar

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